| | | |
| December 12, 2020 | L | Indy Fuel 3 at Wheeling Nailers 2 | Final |
| December 18, 2020 | L | Orlando Solar Bears 4 at Wheeling Nailers 2 | Final |
| December 19, 2020 | L | Orlando Solar Bears 3 at Wheeling Nailers 2 | Final (OT) |
| December 26, 2020 | L | Wheeling Nailers 1 at Indy Fuel 2 | Final (OT) |
| December 27, 2020 | L | Indy Fuel 4 at Wheeling Nailers 3 | Final |
| December 31, 2020 | W | Indy Fuel 3 at Wheeling Nailers 4 | Final |
| January 2, 2021 | L | Wheeling Nailers 4 at Indy Fuel 5 | Final (OT) |
| January 3, 2021 | | Wheeling Nailers at Indy Fuel | 1:05 p.m. |
| January 6, 2021 | W | Wheeling Nailers 5 at Greenville Swamp Rabbits 4 | Final (OT) |
| January 8, 2021 | L | Wheeling Nailers 2 at South Carolina Stingrays 4 | Final |
| January 9, 2021 | L | Wheeling Nailers 3 at South Carolina Stingrays 6 | Final |
| January 22, 2021 | | South Carolina Stingrays at Wheeling Nailers | Ppd. |
| January 23, 2021 | | South Carolina Stingrays at Wheeling Nailers | Ppd. |
| January 24, 2021 | | South Carolina Stingrays at Wheeling Nailers | Ppd. |
| January 30, 2021 | L | Indy Fuel 5 at Wheeling Nailers 4 | Final |
| January 31, 2021 | W | Wheeling Nailers 4 at Indy Fuel 3 | Final (OT) |
| February 4, 2021 | L | Tulsa Oilers 4 at Wheeling Nailers 2 | Final |
| February 5, 2021 | L | Tulsa Oilers 3 at Wheeling Nailers 2 | Final |
| February 10, 2021 | L | Wheeling Nailers 1 at Indy Fuel 2 | Final (OT) |
| February 12, 2021 | W | Fort Wayne Komets 2 at Wheeling Nailers 3 | Final (SO) |
| February 13, 2021 | W | Fort Wayne Komets 3 at Wheeling Nailers 4 | Final (OT) |
| February 14, 2021 | L | Indy Fuel 6 at Wheeling Nailers 1 | Final |
| February 19, 2021 | L | Wheeling Nailers 1 at Fort Wayne Komets 4 | Final |
| February 20, 2021 | L | Wheeling Nailers 2 at Fort Wayne Komets 4 | Final |
| February 21, 2021 | L | Wheeling Nailers 2 at Fort Wayne Komets 6 | Final |
| February 24, 2021 | L | Indy Fuel 4 at Wheeling Nailers 1 | Final |
| February 26, 2021 | W | Utah Grizzlies 2 at Wheeling Nailers 5 | Final |
| February 27, 2021 | L | Utah Grizzlies 4 at Wheeling Nailers 3 | Final |
| February 28, 2021 | W | Utah Grizzlies 1 at Wheeling Nailers 6 | Final |
| March 3, 2021 | L | Wheeling Nailers 0 at Indy Fuel 6 | Final |
| March 5, 2021 | L | Wheeling Nailers 2 at Fort Wayne Komets 4 | Final |
| March 6, 2021 | L | Wheeling Nailers 3 at Fort Wayne Komets 5 | Final |
| March 9, 2021 | W | Indy Fuel 0 at Wheeling Nailers 6 | Final |
| March 12, 2021 | L | Fort Wayne Komets 3 at Wheeling Nailers 2 | Final (OT) |
| March 13, 2021 | L | Fort Wayne Komets 3 at Wheeling Nailers 2 | Final |
| March 14, 2021 | L | Wheeling Nailers 1 at Indy Fuel 3 | Final |
| March 19, 2021 | L | Wichita Thunder 3 at Wheeling Nailers 2 | Final |
| March 20, 2021 | W | Wichita Thunder 1 at Wheeling Nailers 7 | Final |
| March 21, 2021 | L | Wichita Thunder 6 at Wheeling Nailers 4 | Final |
| March 24, 2021 | W | Wheeling Nailers 6 at Florida Everblades 2 | Final |
| March 26, 2021 | L | Wheeling Nailers 2 at Florida Everblades 5 | Final |
| March 27, 2021 | L | Wheeling Nailers 3 at Florida Everblades 5 | Final |
| April 1, 2021 | W | Jacksonville Icemen 3 at Wheeling Nailers 5 | Final |
| April 2, 2021 | W | Wheeling Nailers 2 at Indy Fuel 1 | Final |
| April 3, 2021 | W | Wheeling Nailers 6 at Fort Wayne Komets 3 | Final |
| April 7, 2021 | W | Fort Wayne Komets 3 at Wheeling Nailers 4 | Final (OT) |
| April 9, 2021 | L | South Carolina Stingrays 3 at Wheeling Nailers 2 | Final (SO) |
| April 10, 2021 | | South Carolina Stingrays at Wheeling Nailers | Susp. |
| April 11, 2021 | | South Carolina Stingrays at Wheeling Nailers | Cancelled |
| April 12, 2021 | | South Carolina Stingrays at Wheeling Nailers | Cancelled |
| April 14, 2021 | W | Indy Fuel 1 at Wheeling Nailers 3 | Final |
| April 15, 2021 | | Wheeling Nailers at Indy Fuel | Ppd. |
| April 16, 2021 | L | Wheeling Nailers 2 at Fort Wayne Komets 6 | Final |
| April 18, 2021 | W | Fort Wayne Komets 3 at Wheeling Nailers 5 | Final |
| April 23, 2021 | L | Wheeling Nailers 2 at Fort Wayne Komets 5 | Final |
| April 24, 2021 | L | Wheeling Nailers 2 at Fort Wayne Komets 7 | Final |
| April 25, 2021 | W | Fort Wayne Komets 3 at Wheeling Nailers 5 | Final |
| April 28, 2021 | | Indy Fuel at Wheeling Nailers | Ppd. |
| April 30, 2021 | L | Wheeling Nailers 1 at Fort Wayne Komets 3 | Final |
| May 1, 2021 | L | Fort Wayne Komets 6 at Wheeling Nailers 2 | Final |
| May 2, 2021 | | Indy Fuel at Wheeling Nailers | Ppd. |
| May 7, 2021 | L | Wheeling Nailers 1 at Jacksonville Icemen 3 | Final |
| May 8, 2021 | W | Wheeling Nailers 8 at Jacksonville Icemen 5 | Final |
| May 9, 2021 | L | Wheeling Nailers 3 at Jacksonville Icemen 6 | Final |
| May 12, 2021 | W | Wheeling Nailers 4 at Fort Wayne Komets 3 | Final |
| May 14, 2021 | L | Wheeling Nailers 1 at Fort Wayne Komets 2 | Final |
| May 15, 2021 | L | Greenville Swamp Rabbits 2 at Wheeling Nailers 1 | Final |
| May 16, 2021 | L | Greenville Swamp Rabbits 6 at Wheeling Nailers 3 | Final |
| May 21, 2021 | L | Wheeling Nailers 2 at Greenville Swamp Rabbits 5 | Final |
| May 22, 2021 | L | Wheeling Nailers 3 at Greenville Swamp Rabbits 4 | Final (OT) |
| May 23, 2021 | W | Wheeling Nailers 4 at Greenville Swamp Rabbits 2 | Final |
| May 26, 2021 | W | Indy Fuel 1 at Wheeling Nailers 5 | Final |
| May 28, 2021 | L | Wheeling Nailers 0 at South Carolina Stingrays 1 | Final |
| May 29, 2021 | L | Wheeling Nailers 2 at South Carolina Stingrays 6 | Final |
| May 30, 2021 | L | Wheeling Nailers 2 at Greenville Swamp Rabbits 3 | Final |
| June 1, 2021 | L | Wheeling Nailers 1 at South Carolina Stingrays 3 | Final |
| June 4, 2021 | L | Indy Fuel 3 at Wheeling Nailers 1 | Final |
| June 5, 2021 | W | Indy Fuel 2 at Wheeling Nailers 5 | Final |
Wheeling Nailers Schedule
