| | | |
| February 26, 2022 | Minnesota United FC 1 at Philadelphia Union 1 | Final |
| February 26, 2022 | Vancouver Whitecaps FC 0 at Columbus Crew SC 4 | Final |
| February 26, 2022 | Colorado Rapids 0 at Los Angeles FC 3 | Final |
| February 26, 2022 | Toronto FC 1 at FC Dallas 1 | Final |
| February 26, 2022 | FC Cincinnati 0 at Austin FC 5 | Final |
| February 26, 2022 | Charlotte FC 0 at D.C. United 3 | Final |
| February 26, 2022 | Chicago Fire FC 0 at Inter Miami CF 0 | Final |
| February 26, 2022 | New York Red Bulls 3 at San Jose Earthquakes 1 | Final |
| February 26, 2022 | New England Revolution 2 at Portland Timbers 2 | Final |
| February 27, 2022 | Club de Foot Montreal 0 at Orlando City SC 2 | Final |
| February 27, 2022 | Sporting Kansas City 1 at Atlanta United FC 3 | Final |
| February 27, 2022 | New York City FC 0 at LA Galaxy 1 | Final |
| February 27, 2022 | Real Salt Lake 0 at Houston Dynamo FC 0 | Final |
| February 27, 2022 | Nashville SC 1 at Seattle Sounders FC 0 | Final |
| March 5, 2022 | FC Dallas 0 at New England Revolution 1 | Final |
| March 5, 2022 | New York Red Bulls 4 at Toronto FC 1 | Final |
| March 5, 2022 | Houston Dynamo FC 0 at Sporting Kansas City 1 | Final |
| March 5, 2022 | Philadelphia Union 2 at Club de Foot Montreal 1 | Final |
| March 5, 2022 | Columbus Crew SC 3 at San Jose Earthquakes 3 | Final |
| March 5, 2022 | Orlando City SC 0 at Chicago Fire FC 0 | Final |
| March 5, 2022 | Atlanta United FC 0 at Colorado Rapids 3 | Final |
| March 5, 2022 | D.C. United 1 at FC Cincinnati 0 | Final |
| March 5, 2022 | Nashville SC 1 at Minnesota United FC 1 | Final |
| March 5, 2022 | Seattle Sounders FC 0 at Real Salt Lake 1 | Final |
| March 5, 2022 | New York City FC 0 at Vancouver Whitecaps FC 0 | Final |
| March 5, 2022 | LA Galaxy 1 at Charlotte FC 0 | Final |
| March 6, 2022 | Inter Miami CF 1 at Austin FC 5 | Final |
| March 6, 2022 | Portland Timbers 1 at Los Angeles FC 1 | Final |
| March 12, 2022 | Club de Foot Montreal 1 at New York City FC 4 | Final |
| March 12, 2022 | Toronto FC 1 at Columbus Crew SC 2 | Final |
| March 12, 2022 | Los Angeles FC 2 at Inter Miami CF 0 | Final |
| March 12, 2022 | LA Galaxy 2 at Seattle Sounders FC 3 | Final |
| March 12, 2022 | Vancouver Whitecaps FC 1 at Houston Dynamo FC 2 | Final |
| March 12, 2022 | Chicago Fire FC 2 at D.C. United 0 | Final |
| March 12, 2022 | Real Salt Lake 3 at New England Revolution 2 | Final |
| March 12, 2022 | FC Cincinnati 2 at Orlando City SC 1 | Final |
| March 12, 2022 | San Jose Earthquakes 0 at Philadelphia Union 2 | Final |
| March 12, 2022 | Nashville SC 0 at FC Dallas 2 | Final |
| March 12, 2022 | Sporting Kansas City 0 at Colorado Rapids 2 | Final |
| March 12, 2022 | Austin FC 0 at Portland Timbers 1 | Final |
| March 13, 2022 | Charlotte FC 1 at Atlanta United FC 2 | Final |
| March 13, 2022 | Minnesota United FC 1 at New York Red Bulls 0 | Final |
| March 19, 2022 | Inter Miami CF 1 at FC Cincinnati 3 | Final |
| March 19, 2022 | Philadelphia Union 2 at New York City FC 0 | Final |
| March 19, 2022 | D.C. United 1 at Toronto FC 2 | Final |
| March 19, 2022 | Orlando City SC 1 at LA Galaxy 0 | Final |
| March 19, 2022 | Club de Foot Montreal 3 at Atlanta United FC 3 | Final |
| March 19, 2022 | Sporting Kansas City 1 at Chicago Fire FC 3 | Final |
| March 19, 2022 | New England Revolution 1 at Charlotte FC 3 | Final |
| March 19, 2022 | San Jose Earthquakes 0 at Minnesota United FC 1 | Final |
| March 19, 2022 | Portland Timbers 1 at FC Dallas 4 | Final |
| March 19, 2022 | Colorado Rapids 1 at Houston Dynamo FC 1 | Final |
| March 19, 2022 | Nashville SC 1 at Real Salt Lake 2 | Final |
| March 20, 2022 | Columbus Crew SC 1 at New York Red Bulls 1 | Final |
| March 20, 2022 | Seattle Sounders FC 1 at Austin FC 1 | Final |
| March 20, 2022 | Vancouver Whitecaps FC 1 at Los Angeles FC 3 | Final |
| March 26, 2022 | FC Cincinnati 0 at Charlotte FC 2 | Final |
| March 26, 2022 | Real Salt Lake 0 at Sporting Kansas City 1 | Final |
| March 27, 2022 | Orlando City SC 1 at Portland Timbers 1 | Final |
| April 2, 2022 | FC Dallas 0 at Chicago Fire FC 0 | Final |
| April 2, 2022 | Club de Foot Montreal 4 at FC Cincinnati 3 | Final |
| April 2, 2022 | New York City FC 1 at Toronto FC 2 | Final |
| April 2, 2022 | Nashville SC 1 at Columbus Crew SC 0 | Final |
| April 2, 2022 | Atlanta United FC 1 at D.C. United 0 | Final |
| April 2, 2022 | New York Red Bulls 1 at New England Revolution 0 | Final |
| April 2, 2022 | Los Angeles FC 4 at Orlando City SC 2 | Final |
| April 2, 2022 | Charlotte FC 0 at Philadelphia Union 2 | Final |
| April 2, 2022 | Austin FC 2 at San Jose Earthquakes 2 | Final |
| April 2, 2022 | Houston Dynamo FC 3 at Inter Miami CF 1 | Final |
| April 2, 2022 | Seattle Sounders FC 2 at Minnesota United FC 1 | Final |
| April 2, 2022 | Sporting Kansas City 0 at Vancouver Whitecaps FC 1 | Final |
| April 2, 2022 | Real Salt Lake 1 at Colorado Rapids 1 | Final |
| April 3, 2022 | LA Galaxy 3 at Portland Timbers 1 | Final |
| April 9, 2022 | Chicago Fire FC 0 at Orlando City SC 1 | Final |
| April 9, 2022 | New England Revolution 2 at Inter Miami CF 3 | Final |
| April 9, 2022 | Club de Foot Montreal 2 at New York Red Bulls 1 | Final |
| April 9, 2022 | Columbus Crew SC 0 at Philadelphia Union 1 | Final |
| April 9, 2022 | Los Angeles FC 1 at LA Galaxy 2 | Final |
| April 9, 2022 | Toronto FC 2 at Real Salt Lake 2 | Final |
| April 9, 2022 | Colorado Rapids 1 at FC Dallas 3 | Final |
| April 9, 2022 | San Jose Earthquakes 3 at Houston Dynamo FC 4 | Final |
| April 9, 2022 | Nashville SC 2 at Sporting Kansas City 1 | Final |
| April 9, 2022 | Portland Timbers 3 at Vancouver Whitecaps FC 2 | Final |
| April 10, 2022 | Atlanta United FC 0 at Charlotte FC 1 | Final |
| April 10, 2022 | Minnesota United FC 0 at Austin FC 1 | Final |
| April 16, 2022 | Vancouver Whitecaps FC 1 at Club de Foot Montreal 2 | Final |
| April 16, 2022 | Nashville SC 2 at San Jose Earthquakes 2 | Final |
| April 16, 2022 | FC Cincinnati 0 at Atlanta United FC 0 | Final |
| April 16, 2022 | Portland Timbers 0 at Houston Dynamo FC 0 | Final |
| April 16, 2022 | FC Dallas 0 at New York Red Bulls 0 | Final |
| April 16, 2022 | Orlando City SC 2 at Columbus Crew SC 0 | Final |
| April 16, 2022 | Austin FC 3 at D.C. United 2 | Final |
| April 16, 2022 | Charlotte FC 1 at New England Revolution 2 | Final |
| April 16, 2022 | Philadelphia Union 1 at Toronto FC 2 | Final |
| April 16, 2022 | LA Galaxy 0 at Chicago Fire FC 0 | Final |
| April 16, 2022 | Colorado Rapids 1 at Minnesota United FC 3 | Final |
| April 16, 2022 | Inter Miami CF 1 at Seattle Sounders FC 0 | Final |
| April 17, 2022 | Real Salt Lake 0 at New York City FC 6 | Final |
| April 17, 2022 | Sporting Kansas City 1 at Los Angeles FC 3 | Final |
| April 23, 2022 | Houston Dynamo FC 1 at FC Dallas 2 | Final |
| April 23, 2022 | Club de Foot Montreal 1 at Philadelphia Union 1 | Final |
| April 23, 2022 | Chicago Fire FC 0 at Minnesota United FC 3 | Final |
| April 23, 2022 | New England Revolution 2 at D.C. United 3 | Final |
| April 23, 2022 | Vancouver Whitecaps FC 0 at Austin FC 3 | Final |
| April 23, 2022 | Columbus Crew SC 0 at Sporting Kansas City 0 | Final |
| April 23, 2022 | Charlotte FC 0 at Colorado Rapids 0 | Final |
| April 23, 2022 | Real Salt Lake 0 at Portland Timbers 0 | Final |
| April 23, 2022 | Nashville SC 0 at LA Galaxy 1 | Final |
| April 23, 2022 | Seattle Sounders FC 3 at San Jose Earthquakes 4 | Final |
| April 24, 2022 | Atlanta United FC 1 at Inter Miami CF 2 | Final |
| April 24, 2022 | New York Red Bulls 3 at Orlando City SC 0 | Final |
| April 24, 2022 | Los Angeles FC 2 at FC Cincinnati 1 | Final |
| April 24, 2022 | Toronto FC 4 at New York City FC 5 | Final |
| April 30, 2022 | Austin FC 2 at Houston Dynamo FC 1 | Final |
| April 30, 2022 | FC Cincinnati 2 at Toronto FC 1 | Final |
| April 30, 2022 | LA Galaxy 0 at Real Salt Lake 1 | Final |
| April 30, 2022 | Atlanta United FC 1 at Club de Foot Montreal 2 | Final |
| April 30, 2022 | D.C. United 0 at Columbus Crew SC 3 | Final |
| April 30, 2022 | Inter Miami CF 0 at New England Revolution 2 | Final |
| April 30, 2022 | Charlotte FC 1 at Orlando City SC 2 | Final |
| April 30, 2022 | New York Red Bulls 2 at Chicago Fire FC 1 | Final |
| April 30, 2022 | FC Dallas 2 at Sporting Kansas City 2 | Final |
| April 30, 2022 | Portland Timbers 0 at Colorado Rapids 2 | Final |
| May 1, 2022 | San Jose Earthquakes 0 at New York City FC 3 | Final |
| May 1, 2022 | Philadelphia Union 1 at Nashville SC 1 | Final |
| May 1, 2022 | Minnesota United FC 0 at Los Angeles FC 2 | Final |
| May 4, 2022 | Toronto FC 0 at FC Cincinnati 2 | Final |
| May 7, 2022 | Colorado Rapids 0 at San Jose Earthquakes 1 | Final |
| May 7, 2022 | Inter Miami CF 0 at Charlotte FC 1 | Final |
| May 7, 2022 | Orlando City SC 1 at Club de Foot Montreal 4 | Final |
| May 7, 2022 | Chicago Fire FC 1 at Atlanta United FC 4 | Final |
| May 7, 2022 | Sporting Kansas City 0 at New York City FC 0 | Final |
| May 7, 2022 | Portland Timbers 1 at New York Red Bulls 1 | Final |
| May 7, 2022 | Houston Dynamo FC 0 at D.C. United 2 | Final |
| May 7, 2022 | Columbus Crew SC 2 at New England Revolution 2 | Final |
| May 7, 2022 | FC Cincinnati 1 at Minnesota United FC 0 | Final |
| May 7, 2022 | Seattle Sounders FC 0 at FC Dallas 2 | Final |
| May 7, 2022 | Philadelphia Union 2 at Los Angeles FC 2 | Final |
| May 8, 2022 | Toronto FC 0 at Vancouver Whitecaps FC 1 | Final |
| May 8, 2022 | Real Salt Lake 0 at Nashville SC 2 | Final |
| May 8, 2022 | LA Galaxy 1 at Austin FC 0 | Final |
| May 14, 2022 | Orlando City SC 1 at Toronto FC 0 | Final |
| May 14, 2022 | Los Angeles FC 0 at Colorado Rapids 2 | Final |
| May 14, 2022 | Club de Foot Montreal 2 at Charlotte FC 0 | Final |
| May 14, 2022 | Columbus Crew SC 0 at New York City FC 2 | Final |
| May 14, 2022 | San Jose Earthquakes 3 at Vancouver Whitecaps FC 3 | Final |
| May 14, 2022 | New York Red Bulls 1 at Philadelphia Union 1 | Final |
| May 14, 2022 | FC Cincinnati 2 at Chicago Fire FC 1 | Final |
| May 14, 2022 | D.C. United 2 at Inter Miami CF 2 | Final |
| May 14, 2022 | Nashville SC 0 at Houston Dynamo FC 2 | Final |
| May 14, 2022 | Austin FC 1 at Real Salt Lake 2 | Final |
| May 14, 2022 | Sporting Kansas City 2 at Portland Timbers 7 | Final |
| May 14, 2022 | FC Dallas 3 at LA Galaxy 1 | Final |
| May 15, 2022 | New England Revolution 2 at Atlanta United FC 2 | Final |
| May 15, 2022 | Minnesota United FC 1 at Seattle Sounders FC 3 | Final |
| May 18, 2022 | New York City FC 2 at D.C. United 0 | Final |
| May 18, 2022 | Chicago Fire FC 3 at New York Red Bulls 3 | Final |
| May 18, 2022 | Inter Miami CF 0 at Philadelphia Union 0 | Final |
| May 18, 2022 | LA Galaxy 1 at Minnesota United FC 1 | Final |
| May 18, 2022 | Seattle Sounders FC 1 at Houston Dynamo FC 0 | Final |
| May 18, 2022 | Club de Foot Montreal 1 at Nashville SC 2 | Final |
| May 18, 2022 | Colorado Rapids 1 at Sporting Kansas City 2 | Final |
| May 18, 2022 | FC Dallas 1 at Vancouver Whitecaps FC 2 | Final |
| May 18, 2022 | Austin FC 2 at Los Angeles FC 1 | Final |
| May 18, 2022 | Portland Timbers 2 at San Jose Earthquakes 3 | Final |
| May 21, 2022 | Los Angeles FC 2 at Columbus Crew SC 0 | Final |
| May 21, 2022 | New England Revolution 3 at FC Cincinnati 2 | Final |
| May 21, 2022 | Toronto FC 2 at D.C. United 2 | Final |
| May 21, 2022 | Atlanta United FC 2 at Nashville SC 2 | Final |
| May 22, 2022 | Real Salt Lake 2 at Club de Foot Montreal 1 | Final |
| May 22, 2022 | Vancouver Whitecaps FC 1 at Charlotte FC 2 | Final |
| May 22, 2022 | Chicago Fire FC 0 at New York City FC 1 | Final |
| May 22, 2022 | New York Red Bulls 0 at Inter Miami CF 2 | Final |
| May 22, 2022 | Minnesota United FC 2 at FC Dallas 1 | Final |
| May 22, 2022 | Sporting Kansas City 1 at San Jose Earthquakes 1 | Final |
| May 22, 2022 | Orlando City SC 2 at Austin FC 2 | Final |
| May 22, 2022 | Seattle Sounders FC 0 at Colorado Rapids 1 | Final |
| May 22, 2022 | Houston Dynamo FC 3 at LA Galaxy 0 | Final |
| May 22, 2022 | Philadelphia Union 2 at Portland Timbers 0 | Final |
| May 28, 2022 | San Jose Earthquakes 2 at Los Angeles FC 3 | Final |
| May 28, 2022 | Columbus Crew SC 2 at Atlanta United FC 1 | Final |
| May 28, 2022 | D.C. United 1 at New York Red Bulls 4 | Final |
| May 28, 2022 | Chicago Fire FC 2 at Toronto FC 3 | Final |
| May 28, 2022 | FC Cincinnati 3 at Club de Foot Montreal 4 | Final |
| May 28, 2022 | Philadelphia Union 1 at New England Revolution 1 | Final |
| May 28, 2022 | FC Dallas 3 at Orlando City SC 1 | Final |
| May 28, 2022 | Portland Timbers 1 at Inter Miami CF 2 | Final |
| May 28, 2022 | New York City FC 1 at Minnesota United FC 0 | Final |
| May 28, 2022 | Nashville SC 3 at Colorado Rapids 1 | Final |
| May 28, 2022 | Vancouver Whitecaps FC 1 at Sporting Kansas City 0 | Final |
| May 28, 2022 | Houston Dynamo FC 0 at Real Salt Lake 3 | Final |
| May 29, 2022 | Austin FC 1 at LA Galaxy 4 | Final |
| May 29, 2022 | Charlotte FC 1 at Seattle Sounders FC 2 | Final |
| June 4, 2022 | Real Salt Lake 1 at Vancouver Whitecaps FC 2 | Final |
| June 11, 2022 | New York Red Bulls 0 at Charlotte FC 2 | Final |
| June 11, 2022 | San Jose Earthquakes 0 at Nashville SC 0 | Final |
| June 12, 2022 | New England Revolution 2 at Sporting Kansas City 1 | Final |
| June 14, 2022 | Vancouver Whitecaps FC 0 at Seattle Sounders FC 4 | Final |
| June 15, 2022 | Orlando City SC 1 at New England Revolution 1 | Final |
| June 18, 2022 | Los Angeles FC 1 at Seattle Sounders FC 1 | Final |
| June 18, 2022 | Portland Timbers 1 at LA Galaxy 1 | Final |
| June 18, 2022 | Toronto FC 0 at New York Red Bulls 2 | Final |
| June 18, 2022 | Austin FC 1 at Club de Foot Montreal 0 | Final |
| June 18, 2022 | Charlotte FC 1 at Columbus Crew SC 1 | Final |
| June 18, 2022 | Houston Dynamo FC 1 at Orlando City SC 2 | Final |
| June 18, 2022 | FC Cincinnati 1 at Philadelphia Union 1 | Final |
| June 18, 2022 | D.C. United 0 at Chicago Fire FC 1 | Final |
| June 18, 2022 | Vancouver Whitecaps FC 2 at FC Dallas 0 | Final |
| June 18, 2022 | San Jose Earthquakes 0 at Real Salt Lake 2 | Final |
| June 19, 2022 | Inter Miami CF 0 at Atlanta United FC 2 | Final |
| June 19, 2022 | Minnesota United FC 1 at New England Revolution 2 | Final |
| June 19, 2022 | Colorado Rapids 1 at New York City FC 1 | Final |
| June 19, 2022 | Sporting Kansas City 2 at Nashville SC 1 | Final |
| June 24, 2022 | Orlando City SC 0 at FC Cincinnati 1 | Final |
| June 25, 2022 | Sporting Kansas City 0 at Seattle Sounders FC 3 | Final |
| June 25, 2022 | Nashville SC 3 at D.C. United 1 | Final |
| June 25, 2022 | Charlotte FC 1 at Club de Foot Montreal 2 | Final |
| June 25, 2022 | Atlanta United FC 1 at Toronto FC 2 | Final |
| June 25, 2022 | Chicago Fire FC 0 at Houston Dynamo FC 2 | Final |
| June 25, 2022 | Minnesota United FC 1 at Inter Miami CF 2 | Final |
| June 25, 2022 | FC Dallas 2 at Austin FC 2 | Final |
| June 25, 2022 | Columbus Crew SC 0 at Real Salt Lake 0 | Final |
| June 25, 2022 | Colorado Rapids 0 at Portland Timbers 3 | Final |
| June 26, 2022 | New York Red Bulls 0 at Los Angeles FC 2 | Final |
| June 26, 2022 | New York City FC 1 at Philadelphia Union 2 | Final |
| June 26, 2022 | New England Revolution 0 at Vancouver Whitecaps FC 0 | Final |
| June 29, 2022 | New York City FC 4 at FC Cincinnati 4 | Final |
| June 29, 2022 | Columbus Crew SC 2 at Toronto FC 1 | Final |
| June 29, 2022 | Philadelphia Union 0 at Chicago Fire FC 1 | Final |
| June 29, 2022 | Club de Foot Montreal 2 at Seattle Sounders FC 1 | Final |
| June 29, 2022 | Minnesota United FC 3 at LA Galaxy 2 | Final |
| June 29, 2022 | FC Dallas 1 at Los Angeles FC 3 | Final |
| June 29, 2022 | Houston Dynamo FC 1 at Portland Timbers 2 | Final |
| June 30, 2022 | Austin FC 1 at Charlotte FC 0 | Final |
| June 30, 2022 | Atlanta United FC 1 at New York Red Bulls 2 | Final |
| July 2, 2022 | Seattle Sounders FC 2 at Toronto FC 0 | Final |
| July 2, 2022 | Los Angeles FC 0 at Vancouver Whitecaps FC 1 | Final |
| July 3, 2022 | Atlanta United FC 2 at New York City FC 2 | Final |
| July 3, 2022 | Philadelphia Union 0 at Columbus Crew SC 0 | Final |
| July 3, 2022 | FC Cincinnati 2 at New England Revolution 2 | Final |
| July 3, 2022 | Real Salt Lake 2 at Minnesota United FC 3 | Final |
| July 3, 2022 | New York Red Bulls 1 at Sporting Kansas City 0 | Final |
| July 3, 2022 | Charlotte FC 2 at Houston Dynamo FC 1 | Final |
| July 3, 2022 | Portland Timbers 2 at Nashville SC 2 | Final |
| July 3, 2022 | Chicago Fire FC 1 at San Jose Earthquakes 2 | Final |
| July 4, 2022 | D.C. United 5 at Orlando City SC 3 | Final |
| July 4, 2022 | Austin FC 3 at Colorado Rapids 2 | Final |
| July 4, 2022 | Inter Miami CF 1 at FC Dallas 1 | Final |
| July 4, 2022 | Club de Foot Montreal 0 at LA Galaxy 4 | Final |
| July 8, 2022 | D.C. United 0 at Philadelphia Union 7 | Final |
| July 8, 2022 | LA Galaxy 2 at Los Angeles FC 3 | Final |
| July 8, 2022 | Minnesota United FC 3 at Vancouver Whitecaps FC 1 | Final |
| July 9, 2022 | New England Revolution 2 at New York City FC 4 | Final |
| July 9, 2022 | Portland Timbers 3 at Seattle Sounders FC 0 | Final |
| July 9, 2022 | Austin FC 3 at Atlanta United FC 0 | Final |
| July 9, 2022 | Nashville SC 1 at Charlotte FC 4 | Final |
| July 9, 2022 | Sporting Kansas City 2 at Club de Foot Montreal 1 | Final |
| July 9, 2022 | New York Red Bulls 1 at FC Cincinnati 1 | Final |
| July 9, 2022 | San Jose Earthquakes 2 at Toronto FC 2 | Final |
| July 9, 2022 | Columbus Crew SC 3 at Chicago Fire FC 2 | Final |
| July 9, 2022 | Inter Miami CF 0 at Orlando City SC 1 | Final |
| July 9, 2022 | FC Dallas 2 at Houston Dynamo FC 2 | Final |
| July 9, 2022 | Colorado Rapids 2 at Real Salt Lake 2 | Final |
| July 12, 2022 | Houston Dynamo FC 1 at Austin FC 3 | Final |
| July 13, 2022 | Real Salt Lake 1 at Atlanta United FC 2 | Final |
| July 13, 2022 | Toronto FC 0 at Chicago Fire FC 2 | Final |
| July 13, 2022 | Columbus Crew SC 2 at D.C. United 2 | Final |
| July 13, 2022 | Vancouver Whitecaps FC 2 at FC Cincinnati 2 | Final |
| July 13, 2022 | Philadelphia Union 2 at Inter Miami CF 1 | Final |
| July 13, 2022 | Sporting Kansas City 1 at Minnesota United FC 1 | Final |
| July 13, 2022 | Seattle Sounders FC 0 at Nashville SC 1 | Final |
| July 13, 2022 | Orlando City SC 1 at Colorado Rapids 1 | Final |
| July 13, 2022 | New York City FC 1 at FC Dallas 0 | Final |
| July 13, 2022 | San Jose Earthquakes 3 at LA Galaxy 2 | Final |
| July 16, 2022 | Toronto FC 0 at Club de Foot Montreal 1 | Final |
| July 16, 2022 | New England Revolution 1 at Philadelphia Union 2 | Final |
| July 16, 2022 | Seattle Sounders FC 0 at Chicago Fire FC 1 | Final |
| July 16, 2022 | Charlotte FC 2 at Inter Miami CF 3 | Final |
| July 16, 2022 | D.C. United 0 at Minnesota United FC 2 | Final |
| July 16, 2022 | LA Galaxy 0 at Colorado Rapids 2 | Final |
| July 16, 2022 | Austin FC 1 at FC Dallas 1 | Final |
| July 17, 2022 | Orlando City SC 1 at Atlanta United FC 1 | Final |
| July 17, 2022 | New York City FC 1 at New York Red Bulls 0 | Final |
| July 17, 2022 | FC Cincinnati 0 at Columbus Crew SC 2 | Final |
| July 17, 2022 | Los Angeles FC 2 at Nashville SC 1 | Final |
| July 17, 2022 | Sporting Kansas City 0 at Real Salt Lake 3 | Final |
| July 17, 2022 | Houston Dynamo FC 2 at San Jose Earthquakes 1 | Final |
| July 17, 2022 | Vancouver Whitecaps FC 1 at Portland Timbers 1 | Final |
| July 23, 2022 | Inter Miami CF 0 at New York City FC 2 | Final |
| July 23, 2022 | New England Revolution 0 at Columbus Crew SC 0 | Final |
| July 23, 2022 | Nashville SC 1 at FC Cincinnati 1 | Final |
| July 23, 2022 | Philadelphia Union 1 at Orlando City SC 0 | Final |
| July 23, 2022 | Charlotte FC 0 at Toronto FC 4 | Final |
| July 23, 2022 | Club de Foot Montreal 2 at D.C. United 1 | Final |
| July 23, 2022 | Minnesota United FC 2 at Houston Dynamo FC 1 | Final |
| July 23, 2022 | Los Angeles FC 2 at Sporting Kansas City 0 | Final |
| July 23, 2022 | FC Dallas 1 at Real Salt Lake 0 | Final |
| July 23, 2022 | Colorado Rapids 1 at Seattle Sounders FC 2 | Final |
| July 23, 2022 | Chicago Fire FC 3 at Vancouver Whitecaps FC 1 | Final |
| July 23, 2022 | San Jose Earthquakes 1 at Portland Timbers 2 | Final |
| July 24, 2022 | New York Red Bulls 4 at Austin FC 3 | Final |
| July 24, 2022 | Atlanta United FC 0 at LA Galaxy 2 | Final |
| July 29, 2022 | Seattle Sounders FC 1 at Los Angeles FC 2 | Final |
| July 30, 2022 | Real Salt Lake 2 at San Jose Earthquakes 2 | Final |
| July 30, 2022 | Portland Timbers 4 at Minnesota United FC 4 | Final |
| July 30, 2022 | Atlanta United FC 0 at Chicago Fire FC 0 | Final |
| July 30, 2022 | Columbus Crew SC at Charlotte FC | Ppd. |
| July 30, 2022 | New York City FC 0 at Club de Foot Montreal 0 | Final |
| July 30, 2022 | Houston Dynamo FC 0 at Philadelphia Union 6 | Final |
| July 30, 2022 | FC Cincinnati 4 at Inter Miami CF 4 | Final |
| July 30, 2022 | Vancouver Whitecaps FC 1 at Nashville SC 1 | Final |
| July 30, 2022 | Toronto FC 0 at New England Revolution 0 | Final |
| July 30, 2022 | Austin FC 2 at Sporting Kansas City 0 | Final |
| July 30, 2022 | LA Galaxy 0 at FC Dallas 1 | Final |
| July 31, 2022 | Orlando City SC 1 at D.C. United 2 | Final |
| August 2, 2022 | Colorado Rapids 5 at New York Red Bulls 4 | Final |
| August 2, 2022 | FC Dallas 0 at Seattle Sounders FC 1 | Final |
| August 3, 2022 | D.C. United 0 at Charlotte FC 3 | Final |
| August 3, 2022 | Club de Foot Montreal 2 at Columbus Crew SC 1 | Final |
| August 3, 2022 | Nashville SC 1 at Portland Timbers 1 | Final |
| August 3, 2022 | Inter Miami CF 1 at San Jose Earthquakes 0 | Final |
| August 5, 2022 | Houston Dynamo FC 1 at Vancouver Whitecaps FC 2 | Final |
| August 6, 2022 | Seattle Sounders FC 1 at Atlanta United FC 2 | Final |
| August 6, 2022 | Chicago Fire FC 3 at Charlotte FC 2 | Final |
| August 6, 2022 | Inter Miami CF 2 at Club de Foot Montreal 2 | Final |
| August 6, 2022 | New York City FC 2 at Columbus Crew SC 3 | Final |
| August 6, 2022 | New York Red Bulls 0 at D.C. United 0 | Final |
| August 6, 2022 | Philadelphia Union 1 at FC Cincinnati 3 | Final |
| August 6, 2022 | New England Revolution 3 at Orlando City SC 0 | Final |
| August 6, 2022 | Toronto FC 4 at Nashville SC 3 | Final |
| August 6, 2022 | LA Galaxy 2 at Sporting Kansas City 4 | Final |
| August 6, 2022 | San Jose Earthquakes 3 at Austin FC 3 | Final |
| August 6, 2022 | Minnesota United FC 3 at Colorado Rapids 4 | Final |
| August 6, 2022 | Los Angeles FC 4 at Real Salt Lake 1 | Final |
| August 6, 2022 | FC Dallas 1 at Portland Timbers 1 | Final |
| August 13, 2022 | Orlando City SC 1 at New York Red Bulls 0 | Final |
| August 13, 2022 | Atlanta United FC 2 at FC Cincinnati 2 | Final |
| August 13, 2022 | D.C. United 0 at New England Revolution 1 | Final |
| August 13, 2022 | Chicago Fire FC 1 at Philadelphia Union 4 | Final |
| August 13, 2022 | Portland Timbers 1 at Toronto FC 3 | Final |
| August 13, 2022 | New York City FC 2 at Inter Miami CF 3 | Final |
| August 13, 2022 | Sporting Kansas City 3 at Austin FC 4 | Final |
| August 13, 2022 | Columbus Crew SC 1 at Colorado Rapids 1 | Final |
| August 13, 2022 | San Jose Earthquakes 1 at FC Dallas 4 | Final |
| August 13, 2022 | Club de Foot Montreal 3 at Houston Dynamo FC 2 | Final |
| August 13, 2022 | Vancouver Whitecaps FC 2 at LA Galaxy 5 | Final |
| August 13, 2022 | Charlotte FC 0 at Los Angeles FC 5 | Final |
| August 14, 2022 | Minnesota United FC 2 at Nashville SC 1 | Final |
| August 14, 2022 | Real Salt Lake 2 at Seattle Sounders FC 1 | Final |
| August 16, 2022 | D.C. United 0 at Los Angeles FC 1 | Final |
| August 17, 2022 | New York Red Bulls 2 at Atlanta United FC 1 | Final |
| August 17, 2022 | New England Revolution 2 at Toronto FC 2 | Final |
| August 17, 2022 | Charlotte FC 3 at New York City FC 1 | Final |
| August 17, 2022 | Philadelphia Union 0 at FC Dallas 1 | Final |
| August 17, 2022 | Colorado Rapids 1 at Vancouver Whitecaps FC 2 | Final |
| August 19, 2022 | Seattle Sounders FC 3 at LA Galaxy 3 | Final |
| August 20, 2022 | FC Cincinnati 1 at New York Red Bulls 1 | Final |
| August 20, 2022 | New England Revolution 0 at Club de Foot Montreal 4 | Final |
| August 20, 2022 | Philadelphia Union 6 at D.C. United 0 | Final |
| August 20, 2022 | Toronto FC 1 at Inter Miami CF 2 | Final |
| August 20, 2022 | Austin FC 1 at Minnesota United FC 2 | Final |
| August 20, 2022 | Houston Dynamo FC 1 at Colorado Rapids 1 | Final |
| August 20, 2022 | Vancouver Whitecaps FC 1 at Real Salt Lake 1 | Final |
| August 20, 2022 | Los Angeles FC 1 at San Jose Earthquakes 2 | Final |
| August 21, 2022 | Atlanta United FC 2 at Columbus Crew SC 2 | Final |
| August 21, 2022 | New York City FC 2 at Chicago Fire FC 0 | Final |
| August 21, 2022 | Orlando City SC 2 at Charlotte FC 1 | Final |
| August 21, 2022 | Portland Timbers 1 at Sporting Kansas City 4 | Final |
| August 21, 2022 | FC Dallas 0 at Nashville SC 4 | Final |
| August 26, 2022 | Los Angeles FC 1 at Austin FC 4 | Final |
| August 26, 2022 | Seattle Sounders FC 1 at Portland Timbers 2 | Final |
| August 27, 2022 | Houston Dynamo FC 1 at Minnesota United FC 2 | Final |
| August 27, 2022 | Toronto FC 2 at Charlotte FC 0 | Final |
| August 27, 2022 | Inter Miami CF 1 at New York Red Bulls 3 | Final |
| August 27, 2022 | Columbus Crew SC 2 at FC Cincinnati 2 | Final |
| August 27, 2022 | Colorado Rapids 0 at Philadelphia Union 6 | Final |
| August 27, 2022 | Club de Foot Montreal 2 at Chicago Fire FC 0 | Final |
| August 27, 2022 | San Jose Earthquakes 0 at Sporting Kansas City 1 | Final |
| August 27, 2022 | Real Salt Lake 1 at FC Dallas 1 | Final |
| August 27, 2022 | Nashville SC 3 at Vancouver Whitecaps FC 0 | Final |
| August 28, 2022 | D.C. United 2 at Atlanta United FC 3 | Final |
| August 28, 2022 | New York City FC 1 at Orlando City SC 2 | Final |
| August 28, 2022 | LA Galaxy 2 at New England Revolution 1 | Final |
| August 31, 2022 | D.C. United 2 at New York City FC 1 | Final |
| August 31, 2022 | Atlanta United FC 1 at Philadelphia Union 4 | Final |
| August 31, 2022 | New York Red Bulls 1 at Club de Foot Montreal 0 | Final |
| August 31, 2022 | Inter Miami CF 0 at Columbus Crew SC 1 | Final |
| August 31, 2022 | Chicago Fire FC 0 at New England Revolution 0 | Final |
| August 31, 2022 | Seattle Sounders FC 2 at Orlando City SC 3 | Final |
| August 31, 2022 | LA Galaxy 2 at Toronto FC 2 | Final |
| August 31, 2022 | Los Angeles FC 1 at Houston Dynamo FC 2 | Final |
| August 31, 2022 | Colorado Rapids 1 at Nashville SC 4 | Final |
| August 31, 2022 | Portland Timbers 2 at Austin FC 1 | Final |
| August 31, 2022 | Minnesota United FC 0 at Real Salt Lake 3 | Final |
| September 3, 2022 | FC Dallas 3 at Minnesota United FC 0 | Final |
| September 3, 2022 | Chicago Fire FC 0 at Columbus Crew SC 0 | Final |
| September 3, 2022 | Philadelphia Union 2 at New York Red Bulls 0 | Final |
| September 3, 2022 | Charlotte FC 0 at FC Cincinnati 2 | Final |
| September 3, 2022 | Austin FC 0 at Nashville SC 3 | Final |
| September 4, 2022 | Atlanta United FC 1 at Portland Timbers 2 | Final |
| September 4, 2022 | Colorado Rapids 0 at D.C. United 0 | Final |
| September 4, 2022 | Club de Foot Montreal 4 at Toronto FC 3 | Final |
| September 4, 2022 | Sporting Kansas City 2 at LA Galaxy 2 | Final |
| September 4, 2022 | New York City FC 0 at New England Revolution 3 | Final |
| September 4, 2022 | Houston Dynamo FC 1 at Seattle Sounders FC 2 | Final |
| September 4, 2022 | Vancouver Whitecaps FC 0 at San Jose Earthquakes 2 | Final |
| September 4, 2022 | Real Salt Lake 0 at Los Angeles FC 2 | Final |
| September 7, 2022 | FC Cincinnati 1 at New York City FC 1 | Final |
| September 9, 2022 | Columbus Crew SC 2 at Club de Foot Montreal 2 | Final |
| September 10, 2022 | New England Revolution 1 at New York Red Bulls 2 | Final |
| September 10, 2022 | New York City FC 0 at Charlotte FC 1 | Final |
| September 10, 2022 | LA Galaxy 1 at Nashville SC 1 | Final |
| September 10, 2022 | Toronto FC 2 at Atlanta United FC 4 | Final |
| September 10, 2022 | San Jose Earthquakes 0 at FC Cincinnati 6 | Final |
| September 10, 2022 | Orlando City SC 1 at Philadelphia Union 5 | Final |
| September 10, 2022 | Inter Miami CF 1 at Chicago Fire FC 3 | Final |
| September 10, 2022 | Austin FC 0 at Seattle Sounders FC 3 | Final |
| September 10, 2022 | Los Angeles FC 1 at FC Dallas 2 | Final |
| September 10, 2022 | Sporting Kansas City 0 at Houston Dynamo FC 0 | Final |
| September 10, 2022 | Vancouver Whitecaps FC 1 at Colorado Rapids 3 | Final |
| September 10, 2022 | D.C. United 0 at Real Salt Lake 0 | Final |
| September 10, 2022 | Minnesota United FC 0 at Portland Timbers 1 | Final |
| September 13, 2022 | Chicago Fire FC 2 at Club de Foot Montreal 3 | Final |
| September 13, 2022 | Columbus Crew SC 1 at Inter Miami CF 2 | Final |
| September 13, 2022 | Los Angeles FC 1 at Minnesota United FC 1 | Final |
| September 13, 2022 | New England Revolution 1 at Houston Dynamo FC 3 | Final |
| September 13, 2022 | D.C. United 0 at Sporting Kansas City 3 | Final |
| September 14, 2022 | Atlanta United FC 1 at Orlando City SC 0 | Final |
| September 14, 2022 | Real Salt Lake 0 at Austin FC 3 | Final |
| September 14, 2022 | San Jose Earthquakes 1 at Colorado Rapids 2 | Final |
| September 14, 2022 | LA Galaxy 0 at Vancouver Whitecaps FC 3 | Final |
| September 17, 2022 | New York Red Bulls 0 at New York City FC 2 | Final |
| September 17, 2022 | Philadelphia Union 0 at Atlanta United FC 0 | Final |
| September 17, 2022 | Club de Foot Montreal 1 at New England Revolution 0 | Final |
| September 17, 2022 | Toronto FC 0 at Orlando City SC 4 | Final |
| September 17, 2022 | Charlotte FC 3 at Chicago Fire FC 2 | Final |
| September 17, 2022 | Minnesota United FC 1 at Sporting Kansas City 4 | Final |
| September 17, 2022 | Nashville SC 1 at Austin FC 1 | Final |
| September 17, 2022 | FC Cincinnati 2 at Real Salt Lake 1 | Final |
| September 17, 2022 | Seattle Sounders FC 1 at Vancouver Whitecaps FC 2 | Final |
| September 17, 2022 | Colorado Rapids 1 at LA Galaxy 4 | Final |
| September 17, 2022 | FC Dallas 1 at San Jose Earthquakes 1 | Final |
| September 18, 2022 | Portland Timbers 1 at Columbus Crew SC 1 | Final |
| September 18, 2022 | Inter Miami CF 3 at D.C. United 2 | Final |
| September 18, 2022 | Houston Dynamo FC 1 at Los Angeles FC 3 | Final |
| September 24, 2022 | LA Galaxy at San Jose Earthquakes | 10:00 p.m. |
| September 27, 2022 | FC Cincinnati at Seattle Sounders FC | 10:00 p.m. |
| September 30, 2022 | Inter Miami CF at Toronto FC | 7:30 p.m. |
| October 1, 2022 | Minnesota United FC at San Jose Earthquakes | 9:00 a.m. |
| October 1, 2022 | Atlanta United FC at New England Revolution | 1:30 p.m. |
| October 1, 2022 | FC Dallas at Colorado Rapids | 3:30 p.m. |
| October 1, 2022 | Philadelphia Union at Charlotte FC | 7:00 p.m. |
| October 1, 2022 | D.C. United at Club de Foot Montreal | 7:30 p.m. |
| October 1, 2022 | New York Red Bulls at Columbus Crew SC | 7:30 p.m. |
| October 1, 2022 | Chicago Fire FC at FC Cincinnati | 7:30 p.m. |
| October 1, 2022 | Austin FC at Vancouver Whitecaps FC | 10:00 p.m. |
| October 1, 2022 | Real Salt Lake at LA Galaxy | 10:30 p.m. |
| October 2, 2022 | Orlando City SC at New York City FC | 1:00 p.m. |
| October 2, 2022 | Los Angeles FC at Portland Timbers | 3:00 p.m. |
| October 2, 2022 | Seattle Sounders FC at Sporting Kansas City | 5:00 p.m. |
| October 2, 2022 | Houston Dynamo FC at Nashville SC | 8:30 p.m. |
| October 5, 2022 | Columbus Crew SC at Charlotte FC | 7:00 p.m. |
| October 5, 2022 | Orlando City SC at Inter Miami CF | 8:00 p.m. |
| October 9, 2022 | New York City FC at Atlanta United FC | 9:00 a.m. |
| October 9, 2022 | New England Revolution at Chicago Fire FC | 9:00 a.m. |
| October 9, 2022 | FC Cincinnati at D.C. United | 9:00 a.m. |
| October 9, 2022 | Club de Foot Montreal at Inter Miami CF | 9:00 a.m. |
| October 9, 2022 | Charlotte FC at New York Red Bulls | 9:00 a.m. |
| October 9, 2022 | Columbus Crew SC at Orlando City SC | 9:00 a.m. |
| October 9, 2022 | Toronto FC at Philadelphia Union | 9:00 a.m. |
| October 9, 2022 | Colorado Rapids at Austin FC | 5:00 p.m. |
| October 9, 2022 | Sporting Kansas City at FC Dallas | 5:00 p.m. |
| October 9, 2022 | LA Galaxy at Houston Dynamo FC | 5:00 p.m. |
| October 9, 2022 | Nashville SC at Los Angeles FC | 5:00 p.m. |
| October 9, 2022 | Vancouver Whitecaps FC at Minnesota United FC | 5:00 p.m. |
| October 9, 2022 | Portland Timbers at Real Salt Lake | 5:00 p.m. |
| October 9, 2022 | San Jose Earthquakes at Seattle Sounders FC | 5:00 p.m. |
Major League Soccer Schedule
