| | | |
| February 29, 2020 | Colorado Rapids 2 at D.C. United 1 | Final |
| February 29, 2020 | New England Revolution 1 at Montreal Impact 2 | Final |
| February 29, 2020 | LA Galaxy 1 at Houston Dynamo 1 | Final |
| February 29, 2020 | Toronto FC 2 at San Jose Earthquakes 2 | Final |
| February 29, 2020 | Philadelphia Union 0 at FC Dallas 2 | Final |
| February 29, 2020 | Real Salt Lake 0 at Orlando City SC 0 | Final |
| February 29, 2020 | Atlanta United FC 2 at Nashville SC 1 | Final |
| February 29, 2020 | Sporting Kansas City 3 at Vancouver Whitecaps FC 1 | Final |
| March 1, 2020 | New York City FC 0 at Columbus Crew SC 1 | Final |
| March 1, 2020 | FC Cincinnati 2 at New York Red Bulls 3 | Final |
| March 1, 2020 | Chicago Fire 1 at Seattle Sounders FC 2 | Final |
| March 1, 2020 | Inter Miami CF 0 at Los Angeles FC 1 | Final |
| March 1, 2020 | Minnesota United FC 3 at Portland Timbers 1 | Final |
| March 7, 2020 | Chicago Fire 1 at New England Revolution 1 | Final |
| March 7, 2020 | New York Red Bulls 1 at Real Salt Lake 1 | Final |
| March 7, 2020 | Montreal Impact 2 at FC Dallas 2 | Final |
| March 7, 2020 | Inter Miami CF 1 at D.C. United 2 | Final |
| March 7, 2020 | New York City FC 0 at Toronto FC 1 | Final |
| March 7, 2020 | FC Cincinnati 1 at Atlanta United FC 2 | Final |
| March 7, 2020 | Minnesota United FC 5 at San Jose Earthquakes 2 | Final |
| March 7, 2020 | Houston Dynamo 0 at Sporting Kansas City 4 | Final |
| March 7, 2020 | Orlando City SC 1 at Colorado Rapids 2 | Final |
| March 7, 2020 | Vancouver Whitecaps FC 1 at LA Galaxy 0 | Final |
| March 7, 2020 | Columbus Crew SC 1 at Seattle Sounders FC 1 | Final |
| March 8, 2020 | Nashville SC 0 at Portland Timbers 1 | Final |
| March 8, 2020 | Philadelphia Union 3 at Los Angeles FC 3 | Final |
| March 14, 2020 | FC Dallas at New York City FC | Ppd. |
| March 14, 2020 | LA Galaxy at Inter Miami CF | Ppd. |
| March 14, 2020 | Nashville SC at Toronto FC | Ppd. |
| March 14, 2020 | Real Salt Lake at Columbus Crew SC | Ppd. |
| March 14, 2020 | D.C. United at FC Cincinnati | Ppd. |
| March 14, 2020 | Sporting Kansas City at Atlanta United FC | Ppd. |
| March 14, 2020 | Colorado Rapids at Vancouver Whitecaps FC | Ppd. |
| March 14, 2020 | Chicago Fire at Orlando City SC | Ppd. |
| March 14, 2020 | San Jose Earthquakes at Philadelphia Union | Ppd. |
| March 14, 2020 | Seattle Sounders FC at Houston Dynamo | Ppd. |
| March 15, 2020 | Portland Timbers at New England Revolution | Ppd. |
| March 15, 2020 | New York Red Bulls at Minnesota United FC | Ppd. |
| March 21, 2020 | Vancouver Whitecaps FC at New York City FC | Ppd. |
| March 21, 2020 | Columbus Crew SC at Nashville SC | Ppd. |
| March 21, 2020 | Toronto FC at FC Cincinnati | Ppd. |
| March 21, 2020 | Montreal Impact at Minnesota United FC | Ppd. |
| March 21, 2020 | Atlanta United FC at Chicago Fire | Ppd. |
| March 21, 2020 | New York Red Bulls at Inter Miami CF | Ppd. |
| March 21, 2020 | Houston Dynamo at Colorado Rapids | Ppd. |
| March 21, 2020 | New England Revolution at Real Salt Lake | Ppd. |
| March 21, 2020 | Sporting Kansas City at San Jose Earthquakes | Ppd. |
| March 21, 2020 | FC Dallas at Seattle Sounders FC | Ppd. |
| March 22, 2020 | D.C. United at Philadelphia Union | Ppd. |
| March 22, 2020 | Orlando City SC at LA Galaxy | Ppd. |
| March 22, 2020 | Portland Timbers at Los Angeles FC | Ppd. |
| March 28, 2020 | Orlando City SC at New York Red Bulls | Ppd. |
| March 28, 2020 | Real Salt Lake at Sporting Kansas City | Ppd. |
| March 28, 2020 | Philadelphia Union at Portland Timbers | Ppd. |
| April 4, 2020 | New York Red Bulls at Chicago Fire | Ppd. |
| April 4, 2020 | Montreal Impact at Orlando City SC | Ppd. |
| April 4, 2020 | Los Angeles FC at FC Dallas | Ppd. |
| April 4, 2020 | Toronto FC at Columbus Crew SC | Ppd. |
| April 4, 2020 | Colorado Rapids at New England Revolution | Ppd. |
| April 4, 2020 | San Jose Earthquakes at Minnesota United FC | Ppd. |
| April 4, 2020 | Portland Timbers at Houston Dynamo | Ppd. |
| April 4, 2020 | Real Salt Lake at Vancouver Whitecaps FC | Ppd. |
| April 4, 2020 | Sporting Kansas City at LA Galaxy | Ppd. |
| April 5, 2020 | Philadelphia Union at Inter Miami CF | Ppd. |
| April 5, 2020 | Atlanta United FC at FC Cincinnati | Ppd. |
| April 8, 2020 | Seattle Sounders FC at New England Revolution | Ppd. |
| April 11, 2020 | Montreal Impact at Philadelphia Union | Ppd. |
| April 11, 2020 | Inter Miami CF at Houston Dynamo | Ppd. |
| April 11, 2020 | D.C. United at San Jose Earthquakes | Ppd. |
| April 11, 2020 | Orlando City SC at Columbus Crew SC | Ppd. |
| April 11, 2020 | FC Cincinnati at New England Revolution | Ppd. |
| April 11, 2020 | New York Red Bulls at Toronto FC | Ppd. |
| April 11, 2020 | LA Galaxy at Minnesota United FC | Ppd. |
| April 11, 2020 | Sporting Kansas City at Nashville SC | Ppd. |
| April 11, 2020 | Colorado Rapids at Real Salt Lake | Ppd. |
| April 11, 2020 | Los Angeles FC at Vancouver Whitecaps FC | Ppd. |
| April 11, 2020 | FC Dallas at Portland Timbers | Ppd. |
| April 12, 2020 | Chicago Fire at New York City FC | Ppd. |
| April 15, 2020 | LA Galaxy at Philadelphia Union | Ppd. |
| April 15, 2020 | Toronto FC at D.C. United | Ppd. |
| April 15, 2020 | Minnesota United FC at Houston Dynamo | Ppd. |
| April 15, 2020 | San Jose Earthquakes at Colorado Rapids | Ppd. |
| April 18, 2020 | Houston Dynamo at Montreal Impact | Ppd. |
| April 18, 2020 | New England Revolution at New York Red Bulls | Ppd. |
| April 18, 2020 | LA Galaxy at Toronto FC | Ppd. |
| April 18, 2020 | San Jose Earthquakes at Inter Miami CF | Ppd. |
| April 18, 2020 | FC Cincinnati at Orlando City SC | Ppd. |
| April 18, 2020 | FC Dallas at Minnesota United FC | Ppd. |
| April 18, 2020 | D.C. United at Nashville SC | Ppd. |
| April 18, 2020 | Colorado Rapids at Sporting Kansas City | Ppd. |
| April 18, 2020 | Vancouver Whitecaps FC at Seattle Sounders FC | Ppd. |
| April 18, 2020 | Real Salt Lake at Los Angeles FC | Ppd. |
| April 19, 2020 | Columbus Crew SC at Chicago Fire | Ppd. |
| April 19, 2020 | New York City FC at Philadelphia Union | Ppd. |
| April 19, 2020 | Portland Timbers at Atlanta United FC | Ppd. |
| April 25, 2020 | Montreal Impact at New England Revolution | Ppd. |
| April 25, 2020 | Toronto FC at Inter Miami CF | Ppd. |
| April 25, 2020 | Los Angeles FC at Chicago Fire | Ppd. |
| April 25, 2020 | Philadelphia Union at Columbus Crew SC | Ppd. |
| April 25, 2020 | Minnesota United FC at Sporting Kansas City | Ppd. |
| April 25, 2020 | FC Dallas at Colorado Rapids | Ppd. |
| April 25, 2020 | Seattle Sounders FC at Real Salt Lake | Ppd. |
| April 25, 2020 | Vancouver Whitecaps FC at Portland Timbers | Ppd. |
| April 25, 2020 | Houston Dynamo at LA Galaxy | Ppd. |
| April 26, 2020 | Atlanta United FC at Orlando City SC | Ppd. |
| April 26, 2020 | New York Red Bulls at D.C. United | Ppd. |
| April 26, 2020 | San Jose Earthquakes at FC Cincinnati | Ppd. |
| April 26, 2020 | Nashville SC at New York City FC | Ppd. |
| April 29, 2020 | Minnesota United FC at Columbus Crew SC | Ppd. |
| April 29, 2020 | New England Revolution at Toronto FC | Ppd. |
| April 29, 2020 | Inter Miami CF at Real Salt Lake | Ppd. |
| April 29, 2020 | Vancouver Whitecaps FC at San Jose Earthquakes | Ppd. |
| May 2, 2020 | Orlando City SC at Montreal Impact | Ppd. |
| May 2, 2020 | Vancouver Whitecaps FC at Toronto FC | Ppd. |
| May 2, 2020 | LA Galaxy at Portland Timbers | Ppd. |
| May 2, 2020 | D.C. United at Seattle Sounders FC | Ppd. |
| May 2, 2020 | New York City FC at New England Revolution | Ppd. |
| May 2, 2020 | Columbus Crew SC at New York Red Bulls | Ppd. |
| May 2, 2020 | FC Cincinnati at Philadelphia Union | Ppd. |
| May 2, 2020 | Colorado Rapids at Minnesota United FC | Ppd. |
| May 2, 2020 | Chicago Fire at FC Dallas | Ppd. |
| May 2, 2020 | Sporting Kansas City at Los Angeles FC | Ppd. |
| May 3, 2020 | Real Salt Lake at Atlanta United FC | Ppd. |
| May 3, 2020 | San Jose Earthquakes at Houston Dynamo | Ppd. |
| May 3, 2020 | Inter Miami CF at Nashville SC | Ppd. |
| May 6, 2020 | Houston Dynamo at Orlando City SC | Ppd. |
| May 6, 2020 | New York Red Bulls at FC Cincinnati | Ppd. |
| May 6, 2020 | LA Galaxy at Colorado Rapids | Ppd. |
| May 9, 2020 | Montreal Impact at Columbus Crew SC | Ppd. |
| May 9, 2020 | Inter Miami CF at Chicago Fire | Ppd. |
| May 9, 2020 | Toronto FC at Sporting Kansas City | Ppd. |
| May 9, 2020 | Houston Dynamo at D.C. United | Ppd. |
| May 9, 2020 | New England Revolution at FC Cincinnati | Ppd. |
| May 9, 2020 | Minnesota United FC at Orlando City SC | Ppd. |
| May 9, 2020 | Atlanta United FC at Philadelphia Union | Ppd. |
| May 9, 2020 | FC Dallas at Nashville SC | Ppd. |
| May 9, 2020 | Portland Timbers at Real Salt Lake | Ppd. |
| May 9, 2020 | Los Angeles FC at San Jose Earthquakes | Ppd. |
| May 9, 2020 | Colorado Rapids at Seattle Sounders FC | Ppd. |
| May 10, 2020 | New York Red Bulls at LA Galaxy | Ppd. |
| May 13, 2020 | Toronto FC at New York City FC | Ppd. |
| May 13, 2020 | Real Salt Lake at Minnesota United FC | Ppd. |
| May 13, 2020 | Philadelphia Union at Nashville SC | Ppd. |
| May 13, 2020 | Seattle Sounders FC at San Jose Earthquakes | Ppd. |
| May 16, 2020 | Chicago Fire at Montreal Impact | Ppd. |
| May 16, 2020 | Atlanta United FC at New York Red Bulls | Ppd. |
| May 16, 2020 | LA Galaxy at Los Angeles FC | Ppd. |
| May 16, 2020 | FC Cincinnati at Toronto FC | Ppd. |
| May 16, 2020 | Orlando City SC at D.C. United | Ppd. |
| May 16, 2020 | Colorado Rapids at New York City FC | Ppd. |
| May 16, 2020 | Columbus Crew SC at New England Revolution | Ppd. |
| May 16, 2020 | Sporting Kansas City at Philadelphia Union | Ppd. |
| May 16, 2020 | Nashville SC at Vancouver Whitecaps FC | Ppd. |
| May 16, 2020 | Minnesota United FC at Inter Miami CF | Ppd. |
| May 16, 2020 | Houston Dynamo at FC Dallas | Ppd. |
| May 16, 2020 | San Jose Earthquakes at Real Salt Lake | Ppd. |
| May 17, 2020 | Seattle Sounders FC at Portland Timbers | Ppd. |
| May 23, 2020 | San Jose Earthquakes at Montreal Impact | Ppd. |
| May 23, 2020 | LA Galaxy at Real Salt Lake | Ppd. |
| May 23, 2020 | FC Dallas at Vancouver Whitecaps FC | Ppd. |
| May 23, 2020 | Toronto FC at New England Revolution | Ppd. |
| May 23, 2020 | D.C. United at New York Red Bulls | Ppd. |
| May 23, 2020 | Columbus Crew SC at Orlando City SC | Ppd. |
| May 23, 2020 | FC Cincinnati at Chicago Fire | Ppd. |
| May 23, 2020 | Portland Timbers at Minnesota United FC | Ppd. |
| May 23, 2020 | Nashville SC at Houston Dynamo | Ppd. |
| May 23, 2020 | Seattle Sounders FC at Sporting Kansas City | Ppd. |
| May 23, 2020 | Philadelphia Union at Colorado Rapids | Ppd. |
| May 24, 2020 | Inter Miami CF at Atlanta United FC | Ppd. |
| May 24, 2020 | New York City FC at Los Angeles FC | Ppd. |
| May 27, 2020 | Toronto FC at Atlanta United FC | Ppd. |
| May 27, 2020 | Vancouver Whitecaps FC at Columbus Crew SC | Ppd. |
| May 27, 2020 | Portland Timbers at Chicago Fire | Ppd. |
| May 27, 2020 | FC Cincinnati at Inter Miami CF | Ppd. |
| May 27, 2020 | D.C. United at LA Galaxy | Ppd. |
| May 27, 2020 | Montreal Impact at Seattle Sounders FC | Ppd. |
| May 30, 2020 | Atlanta United FC at San Jose Earthquakes | Ppd. |
| May 30, 2020 | Nashville SC at FC Cincinnati | Ppd. |
| May 30, 2020 | Portland Timbers at Orlando City SC | Ppd. |
| May 30, 2020 | Columbus Crew SC at Philadelphia Union | Ppd. |
| May 30, 2020 | New England Revolution at Chicago Fire | Ppd. |
| May 30, 2020 | Vancouver Whitecaps FC at D.C. United | Ppd. |
| May 30, 2020 | Sporting Kansas City at FC Dallas | Ppd. |
| May 30, 2020 | Houston Dynamo at Los Angeles FC | Ppd. |
| May 31, 2020 | Colorado Rapids at Montreal Impact | Ppd. |
| May 31, 2020 | New York Red Bulls at New York City FC | Ppd. |
| May 31, 2020 | Real Salt Lake at Seattle Sounders FC | Ppd. |
| May 31, 2020 | Inter Miami CF at Toronto FC | Ppd. |
| May 31, 2020 | Minnesota United FC at LA Galaxy | Ppd. |
| June 6, 2020 | Philadelphia Union at New York Red Bulls | Ppd. |
| June 6, 2020 | D.C. United at New England Revolution | Ppd. |
| June 6, 2020 | FC Dallas at Real Salt Lake | Ppd. |
| June 6, 2020 | Orlando City SC at Sporting Kansas City | Ppd. |
| June 6, 2020 | Montreal Impact at Vancouver Whitecaps FC | Ppd. |
| June 13, 2020 | Sporting Kansas City at Portland Timbers | Ppd. |
| June 13, 2020 | Chicago Fire at Columbus Crew SC | Ppd. |
| June 13, 2020 | New York Red Bulls at Orlando City SC | Ppd. |
| June 13, 2020 | Real Salt Lake at Philadelphia Union | Ppd. |
| June 13, 2020 | Montreal Impact at Toronto FC | Ppd. |
| June 13, 2020 | FC Cincinnati at D.C. United | Ppd. |
| June 13, 2020 | FC Dallas at Inter Miami CF | Ppd. |
| June 13, 2020 | Nashville SC at Minnesota United FC | Ppd. |
| June 13, 2020 | Atlanta United FC at Houston Dynamo | Ppd. |
| June 13, 2020 | Los Angeles FC at Colorado Rapids | Ppd. |
| June 13, 2020 | San Jose Earthquakes at LA Galaxy | Ppd. |
| June 13, 2020 | Seattle Sounders FC at Vancouver Whitecaps FC | Ppd. |
| June 14, 2020 | New England Revolution at New York City FC | Ppd. |
| June 17, 2020 | Inter Miami CF at Montreal Impact | Ppd. |
| June 17, 2020 | Atlanta United FC at New York City FC | Ppd. |
| June 17, 2020 | Chicago Fire at Toronto FC | Ppd. |
| June 17, 2020 | Columbus Crew SC at FC Dallas | Ppd. |
| June 17, 2020 | LA Galaxy at Sporting Kansas City | Ppd. |
| June 17, 2020 | New York Red Bulls at Vancouver Whitecaps FC | Ppd. |
| June 17, 2020 | Minnesota United FC at Los Angeles FC | Ppd. |
| June 17, 2020 | Colorado Rapids at Portland Timbers | Ppd. |
| June 20, 2020 | Philadelphia Union at Atlanta United FC | Ppd. |
| June 20, 2020 | Los Angeles FC at Montreal Impact | Ppd. |
| June 20, 2020 | D.C. United at Columbus Crew SC | Ppd. |
| June 20, 2020 | New York City FC at FC Cincinnati | Ppd. |
| June 20, 2020 | Orlando City SC at New England Revolution | Ppd. |
| June 20, 2020 | Chicago Fire at Inter Miami CF | Ppd. |
| June 20, 2020 | Minnesota United FC at FC Dallas | Ppd. |
| June 20, 2020 | Toronto FC at Colorado Rapids | Ppd. |
| June 20, 2020 | Vancouver Whitecaps FC at Sporting Kansas City | Ppd. |
| June 20, 2020 | Houston Dynamo at Real Salt Lake | Ppd. |
| June 20, 2020 | Nashville SC at San Jose Earthquakes | Ppd. |
| June 21, 2020 | Seattle Sounders FC at LA Galaxy | Ppd. |
| June 21, 2020 | Portland Timbers at New York Red Bulls | Ppd. |
| June 27, 2020 | New York City FC at Seattle Sounders FC | Ppd. |
| June 27, 2020 | Vancouver Whitecaps FC at Philadelphia Union | Ppd. |
| June 27, 2020 | Atlanta United FC at Columbus Crew SC | Ppd. |
| June 27, 2020 | FC Dallas at FC Cincinnati | Ppd. |
| June 27, 2020 | Montreal Impact at New York Red Bulls | Ppd. |
| June 27, 2020 | Orlando City SC at Chicago Fire | Ppd. |
| June 27, 2020 | Minnesota United FC at D.C. United | Ppd. |
| June 27, 2020 | New England Revolution at Inter Miami CF | Ppd. |
| June 27, 2020 | Real Salt Lake at Toronto FC | Ppd. |
| June 27, 2020 | Colorado Rapids at Houston Dynamo | Ppd. |
| June 27, 2020 | LA Galaxy at San Jose Earthquakes | Ppd. |
| June 27, 2020 | Nashville SC at Los Angeles FC | Ppd. |
| June 28, 2020 | Portland Timbers at Sporting Kansas City | Ppd. |
| July 1, 2020 | Montreal Impact at Atlanta United FC | Ppd. |
| July 1, 2020 | Orlando City SC at New York City FC | Ppd. |
| July 1, 2020 | Inter Miami CF at FC Cincinnati | Ppd. |
| July 1, 2020 | FC Dallas at D.C. United | Ppd. |
| July 1, 2020 | Vancouver Whitecaps FC at Minnesota United FC | Ppd. |
| July 1, 2020 | Sporting Kansas City at Real Salt Lake | Ppd. |
| July 1, 2020 | Nashville SC at LA Galaxy | Ppd. |
| July 1, 2020 | Columbus Crew SC at Portland Timbers | Ppd. |
| July 3, 2020 | New England Revolution at Houston Dynamo | Ppd. |
| July 4, 2020 | D.C. United at Atlanta United FC | Ppd. |
| July 4, 2020 | Philadelphia Union at Montreal Impact | Ppd. |
| July 4, 2020 | Toronto FC at Orlando City SC | Ppd. |
| July 4, 2020 | San Jose Earthquakes at FC Dallas | Ppd. |
| July 4, 2020 | New York Red Bulls at Colorado Rapids | Ppd. |
| July 4, 2020 | FC Cincinnati at Vancouver Whitecaps FC | Ppd. |
| July 4, 2020 | Real Salt Lake at LA Galaxy | Ppd. |
| July 5, 2020 | Inter Miami CF at Columbus Crew SC | Ppd. |
| July 5, 2020 | Los Angeles FC at Sporting Kansas City | Ppd. |
| July 5, 2020 | New York City FC at Chicago Fire | Ppd. |
| July 5, 2020 | Portland Timbers at Nashville SC | Ppd. |
| July 5, 2020 | Minnesota United FC at Seattle Sounders FC | Ppd. |
| July 8, 2020 | Inter Miami CF 1 at Orlando City SC 2 (Orlando Tournament) | Final |
| July 8, 2020 | Chicago Fire at Nashville SC (Orlando Tournament) | Ppd. |
| July 9, 2020 | Philadelphia Union 1 at New York City FC 0 (Orlando Tournament) | Final |
| July 9, 2020 | New England Revolution 1 at Montreal Impact 0 (Orlando Tournament) | Final |
| July 9, 2020 | Vancouver Whitecaps FC at FC Dallas (Orlando Tournament) | Ppd. |
| July 10, 2020 | San Jose Earthquakes 0 at Seattle Sounders FC 0 (Orlando Tournament) | Final |
| July 11, 2020 | New York Red Bulls 1 at Atlanta United FC 0 (Orlando Tournament) | Final |
| July 11, 2020 | Columbus Crew SC 4 at FC Cincinnati 0 (Orlando Tournament) | Final |
| July 12, 2020 | D.C. United at Toronto FC (Orlando Tournament) | Ppd. |
| July 12, 2020 | Minnesota United FC 2 at Sporting Kansas City 1 (Orlando Tournament) | Final |
| July 12, 2020 | Colorado Rapids 0 at Real Salt Lake 2 (Orlando Tournament) | Final |
| July 13, 2020 | D.C. United 2 at Toronto FC 2 (Orlando Tournament) | Final |
| July 13, 2020 | Houston Dynamo 3 at Los Angeles FC 3 (Orlando Tournament) | Final |
| July 13, 2020 | Portland Timbers 2 at LA Galaxy 1 (Orlando Tournament) | Final |
| July 14, 2020 | Inter Miami CF 1 at Philadelphia Union 2 (Orlando Tournament) | Final |
| July 14, 2020 | Seattle Sounders FC 1 at Chicago Fire 2 (Orlando Tournament) | Final |
| July 14, 2020 | Orlando City SC 3 at New York City FC 1 (Orlando Tournament) | Final |
| July 15, 2020 | San Jose Earthquakes 4 at Vancouver Whitecaps FC 3 (Orlando Tournament) | Final |
| July 16, 2020 | FC Cincinnati 1 at Atlanta United FC 0 (Orlando Tournament) | Final |
| July 16, 2020 | Toronto FC 4 at Montreal Impact 3 (Orlando Tournament) | Final |
| July 16, 2020 | New York Red Bulls 0 at Columbus Crew SC 2 (Orlando Tournament) | Final |
| July 17, 2020 | New England Revolution 1 at D.C. United 1 (Orlando Tournament) | Final |
| July 17, 2020 | Colorado Rapids 2 at Sporting Kansas City 3 (Orlando Tournament) | Final |
| July 17, 2020 | Minnesota United FC 0 at Real Salt Lake 0 (Orlando Tournament) | Final |
| July 18, 2020 | Houston Dynamo 1 at Portland Timbers 2 (Orlando Tournament) | Final |
| July 18, 2020 | LA Galaxy 2 at Los Angeles FC 6 (Orlando Tournament) | Final |
| July 19, 2020 | San Jose Earthquakes 2 at Chicago Fire 0 (Orlando Tournament) | Final |
| July 19, 2020 | Inter Miami CF 1 at Philadelphia Union 2 (Orlando Tournament) | Final |
| July 19, 2020 | Vancouver Whitecaps FC 0 at Seattle Sounders FC 3 (Orlando Tournament) | Final |
| July 20, 2020 | New York City FC 1 at Inter Miami CF 0 (Orlando Tournament) | Final |
| July 20, 2020 | Orlando City SC 1 at Philadelphia Union 1 (Orlando Tournament) | Final |
| July 21, 2020 | New England Revolution 0 at Toronto FC 0 (Orlando Tournament) | Final |
| July 21, 2020 | Columbus Crew SC 1 at Atlanta United FC 0 (Orlando Tournament) | Final |
| July 21, 2020 | D.C. United 0 at Montreal Impact 1 (Orlando Tournament) | Final |
| July 22, 2020 | Sporting Kansas City 2 at Real Salt Lake 0 (Orlando Tournament) | Final |
| July 22, 2020 | New York Red Bulls 0 at FC Cincinnati 2 (Orlando Tournament) | Final |
| July 22, 2020 | Minnesota United FC 2 at Colorado Rapids 2 (Orlando Tournament) | Final |
| July 23, 2020 | Vancouver Whitecaps FC 2 at Chicago Fire 0 (Orlando Tournament) | Final (7) |
| July 23, 2020 | Houston Dynamo 1 at LA Galaxy 1 (Orlando Tournament) | Final (7) |
| July 23, 2020 | Portland Timbers 2 at Los Angeles FC 2 (Orlando Tournament) | Final (7) |
| July 25, 2020 | Montreal Impact 0 at Orlando City SC 1 (Orlando Tournament; Playoff) | Final |
| July 25, 2020 | New England Revolution 0 at Philadelphia Union 1 (Orlando Tournament; Playoff) | Final |
| July 26, 2020 | New York City FC 3 at Toronto FC 1 (Orlando Tournament; Playoff) | Final |
| July 26, 2020 | Vancouver Whitecaps FC 0 at Sporting Kansas City 0 (Orlando Tournament; Playoff; PK 3-1 KC) | Final |
| July 27, 2020 | Real Salt Lake 2 at San Jose Earthquakes 5 (Orlando Tournament; Playoff) | Final |
| July 27, 2020 | Los Angeles FC 4 at Seattle Sounders FC 1 (Orlando Tournament; Playoff) | Final |
| July 28, 2020 | Minnesota United FC 1 at Columbus Crew SC 1 (Orlando Tournament; Playoff; PK 5-3 Min) | Final |
| July 28, 2020 | FC Cincinnati 1 at Portland Timbers 1 (Orlando Tournament; Playoff; PK 4-2 Por) | Final |
| July 30, 2020 | Sporting Kansas City 1 at Philadelphia Union 3 (Orlando Tournament; Playoff) | Final |
| July 31, 2020 | Los Angeles FC 1 at Orlando City SC 1 (Orlando Tournament; Playoff) | Final |
| August 1, 2020 | Minnesota United FC 4 at San Jose Earthquakes 1 (Orlando Tournament; Playoff) | Final |
| August 1, 2020 | Portland Timbers 3 at New York City FC 1 (Orlando Tournament; Playoff) | Final |
| August 5, 2020 | Portland Timbers 2 at Philadelphia Union 1 (Orlando Tournament; Playoff) | Final |
| August 6, 2020 | Minnesota United FC 1 at Orlando City SC 3 (Orlando Tournament; Playoff) | Final |
| August 11, 2020 | Orlando City SC 1 at Portland Timbers 2 (Orlando Tournament; Championship) | Final |
| August 12, 2020 | Nashville SC 1 at FC Dallas 0 | Final |
| August 16, 2020 | Nashville SC at FC Dallas | 8:30 p.m. |
| August 20, 2020 | New York City FC at New York Red Bulls | 7:00 p.m. |
| August 20, 2020 | Chicago Fire at Columbus Crew SC | 7:30 p.m. |
| August 21, 2020 | D.C. United at FC Cincinnati | 7:30 p.m. |
| August 21, 2020 | Sporting Kansas City at Minnesota United FC | 7:30 p.m. |
| August 21, 2020 | FC Dallas at Houston Dynamo | 8:00 p.m. |
| August 21, 2020 | Philadelphia Union at New England Revolution | 8:00 p.m. |
| August 22, 2020 | LA Galaxy at Los Angeles FC | 6:00 p.m. |
| August 22, 2020 | Nashville SC at Atlanta United FC | 7:00 p.m. |
| August 22, 2020 | Orlando City SC at Inter Miami CF | 8:00 p.m. |
| August 22, 2020 | Real Salt Lake at Colorado Rapids | 9:00 p.m. |
| August 23, 2020 | Seattle Sounders FC at Portland Timbers | 10:00 p.m. |
| August 24, 2020 | Columbus Crew SC at New York City FC | 7:00 p.m. |
| August 25, 2020 | New England Revolution at D.C. United | 7:00 p.m. |
| August 25, 2020 | FC Cincinnati at Chicago Fire | 7:30 p.m. |
| August 25, 2020 | New York Red Bulls at Philadelphia Union | 7:30 p.m. |
| August 25, 2020 | Houston Dynamo at Sporting Kansas City | 8:30 p.m. |
| August 26, 2020 | Seattle Sounders FC at LA Galaxy | |
| August 26, 2020 | Nashville SC at Orlando City SC | 7:30 p.m. |
| August 26, 2020 | Atlanta United FC at Inter Miami CF | 8:00 p.m. |
| August 26, 2020 | Colorado Rapids at FC Dallas | 8:30 p.m. |
| August 26, 2020 | Los Angeles FC at Real Salt Lake | 9:30 p.m. |
| August 26, 2020 | Portland Timbers at San Jose Earthquakes | 10:30 p.m. |
| August 29, 2020 | San Jose Earthquakes at LA Galaxy | |
| August 29, 2020 | Orlando City SC at Atlanta United FC | 3:30 p.m. |
| August 29, 2020 | Columbus Crew SC at FC Cincinnati | 7:30 p.m. |
| August 29, 2020 | Chicago Fire at New York City FC | 7:30 p.m. |
| August 29, 2020 | D.C. United at Philadelphia Union | 7:30 p.m. |
| August 29, 2020 | New York Red Bulls at New England Revolution | 8:00 p.m. |
| August 29, 2020 | Minnesota United FC at FC Dallas | 8:30 p.m. |
| August 29, 2020 | Sporting Kansas City at Colorado Rapids | 9:00 p.m. |
| August 29, 2020 | Real Salt Lake at Portland Timbers | 10:30 p.m. |
| August 30, 2020 | Inter Miami CF at Nashville SC | 8:30 p.m. |
| August 30, 2020 | Los Angeles FC at Seattle Sounders FC | 10:00 p.m. |
| September 1, 2020 | Chicago Fire at FC Cincinnati | 7:30 p.m. |
| September 2, 2020 | Inter Miami CF at Atlanta United FC | 7:00 p.m. |
| September 2, 2020 | Philadelphia Union at Columbus Crew SC | 7:30 p.m. |
| September 2, 2020 | D.C. United at New York Red Bulls | 7:30 p.m. |
| September 2, 2020 | Minnesota United FC at Houston Dynamo | 8:00 p.m. |
| September 2, 2020 | New York City FC at New England Revolution | 8:00 p.m. |
| September 2, 2020 | Orlando City SC at Nashville SC | 8:30 p.m. |
| September 2, 2020 | FC Dallas at Sporting Kansas City | 8:30 p.m. |
| September 2, 2020 | Seattle Sounders FC at Real Salt Lake | 9:30 p.m. |
| September 2, 2020 | San Jose Earthquakes at Los Angeles FC | 10:30 p.m. |
| September 2, 2020 | LA Galaxy at Portland Timbers | 10:30 p.m. |
| September 5, 2020 | Sporting Kansas City at Houston Dynamo | 8:00 p.m. |
| September 5, 2020 | Colorado Rapids at San Jose Earthquakes | 10:30 p.m. |
| September 6, 2020 | Los Angeles FC at LA Galaxy | |
| September 6, 2020 | New York City FC at D.C. United | 7:00 p.m. |
| September 6, 2020 | Philadelphia Union at New York Red Bulls | 7:00 p.m. |
| September 6, 2020 | New England Revolution at Chicago Fire | 7:30 p.m. |
| September 6, 2020 | FC Cincinnati at Columbus Crew SC | 7:30 p.m. |
| September 6, 2020 | Atlanta United FC at Orlando City SC | 7:30 p.m. |
| September 6, 2020 | Nashville SC at Inter Miami CF | 8:00 p.m. |
| September 6, 2020 | Real Salt Lake at Minnesota United FC | 8:00 p.m. |
| September 6, 2020 | Portland Timbers at Seattle Sounders FC | 10:00 p.m. |
| September 9, 2020 | FC Dallas at Minnesota United FC | 8:00 p.m. |
| September 9, 2020 | Houston Dynamo at Colorado Rapids | 9:00 p.m. |
| September 10, 2020 | San Jose Earthquakes at Seattle Sounders FC | 10:00 p.m. |
| September 12, 2020 | New York Red Bulls at D.C. United | 7:00 p.m. |
| September 12, 2020 | FC Cincinnati at New York City FC | 7:00 p.m. |
| September 12, 2020 | Columbus Crew SC at Chicago Fire | 7:30 p.m. |
| September 12, 2020 | Inter Miami CF at Orlando City SC | 7:30 p.m. |
| September 12, 2020 | New England Revolution at Philadelphia Union | 7:30 p.m. |
| September 12, 2020 | Atlanta United FC at Nashville SC | 8:30 p.m. |
| September 12, 2020 | Colorado Rapids at Real Salt Lake | 9:30 p.m. |
| September 13, 2020 | Minnesota United FC at Sporting Kansas City | 8:30 p.m. |
| September 13, 2020 | Portland Timbers at Los Angeles FC | 11:00 p.m. |
| September 13, 2020 | LA Galaxy at San Jose Earthquakes | 11:00 p.m. |
| September 14, 2020 | Houston Dynamo at FC Dallas | 8:30 p.m. |
Major League Soccer Schedule
