| | | |
| October 1, 2021 | L | Medicine Hat Tigers 0 at Swift Current Broncos 2 | Final |
| October 2, 2021 | L | Swift Current Broncos 3 at Medicine Hat Tigers 2 | Final |
| October 8, 2021 | W | Medicine Hat Tigers 4 at Red Deer Rebels 2 | Final |
| October 9, 2021 | W | Edmonton Oil Kings 2 at Medicine Hat Tigers 3 | Final (SO) |
| October 15, 2021 | L | Medicine Hat Tigers 0 at Saskatoon Blades 4 | Final |
| October 16, 2021 | L | Medicine Hat Tigers 2 at Prince Albert Raiders 3 | Final (SO) |
| October 19, 2021 | W | Swift Current Broncos 4 at Medicine Hat Tigers 5 | Final (OT) |
| October 22, 2021 | W | Prince Albert Raiders 2 at Medicine Hat Tigers 6 | Final |
| October 23, 2021 | L | Medicine Hat Tigers 4 at Edmonton Oil Kings 5 | Final |
| October 29, 2021 | L | Medicine Hat Tigers 3 at Moose Jaw Warriors 4 | Final (OT) |
| October 30, 2021 | L | Saskatoon Blades 4 at Medicine Hat Tigers 2 | Final |
| November 5, 2021 | L | Medicine Hat Tigers 2 at Swift Current Broncos 3 | Final |
| November 6, 2021 | L | Moose Jaw Warriors 3 at Medicine Hat Tigers 2 | Final (OT) |
| November 13, 2021 | L | Calgary Hitmen 4 at Medicine Hat Tigers 2 | Final |
| November 14, 2021 | L | Medicine Hat Tigers 3 at Calgary Hitmen 4 | Final (OT) |
| November 19, 2021 | L | Medicine Hat Tigers 3 at Lethbridge Hurricanes 7 | Final |
| November 20, 2021 | L | Winnipeg Ice 4 at Medicine Hat Tigers 2 | Final |
| November 23, 2021 | L | Regina Pats 6 at Medicine Hat Tigers 2 | Final |
| November 26, 2021 | L | Medicine Hat Tigers 4 at Brandon Wheat Kings 7 | Final |
| November 27, 2021 | L | Medicine Hat Tigers 2 at Winnipeg Ice 7 | Final |
| December 3, 2021 | L | Medicine Hat Tigers 2 at Edmonton Oil Kings 8 | Final |
| December 4, 2021 | L | Brandon Wheat Kings 4 at Medicine Hat Tigers 1 | Final |
| December 7, 2021 | L | Medicine Hat Tigers 4 at Brandon Wheat Kings 6 | Final |
| December 8, 2021 | L | Medicine Hat Tigers 2 at Regina Pats 4 | Final |
| December 11, 2021 | W | Medicine Hat Tigers 4 at Red Deer Rebels 3 | Final (SO) |
| December 17, 2021 | L | Medicine Hat Tigers 4 at Lethbridge Hurricanes 6 | Final |
| December 18, 2021 | L | Lethbridge Hurricanes 5 at Medicine Hat Tigers 3 | Final |
| December 28, 2021 | L | Medicine Hat Tigers 1 at Calgary Hitmen 3 | Final |
| December 30, 2021 | W | Calgary Hitmen 2 at Medicine Hat Tigers 3 | Final |
| January 1, 2022 | L | Winnipeg Ice 6 at Medicine Hat Tigers 1 | Final |
| January 2, 2022 | L | Medicine Hat Tigers 2 at Calgary Hitmen 4 | Final |
| January 8, 2022 | | Moose Jaw Warriors at Medicine Hat Tigers | Ppd. |
| January 9, 2022 | | Edmonton Oil Kings at Medicine Hat Tigers | Ppd. |
| January 12, 2022 | W | Brandon Wheat Kings 3 at Medicine Hat Tigers 4 | Final (OT) |
| January 14, 2022 | L | Medicine Hat Tigers 2 at Moose Jaw Warriors 6 | Final |
| January 15, 2022 | L | Lethbridge Hurricanes 6 at Medicine Hat Tigers 3 | Final |
| January 16, 2022 | L | Red Deer Rebels 5 at Medicine Hat Tigers 2 | Final |
| January 21, 2022 | L | Medicine Hat Tigers 2 at Saskatoon Blades 9 | Final |
| January 22, 2022 | W | Medicine Hat Tigers 6 at Prince Albert Raiders 4 | Final |
| January 25, 2022 | | Saskatoon Blades at Medicine Hat Tigers | Ppd. |
| January 29, 2022 | L | Calgary Hitmen 6 at Medicine Hat Tigers 5 | Final |
| January 30, 2022 | W | Red Deer Rebels 2 at Medicine Hat Tigers 3 | Final |
| February 2, 2022 | L | Medicine Hat Tigers 2 at Edmonton Oil Kings 6 | Final |
| February 4, 2022 | | Medicine Hat Tigers at Brandon Wheat Kings | Ppd. |
| February 5, 2022 | | Medicine Hat Tigers at Winnipeg Ice | Ppd. |
| February 5, 2022 | L | Moose Jaw Warriors 5 at Medicine Hat Tigers 2 | Final |
| February 6, 2022 | | Medicine Hat Tigers at Winnipeg Ice | Ppd. |
| February 12, 2022 | L | Edmonton Oil Kings 5 at Medicine Hat Tigers 3 | Final |
| February 16, 2022 | L | Brandon Wheat Kings 4 at Medicine Hat Tigers 1 | Final |
| February 18, 2022 | L | Medicine Hat Tigers 2 at Swift Current Broncos 7 | Final |
| February 19, 2022 | L | Lethbridge Hurricanes 2 at Medicine Hat Tigers 1 | Final |
| February 21, 2022 | L | Prince Albert Raiders 4 at Medicine Hat Tigers 1 | Final |
| February 23, 2022 | L | Medicine Hat Tigers 0 at Regina Pats 2 | Final |
| February 25, 2022 | L | Winnipeg Ice 6 at Medicine Hat Tigers 2 | Final |
| February 26, 2022 | L | Medicine Hat Tigers 2 at Lethbridge Hurricanes 9 | Final |
| March 1, 2022 | L | Red Deer Rebels 11 at Medicine Hat Tigers 1 | Final |
| March 2, 2022 | L | Medicine Hat Tigers 2 at Edmonton Oil Kings 5 | Final |
| March 5, 2022 | W | Swift Current Broncos 0 at Medicine Hat Tigers 2 | Final |
| March 9, 2022 | L | Edmonton Oil Kings 7 at Medicine Hat Tigers 3 | Final |
| March 11, 2022 | L | Medicine Hat Tigers 3 at Red Deer Rebels 6 | Final |
| March 12, 2022 | L | Red Deer Rebels 6 at Medicine Hat Tigers 2 | Final |
| March 15, 2022 | W | Regina Pats 4 at Medicine Hat Tigers 5 | Final (SO) |
| March 18, 2022 | L | Medicine Hat Tigers 1 at Swift Current Broncos 5 | Final |
| March 19, 2022 | L | Swift Current Broncos 2 at Medicine Hat Tigers 0 | Final |
| March 25, 2022 | L | Medicine Hat Tigers 0 at Red Deer Rebels 3 | Final |
| March 26, 2022 | L | Calgary Hitmen 2 at Medicine Hat Tigers 0 | Final |
| March 30, 2022 | L | Medicine Hat Tigers 2 at Calgary Hitmen 3 | Final |
| April 1, 2022 | L | Medicine Hat Tigers 3 at Lethbridge Hurricanes 6 | Final |
| April 2, 2022 | L | Lethbridge Hurricanes 6 at Medicine Hat Tigers 1 | Final |
| April 5, 2022 | L | Saskatoon Blades 4 at Medicine Hat Tigers 0 | Final |
| April 8, 2022 | L | Medicine Hat Tigers 3 at Brandon Wheat Kings 6 | Final |
| April 9, 2022 | L | Medicine Hat Tigers 1 at Winnipeg Ice 6 | Final |
| April 10, 2022 | L | Medicine Hat Tigers 2 at Winnipeg Ice 8 | Final |
| April 15, 2022 | L | Edmonton Oil Kings 3 at Medicine Hat Tigers 0 | Final |
Medicine Hat Tigers Schedule
