| | | |
| March 3, 2018 | Columbus Crew SC 2 at Toronto FC 0 | Final |
| March 3, 2018 | Atlanta United FC 0 at Houston Dynamo 4 | Final |
| March 3, 2018 | New England Revolution 0 at Philadelphia Union 2 | Final |
| March 3, 2018 | D.C. United 1 at Orlando City SC 1 | Final |
| March 3, 2018 | Real Salt Lake 1 at FC Dallas 1 | Final |
| March 3, 2018 | Minnesota United FC 2 at San Jose Earthquakes 3 | Final |
| March 4, 2018 | Los Angeles FC 1 at Seattle Sounders FC 0 | Final |
| March 4, 2018 | Montreal Impact 1 at Vancouver Whitecaps FC 2 | Final |
| March 4, 2018 | New York City FC 2 at Sporting Kansas City 0 | Final |
| March 4, 2018 | Portland Timbers 1 at Los Angeles Galaxy 2 | Final |
| March 10, 2018 | Montreal Impact 2 at Columbus Crew SC 3 | Final |
| March 10, 2018 | Colorado Rapids 1 at New England Revolution 2 | Final |
| March 10, 2018 | Los Angeles FC 5 at Real Salt Lake 1 | Final |
| March 10, 2018 | Sporting Kansas City 4 at Chicago Fire 3 | Final |
| March 10, 2018 | Vancouver Whitecaps FC 2 at Houston Dynamo 1 | Final |
| March 10, 2018 | Portland Timbers 0 at New York Red Bulls 4 | Final |
| March 10, 2018 | Minnesota United FC 2 at Orlando City SC 1 | Final |
| March 11, 2018 | D.C. United 1 at Atlanta United FC 3 | Final |
| March 11, 2018 | Los Angeles Galaxy 1 at New York City FC 2 | Final |
| March 17, 2018 | Houston Dynamo 2 at D.C. United 2 | Final |
| March 17, 2018 | Chicago Fire 1 at Minnesota United FC 2 | Final |
| March 17, 2018 | Columbus Crew SC 0 at Philadelphia Union 0 | Final |
| March 17, 2018 | Toronto FC 0 at Montreal Impact 1 | Final |
| March 17, 2018 | Orlando City SC 0 at New York City FC 2 | Final |
| March 17, 2018 | FC Cincinnati 1 at Charleston Battery 0 | Final |
| March 17, 2018 | Vancouver Whitecaps FC 1 at Atlanta United FC 4 | Final |
| March 17, 2018 | San Jose Earthquakes 2 at Sporting Kansas City 3 | Final |
| March 17, 2018 | New York Red Bulls 0 at Real Salt Lake 1 | Final |
| March 18, 2018 | Seattle Sounders FC 0 at FC Dallas 3 | Final |
| March 24, 2018 | New York City FC 2 at New England Revolution 2 | Final |
| March 24, 2018 | Portland Timbers 1 at FC Dallas 1 | Final |
| March 24, 2018 | D.C. United 1 at Columbus Crew SC 3 | Final |
| March 24, 2018 | Minnesota United FC 0 at New York Red Bulls 3 | Final |
| March 24, 2018 | Sporting Kansas City 2 at Colorado Rapids 2 | Final |
| March 24, 2018 | Los Angeles Galaxy 0 at Vancouver Whitecaps FC 0 | Final |
| March 30, 2018 | Real Salt Lake 1 at Toronto FC 3 | Final |
| March 31, 2018 | New York Red Bulls 3 at Orlando City SC 4 | Final |
| March 31, 2018 | Vancouver Whitecaps FC 2 at Columbus Crew SC 1 | Final |
| March 31, 2018 | Los Angeles FC 3 at Los Angeles Galaxy 4 | Final |
| March 31, 2018 | Portland Timbers 2 at Chicago Fire 2 | Final |
| March 31, 2018 | FC Cincinnati 1 at Indy Eleven 0 | Final |
| March 31, 2018 | Atlanta United FC 1 at Minnesota United FC 0 | Final |
| March 31, 2018 | New York City FC 2 at San Jose Earthquakes 1 | Final |
| March 31, 2018 | New England Revolution 2 at Houston Dynamo 0 | Final |
| March 31, 2018 | D.C. United 0 at Sporting Kansas City 1 | Final |
| March 31, 2018 | Philadelphia Union 0 at Colorado Rapids 3 | Final |
| March 31, 2018 | Montreal Impact 1 at Seattle Sounders FC 0 | Final |
| April 6, 2018 | Montreal Impact 0 at New England Revolution 4 | Final |
| April 7, 2018 | Los Angeles FC 0 at Atlanta United FC 5 | Final |
| April 7, 2018 | Louisville City FC 1 at FC Cincinnati 0 | Final |
| April 7, 2018 | San Jose Earthquakes 1 at Philadelphia Union 1 | Final |
| April 7, 2018 | Colorado Rapids 1 at FC Dallas 1 | Final |
| April 7, 2018 | Columbus Crew SC 0 at Chicago Fire 1 | Final |
| April 7, 2018 | Vancouver Whitecaps FC 1 at Real Salt Lake 2 | Final |
| April 8, 2018 | Portland Timbers 2 at Orlando City SC 3 | Final |
| April 8, 2018 | Sporting Kansas City 2 at Los Angeles Galaxy 0 | Final |
| April 11, 2018 | Real Salt Lake 0 at New York City FC 4 | Final |
| April 13, 2018 | Orlando City SC 2 at Philadelphia Union 0 | Final |
| April 13, 2018 | Los Angeles FC 2 at Vancouver Whitecaps FC 0 | Final |
| April 14, 2018 | Montreal Impact 1 at New York Red Bulls 3 | Final |
| April 14, 2018 | Toronto FC 0 at Colorado Rapids 2 | Final |
| April 14, 2018 | Los Angeles Galaxy 1 at Chicago Fire 0 | Final |
| April 14, 2018 | Columbus Crew SC 0 at D.C. United 1 | Final |
| April 14, 2018 | FC Dallas 1 at New England Revolution 0 | Final |
| April 14, 2018 | Minnesota United FC 2 at Portland Timbers 3 | Final |
| April 14, 2018 | Houston Dynamo 2 at San Jose Earthquakes 2 | Final |
| April 15, 2018 | FC Cincinnati 1 at Bethlehem Steel FC 1 | Final |
| April 15, 2018 | Seattle Sounders FC 2 at Sporting Kansas City 2 | Final |
| April 15, 2018 | New York City FC 2 at Atlanta United FC 2 | Final |
| April 20, 2018 | Vancouver Whitecaps FC 0 at Sporting Kansas City 6 | Final |
| April 21, 2018 | Los Angeles FC 5 at Montreal Impact 3 | Final |
| April 21, 2018 | Chicago Fire 2 at New York Red Bulls 1 | Final |
| April 21, 2018 | Toronto FC 1 at Houston Dynamo 5 | Final |
| April 21, 2018 | Pittsburgh Riverhounds SC 2 at FC Cincinnati 2 | Final |
| April 21, 2018 | New England Revolution 2 at Columbus Crew SC 2 | Final |
| April 21, 2018 | San Jose Earthquakes 2 at Orlando City SC 3 | Final |
| April 21, 2018 | Philadelphia Union 0 at FC Dallas 2 | Final |
| April 21, 2018 | Colorado Rapids 0 at Real Salt Lake 3 | Final |
| April 21, 2018 | Atlanta United FC 2 at Los Angeles Galaxy 0 | Final |
| April 22, 2018 | Minnesota United FC 1 at Seattle Sounders FC 3 | Final |
| April 22, 2018 | New York City FC 0 at Portland Timbers 3 | Final |
| April 27, 2018 | Real Salt Lake 0 at Vancouver Whitecaps FC 2 | Final |
| April 28, 2018 | Montreal Impact 1 at Atlanta United FC 4 | Final |
| April 28, 2018 | FC Cincinnati 3 at Ottawa Fury FC 0 | Final |
| April 28, 2018 | Chicago Fire 2 at Toronto FC 2 | Final |
| April 28, 2018 | D.C. United 2 at Philadelphia Union 3 | Final |
| April 28, 2018 | San Jose Earthquakes 1 at Columbus Crew SC 2 | Final |
| April 28, 2018 | Sporting Kansas City 0 at New England Revolution 1 | Final |
| April 28, 2018 | Houston Dynamo 1 at Minnesota United FC 2 | Final |
| April 28, 2018 | New York Red Bulls 3 at Los Angeles Galaxy 2 | Final |
| April 29, 2018 | Orlando City SC 2 at Colorado Rapids 1 | Final |
| April 29, 2018 | FC Dallas 1 at New York City FC 3 | Final |
| April 29, 2018 | Seattle Sounders FC 0 at Los Angeles FC 1 | Final |
| May 2, 2018 | FC Cincinnati 3 at Indy Eleven 2 | Final |
| May 4, 2018 | Philadelphia Union 0 at Toronto FC 3 | Final |
| May 5, 2018 | New England Revolution 2 at Montreal Impact 4 | Final |
| May 5, 2018 | Vancouver Whitecaps FC 0 at Minnesota United FC 1 | Final |
| May 5, 2018 | New York City FC 0 at New York Red Bulls 4 | Final |
| May 5, 2018 | FC Dallas 1 at Los Angeles FC 1 | Final |
| May 5, 2018 | Columbus Crew SC 0 at Seattle Sounders FC 0 | Final |
| May 5, 2018 | Atlanta United 2 2 at FC Cincinnati 4 | Final |
| May 5, 2018 | Atlanta United FC 2 at Chicago Fire 1 | Final |
| May 5, 2018 | Los Angeles Galaxy 2 at Houston Dynamo 3 | Final |
| May 5, 2018 | Colorado Rapids 0 at Sporting Kansas City 1 | Final |
| May 5, 2018 | Portland Timbers 1 at San Jose Earthquakes 0 | Final |
| May 6, 2018 | Real Salt Lake 1 at Orlando City SC 3 | Final |
| May 9, 2018 | Sporting Kansas City 2 at Atlanta United FC 0 | Final |
| May 9, 2018 | Philadelphia Union 0 at Columbus Crew SC 1 | Final |
| May 9, 2018 | Seattle Sounders FC 2 at Toronto FC 1 | Final |
| May 9, 2018 | Montreal Impact 0 at Chicago Fire 1 | Final |
| May 9, 2018 | Minnesota United FC 0 at Los Angeles FC 2 | Final |
| May 11, 2018 | Houston Dynamo 1 at Vancouver Whitecaps FC 1 | Final |
| May 12, 2018 | San Jose Earthquakes 3 at Minnesota United FC 1 | Final |
| May 12, 2018 | Philadelphia Union 2 at Montreal Impact 0 | Final |
| May 12, 2018 | Los Angeles Galaxy 2 at FC Dallas 3 | Final |
| May 12, 2018 | FC Cincinnati 1 at Charlotte Independence 4 | Final |
| May 12, 2018 | Chicago Fire 0 at Columbus Crew SC 3 | Final |
| May 12, 2018 | Toronto FC 2 at New England Revolution 3 | Final |
| May 12, 2018 | New York Red Bulls 2 at Colorado Rapids 1 | Final |
| May 12, 2018 | D.C. United 2 at Real Salt Lake 3 | Final |
| May 13, 2018 | Seattle Sounders FC 0 at Portland Timbers 1 | Final |
| May 13, 2018 | Atlanta United FC 2 at Orlando City SC 1 | Final |
| May 13, 2018 | New York City FC 2 at Los Angeles FC 2 | Final |
| May 16, 2018 | San Jose Earthquakes 1 at Vancouver Whitecaps FC 1 | Final |
| May 18, 2018 | Orlando City SC 1 at Toronto FC 2 | Final |
| May 19, 2018 | Colorado Rapids 0 at New York City FC 4 | Final |
| May 19, 2018 | Los Angeles FC 1 at Portland Timbers 2 | Final |
| May 19, 2018 | Vancouver Whitecaps FC 2 at FC Dallas 2 | Final |
| May 19, 2018 | North Carolina FC 1 at FC Cincinnati 4 | Final |
| May 19, 2018 | Columbus Crew SC 1 at New England Revolution 0 | Final |
| May 19, 2018 | Real Salt Lake 1 at Philadelphia Union 4 | Final |
| May 19, 2018 | D.C. United 3 at San Jose Earthquakes 1 | Final |
| May 20, 2018 | Sporting Kansas City 1 at Minnesota United FC 1 | Final |
| May 20, 2018 | Houston Dynamo 3 at Chicago Fire 2 | Final |
| May 20, 2018 | New York Red Bulls 3 at Atlanta United FC 1 | Final |
| May 21, 2018 | Los Angeles Galaxy 1 at Montreal Impact 0 | Final |
| May 25, 2018 | FC Dallas 1 at Toronto FC 0 | Final |
| May 25, 2018 | New York City FC 1 at Houston Dynamo 3 | Final |
| May 25, 2018 | San Jose Earthquakes 0 at Los Angeles Galaxy 1 | Final |
| May 26, 2018 | Real Salt Lake 1 at Seattle Sounders FC 0 | Final |
| May 26, 2018 | New England Revolution 3 at Vancouver Whitecaps FC 3 | Final |
| May 26, 2018 | Louisville City FC 2 at FC Cincinnati 0 | Final |
| May 26, 2018 | Philadelphia Union 0 at New York Red Bulls 0 | Final |
| May 26, 2018 | Chicago Fire 2 at Orlando City SC 1 | Final |
| May 26, 2018 | Montreal Impact 0 at Minnesota United FC 2 | Final |
| May 26, 2018 | Portland Timbers 3 at Colorado Rapids 2 | Final |
| May 26, 2018 | D.C. United 1 at Los Angeles FC 1 | Final |
| May 27, 2018 | Columbus Crew SC 0 at Sporting Kansas City 0 | Final |
| May 30, 2018 | Atlanta United FC 1 at New England Revolution 1 | Final |
| May 30, 2018 | Chicago Fire 1 at Philadelphia Union 3 | Final |
| May 30, 2018 | Houston Dynamo 1 at Real Salt Lake 2 | Final |
| May 30, 2018 | FC Dallas 3 at Los Angeles Galaxy 2 | Final |
| June 1, 2018 | Vancouver Whitecaps FC 2 at Colorado Rapids 1 | Final |
| June 2, 2018 | FC Cincinnati 2 at New York Red Bulls II 1 | Final |
| June 2, 2018 | Los Angeles Galaxy 1 at Portland Timbers 1 | Final |
| June 2, 2018 | Philadelphia Union 1 at Atlanta United FC 3 | Final |
| June 2, 2018 | Toronto FC 3 at Columbus Crew SC 3 | Final |
| June 2, 2018 | Houston Dynamo 0 at Montreal Impact 1 | Final |
| June 2, 2018 | New York Red Bulls 1 at New England Revolution 2 | Final |
| June 2, 2018 | Orlando City SC 0 at New York City FC 3 | Final |
| June 2, 2018 | Los Angeles FC 1 at FC Dallas 2 | Final |
| June 2, 2018 | San Jose Earthquakes 1 at Chicago Fire 2 | Final |
| June 2, 2018 | Seattle Sounders FC 0 at Real Salt Lake 2 | Final |
| June 3, 2018 | Minnesota United FC 1 at Sporting Kansas City 3 | Final |
| June 8, 2018 | Toronto FC 2 at Philadelphia Union 0 | Final |
| June 9, 2018 | Atlanta United FC 1 at New York City FC 1 | Final |
| June 9, 2018 | New York Red Bulls 1 at Columbus Crew SC 1 | Final |
| June 9, 2018 | FC Cincinnati 2 at North Carolina FC 0 | Final |
| June 9, 2018 | Montreal Impact 0 at FC Dallas 2 | Final |
| June 9, 2018 | New England Revolution 1 at Chicago Fire 1 | Final |
| June 9, 2018 | Colorado Rapids 0 at Houston Dynamo 2 | Final |
| June 9, 2018 | D.C. United 1 at Seattle Sounders FC 2 | Final |
| June 9, 2018 | Orlando City SC 2 at Vancouver Whitecaps FC 5 | Final |
| June 9, 2018 | Real Salt Lake 0 at Los Angeles Galaxy 3 | Final |
| June 9, 2018 | Sporting Kansas City 0 at Portland Timbers 0 | Final |
| June 9, 2018 | Los Angeles FC 4 at San Jose Earthquakes 3 | Final |
| June 13, 2018 | Bethlehem Steel FC 2 at FC Cincinnati 2 | Final |
| June 13, 2018 | Atlanta United FC 2 at Columbus Crew SC 0 | Final |
| June 13, 2018 | Orlando City SC 0 at Montreal Impact 3 | Final |
| June 13, 2018 | Seattle Sounders FC 1 at New York Red Bulls 2 | Final |
| June 13, 2018 | D.C. United 4 at Toronto FC 4 | Final |
| June 13, 2018 | Chicago Fire 2 at Colorado Rapids 2 | Final |
| June 13, 2018 | New England Revolution 2 at San Jose Earthquakes 2 | Final |
| June 16, 2018 | Richmond Kickers 0 at FC Cincinnati 4 | Final |
| June 23, 2018 | Vancouver Whitecaps FC 0 at Philadelphia Union 4 | Final |
| June 23, 2018 | FC Dallas 0 at New York Red Bulls 3 | Final |
| June 23, 2018 | Montreal Impact 2 at Orlando City SC 0 | Final |
| June 23, 2018 | Houston Dynamo 2 at Sporting Kansas City 3 | Final |
| June 23, 2018 | Minnesota United FC 2 at Colorado Rapids 3 | Final |
| June 23, 2018 | San Jose Earthquakes 1 at Real Salt Lake 1 | Final |
| June 23, 2018 | Chicago Fire 1 at Seattle Sounders FC 1 | Final |
| June 23, 2018 | Columbus Crew SC 0 at Los Angeles FC 2 | Final |
| June 24, 2018 | Portland Timbers 1 at Atlanta United FC 1 | Final |
| June 24, 2018 | Toronto FC 1 at New York City FC 2 | Final |
| June 27, 2018 | FC Cincinnati 3 at Toronto FC II 3 | Final |
| June 29, 2018 | FC Dallas 1 at Minnesota United FC 0 | Final |
| June 30, 2018 | Portland Timbers 3 at Seattle Sounders FC 2 | Final |
| June 30, 2018 | Ottawa Fury FC 0 at FC Cincinnati 2 | Final |
| June 30, 2018 | Orlando City SC 0 at Atlanta United FC 4 | Final |
| June 30, 2018 | Sporting Kansas City 0 at Montreal Impact 2 | Final |
| June 30, 2018 | Real Salt Lake 1 at Columbus Crew SC 2 | Final |
| June 30, 2018 | D.C. United 2 at New England Revolution 3 | Final |
| June 30, 2018 | New York City FC 2 at Chicago Fire 3 | Final |
| June 30, 2018 | Philadelphia Union 1 at Los Angeles FC 4 | Final |
| June 30, 2018 | Los Angeles Galaxy 3 at San Jose Earthquakes 3 | Final |
| July 1, 2018 | New York Red Bulls 1 at Toronto FC 0 | Final |
| July 1, 2018 | Colorado Rapids 1 at Vancouver Whitecaps FC 0 | Final |
| July 3, 2018 | Los Angeles FC 2 at Houston Dynamo 2 | Final |
| July 4, 2018 | Toronto FC 3 at Minnesota United FC 4 | Final |
| July 4, 2018 | Atlanta United FC 2 at FC Dallas 3 | Final |
| July 4, 2018 | Seattle Sounders FC 2 at Colorado Rapids 1 | Final |
| July 4, 2018 | Sporting Kansas City 2 at Real Salt Lake 4 | Final |
| July 4, 2018 | D.C. United 2 at Los Angeles Galaxy 2 | Final |
| July 7, 2018 | Chicago Fire 2 at Vancouver Whitecaps FC 3 | Final |
| July 7, 2018 | Colorado Rapids 1 at Montreal Impact 2 | Final |
| July 7, 2018 | Seattle Sounders FC 0 at New England Revolution 0 | Final |
| July 7, 2018 | FC Cincinnati 0 at Nashville SC 0 | Final |
| July 7, 2018 | Atlanta United FC 2 at Philadelphia Union 0 | Final |
| July 7, 2018 | Toronto FC 2 at Sporting Kansas City 2 | Final |
| July 7, 2018 | Minnesota United FC 0 at Houston Dynamo 3 | Final |
| July 7, 2018 | FC Dallas 0 at Real Salt Lake 2 | Final |
| July 7, 2018 | Columbus Crew SC 0 at Los Angeles Galaxy 4 | Final |
| July 7, 2018 | Orlando City SC 1 at Los Angeles FC 4 | Final |
| July 7, 2018 | San Jose Earthquakes 1 at Portland Timbers 2 | Final |
| July 8, 2018 | New York City FC 1 at New York Red Bulls 0 | Final |
| July 11, 2018 | Montreal Impact 0 at New York City FC 3 | Final |
| July 11, 2018 | Philadelphia Union 4 at Chicago Fire 3 | Final |
| July 14, 2018 | Tampa Bay Rowdies 0 at FC Cincinnati 2 | Final |
| July 14, 2018 | Columbus Crew SC 0 at New York City FC 2 | Final |
| July 14, 2018 | Sporting Kansas City 2 at New York Red Bulls 3 | Final |
| July 14, 2018 | San Jose Earthquakes 0 at Montreal Impact 2 | Final |
| July 14, 2018 | Los Angeles Galaxy 3 at New England Revolution 2 | Final |
| July 14, 2018 | Vancouver Whitecaps FC 1 at D.C. United 3 | Final |
| July 14, 2018 | Chicago Fire 1 at FC Dallas 3 | Final |
| July 14, 2018 | Real Salt Lake 2 at Minnesota United FC 3 | Final |
| July 14, 2018 | Toronto FC 1 at Orlando City SC 2 | Final |
| July 14, 2018 | Houston Dynamo 0 at Colorado Rapids 0 | Final |
| July 15, 2018 | Seattle Sounders FC 1 at Atlanta United FC 1 | Final |
| July 15, 2018 | Portland Timbers 0 at Los Angeles FC 0 | Final |
| July 18, 2018 | Charlotte Independence 0 at FC Cincinnati 2 | Final |
| July 18, 2018 | New England Revolution 1 at Minnesota United FC 2 | Final |
| July 21, 2018 | D.C. United 1 at Atlanta United FC 3 | Final |
| July 21, 2018 | Vancouver Whitecaps FC 0 at Seattle Sounders FC 2 | Final |
| July 21, 2018 | New York Red Bulls II 1 at FC Cincinnati 2 | Final |
| July 21, 2018 | Toronto FC 2 at Chicago Fire 1 | Final |
| July 21, 2018 | New England Revolution 0 at New York Red Bulls 2 | Final |
| July 21, 2018 | Los Angeles Galaxy 3 at Philadelphia Union 1 | Final |
| July 21, 2018 | Orlando City SC 2 at Columbus Crew SC 3 | Final |
| July 21, 2018 | FC Dallas 1 at Houston Dynamo 1 | Final |
| July 21, 2018 | Colorado Rapids 2 at Real Salt Lake 2 | Final |
| July 21, 2018 | Montreal Impact 2 at Portland Timbers 2 | Final |
| July 22, 2018 | Los Angeles FC 1 at Minnesota United FC 5 | Final |
| July 25, 2018 | New York Red Bulls 1 at D.C. United 0 | Final |
| July 25, 2018 | Philadelphia Union 3 at Houston Dynamo 1 | Final |
| July 25, 2018 | Seattle Sounders FC 1 at San Jose Earthquakes 0 | Final |
| July 26, 2018 | New York City FC 2 at Orlando City SC 0 | Final |
| July 26, 2018 | Los Angeles Galaxy 2 at Los Angeles FC 2 | Final |
| July 28, 2018 | Atlanta United FC 2 at Montreal Impact 1 | Final |
| July 28, 2018 | Columbus Crew SC 3 at New York Red Bulls 2 | Final |
| July 28, 2018 | Chicago Fire 0 at Toronto FC 3 | Final |
| July 28, 2018 | Colorado Rapids 1 at D.C. United 2 | Final |
| July 28, 2018 | FC Dallas 3 at Sporting Kansas City 2 | Final |
| July 28, 2018 | Minnesota United FC 2 at Vancouver Whitecaps FC 4 | Final |
| July 28, 2018 | Real Salt Lake 0 at San Jose Earthquakes 0 | Final |
| July 28, 2018 | Houston Dynamo 1 at Portland Timbers 2 | Final |
| July 29, 2018 | New York City FC 1 at Seattle Sounders FC 3 | Final |
| July 29, 2018 | Orlando City SC 3 at Los Angeles Galaxy 4 | Final |
| August 4, 2018 | Toronto FC 2 at Atlanta United FC 2 | Final |
| August 4, 2018 | Nashville SC 1 at FC Cincinnati 1 | Final |
| August 4, 2018 | D.C. United 1 at Montreal Impact 1 | Final |
| August 4, 2018 | New England Revolution 3 at Orlando City SC 3 | Final |
| August 4, 2018 | San Jose Earthquakes 3 at FC Dallas 1 | Final |
| August 4, 2018 | Seattle Sounders FC 2 at Minnesota United FC 1 | Final |
| August 4, 2018 | Vancouver Whitecaps FC 2 at New York City FC 2 | Final |
| August 4, 2018 | Los Angeles Galaxy 1 at Colorado Rapids 2 | Final |
| August 4, 2018 | Sporting Kansas City 1 at Houston Dynamo 0 | Final |
| August 4, 2018 | Chicago Fire 1 at Real Salt Lake 2 | Final |
| August 4, 2018 | Philadelphia Union 0 at Portland Timbers 3 | Final |
| August 5, 2018 | Los Angeles FC 1 at New York Red Bulls 2 | Final |
| August 11, 2018 | Houston Dynamo 0 at Columbus Crew SC 1 | Final |
| August 11, 2018 | Philadelphia Union 3 at New England Revolution 2 | Final |
| August 11, 2018 | New York Red Bulls 1 at Chicago Fire 0 | Final |
| August 11, 2018 | San Jose Earthquakes 1 at Colorado Rapids 2 | Final |
| August 11, 2018 | Montreal Impact 1 at Real Salt Lake 1 | Final |
| August 11, 2018 | Sporting Kansas City 2 at Los Angeles FC 0 | Final |
| August 11, 2018 | Minnesota United FC 2 at Los Angeles Galaxy 2 | Final |
| August 11, 2018 | Vancouver Whitecaps FC 2 at Portland Timbers 1 | Final |
| August 12, 2018 | New York City FC 3 at Toronto FC 2 | Final |
| August 12, 2018 | Penn FC 0 at FC Cincinnati 1 | Final |
| August 12, 2018 | Orlando City SC 2 at D.C. United 3 | Final |
| August 12, 2018 | FC Dallas 1 at Seattle Sounders FC 2 | Final |
| August 14, 2018 | Colorado Rapids 2 at Los Angeles Galaxy 2 | Final |
| August 15, 2018 | Portland Timbers 1 at D.C. United 4 | Final |
| August 15, 2018 | Real Salt Lake 0 at Los Angeles FC 2 | Final |
| August 18, 2018 | Los Angeles Galaxy 0 at Seattle Sounders FC 5 | Final |
| August 18, 2018 | Charleston Battery 0 at FC Cincinnati 3 | Final |
| August 18, 2018 | New York City FC 0 at Philadelphia Union 2 | Final |
| August 18, 2018 | New York Red Bulls 2 at Vancouver Whitecaps FC 2 | Final |
| August 18, 2018 | Chicago Fire 1 at Montreal Impact 2 | Final |
| August 18, 2018 | Minnesota United FC 0 at FC Dallas 2 | Final |
| August 18, 2018 | Portland Timbers 0 at Sporting Kansas City 3 | Final |
| August 18, 2018 | Real Salt Lake 2 at Houston Dynamo 1 | Final |
| August 18, 2018 | Toronto FC 1 at San Jose Earthquakes 1 | Final |
| August 19, 2018 | Columbus Crew SC 1 at Atlanta United FC 3 | Final |
| August 19, 2018 | New England Revolution 0 at D.C. United 2 | Final |
| August 19, 2018 | Colorado Rapids 0 at Los Angeles FC 2 | Final |
| August 22, 2018 | FC Cincinnati 5 at Atlanta United 2 1 | Final |
| August 22, 2018 | New York Red Bulls 1 at New York City FC 1 | Final |
| August 23, 2018 | Columbus Crew SC 1 at Chicago Fire 1 | Final |
| August 23, 2018 | FC Dallas 1 at Houston Dynamo 1 | Final |
| August 24, 2018 | Atlanta United FC 2 at Orlando City SC 1 | Final |
| August 24, 2018 | Los Angeles FC 1 at Los Angeles Galaxy 1 | Final |
| August 25, 2018 | FC Cincinnati 2 at Tampa Bay Rowdies 1 | Final |
| August 25, 2018 | New England Revolution 0 at Philadelphia Union 1 | Final |
| August 25, 2018 | Montreal Impact 1 at Toronto FC 3 | Final |
| August 25, 2018 | Minnesota United FC 0 at Sporting Kansas City 2 | Final |
| August 25, 2018 | Real Salt Lake 6 at Colorado Rapids 0 | Final |
| August 25, 2018 | Vancouver Whitecaps FC 3 at San Jose Earthquakes 2 | Final |
| August 26, 2018 | D.C. United 0 at New York Red Bulls 1 | Final |
| August 26, 2018 | Seattle Sounders FC 1 at Portland Timbers 0 | Final |
| August 29, 2018 | Philadelphia Union 2 at D.C. United 0 | Final |
| August 29, 2018 | Houston Dynamo 0 at New York Red Bulls 1 | Final |
| August 29, 2018 | Toronto FC 0 at Portland Timbers 2 | Final |
| August 29, 2018 | FC Dallas 3 at San Jose Earthquakes 4 | Final |
| September 1, 2018 | Sporting Kansas City 1 at Seattle Sounders FC 3 | Final |
| September 1, 2018 | Pittsburgh Riverhounds SC 1 at FC Cincinnati 2 | Final |
| September 1, 2018 | New York Red Bulls 0 at Montreal Impact 3 | Final |
| September 1, 2018 | Portland Timbers 1 at New England Revolution 1 | Final |
| September 1, 2018 | Philadelphia Union 2 at Orlando City SC 2 | Final |
| September 1, 2018 | New York City FC 1 at Columbus Crew SC 2 | Final |
| September 1, 2018 | Houston Dynamo 2 at FC Dallas 4 | Final |
| September 1, 2018 | Los Angeles FC 4 at Toronto FC 2 | Final |
| September 1, 2018 | Los Angeles Galaxy 2 at Real Salt Lake 6 | Final |
| September 1, 2018 | San Jose Earthquakes 1 at Vancouver Whitecaps FC 2 | Final |
| September 2, 2018 | Atlanta United FC 1 at D.C. United 3 | Final |
| September 5, 2018 | New England Revolution 1 at New York City FC 0 | Final |
| September 8, 2018 | D.C. United 1 at New York City FC 1 | Final |
| September 8, 2018 | FC Cincinnati 1 at Louisville City FC 0 | Final |
| September 8, 2018 | Orlando City SC 0 at Sporting Kansas City 1 | Final |
| September 8, 2018 | Colorado Rapids 0 at Portland Timbers 2 | Final |
| September 11, 2018 | FC Cincinnati 1 at Louisville City FC 0 | Final |
| September 12, 2018 | Minnesota United FC 1 at D.C. United 2 | Final |
| September 15, 2018 | Atlanta United FC 3 at Colorado Rapids 0 | Final |
| September 15, 2018 | Montreal Impact 4 at Philadelphia Union 1 | Final |
| September 15, 2018 | Los Angeles Galaxy 3 at Toronto FC 5 | Final |
| September 15, 2018 | Columbus Crew SC 0 at FC Dallas 0 | Final |
| September 15, 2018 | Portland Timbers 1 at Houston Dynamo 4 | Final |
| September 15, 2018 | Minnesota United FC 1 at Real Salt Lake 1 | Final |
| September 15, 2018 | Seattle Sounders FC 2 at Vancouver Whitecaps FC 1 | Final |
| September 15, 2018 | New England Revolution 1 at Los Angeles FC 1 | Final |
| September 15, 2018 | Sporting Kansas City 5 at San Jose Earthquakes 1 | Final |
| September 16, 2018 | New York Red Bulls 3 at D.C. United 3 | Final |
| September 16, 2018 | Toronto FC II 3 at FC Cincinnati 4 | Final |
| September 16, 2018 | Orlando City SC 0 at Chicago Fire 4 | Final |
| September 19, 2018 | Columbus Crew SC 2 at Portland Timbers 3 | Final |
| September 19, 2018 | Atlanta United FC 4 at San Jose Earthquakes 3 | Final |
| September 19, 2018 | Philadelphia Union 1 at Seattle Sounders FC 0 | Final |
| September 22, 2018 | San Jose Earthquakes 0 at Los Angeles FC 2 | Final |
| September 22, 2018 | Toronto FC 0 at New York Red Bulls 2 | Final |
| September 22, 2018 | FC Cincinnati 2 at Penn FC 1 | Final |
| September 22, 2018 | Real Salt Lake 0 at Atlanta United FC 2 | Final |
| September 22, 2018 | Colorado Rapids 1 at Columbus Crew SC 2 | Final |
| September 22, 2018 | New York City FC 1 at Montreal Impact 1 | Final |
| September 22, 2018 | Chicago Fire 2 at New England Revolution 2 | Final |
| September 22, 2018 | Houston Dynamo 0 at Orlando City SC 0 | Final |
| September 22, 2018 | Portland Timbers 2 at Minnesota United FC 3 | Final |
| September 23, 2018 | Sporting Kansas City 0 at Philadelphia Union 2 | Final |
| September 23, 2018 | Seattle Sounders FC 0 at Los Angeles Galaxy 3 | Final |
| September 23, 2018 | FC Dallas 2 at Vancouver Whitecaps FC 1 | Final |
| September 26, 2018 | FC Cincinnati 4 at Richmond Kickers 1 | Final |
| September 26, 2018 | Chicago Fire 0 at New York City FC 2 | Final |
| September 29, 2018 | Los Angeles FC 1 at Chicago Fire 3 | Final |
| September 29, 2018 | Colorado Rapids 0 at Seattle Sounders FC 4 | Final |
| September 29, 2018 | Indy Eleven 0 at FC Cincinnati 3 | Final |
| September 29, 2018 | Montreal Impact 0 at D.C. United 5 | Final |
| September 29, 2018 | Philadelphia Union 0 at Columbus Crew SC 0 | Final |
| September 29, 2018 | New England Revolution 1 at Toronto FC 4 | Final |
| September 29, 2018 | New York City FC 1 at Minnesota United FC 2 | Final |
| September 29, 2018 | San Jose Earthquakes 2 at Houston Dynamo 3 | Final |
| September 29, 2018 | Vancouver Whitecaps FC 0 at Los Angeles Galaxy 3 | Final |
| September 29, 2018 | FC Dallas 0 at Portland Timbers 0 | Final |
| September 30, 2018 | Atlanta United FC 0 at New York Red Bulls 2 | Final |
| September 30, 2018 | Real Salt Lake 1 at Sporting Kansas City 1 | Final |
| October 6, 2018 | Minnesota United FC 1 at Philadelphia Union 5 | Final |
| October 6, 2018 | Columbus Crew SC 0 at Montreal Impact 3 | Final |
| October 6, 2018 | New England Revolution 1 at Atlanta United FC 2 | Final |
| October 6, 2018 | Vancouver Whitecaps FC 2 at Toronto FC 1 | Final |
| October 6, 2018 | FC Cincinnati 0 at Pittsburgh Riverhounds SC 0 | Final |
| October 6, 2018 | Orlando City SC 0 at FC Dallas 2 | Final |
| October 6, 2018 | Los Angeles Galaxy 1 at Sporting Kansas City 1 | Final |
| October 6, 2018 | Los Angeles FC 3 at Colorado Rapids 0 | Final |
| October 6, 2018 | Portland Timbers 4 at Real Salt Lake 1 | Final |
| October 6, 2018 | New York Red Bulls 3 at San Jose Earthquakes 1 | Final |
| October 7, 2018 | Chicago Fire 1 at D.C. United 2 | Final |
| October 8, 2018 | Houston Dynamo 1 at Seattle Sounders FC 4 | Final |
| October 12, 2018 | Houston Dynamo 2 at Los Angeles FC 4 | Final |
| October 13, 2018 | FC Cincinnati 3 at Nashville SC 3 | Final |
| October 13, 2018 | Colorado Rapids 2 at Minnesota United FC 0 | Final |
| October 13, 2018 | FC Dallas 0 at D.C. United 1 | Final |
| October 13, 2018 | Orlando City SC 0 at New England Revolution 2 | Final |
| October 17, 2018 | Toronto FC 0 at D.C. United 1 | Final |
| October 17, 2018 | Seattle Sounders FC 2 at Orlando City SC 1 | Final |
| October 17, 2018 | Sporting Kansas City 4 at Vancouver Whitecaps FC 1 | Final |
| October 18, 2018 | New England Revolution 1 at Real Salt Lake 4 | Final |
| October 20, 2018 | Nashville SC 1 at FC Cincinnati 1 (Playoff, CIN wins SO) | Final |
| October 21, 2018 | Chicago Fire 1 at Atlanta United FC 2 | Final |
| October 21, 2018 | New York City FC 1 at D.C. United 3 | Final |
| October 21, 2018 | Toronto FC 0 at Montreal Impact 2 | Final |
| October 21, 2018 | Columbus Crew SC 1 at Orlando City SC 2 | Final |
| October 21, 2018 | New York Red Bulls 1 at Philadelphia Union 0 | Final |
| October 21, 2018 | Sporting Kansas City 3 at FC Dallas 0 | Final |
| October 21, 2018 | Seattle Sounders FC 3 at Houston Dynamo 2 | Final |
| October 21, 2018 | Vancouver Whitecaps FC 2 at Los Angeles FC 2 | Final |
| October 21, 2018 | Los Angeles Galaxy 3 at Minnesota United FC 1 | Final |
| October 21, 2018 | Real Salt Lake 0 at Portland Timbers 3 | Final |
| October 21, 2018 | Colorado Rapids 0 at San Jose Earthquakes 0 | Final |
| October 27, 2018 | New York Red Bulls II 1 at FC Cincinnati 0 (Playoff) | Final |
| October 28, 2018 | D.C. United 0 at Chicago Fire 0 | Final |
| October 28, 2018 | FC Dallas 1 at Colorado Rapids 2 | Final |
| October 28, 2018 | Minnesota United FC 2 at Columbus Crew SC 3 | Final |
| October 28, 2018 | Houston Dynamo 3 at Los Angeles Galaxy 2 | Final |
| October 28, 2018 | Montreal Impact 0 at New England Revolution 1 | Final |
| October 28, 2018 | Philadelphia Union 1 at New York City FC 3 | Final |
| October 28, 2018 | Orlando City SC 0 at New York Red Bulls 1 | Final |
| October 28, 2018 | San Jose Earthquakes 1 at Seattle Sounders FC 2 | Final |
| October 28, 2018 | Los Angeles FC 1 at Sporting Kansas City 2 | Final |
| October 28, 2018 | Atlanta United FC 1 at Toronto FC 4 | Final |
| October 28, 2018 | Portland Timbers 1 at Vancouver Whitecaps FC 2 | Final |
| October 31, 2018 | Philadelphia Union 1 at New York City FC 3 (Playoff) | Final |
| October 31, 2018 | Portland Timbers 2 at FC Dallas 1 (Playoff) | Final |
| November 1, 2018 | Columbus Crew SC 2 at D.C. United 2 (Playoff, (COL 3-2 in penalties)) | Final |
| November 1, 2018 | Real Salt Lake 3 at Los Angeles FC 2 (Playoff) | Final |
| November 4, 2018 | New York Red Bulls 0 at Columbus Crew SC 1 (Playoff Gm. 1) | Final |
| November 4, 2018 | Seattle Sounders FC 1 at Portland Timbers 2 (Playoff Gm. 1) | Final |
| November 4, 2018 | Atlanta United FC 1 at New York City FC 0 (Playoff Gm. 1) | Final |
| November 4, 2018 | Sporting Kansas City 1 at Real Salt Lake 1 (Playoff Gm. 1) | Final |
| November 8, 2018 | Portland Timbers 2 at Seattle Sounders FC 3 (Playoff Gm. 2; PK 4-2 POR) | Final |
| November 11, 2018 | Real Salt Lake 2 at Sporting Kansas City 4 (Playoff Gm. 2) | Final |
| November 11, 2018 | New York City FC 1 at Atlanta United FC 3 (Playoff Gm. 2) | Final |
| November 11, 2018 | Columbus Crew SC 0 at New York Red Bulls 3 (Playoff Gm. 2) | Final |
| November 25, 2018 | New York Red Bulls 0 at Atlanta United FC 3 (Playoff Gm. 1) | Final |
| November 25, 2018 | Sporting Kansas City 0 at Portland Timbers 0 (Playoff Gm. 1) | Final |
| November 29, 2018 | Atlanta United FC 0 at New York Red Bulls 1 (Playoff Gm. 2) | Final |
| November 29, 2018 | Portland Timbers 3 at Sporting Kansas City 2 (Playoff Gm. 2) | Final |
| December 8, 2018 | Portland Timbers 0 at Atlanta United FC 2 (Championship) | Final |
Major League Soccer Schedule
