| | | |
| March 2, 2019 | Toronto FC 3 at Philadelphia Union 1 | Final |
| March 2, 2019 | New York City FC 2 at Orlando City SC 2 | Final |
| March 2, 2019 | New York Red Bulls 1 at Columbus Crew SC 1 | Final |
| March 2, 2019 | New England Revolution 1 at FC Dallas 1 | Final |
| March 2, 2019 | Portland Timbers 3 at Colorado Rapids 3 | Final |
| March 2, 2019 | Real Salt Lake 1 at Houston Dynamo 1 | Final |
| March 2, 2019 | Minnesota United FC 3 at Vancouver Whitecaps FC 2 | Final |
| March 2, 2019 | Chicago Fire 1 at LA Galaxy 2 | Final |
| March 2, 2019 | Montreal Impact 2 at San Jose Earthquakes 1 | Final |
| March 2, 2019 | FC Cincinnati 1 at Seattle Sounders FC 4 | Final |
| March 3, 2019 | Atlanta United FC 0 at D.C. United 2 | Final |
| March 3, 2019 | Sporting Kansas City 1 at Los Angeles FC 2 | Final |
| March 9, 2019 | Orlando City SC 1 at Chicago Fire 1 | Final |
| March 9, 2019 | Columbus Crew SC 2 at New England Revolution 0 | Final |
| March 9, 2019 | LA Galaxy 0 at FC Dallas 2 | Final |
| March 9, 2019 | Montreal Impact 1 at Houston Dynamo 2 | Final |
| March 9, 2019 | Vancouver Whitecaps FC 0 at Real Salt Lake 1 | Final |
| March 9, 2019 | Minnesota United FC 3 at San Jose Earthquakes 0 | Final |
| March 9, 2019 | Colorado Rapids 0 at Seattle Sounders FC 2 | Final |
| March 10, 2019 | D.C. United 0 at New York City FC 0 | Final |
| March 10, 2019 | Philadelphia Union 0 at Sporting Kansas City 2 | Final |
| March 10, 2019 | FC Cincinnati 1 at Atlanta United FC 1 | Final |
| March 10, 2019 | Portland Timbers 1 at Los Angeles FC 4 | Final |
| March 16, 2019 | Seattle Sounders FC 4 at Chicago Fire 2 | Final |
| March 16, 2019 | FC Dallas 0 at Columbus Crew SC 1 | Final |
| March 16, 2019 | Vancouver Whitecaps FC 2 at Houston Dynamo 3 | Final |
| March 16, 2019 | San Jose Earthquakes 1 at New York Red Bulls 4 | Final |
| March 16, 2019 | Montreal Impact 3 at Orlando City SC 1 | Final |
| March 16, 2019 | Real Salt Lake 0 at D.C. United 5 | Final |
| March 16, 2019 | Minnesota United FC 2 at LA Galaxy 3 | Final |
| March 17, 2019 | Los Angeles FC 2 at New York City FC 2 | Final |
| March 17, 2019 | Portland Timbers 0 at FC Cincinnati 3 | Final |
| March 17, 2019 | Philadelphia Union 1 at Atlanta United FC 1 | Final |
| March 17, 2019 | New England Revolution 2 at Toronto FC 3 | Final |
| March 17, 2019 | Sporting Kansas City 1 at Colorado Rapids 1 | Final |
| March 23, 2019 | Colorado Rapids 1 at FC Dallas 2 | Final |
| March 23, 2019 | Orlando City SC 1 at New York Red Bulls 0 | Final |
| March 23, 2019 | Columbus Crew SC 0 at Philadelphia Union 3 | Final |
| March 23, 2019 | Real Salt Lake 1 at Los Angeles FC 2 | Final |
| March 24, 2019 | FC Cincinnati 2 at New England Revolution 0 | Final |
| March 29, 2019 | New York City FC 0 at Toronto FC 4 | Final |
| March 30, 2019 | New York Red Bulls 0 at Chicago Fire 1 | Final |
| March 30, 2019 | Minnesota United FC 1 at New England Revolution 2 | Final |
| March 30, 2019 | Montreal Impact 1 at Sporting Kansas City 7 | Final |
| March 30, 2019 | Los Angeles FC 5 at San Jose Earthquakes 0 | Final |
| March 30, 2019 | Atlanta United FC 0 at Columbus Crew SC 2 | Final |
| March 30, 2019 | Philadelphia Union 2 at FC Cincinnati 0 | Final |
| March 30, 2019 | Houston Dynamo 4 at Colorado Rapids 1 | Final |
| March 30, 2019 | FC Dallas 4 at Real Salt Lake 2 | Final |
| March 30, 2019 | Seattle Sounders FC 0 at Vancouver Whitecaps FC 0 | Final |
| March 31, 2019 | D.C. United 2 at Orlando City SC 1 | Final |
| March 31, 2019 | Portland Timbers 1 at LA Galaxy 2 | Final |
| April 5, 2019 | LA Galaxy 2 at Vancouver Whitecaps FC 0 | Final |
| April 6, 2019 | Montreal Impact 0 at New York City FC 0 | Final |
| April 6, 2019 | Los Angeles FC 4 at D.C. United 0 | Final |
| April 6, 2019 | Chicago Fire 2 at Toronto FC 2 | Final |
| April 6, 2019 | Minnesota United FC 2 at New York Red Bulls 1 | Final |
| April 6, 2019 | New England Revolution 0 at Columbus Crew SC 1 | Final |
| April 6, 2019 | Colorado Rapids 3 at Orlando City SC 4 | Final |
| April 6, 2019 | FC Dallas 1 at Philadelphia Union 2 | Final |
| April 6, 2019 | Portland Timbers 0 at San Jose Earthquakes 3 | Final |
| April 6, 2019 | Real Salt Lake 0 at Seattle Sounders FC 1 | Final |
| April 7, 2019 | Sporting Kansas City 1 at FC Cincinnati 1 | Final |
| April 9, 2019 | Montreal Impact 0 at D.C. United 0 | Final |
| April 12, 2019 | Vancouver Whitecaps FC 1 at Chicago Fire 1 | Final |
| April 13, 2019 | Columbus Crew SC 0 at Montreal Impact 1 | Final |
| April 13, 2019 | San Jose Earthquakes 1 at Houston Dynamo 2 | Final |
| April 13, 2019 | Toronto FC 2 at Seattle Sounders FC 3 | Final |
| April 13, 2019 | New York City FC 3 at Minnesota United FC 3 | Final |
| April 13, 2019 | Atlanta United FC 2 at New England Revolution 0 | Final |
| April 13, 2019 | Portland Timbers 1 at FC Dallas 2 | Final |
| April 13, 2019 | D.C. United 3 at Colorado Rapids 2 | Final |
| April 13, 2019 | Orlando City SC 1 at Real Salt Lake 2 | Final |
| April 13, 2019 | Philadelphia Union 0 at LA Galaxy 2 | Final |
| April 13, 2019 | FC Cincinnati 0 at Los Angeles FC 2 | Final |
| April 14, 2019 | New York Red Bulls 2 at Sporting Kansas City 2 | Final |
| April 17, 2019 | Los Angeles FC 0 at Vancouver Whitecaps FC 1 | Final |
| April 19, 2019 | Real Salt Lake 2 at FC Cincinnati 0 | 19:01 HT |
| April 19, 2019 | Minnesota United FC 1 at Toronto FC 0 | 18 Min. |
| April 19, 2019 | Houston Dynamo at LA Galaxy | 10:30 p.m. |
| April 20, 2019 | Colorado Rapids at Chicago Fire | 1:00 p.m. |
| April 20, 2019 | Montreal Impact at Philadelphia Union | 1:00 p.m. |
| April 20, 2019 | Vancouver Whitecaps FC at Orlando City SC | 3:00 p.m. |
| April 20, 2019 | FC Dallas at Atlanta United FC | 4:00 p.m. |
| April 20, 2019 | Portland Timbers at Columbus Crew SC | 7:30 p.m. |
| April 20, 2019 | New York Red Bulls at New England Revolution | 7:30 p.m. |
| April 20, 2019 | Sporting Kansas City at San Jose Earthquakes | 10:00 p.m. |
| April 21, 2019 | New York City FC at D.C. United | 4:00 p.m. |
| April 21, 2019 | Seattle Sounders FC at Los Angeles FC | 7:00 p.m. |
| April 24, 2019 | Chicago Fire at New York City FC | 7:00 p.m. |
| April 24, 2019 | D.C. United at Columbus Crew SC | 7:30 p.m. |
| April 24, 2019 | Montreal Impact at New England Revolution | 7:30 p.m. |
| April 24, 2019 | LA Galaxy at Minnesota United FC | 8:00 p.m. |
| April 24, 2019 | San Jose Earthquakes at Seattle Sounders FC | 10:30 p.m. |
| April 27, 2019 | Orlando City SC at New York City FC | 1:00 p.m. |
| April 27, 2019 | Portland Timbers at Toronto FC | 3:00 p.m. |
| April 27, 2019 | San Jose Earthquakes at FC Dallas | 3:30 p.m. |
| April 27, 2019 | Philadelphia Union at Vancouver Whitecaps FC | 5:00 p.m. |
| April 27, 2019 | Colorado Rapids at Atlanta United FC | 6:00 p.m. |
| April 27, 2019 | FC Cincinnati at New York Red Bulls | 7:00 p.m. |
| April 27, 2019 | Columbus Crew SC at Houston Dynamo | 8:30 p.m. |
| April 27, 2019 | New England Revolution at Sporting Kansas City | 8:30 p.m. |
| April 28, 2019 | Chicago Fire at Montreal Impact | 12:30 p.m. |
| April 28, 2019 | D.C. United at Minnesota United FC | 1:30 p.m. |
| April 28, 2019 | Los Angeles FC at Seattle Sounders FC | 3:30 p.m. |
| April 28, 2019 | Real Salt Lake at LA Galaxy | 8:00 p.m. |
| May 1, 2019 | FC Cincinnati at Philadelphia Union | 7:30 p.m. |
| May 3, 2019 | Vancouver Whitecaps FC at Colorado Rapids | 9:00 p.m. |
| May 4, 2019 | LA Galaxy at New York Red Bulls | 2:00 p.m. |
| May 4, 2019 | FC Dallas at Houston Dynamo | 4:00 p.m. |
| May 4, 2019 | Toronto FC at Orlando City SC | 4:00 p.m. |
| May 4, 2019 | New York City FC at Montreal Impact | 5:00 p.m. |
| May 4, 2019 | New England Revolution at Philadelphia Union | 7:30 p.m. |
| May 4, 2019 | Columbus Crew SC at D.C. United | 8:00 p.m. |
| May 4, 2019 | Seattle Sounders FC at Minnesota United FC | 8:00 p.m. |
| May 4, 2019 | Portland Timbers at Real Salt Lake | 9:00 p.m. |
| May 4, 2019 | FC Cincinnati at San Jose Earthquakes | 10:00 p.m. |
| May 4, 2019 | Chicago Fire at Los Angeles FC | 10:30 p.m. |
| May 5, 2019 | Atlanta United FC at Sporting Kansas City | 9:00 p.m. |
| May 8, 2019 | Toronto FC at Atlanta United FC | 7:00 p.m. |
| May 8, 2019 | LA Galaxy at Columbus Crew SC | 7:30 p.m. |
| May 8, 2019 | New England Revolution at Chicago Fire | 8:00 p.m. |
| May 8, 2019 | Montreal Impact at New York Red Bulls | 8:00 p.m. |
| May 10, 2019 | Portland Timbers at Vancouver Whitecaps FC | 10:00 p.m. |
| May 11, 2019 | Montreal Impact at FC Cincinnati | 1:00 p.m. |
| May 11, 2019 | New York Red Bulls at FC Dallas | 2:00 p.m. |
| May 11, 2019 | Philadelphia Union at Toronto FC | 3:00 p.m. |
| May 11, 2019 | New York City FC at LA Galaxy | 4:00 p.m. |
| May 11, 2019 | Los Angeles FC at Columbus Crew SC | 7:30 p.m. |
| May 11, 2019 | San Jose Earthquakes at New England Revolution | 7:30 p.m. |
| May 11, 2019 | Minnesota United FC at Chicago Fire | 8:00 p.m. |
| May 11, 2019 | Real Salt Lake at Colorado Rapids | 9:00 p.m. |
| May 11, 2019 | Houston Dynamo at Seattle Sounders FC | 10:00 p.m. |
| May 12, 2019 | Orlando City SC at Atlanta United FC | 2:30 p.m. |
| May 12, 2019 | Sporting Kansas City at D.C. United | 7:00 p.m. |
| May 15, 2019 | D.C. United at Toronto FC | 8:00 p.m. |
| May 15, 2019 | Portland Timbers at Houston Dynamo | 8:30 p.m. |
| May 15, 2019 | Atlanta United FC at Vancouver Whitecaps FC | 10:00 p.m. |
| May 15, 2019 | Orlando City SC at Seattle Sounders FC | 10:30 p.m. |
| May 16, 2019 | FC Dallas at Los Angeles FC | 10:00 p.m. |
| May 18, 2019 | New England Revolution at Montreal Impact | 1:00 p.m. |
| May 18, 2019 | Toronto FC at Real Salt Lake | 3:00 p.m. |
| May 18, 2019 | Chicago Fire at San Jose Earthquakes | 3:30 p.m. |
| May 18, 2019 | Seattle Sounders FC at Philadelphia Union | 7:30 p.m. |
| May 18, 2019 | Columbus Crew SC at Minnesota United FC | 8:00 p.m. |
| May 18, 2019 | D.C. United at Houston Dynamo | 8:30 p.m. |
| May 18, 2019 | Vancouver Whitecaps FC at Sporting Kansas City | 8:30 p.m. |
| May 19, 2019 | Los Angeles FC at FC Dallas | 3:00 p.m. |
| May 19, 2019 | FC Cincinnati at Orlando City SC | 3:00 p.m. |
| May 19, 2019 | Atlanta United FC at New York Red Bulls | 5:00 p.m. |
| May 19, 2019 | Colorado Rapids at LA Galaxy | 8:00 p.m. |
| May 22, 2019 | Vancouver Whitecaps FC at New York Red Bulls | 8:00 p.m. |
| May 24, 2019 | LA Galaxy at Orlando City SC | 7:00 p.m. |
| May 24, 2019 | Atlanta United FC at Real Salt Lake | 9:00 p.m. |
| May 24, 2019 | Montreal Impact at Los Angeles FC | 10:30 p.m. |
| May 25, 2019 | New York City FC at Chicago Fire | 3:30 p.m. |
| May 25, 2019 | FC Dallas at Vancouver Whitecaps FC | 7:00 p.m. |
| May 25, 2019 | New York Red Bulls at FC Cincinnati | 7:30 p.m. |
| May 25, 2019 | D.C. United at New England Revolution | 7:30 p.m. |
| May 25, 2019 | Portland Timbers at Philadelphia Union | 7:30 p.m. |
| May 25, 2019 | Houston Dynamo at Minnesota United FC | 8:00 p.m. |
| May 25, 2019 | Columbus Crew SC at Colorado Rapids | 9:00 p.m. |
| May 26, 2019 | Seattle Sounders FC at Sporting Kansas City | 6:00 p.m. |
| May 26, 2019 | San Jose Earthquakes at Toronto FC | 7:30 p.m. |
| May 29, 2019 | Minnesota United FC at Atlanta United FC | 7:00 p.m. |
| May 29, 2019 | Real Salt Lake at Montreal Impact | 7:30 p.m. |
| May 29, 2019 | Colorado Rapids at Philadelphia Union | 7:30 p.m. |
| May 29, 2019 | Chicago Fire at D.C. United | 8:00 p.m. |
| May 29, 2019 | LA Galaxy at Sporting Kansas City | 8:30 p.m. |
| May 31, 2019 | Toronto FC at Vancouver Whitecaps FC | 10:00 p.m. |
| June 1, 2019 | Orlando City SC at Montreal Impact | 4:00 p.m. |
| June 1, 2019 | Chicago Fire at Atlanta United FC | 6:00 p.m. |
| June 1, 2019 | Real Salt Lake at New York Red Bulls | 7:00 p.m. |
| June 1, 2019 | New York City FC at Columbus Crew SC | 7:30 p.m. |
| June 1, 2019 | San Jose Earthquakes at D.C. United | 8:00 p.m. |
| June 1, 2019 | Seattle Sounders FC at FC Dallas | 8:00 p.m. |
| June 1, 2019 | Sporting Kansas City at Houston Dynamo | 8:30 p.m. |
| June 1, 2019 | FC Cincinnati at Colorado Rapids | 9:00 p.m. |
| June 1, 2019 | Los Angeles FC at Portland Timbers | 10:30 p.m. |
| June 2, 2019 | Philadelphia Union at Minnesota United FC | 4:00 p.m. |
| June 2, 2019 | New England Revolution at LA Galaxy | 10:30 p.m. |
| June 5, 2019 | Seattle Sounders FC at Montreal Impact | 7:30 p.m. |
| June 6, 2019 | FC Cincinnati at New York City FC | 7:00 p.m. |
| June 7, 2019 | Sporting Kansas City at Toronto FC | 8:00 p.m. |
| June 8, 2019 | FC Dallas at San Jose Earthquakes | 4:30 p.m. |
| June 8, 2019 | New York Red Bulls at Philadelphia Union | 7:30 p.m. |
| June 8, 2019 | Minnesota United FC at Colorado Rapids | 9:00 p.m. |
| June 22, 2019 | LA Galaxy at FC Cincinnati | 7:30 p.m. |
| June 22, 2019 | Real Salt Lake at Chicago Fire | 8:00 p.m. |
| June 22, 2019 | Toronto FC at FC Dallas | 8:00 p.m. |
| June 22, 2019 | Colorado Rapids at Vancouver Whitecaps FC | 10:00 p.m. |
| June 22, 2019 | Houston Dynamo at Portland Timbers | 11:00 p.m. |
| June 23, 2019 | Sporting Kansas City at Columbus Crew SC | 7:30 p.m. |
| June 26, 2019 | Portland Timbers at Montreal Impact | 7:30 p.m. |
| June 26, 2019 | Philadelphia Union at New England Revolution | 7:30 p.m. |
| June 26, 2019 | Orlando City SC at D.C. United | 8:00 p.m. |
| June 26, 2019 | Atlanta United FC at Toronto FC | 8:00 p.m. |
| June 26, 2019 | Vancouver Whitecaps FC at FC Dallas | 9:00 p.m. |
| June 26, 2019 | Houston Dynamo at San Jose Earthquakes | 10:30 p.m. |
| June 28, 2019 | Chicago Fire at New York Red Bulls | 8:00 p.m. |
| June 28, 2019 | Los Angeles FC at Colorado Rapids | 10:00 p.m. |
| June 29, 2019 | FC Cincinnati at Minnesota United FC | 4:00 p.m. |
| June 29, 2019 | Montreal Impact at Atlanta United FC | 6:00 p.m. |
| June 29, 2019 | Philadelphia Union at New York City FC | 7:00 p.m. |
| June 29, 2019 | Orlando City SC at Columbus Crew SC | 7:30 p.m. |
| June 29, 2019 | Houston Dynamo at New England Revolution | 7:30 p.m. |
| June 29, 2019 | Toronto FC at D.C. United | 8:00 p.m. |
| June 29, 2019 | Sporting Kansas City at Real Salt Lake | 10:00 p.m. |
| June 29, 2019 | LA Galaxy at San Jose Earthquakes | 10:00 p.m. |
| June 29, 2019 | Vancouver Whitecaps FC at Seattle Sounders FC | 10:00 p.m. |
| June 30, 2019 | FC Dallas at Portland Timbers | 11:00 p.m. |
| July 3, 2019 | Seattle Sounders FC at New York City FC | 7:00 p.m. |
| July 3, 2019 | Philadelphia Union at Orlando City SC | 7:30 p.m. |
| July 3, 2019 | Atlanta United FC at Chicago Fire | 8:00 p.m. |
| July 3, 2019 | San Jose Earthquakes at Minnesota United FC | 8:00 p.m. |
| July 3, 2019 | Los Angeles FC at Sporting Kansas City | 8:30 p.m. |
| July 3, 2019 | New York Red Bulls at Houston Dynamo | 9:00 p.m. |
| July 3, 2019 | Columbus Crew SC at Real Salt Lake | 10:00 p.m. |
| July 4, 2019 | New England Revolution at Colorado Rapids | 9:00 p.m. |
| July 4, 2019 | D.C. United at FC Dallas | 9:00 p.m. |
| July 4, 2019 | Toronto FC at LA Galaxy | 10:30 p.m. |
| July 6, 2019 | Orlando City SC at Philadelphia Union | 7:00 p.m. |
| July 6, 2019 | Seattle Sounders FC at Columbus Crew SC | 7:30 p.m. |
| July 6, 2019 | Houston Dynamo at FC Cincinnati | 7:30 p.m. |
| July 6, 2019 | Minnesota United FC at Montreal Impact | 7:30 p.m. |
| July 6, 2019 | Chicago Fire at Sporting Kansas City | 8:30 p.m. |
| July 6, 2019 | Vancouver Whitecaps FC at Los Angeles FC | 10:30 p.m. |
| July 6, 2019 | Real Salt Lake at San Jose Earthquakes | 10:30 p.m. |
| July 7, 2019 | New York Red Bulls at Atlanta United FC | 2:00 p.m. |
| July 7, 2019 | Portland Timbers at New York City FC | 6:30 p.m. |
| July 12, 2019 | New England Revolution at D.C. United | 7:00 p.m. |
| July 12, 2019 | Los Angeles FC at Houston Dynamo | 9:00 p.m. |
| July 12, 2019 | San Jose Earthquakes at LA Galaxy | 11:00 p.m. |
| July 13, 2019 | Toronto FC at Montreal Impact | 7:30 p.m. |
| July 13, 2019 | Columbus Crew SC at Orlando City SC | 7:30 p.m. |
| July 13, 2019 | FC Cincinnati at Chicago Fire | 8:00 p.m. |
| July 13, 2019 | FC Dallas at Minnesota United FC | 9:00 p.m. |
| July 13, 2019 | Philadelphia Union at Real Salt Lake | 10:00 p.m. |
| July 13, 2019 | Sporting Kansas City at Vancouver Whitecaps FC | 10:00 p.m. |
| July 13, 2019 | Colorado Rapids at Portland Timbers | 11:00 p.m. |
| July 14, 2019 | Atlanta United FC at Seattle Sounders FC | 4:00 p.m. |
| July 14, 2019 | New York City FC at New York Red Bulls | 6:30 p.m. |
| July 17, 2019 | Houston Dynamo at Atlanta United FC | 7:00 p.m. |
| July 17, 2019 | Vancouver Whitecaps FC at New England Revolution | 7:00 p.m. |
| July 17, 2019 | Columbus Crew SC at Chicago Fire | 8:00 p.m. |
| July 17, 2019 | New York Red Bulls at Toronto FC | 8:00 p.m. |
| July 18, 2019 | D.C. United at FC Cincinnati | 8:00 p.m. |
| July 18, 2019 | Orlando City SC at Portland Timbers | 10:00 p.m. |
| July 19, 2019 | Los Angeles FC at LA Galaxy | 10:00 p.m. |
| July 20, 2019 | Montreal Impact at Columbus Crew SC | 7:30 p.m. |
| July 20, 2019 | Chicago Fire at Philadelphia Union | 7:30 p.m. |
| July 20, 2019 | Houston Dynamo at Toronto FC | 7:30 p.m. |
| July 20, 2019 | FC Dallas at Sporting Kansas City | 8:30 p.m. |
| July 20, 2019 | New York City FC at Colorado Rapids | 9:00 p.m. |
| July 20, 2019 | Minnesota United FC at Real Salt Lake | 10:00 p.m. |
| July 20, 2019 | San Jose Earthquakes at Vancouver Whitecaps FC | 10:00 p.m. |
| July 21, 2019 | D.C. United at Atlanta United FC | 4:00 p.m. |
| July 21, 2019 | New England Revolution at FC Cincinnati | 6:00 p.m. |
| July 21, 2019 | New York Red Bulls at Orlando City SC | 7:30 p.m. |
| July 21, 2019 | Portland Timbers at Seattle Sounders FC | 9:30 p.m. |
| July 26, 2019 | Sporting Kansas City at New York City FC | 7:30 p.m. |
| July 27, 2019 | D.C. United at Chicago Fire | 8:00 p.m. |
| July 27, 2019 | Real Salt Lake at FC Dallas | 8:00 p.m. |
| July 27, 2019 | Seattle Sounders FC at Houston Dynamo | 8:00 p.m. |
| July 27, 2019 | Atlanta United FC at Los Angeles FC | 8:00 p.m. |
| July 27, 2019 | Vancouver Whitecaps FC at Minnesota United FC | 8:00 p.m. |
| July 27, 2019 | Philadelphia Union at Montreal Impact | 8:00 p.m. |
| July 27, 2019 | Orlando City SC at New England Revolution | 8:00 p.m. |
| July 27, 2019 | Columbus Crew SC at New York Red Bulls | 8:00 p.m. |
| July 27, 2019 | FC Cincinnati at Toronto FC | 8:00 p.m. |
| July 27, 2019 | Colorado Rapids at San Jose Earthquakes | 10:00 p.m. |
| July 27, 2019 | LA Galaxy at Portland Timbers | 10:30 p.m. |
| August 3, 2019 | LA Galaxy at Atlanta United FC | 5:00 p.m. |
| August 3, 2019 | Toronto FC at New York Red Bulls | 6:00 p.m. |
| August 3, 2019 | Los Angeles FC at New England Revolution | 7:30 p.m. |
| August 3, 2019 | FC Dallas at Orlando City SC | 7:30 p.m. |
| August 3, 2019 | Vancouver Whitecaps FC at FC Cincinnati | 8:00 p.m. |
| August 3, 2019 | Montreal Impact at Colorado Rapids | 9:00 p.m. |
| August 3, 2019 | Chicago Fire at Houston Dynamo | 9:00 p.m. |
| August 3, 2019 | New York City FC at Real Salt Lake | 10:00 p.m. |
| August 3, 2019 | Columbus Crew SC at San Jose Earthquakes | 10:30 p.m. |
| August 4, 2019 | Portland Timbers at Minnesota United FC | 4:00 p.m. |
| August 4, 2019 | Philadelphia Union at D.C. United | 7:30 p.m. |
| August 4, 2019 | Sporting Kansas City at Seattle Sounders FC | 10:00 p.m. |
| August 8, 2019 | Houston Dynamo at New York City FC | 7:00 p.m. |
| August 10, 2019 | New England Revolution at Seattle Sounders FC | 4:00 p.m. |
| August 10, 2019 | FC Cincinnati at Columbus Crew SC | 7:30 p.m. |
| August 10, 2019 | Orlando City SC at Toronto FC | 7:30 p.m. |
| August 10, 2019 | Minnesota United FC at FC Dallas | 8:00 p.m. |
| August 10, 2019 | Real Salt Lake at Sporting Kansas City | 8:30 p.m. |
| August 10, 2019 | Montreal Impact at Chicago Fire | 9:00 p.m. |
| August 10, 2019 | San Jose Earthquakes at Colorado Rapids | 9:00 p.m. |
| August 10, 2019 | Vancouver Whitecaps FC at Portland Timbers | 11:00 p.m. |
| August 11, 2019 | New York City FC at Atlanta United FC | 4:00 p.m. |
| August 11, 2019 | Houston Dynamo at Philadelphia Union | 6:00 p.m. |
| August 11, 2019 | LA Galaxy at D.C. United | 7:30 p.m. |
| August 11, 2019 | New York Red Bulls at Los Angeles FC | 10:00 p.m. |
| August 14, 2019 | Sporting Kansas City at Orlando City SC | 7:30 p.m. |
| August 14, 2019 | Colorado Rapids at Minnesota United FC | 8:00 p.m. |
| August 14, 2019 | Seattle Sounders FC at Real Salt Lake | 10:00 p.m. |
| August 14, 2019 | FC Dallas at LA Galaxy | 10:30 p.m. |
| August 14, 2019 | Chicago Fire at Portland Timbers | 11:00 p.m. |
| August 17, 2019 | New England Revolution at New York Red Bulls | 7:00 p.m. |
| August 17, 2019 | Toronto FC at Columbus Crew SC | 7:30 p.m. |
| August 17, 2019 | New York City FC at FC Cincinnati | 7:30 p.m. |
| August 17, 2019 | FC Dallas at Montreal Impact | 7:30 p.m. |
| August 17, 2019 | Philadelphia Union at Chicago Fire | 8:00 p.m. |
| August 17, 2019 | Orlando City SC at Minnesota United FC | 8:00 p.m. |
| August 17, 2019 | San Jose Earthquakes at Sporting Kansas City | 8:30 p.m. |
| August 17, 2019 | Colorado Rapids at Houston Dynamo | 9:00 p.m. |
| August 17, 2019 | Seattle Sounders FC at LA Galaxy | 10:00 p.m. |
| August 17, 2019 | Los Angeles FC at Real Salt Lake | 10:00 p.m. |
| August 17, 2019 | D.C. United at Vancouver Whitecaps FC | 10:00 p.m. |
| August 18, 2019 | Atlanta United FC at Portland Timbers | 10:00 p.m. |
| August 21, 2019 | Columbus Crew SC at New York City FC | 7:00 p.m. |
| August 21, 2019 | New York Red Bulls at D.C. United | 8:00 p.m. |
| August 21, 2019 | San Jose Earthquakes at Los Angeles FC | 10:30 p.m. |
| August 22, 2019 | Minnesota United FC at Sporting Kansas City | 9:30 p.m. |
| August 23, 2019 | Atlanta United FC at Orlando City SC | 8:00 p.m. |
| August 23, 2019 | Seattle Sounders FC at Portland Timbers | 10:00 p.m. |
| August 24, 2019 | New York Red Bulls at New York City FC | 7:00 p.m. |
| August 24, 2019 | Chicago Fire at New England Revolution | 7:30 p.m. |
| August 24, 2019 | D.C. United at Philadelphia Union | 7:30 p.m. |
| August 24, 2019 | Montreal Impact at Toronto FC | 7:30 p.m. |
| August 24, 2019 | Houston Dynamo at FC Dallas | 8:00 p.m. |
| August 24, 2019 | Colorado Rapids at Real Salt Lake | 10:00 p.m. |
| August 24, 2019 | Vancouver Whitecaps FC at San Jose Earthquakes | 10:00 p.m. |
| August 25, 2019 | Columbus Crew SC at FC Cincinnati | 8:00 p.m. |
| August 25, 2019 | LA Galaxy at Los Angeles FC | 10:00 p.m. |
| August 28, 2019 | Vancouver Whitecaps FC at Montreal Impact | 8:00 p.m. |
| August 31, 2019 | Colorado Rapids at New York Red Bulls | 7:00 p.m. |
| August 31, 2019 | Chicago Fire at Columbus Crew SC | 7:30 p.m. |
| August 31, 2019 | D.C. United at Montreal Impact | 7:30 p.m. |
| August 31, 2019 | Toronto FC at New England Revolution | 7:30 p.m. |
| August 31, 2019 | Atlanta United FC at Philadelphia Union | 7:30 p.m. |
| August 31, 2019 | FC Cincinnati at FC Dallas | 8:00 p.m. |
| August 31, 2019 | Houston Dynamo at Sporting Kansas City | 8:30 p.m. |
| August 31, 2019 | New York City FC at Vancouver Whitecaps FC | 10:00 p.m. |
| August 31, 2019 | Real Salt Lake at Portland Timbers | 10:30 p.m. |
| August 31, 2019 | Orlando City SC at San Jose Earthquakes | 10:30 p.m. |
| September 1, 2019 | LA Galaxy at Seattle Sounders FC | 6:00 p.m. |
| September 1, 2019 | Minnesota United FC at Los Angeles FC | 10:30 p.m. |
| September 7, 2019 | New England Revolution at New York City FC | 3:30 p.m. |
| September 7, 2019 | Toronto FC at FC Cincinnati | 7:30 p.m. |
| September 7, 2019 | Los Angeles FC at Orlando City SC | 7:30 p.m. |
| September 7, 2019 | Seattle Sounders FC at Colorado Rapids | 9:00 p.m. |
| September 7, 2019 | Sporting Kansas City at Portland Timbers | 10:30 p.m. |
| September 11, 2019 | Toronto FC at New York City FC | 7:00 p.m. |
| September 11, 2019 | Minnesota United FC at Houston Dynamo | 8:30 p.m. |
| September 11, 2019 | LA Galaxy at Colorado Rapids | 9:00 p.m. |
| September 11, 2019 | San Jose Earthquakes at Real Salt Lake | 9:30 p.m. |
| September 14, 2019 | San Jose Earthquakes at New York City FC | 12:30 p.m. |
| September 14, 2019 | FC Dallas at Chicago Fire | 3:30 p.m. |
| September 14, 2019 | Columbus Crew SC at Atlanta United FC | 7:00 p.m. |
| September 14, 2019 | FC Cincinnati at Montreal Impact | 7:30 p.m. |
| September 14, 2019 | New England Revolution at Orlando City SC | 7:30 p.m. |
| September 14, 2019 | Los Angeles FC at Philadelphia Union | 7:30 p.m. |
| September 14, 2019 | Houston Dynamo at Vancouver Whitecaps FC | 10:00 p.m. |
| September 15, 2019 | New York Red Bulls at Seattle Sounders FC | 3:30 p.m. |
| September 15, 2019 | Colorado Rapids at Toronto FC | 5:00 p.m. |
| September 15, 2019 | Real Salt Lake at Minnesota United FC | 5:30 p.m. |
| September 15, 2019 | D.C. United at Portland Timbers | 7:30 p.m. |
| September 15, 2019 | Sporting Kansas City at LA Galaxy | 10:00 p.m. |
| September 18, 2019 | Atlanta United FC at FC Cincinnati | 7:30 p.m. |
| September 18, 2019 | New York Red Bulls at Portland Timbers | 10:30 p.m. |
| September 18, 2019 | FC Dallas at Seattle Sounders FC | 10:30 p.m. |
| September 21, 2019 | San Jose Earthquakes at Atlanta United FC | 3:30 p.m. |
| September 21, 2019 | Columbus Crew SC at Vancouver Whitecaps FC | 5:00 p.m. |
| September 21, 2019 | Chicago Fire at FC Cincinnati | 7:30 p.m. |
| September 21, 2019 | Real Salt Lake at New England Revolution | 7:30 p.m. |
| September 21, 2019 | Orlando City SC at Houston Dynamo | 8:30 p.m. |
| September 21, 2019 | Colorado Rapids at Sporting Kansas City | 8:30 p.m. |
| September 21, 2019 | Montreal Impact at LA Galaxy | 10:30 p.m. |
| September 21, 2019 | Toronto FC at Los Angeles FC | 10:30 p.m. |
| September 22, 2019 | New York City FC at FC Dallas | 1:00 a.m. |
| September 22, 2019 | Minnesota United FC at Portland Timbers | 4:00 p.m. |
| September 22, 2019 | Philadelphia Union at New York Red Bulls | 6:00 p.m. |
| September 22, 2019 | Seattle Sounders FC at D.C. United | 8:00 p.m. |
| September 25, 2019 | Atlanta United FC at New York City FC | 7:00 p.m. |
| September 25, 2019 | Sporting Kansas City at Minnesota United FC | 8:00 p.m. |
| September 25, 2019 | LA Galaxy at Real Salt Lake | 9:30 p.m. |
| September 25, 2019 | Houston Dynamo at Los Angeles FC | 10:30 p.m. |
| September 25, 2019 | New England Revolution at Portland Timbers | 10:30 p.m. |
| September 25, 2019 | Philadelphia Union at San Jose Earthquakes | 11:00 p.m. |
| September 29, 2019 | Toronto FC at Chicago Fire | 5:00 p.m. |
| September 29, 2019 | Philadelphia Union at Columbus Crew SC | 5:00 p.m. |
| September 29, 2019 | Orlando City SC at FC Cincinnati | 5:00 p.m. |
| September 29, 2019 | Atlanta United FC at Montreal Impact | 5:00 p.m. |
| September 29, 2019 | New York City FC at New England Revolution | 5:00 p.m. |
| September 29, 2019 | D.C. United at New York Red Bulls | 5:00 p.m. |
| September 29, 2019 | FC Dallas at Colorado Rapids | 7:30 p.m. |
| September 29, 2019 | Vancouver Whitecaps FC at LA Galaxy | 7:30 p.m. |
| September 29, 2019 | Los Angeles FC at Minnesota United FC | 7:30 p.m. |
| September 29, 2019 | Houston Dynamo at Real Salt Lake | 7:30 p.m. |
| September 29, 2019 | Seattle Sounders FC at San Jose Earthquakes | 7:30 p.m. |
| September 29, 2019 | Portland Timbers at Sporting Kansas City | 7:30 p.m. |
| October 6, 2019 | New England Revolution at Atlanta United FC | 4:00 p.m. |
| October 6, 2019 | FC Cincinnati at D.C. United | 4:00 p.m. |
| October 6, 2019 | Sporting Kansas City at FC Dallas | 4:00 p.m. |
| October 6, 2019 | LA Galaxy at Houston Dynamo | 4:00 p.m. |
| October 6, 2019 | Colorado Rapids at Los Angeles FC | 4:00 p.m. |
| October 6, 2019 | New York Red Bulls at Montreal Impact | 4:00 p.m. |
| October 6, 2019 | Chicago Fire at Orlando City SC | 4:00 p.m. |
| October 6, 2019 | New York City FC at Philadelphia Union | 4:00 p.m. |
| October 6, 2019 | San Jose Earthquakes at Portland Timbers | 4:00 p.m. |
| October 6, 2019 | Minnesota United FC at Seattle Sounders FC | 4:00 p.m. |
| October 6, 2019 | Columbus Crew SC at Toronto FC | 4:00 p.m. |
| October 6, 2019 | Real Salt Lake at Vancouver Whitecaps FC | 4:00 p.m. |
Major League Soccer Schedule
