| | | |
| March 3, 2018 | Columbus Crew SC 2 at Toronto FC 0 | Final |
| March 3, 2018 | Atlanta United FC 0 at Houston Dynamo 4 | Final |
| March 3, 2018 | New England Revolution 0 at Philadelphia Union 2 | Final |
| March 3, 2018 | D.C. United 1 at Orlando City SC 1 | Final |
| March 3, 2018 | Real Salt Lake 1 at FC Dallas 1 | Final |
| March 3, 2018 | Minnesota United FC 2 at San Jose Earthquakes 3 | Final |
| March 4, 2018 | Los Angeles FC 1 at Seattle Sounders FC 0 | Final |
| March 4, 2018 | Montreal Impact 1 at Vancouver Whitecaps FC 2 | Final |
| March 4, 2018 | New York City FC 2 at Sporting Kansas City 0 | Final |
| March 4, 2018 | Portland Timbers 1 at Los Angeles Galaxy 2 | Final |
| March 10, 2018 | Montreal Impact 2 at Columbus Crew SC 3 | Final |
| March 10, 2018 | Colorado Rapids 1 at New England Revolution 2 | Final |
| March 10, 2018 | Los Angeles FC 5 at Real Salt Lake 1 | Final |
| March 10, 2018 | Sporting Kansas City 4 at Chicago Fire 3 | Final |
| March 10, 2018 | Vancouver Whitecaps FC 2 at Houston Dynamo 1 | Final |
| March 10, 2018 | Portland Timbers 0 at New York Red Bulls 4 | Final |
| March 10, 2018 | Minnesota United FC 2 at Orlando City SC 1 | Final |
| March 11, 2018 | D.C. United 1 at Atlanta United FC 3 | Final |
| March 11, 2018 | Los Angeles Galaxy 1 at New York City FC 2 | Final |
| March 17, 2018 | Houston Dynamo 2 at D.C. United 2 | Final |
| March 17, 2018 | Chicago Fire 1 at Minnesota United FC 2 | Final |
| March 17, 2018 | Columbus Crew SC 0 at Philadelphia Union 0 | Final |
| March 17, 2018 | Toronto FC 0 at Montreal Impact 1 | Final |
| March 17, 2018 | Orlando City SC 0 at New York City FC 2 | Final |
| March 17, 2018 | Vancouver Whitecaps FC 1 at Atlanta United FC 4 | Final |
| March 17, 2018 | San Jose Earthquakes 2 at Sporting Kansas City 3 | Final |
| March 17, 2018 | New York Red Bulls 0 at Real Salt Lake 1 | Final |
| March 18, 2018 | Seattle Sounders FC 0 at FC Dallas 3 | Final |
| March 24, 2018 | New York City FC 2 at New England Revolution 2 | Final |
| March 24, 2018 | Portland Timbers 1 at FC Dallas 1 | Final |
| March 24, 2018 | D.C. United 1 at Columbus Crew SC 3 | Final |
| March 24, 2018 | Minnesota United FC 0 at New York Red Bulls 3 | Final |
| March 24, 2018 | Sporting Kansas City 2 at Colorado Rapids 2 | Final |
| March 24, 2018 | Los Angeles Galaxy 0 at Vancouver Whitecaps FC 0 | Final |
| March 30, 2018 | Real Salt Lake 1 at Toronto FC 3 | Final |
| March 31, 2018 | New York Red Bulls 3 at Orlando City SC 4 | Final |
| March 31, 2018 | Vancouver Whitecaps FC 2 at Columbus Crew SC 1 | Final |
| March 31, 2018 | Los Angeles FC 3 at Los Angeles Galaxy 4 | Final |
| March 31, 2018 | Portland Timbers 2 at Chicago Fire 2 | Final |
| March 31, 2018 | Atlanta United FC 1 at Minnesota United FC 0 | Final |
| March 31, 2018 | New York City FC 2 at San Jose Earthquakes 1 | Final |
| March 31, 2018 | New England Revolution 2 at Houston Dynamo 0 | Final |
| March 31, 2018 | D.C. United 0 at Sporting Kansas City 1 | Final |
| March 31, 2018 | Philadelphia Union 0 at Colorado Rapids 3 | Final |
| March 31, 2018 | Montreal Impact 1 at Seattle Sounders FC 0 | Final |
| April 6, 2018 | Montreal Impact 0 at New England Revolution 4 | Final |
| April 7, 2018 | Los Angeles FC 0 at Atlanta United FC 5 | Final |
| April 7, 2018 | San Jose Earthquakes 1 at Philadelphia Union 1 | Final |
| April 7, 2018 | Colorado Rapids 1 at FC Dallas 1 | Final |
| April 7, 2018 | Columbus Crew SC 0 at Chicago Fire 1 | Final |
| April 7, 2018 | Vancouver Whitecaps FC 1 at Real Salt Lake 2 | Final |
| April 8, 2018 | Portland Timbers 2 at Orlando City SC 3 | Final |
| April 8, 2018 | Sporting Kansas City 2 at Los Angeles Galaxy 0 | Final |
| April 11, 2018 | Real Salt Lake 0 at New York City FC 4 | Final |
| April 13, 2018 | Orlando City SC 2 at Philadelphia Union 0 | Final |
| April 13, 2018 | Los Angeles FC 2 at Vancouver Whitecaps FC 0 | Final |
| April 14, 2018 | Montreal Impact 1 at New York Red Bulls 3 | Final |
| April 14, 2018 | Toronto FC 0 at Colorado Rapids 2 | Final |
| April 14, 2018 | Los Angeles Galaxy 1 at Chicago Fire 0 | Final |
| April 14, 2018 | Columbus Crew SC 0 at D.C. United 1 | Final |
| April 14, 2018 | FC Dallas 1 at New England Revolution 0 | Final |
| April 14, 2018 | Minnesota United FC 2 at Portland Timbers 3 | Final |
| April 14, 2018 | Houston Dynamo 2 at San Jose Earthquakes 2 | Final |
| April 15, 2018 | Seattle Sounders FC 2 at Sporting Kansas City 2 | Final |
| April 15, 2018 | New York City FC 2 at Atlanta United FC 2 | Final |
| April 20, 2018 | Vancouver Whitecaps FC 0 at Sporting Kansas City 6 | Final |
| April 21, 2018 | Los Angeles FC 5 at Montreal Impact 3 | Final |
| April 21, 2018 | Chicago Fire 2 at New York Red Bulls 1 | Final |
| April 21, 2018 | Toronto FC 1 at Houston Dynamo 5 | Final |
| April 21, 2018 | New England Revolution 2 at Columbus Crew SC 2 | Final |
| April 21, 2018 | San Jose Earthquakes 2 at Orlando City SC 3 | Final |
| April 21, 2018 | Philadelphia Union 0 at FC Dallas 2 | Final |
| April 21, 2018 | Colorado Rapids 0 at Real Salt Lake 3 | Final |
| April 21, 2018 | Atlanta United FC 2 at Los Angeles Galaxy 0 | Final |
| April 22, 2018 | Minnesota United FC 1 at Seattle Sounders FC 3 | Final |
| April 22, 2018 | New York City FC 0 at Portland Timbers 3 | Final |
| April 27, 2018 | Real Salt Lake 0 at Vancouver Whitecaps FC 2 | Final |
| April 28, 2018 | Montreal Impact 1 at Atlanta United FC 4 | Final |
| April 28, 2018 | Chicago Fire 2 at Toronto FC 2 | Final |
| April 28, 2018 | D.C. United 2 at Philadelphia Union 3 | Final |
| April 28, 2018 | San Jose Earthquakes 1 at Columbus Crew SC 2 | Final |
| April 28, 2018 | Sporting Kansas City 0 at New England Revolution 1 | Final |
| April 28, 2018 | Houston Dynamo 1 at Minnesota United FC 2 | Final |
| April 28, 2018 | New York Red Bulls 3 at Los Angeles Galaxy 2 | Final |
| April 29, 2018 | Orlando City SC 2 at Colorado Rapids 1 | Final |
| April 29, 2018 | FC Dallas 1 at New York City FC 3 | Final |
| April 29, 2018 | Seattle Sounders FC 0 at Los Angeles FC 1 | Final |
| May 4, 2018 | Philadelphia Union 0 at Toronto FC 3 | Final |
| May 5, 2018 | New England Revolution 2 at Montreal Impact 4 | Final |
| May 5, 2018 | Vancouver Whitecaps FC 0 at Minnesota United FC 1 | Final |
| May 5, 2018 | New York City FC 0 at New York Red Bulls 4 | Final |
| May 5, 2018 | FC Dallas 1 at Los Angeles FC 1 | Final |
| May 5, 2018 | Columbus Crew SC 0 at Seattle Sounders FC 0 | Final |
| May 5, 2018 | Atlanta United FC 2 at Chicago Fire 1 | Final |
| May 5, 2018 | Los Angeles Galaxy 2 at Houston Dynamo 3 | Final |
| May 5, 2018 | Colorado Rapids 0 at Sporting Kansas City 1 | Final |
| May 5, 2018 | Portland Timbers 1 at San Jose Earthquakes 0 | Final |
| May 6, 2018 | Real Salt Lake 1 at Orlando City SC 3 | Final |
| May 9, 2018 | Sporting Kansas City 2 at Atlanta United FC 0 | Final |
| May 9, 2018 | Philadelphia Union 0 at Columbus Crew SC 1 | Final |
| May 9, 2018 | Seattle Sounders FC 2 at Toronto FC 1 | Final |
| May 9, 2018 | Montreal Impact 0 at Chicago Fire 1 | Final |
| May 9, 2018 | Minnesota United FC 0 at Los Angeles FC 2 | Final |
| May 11, 2018 | Houston Dynamo 1 at Vancouver Whitecaps FC 1 | Final |
| May 12, 2018 | San Jose Earthquakes 3 at Minnesota United FC 1 | Final |
| May 12, 2018 | Philadelphia Union 2 at Montreal Impact 0 | Final |
| May 12, 2018 | Los Angeles Galaxy 2 at FC Dallas 3 | Final |
| May 12, 2018 | Chicago Fire 0 at Columbus Crew SC 3 | Final |
| May 12, 2018 | Toronto FC 2 at New England Revolution 3 | Final |
| May 12, 2018 | New York Red Bulls 2 at Colorado Rapids 1 | Final |
| May 12, 2018 | D.C. United 2 at Real Salt Lake 3 | Final |
| May 13, 2018 | Seattle Sounders FC 0 at Portland Timbers 1 | Final |
| May 13, 2018 | Atlanta United FC 2 at Orlando City SC 1 | Final |
| May 13, 2018 | New York City FC 2 at Los Angeles FC 2 | Final |
| May 16, 2018 | San Jose Earthquakes 1 at Vancouver Whitecaps FC 1 | Final |
| May 18, 2018 | Orlando City SC 1 at Toronto FC 2 | Final |
| May 19, 2018 | Colorado Rapids 0 at New York City FC 4 | Final |
| May 19, 2018 | Los Angeles FC 1 at Portland Timbers 2 | Final |
| May 19, 2018 | Vancouver Whitecaps FC 2 at FC Dallas 2 | Final |
| May 19, 2018 | Columbus Crew SC 1 at New England Revolution 0 | Final |
| May 19, 2018 | Real Salt Lake 1 at Philadelphia Union 4 | Final |
| May 19, 2018 | D.C. United 3 at San Jose Earthquakes 1 | Final |
| May 20, 2018 | Sporting Kansas City 1 at Minnesota United FC 1 | Final |
| May 20, 2018 | Houston Dynamo 3 at Chicago Fire 2 | Final |
| May 20, 2018 | New York Red Bulls 3 at Atlanta United FC 1 | Final |
| May 21, 2018 | Los Angeles Galaxy 1 at Montreal Impact 0 | Final |
| May 25, 2018 | FC Dallas 1 at Toronto FC 0 | Final |
| May 25, 2018 | New York City FC 1 at Houston Dynamo 3 | Final |
| May 25, 2018 | San Jose Earthquakes 0 at Los Angeles Galaxy 1 | Final |
| May 26, 2018 | Real Salt Lake 1 at Seattle Sounders FC 0 | Final |
| May 26, 2018 | New England Revolution 3 at Vancouver Whitecaps FC 3 | Final |
| May 26, 2018 | Philadelphia Union 0 at New York Red Bulls 0 | Final |
| May 26, 2018 | Chicago Fire 2 at Orlando City SC 1 | Final |
| May 26, 2018 | Montreal Impact 0 at Minnesota United FC 2 | Final |
| May 26, 2018 | Portland Timbers 3 at Colorado Rapids 2 | Final |
| May 26, 2018 | D.C. United 1 at Los Angeles FC 1 | Final |
| May 27, 2018 | Columbus Crew SC 0 at Sporting Kansas City 0 | Final |
| May 30, 2018 | Atlanta United FC 1 at New England Revolution 1 | Final |
| May 30, 2018 | Chicago Fire 1 at Philadelphia Union 3 | Final |
| May 30, 2018 | Houston Dynamo 1 at Real Salt Lake 2 | Final |
| May 30, 2018 | FC Dallas 3 at Los Angeles Galaxy 2 | Final |
| June 1, 2018 | Vancouver Whitecaps FC 2 at Colorado Rapids 1 | Final |
| June 2, 2018 | Los Angeles Galaxy 1 at Portland Timbers 1 | Final |
| June 2, 2018 | Philadelphia Union 1 at Atlanta United FC 3 | Final |
| June 2, 2018 | Toronto FC 3 at Columbus Crew SC 3 | Final |
| June 2, 2018 | Houston Dynamo 0 at Montreal Impact 1 | Final |
| June 2, 2018 | New York Red Bulls 1 at New England Revolution 2 | Final |
| June 2, 2018 | Orlando City SC 0 at New York City FC 3 | Final |
| June 2, 2018 | Los Angeles FC 1 at FC Dallas 2 | Final |
| June 2, 2018 | San Jose Earthquakes 1 at Chicago Fire 2 | Final |
| June 2, 2018 | Seattle Sounders FC 0 at Real Salt Lake 2 | Final |
| June 3, 2018 | Minnesota United FC 1 at Sporting Kansas City 3 | Final |
| June 8, 2018 | Toronto FC 2 at Philadelphia Union 0 | Final |
| June 9, 2018 | Atlanta United FC 1 at New York City FC 1 | Final |
| June 9, 2018 | New York Red Bulls 1 at Columbus Crew SC 1 | Final |
| June 9, 2018 | Montreal Impact 0 at FC Dallas 2 | Final |
| June 9, 2018 | New England Revolution 1 at Chicago Fire 1 | Final |
| June 9, 2018 | Colorado Rapids 0 at Houston Dynamo 2 | Final |
| June 9, 2018 | D.C. United 1 at Seattle Sounders FC 2 | Final |
| June 9, 2018 | Orlando City SC 2 at Vancouver Whitecaps FC 5 | Final |
| June 9, 2018 | Real Salt Lake 0 at Los Angeles Galaxy 3 | Final |
| June 9, 2018 | Sporting Kansas City 0 at Portland Timbers 0 | Final |
| June 9, 2018 | Los Angeles FC 4 at San Jose Earthquakes 3 | Final |
| June 13, 2018 | Atlanta United FC 2 at Columbus Crew SC 0 | Final |
| June 13, 2018 | Orlando City SC 0 at Montreal Impact 3 | Final |
| June 13, 2018 | Seattle Sounders FC 1 at New York Red Bulls 2 | Final |
| June 13, 2018 | D.C. United 4 at Toronto FC 4 | Final |
| June 13, 2018 | Chicago Fire 2 at Colorado Rapids 2 | Final |
| June 13, 2018 | New England Revolution 2 at San Jose Earthquakes 2 | Final |
| June 23, 2018 | Vancouver Whitecaps FC 0 at Philadelphia Union 4 | Final |
| June 23, 2018 | FC Dallas 0 at New York Red Bulls 3 | Final |
| June 23, 2018 | Montreal Impact 2 at Orlando City SC 0 | Final |
| June 23, 2018 | Houston Dynamo 2 at Sporting Kansas City 3 | Final |
| June 23, 2018 | Minnesota United FC 2 at Colorado Rapids 3 | Final |
| June 23, 2018 | San Jose Earthquakes 1 at Real Salt Lake 1 | Final |
| June 23, 2018 | Chicago Fire 1 at Seattle Sounders FC 1 | Final |
| June 23, 2018 | Columbus Crew SC 0 at Los Angeles FC 2 | Final |
| June 24, 2018 | Portland Timbers 1 at Atlanta United FC 1 | Final |
| June 24, 2018 | Toronto FC 1 at New York City FC 2 | Final |
| June 29, 2018 | FC Dallas 1 at Minnesota United FC 0 | Final |
| June 30, 2018 | Portland Timbers 3 at Seattle Sounders FC 2 | Final |
| June 30, 2018 | Orlando City SC 0 at Atlanta United FC 4 | Final |
| June 30, 2018 | Sporting Kansas City 0 at Montreal Impact 2 | Final |
| June 30, 2018 | Real Salt Lake 1 at Columbus Crew SC 2 | Final |
| June 30, 2018 | D.C. United 2 at New England Revolution 3 | Final |
| June 30, 2018 | New York City FC 2 at Chicago Fire 3 | Final |
| June 30, 2018 | Philadelphia Union 1 at Los Angeles FC 4 | Final |
| June 30, 2018 | Los Angeles Galaxy 3 at San Jose Earthquakes 3 | Final |
| July 1, 2018 | New York Red Bulls 1 at Toronto FC 0 | Final |
| July 1, 2018 | Colorado Rapids 1 at Vancouver Whitecaps FC 0 | Final |
| July 3, 2018 | Los Angeles FC 2 at Houston Dynamo 2 | Final |
| July 4, 2018 | Toronto FC 3 at Minnesota United FC 4 | Final |
| July 4, 2018 | Atlanta United FC 2 at FC Dallas 3 | Final |
| July 4, 2018 | Seattle Sounders FC 2 at Colorado Rapids 1 | Final |
| July 4, 2018 | Sporting Kansas City 2 at Real Salt Lake 4 | Final |
| July 4, 2018 | D.C. United 2 at Los Angeles Galaxy 2 | Final |
| July 7, 2018 | Chicago Fire 2 at Vancouver Whitecaps FC 3 | Final |
| July 7, 2018 | Colorado Rapids 1 at Montreal Impact 2 | Final |
| July 7, 2018 | Seattle Sounders FC 0 at New England Revolution 0 | Final |
| July 7, 2018 | Atlanta United FC 2 at Philadelphia Union 0 | Final |
| July 7, 2018 | Toronto FC 2 at Sporting Kansas City 2 | Final |
| July 7, 2018 | Minnesota United FC 0 at Houston Dynamo 3 | Final |
| July 7, 2018 | FC Dallas 0 at Real Salt Lake 2 | Final |
| July 7, 2018 | Columbus Crew SC 0 at Los Angeles Galaxy 4 | Final |
| July 7, 2018 | Orlando City SC 1 at Los Angeles FC 4 | Final |
| July 7, 2018 | San Jose Earthquakes 1 at Portland Timbers 2 | Final |
| July 8, 2018 | New York City FC 1 at New York Red Bulls 0 | Final |
| July 11, 2018 | Montreal Impact 0 at New York City FC 3 | Final |
| July 11, 2018 | Philadelphia Union 4 at Chicago Fire 3 | Final |
| July 14, 2018 | Columbus Crew SC 0 at New York City FC 2 | Final |
| July 14, 2018 | Sporting Kansas City 2 at New York Red Bulls 3 | Final |
| July 14, 2018 | San Jose Earthquakes 0 at Montreal Impact 2 | Final |
| July 14, 2018 | Los Angeles Galaxy 3 at New England Revolution 2 | Final |
| July 14, 2018 | Vancouver Whitecaps FC 1 at D.C. United 3 | Final |
| July 14, 2018 | Chicago Fire 1 at FC Dallas 3 | Final |
| July 14, 2018 | Real Salt Lake 2 at Minnesota United FC 3 | Final |
| July 14, 2018 | Toronto FC 1 at Orlando City SC 2 | Final |
| July 14, 2018 | Houston Dynamo 0 at Colorado Rapids 0 | Final |
| July 15, 2018 | Seattle Sounders FC 1 at Atlanta United FC 1 | Final |
| July 15, 2018 | Portland Timbers 0 at Los Angeles FC 0 | Final |
| July 18, 2018 | New England Revolution 1 at Minnesota United FC 2 | Final |
| July 21, 2018 | D.C. United 1 at Atlanta United FC 3 | Final |
| July 21, 2018 | Vancouver Whitecaps FC 0 at Seattle Sounders FC 2 | Final |
| July 21, 2018 | Toronto FC 2 at Chicago Fire 1 | Final |
| July 21, 2018 | New England Revolution 0 at New York Red Bulls 2 | Final |
| July 21, 2018 | Los Angeles Galaxy 3 at Philadelphia Union 1 | Final |
| July 21, 2018 | Orlando City SC 2 at Columbus Crew SC 3 | Final |
| July 21, 2018 | FC Dallas 1 at Houston Dynamo 1 | Final |
| July 21, 2018 | Colorado Rapids 2 at Real Salt Lake 2 | Final |
| July 21, 2018 | Montreal Impact 2 at Portland Timbers 2 | Final |
| July 22, 2018 | Los Angeles FC 1 at Minnesota United FC 5 | Final |
| July 25, 2018 | New York Red Bulls 1 at D.C. United 0 | Final |
| July 25, 2018 | Philadelphia Union 3 at Houston Dynamo 1 | Final |
| July 25, 2018 | Seattle Sounders FC 1 at San Jose Earthquakes 0 | Final |
| July 26, 2018 | New York City FC 2 at Orlando City SC 0 | Final |
| July 26, 2018 | Los Angeles Galaxy 2 at Los Angeles FC 2 | Final |
| July 28, 2018 | Atlanta United FC 2 at Montreal Impact 1 | Final |
| July 28, 2018 | Columbus Crew SC 3 at New York Red Bulls 2 | Final |
| July 28, 2018 | Chicago Fire 0 at Toronto FC 3 | Final |
| July 28, 2018 | Colorado Rapids 1 at D.C. United 2 | Final |
| July 28, 2018 | FC Dallas 3 at Sporting Kansas City 2 | Final |
| July 28, 2018 | Minnesota United FC 2 at Vancouver Whitecaps FC 4 | Final |
| July 28, 2018 | Real Salt Lake 0 at San Jose Earthquakes 0 | Final |
| July 28, 2018 | Houston Dynamo 1 at Portland Timbers 2 | Final |
| July 29, 2018 | New York City FC 1 at Seattle Sounders FC 3 | Final |
| July 29, 2018 | Orlando City SC 3 at Los Angeles Galaxy 4 | Final |
| August 4, 2018 | Toronto FC 2 at Atlanta United FC 2 | Final |
| August 4, 2018 | D.C. United 1 at Montreal Impact 1 | Final |
| August 4, 2018 | New England Revolution 3 at Orlando City SC 3 | Final |
| August 4, 2018 | San Jose Earthquakes 3 at FC Dallas 1 | Final |
| August 4, 2018 | Seattle Sounders FC 2 at Minnesota United FC 1 | Final |
| August 4, 2018 | Vancouver Whitecaps FC 2 at New York City FC 2 | Final |
| August 4, 2018 | Los Angeles Galaxy 1 at Colorado Rapids 2 | Final |
| August 4, 2018 | Sporting Kansas City 1 at Houston Dynamo 0 | Final |
| August 4, 2018 | Chicago Fire 1 at Real Salt Lake 2 | Final |
| August 4, 2018 | Philadelphia Union 0 at Portland Timbers 3 | Final |
| August 5, 2018 | Los Angeles FC 1 at New York Red Bulls 2 | Final |
| August 11, 2018 | Houston Dynamo 0 at Columbus Crew SC 1 | Final |
| August 11, 2018 | Philadelphia Union 3 at New England Revolution 2 | Final |
| August 11, 2018 | New York Red Bulls 1 at Chicago Fire 0 | Final |
| August 11, 2018 | San Jose Earthquakes 1 at Colorado Rapids 2 | Final |
| August 11, 2018 | Montreal Impact 1 at Real Salt Lake 1 | Final |
| August 11, 2018 | Sporting Kansas City 2 at Los Angeles FC 0 | Final |
| August 11, 2018 | Minnesota United FC 2 at Los Angeles Galaxy 2 | Final |
| August 11, 2018 | Vancouver Whitecaps FC 2 at Portland Timbers 1 | Final |
| August 12, 2018 | New York City FC 3 at Toronto FC 2 | Final |
| August 12, 2018 | Orlando City SC 2 at D.C. United 3 | Final |
| August 12, 2018 | FC Dallas 1 at Seattle Sounders FC 2 | Final |
| August 14, 2018 | Colorado Rapids 2 at Los Angeles Galaxy 2 | Final |
| August 15, 2018 | Portland Timbers 1 at D.C. United 4 | Final |
| August 15, 2018 | Real Salt Lake 0 at Los Angeles FC 2 | Final |
| August 18, 2018 | Los Angeles Galaxy 0 at Seattle Sounders FC 5 | 84 Min. |
| August 18, 2018 | New York City FC at Philadelphia Union | 7:00 p.m. |
| August 18, 2018 | New York Red Bulls at Vancouver Whitecaps FC | 7:00 p.m. |
| August 18, 2018 | Chicago Fire at Montreal Impact | 7:30 p.m. |
| August 18, 2018 | Minnesota United FC at FC Dallas | 8:00 p.m. |
| August 18, 2018 | Portland Timbers at Sporting Kansas City | 8:30 p.m. |
| August 18, 2018 | Real Salt Lake at Houston Dynamo | 9:00 p.m. |
| August 18, 2018 | Toronto FC at San Jose Earthquakes | 10:00 p.m. |
| August 18, 2018 | Colorado Rapids at Los Angeles FC | 10:30 p.m. |
| August 19, 2018 | Columbus Crew SC at Atlanta United FC | 4:00 p.m. |
| August 19, 2018 | New England Revolution at D.C. United | 6:00 p.m. |
| August 22, 2018 | New York Red Bulls at New York City FC | 7:00 p.m. |
| August 23, 2018 | Columbus Crew SC at Chicago Fire | 7:00 p.m. |
| August 23, 2018 | FC Dallas at Houston Dynamo | 9:00 p.m. |
| August 24, 2018 | Atlanta United FC at Orlando City SC | 8:00 p.m. |
| August 24, 2018 | Los Angeles FC at Los Angeles Galaxy | 10:30 p.m. |
| August 25, 2018 | New England Revolution at Philadelphia Union | 7:00 p.m. |
| August 25, 2018 | Montreal Impact at Toronto FC | 8:00 p.m. |
| August 25, 2018 | Minnesota United FC at Sporting Kansas City | 8:30 p.m. |
| August 25, 2018 | Real Salt Lake at Colorado Rapids | 9:00 p.m. |
| August 25, 2018 | Vancouver Whitecaps FC at San Jose Earthquakes | 10:00 p.m. |
| August 26, 2018 | D.C. United at New York Red Bulls | 7:00 p.m. |
| August 26, 2018 | Seattle Sounders FC at Portland Timbers | 9:30 p.m. |
| August 29, 2018 | Philadelphia Union at D.C. United | 8:00 p.m. |
| August 29, 2018 | Houston Dynamo at New York Red Bulls | 8:00 p.m. |
| August 29, 2018 | Toronto FC at Portland Timbers | 10:30 p.m. |
| August 29, 2018 | FC Dallas at San Jose Earthquakes | 10:30 p.m. |
| September 1, 2018 | Sporting Kansas City at Seattle Sounders FC | 4:00 p.m. |
| September 1, 2018 | New York Red Bulls at Montreal Impact | 7:30 p.m. |
| September 1, 2018 | Portland Timbers at New England Revolution | 7:30 p.m. |
| September 1, 2018 | Philadelphia Union at Orlando City SC | 7:30 p.m. |
| September 1, 2018 | New York City FC at Columbus Crew SC | 8:00 p.m. |
| September 1, 2018 | Houston Dynamo at FC Dallas | 8:00 p.m. |
| September 1, 2018 | Los Angeles FC at Toronto FC | 8:00 p.m. |
| September 1, 2018 | Los Angeles Galaxy at Real Salt Lake | 10:00 p.m. |
| September 1, 2018 | San Jose Earthquakes at Vancouver Whitecaps FC | 10:00 p.m. |
| September 2, 2018 | Atlanta United FC at D.C. United | 5:30 p.m. |
| September 5, 2018 | New England Revolution at New York City FC | 7:00 p.m. |
| September 8, 2018 | D.C. United at New York City FC | 5:00 p.m. |
| September 8, 2018 | Orlando City SC at Sporting Kansas City | 8:30 p.m. |
| September 8, 2018 | Colorado Rapids at Portland Timbers | 10:30 p.m. |
| September 12, 2018 | Minnesota United FC at D.C. United | 7:30 p.m. |
| September 15, 2018 | Atlanta United FC at Colorado Rapids | 3:30 p.m. |
| September 15, 2018 | Montreal Impact at Philadelphia Union | 7:30 p.m. |
| September 15, 2018 | Los Angeles Galaxy at Toronto FC | 7:30 p.m. |
| September 15, 2018 | Columbus Crew SC at FC Dallas | 8:00 p.m. |
| September 15, 2018 | Portland Timbers at Houston Dynamo | 8:30 p.m. |
| September 15, 2018 | Minnesota United FC at Real Salt Lake | 9:30 p.m. |
| September 15, 2018 | Seattle Sounders FC at Vancouver Whitecaps FC | 10:00 p.m. |
| September 15, 2018 | New England Revolution at Los Angeles FC | 10:30 p.m. |
| September 15, 2018 | Sporting Kansas City at San Jose Earthquakes | 10:30 p.m. |
| September 16, 2018 | New York Red Bulls at D.C. United | 1:00 p.m. |
| September 16, 2018 | Orlando City SC at Chicago Fire | 5:00 p.m. |
| September 19, 2018 | Columbus Crew SC at Portland Timbers | 10:30 p.m. |
| September 19, 2018 | Atlanta United FC at San Jose Earthquakes | 10:45 p.m. |
| September 19, 2018 | Philadelphia Union at Seattle Sounders FC | 11:00 p.m. |
| September 22, 2018 | San Jose Earthquakes at Los Angeles FC | 3:30 p.m. |
| September 22, 2018 | Toronto FC at New York Red Bulls | 5:00 p.m. |
| September 22, 2018 | Real Salt Lake at Atlanta United FC | 7:00 p.m. |
| September 22, 2018 | Colorado Rapids at Columbus Crew SC | 7:30 p.m. |
| September 22, 2018 | New York City FC at Montreal Impact | 7:30 p.m. |
| September 22, 2018 | Chicago Fire at New England Revolution | 7:30 p.m. |
| September 22, 2018 | Houston Dynamo at Orlando City SC | 7:30 p.m. |
| September 22, 2018 | Portland Timbers at Minnesota United FC | 8:00 p.m. |
| September 23, 2018 | Sporting Kansas City at Philadelphia Union | 1:00 p.m. |
| September 23, 2018 | Seattle Sounders FC at Los Angeles Galaxy | 7:00 p.m. |
| September 23, 2018 | FC Dallas at Vancouver Whitecaps FC | 7:00 p.m. |
| September 26, 2018 | Chicago Fire at New York City FC | 7:00 p.m. |
| September 29, 2018 | Los Angeles FC at Chicago Fire | 3:30 p.m. |
| September 29, 2018 | Colorado Rapids at Seattle Sounders FC | 4:00 p.m. |
| September 29, 2018 | Montreal Impact at D.C. United | 7:00 p.m. |
| September 29, 2018 | Philadelphia Union at Columbus Crew SC | 7:30 p.m. |
| September 29, 2018 | New England Revolution at Toronto FC | 7:30 p.m. |
| September 29, 2018 | New York City FC at Minnesota United FC | 8:00 p.m. |
| September 29, 2018 | San Jose Earthquakes at Houston Dynamo | 8:30 p.m. |
| September 29, 2018 | Vancouver Whitecaps FC at Los Angeles Galaxy | 10:00 p.m. |
| September 29, 2018 | FC Dallas at Portland Timbers | 10:30 p.m. |
| September 30, 2018 | Atlanta United FC at New York Red Bulls | 1:00 p.m. |
| September 30, 2018 | Real Salt Lake at Sporting Kansas City | 5:00 p.m. |
| October 6, 2018 | Minnesota United FC at Philadelphia Union | 12:00 p.m. |
| October 6, 2018 | Columbus Crew SC at Montreal Impact | 3:00 p.m. |
| October 6, 2018 | New England Revolution at Atlanta United FC | 3:30 p.m. |
| October 6, 2018 | Vancouver Whitecaps FC at Toronto FC | 5:00 p.m. |
| October 6, 2018 | Orlando City SC at FC Dallas | 8:00 p.m. |
| October 6, 2018 | Los Angeles Galaxy at Sporting Kansas City | 8:30 p.m. |
| October 6, 2018 | Los Angeles FC at Colorado Rapids | 9:00 p.m. |
| October 6, 2018 | Portland Timbers at Real Salt Lake | 9:30 p.m. |
| October 6, 2018 | New York Red Bulls at San Jose Earthquakes | 10:30 p.m. |
| October 7, 2018 | Chicago Fire at D.C. United | 1:00 p.m. |
| October 8, 2018 | Houston Dynamo at Seattle Sounders FC | 10:30 p.m. |
| October 13, 2018 | Colorado Rapids at Minnesota United FC | 2:00 p.m. |
| October 13, 2018 | FC Dallas at D.C. United | 5:00 p.m. |
| October 13, 2018 | Orlando City SC at New England Revolution | 7:30 p.m. |
| October 17, 2018 | Toronto FC at D.C. United | 7:30 p.m. |
| October 17, 2018 | Seattle Sounders FC at Orlando City SC | 7:30 p.m. |
| October 17, 2018 | Sporting Kansas City at Vancouver Whitecaps FC | 10:00 p.m. |
| October 18, 2018 | New England Revolution at Real Salt Lake | 9:30 p.m. |
| October 18, 2018 | Houston Dynamo at Los Angeles FC | 10:00 p.m. |
| October 21, 2018 | Chicago Fire at Atlanta United FC | TBA |
| October 21, 2018 | New York City FC at D.C. United | TBA |
| October 21, 2018 | Sporting Kansas City at FC Dallas | TBA |
| October 21, 2018 | Seattle Sounders FC at Houston Dynamo | TBA |
| October 21, 2018 | Vancouver Whitecaps FC at Los Angeles FC | TBA |
| October 21, 2018 | Los Angeles Galaxy at Minnesota United FC | TBA |
| October 21, 2018 | Toronto FC at Montreal Impact | TBA |
| October 21, 2018 | Real Salt Lake at Portland Timbers | TBA |
| October 21, 2018 | Colorado Rapids at San Jose Earthquakes | TBA |
| October 21, 2018 | New York Red Bulls at Philadelphia Union | 12:00 p.m. |
| October 21, 2018 | Columbus Crew SC at Orlando City SC | 3:00 p.m. |
| October 28, 2018 | D.C. United at Chicago Fire | 4:30 p.m. |
| October 28, 2018 | FC Dallas at Colorado Rapids | 4:30 p.m. |
| October 28, 2018 | Minnesota United FC at Columbus Crew SC | 4:30 p.m. |
| October 28, 2018 | Houston Dynamo at Los Angeles Galaxy | 4:30 p.m. |
| October 28, 2018 | Montreal Impact at New England Revolution | 4:30 p.m. |
| October 28, 2018 | Philadelphia Union at New York City FC | 4:30 p.m. |
| October 28, 2018 | Orlando City SC at New York Red Bulls | 4:30 p.m. |
| October 28, 2018 | San Jose Earthquakes at Seattle Sounders FC | 4:30 p.m. |
| October 28, 2018 | Los Angeles FC at Sporting Kansas City | 4:30 p.m. |
| October 28, 2018 | Atlanta United FC at Toronto FC | 4:30 p.m. |
| October 28, 2018 | Portland Timbers at Vancouver Whitecaps FC | 4:30 p.m. |
Major League Soccer Schedule
