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| October 18, 2025 | | Wheeling Nailers at Cincinnati Cyclones | 7:35 p.m. |
| October 25, 2025 | | Wheeling Nailers at Maine Mariners | 6:00 p.m. |
| October 26, 2025 | | Wheeling Nailers at Maine Mariners | 3:00 p.m. |
| November 1, 2025 | | Norfolk Admirals at Wheeling Nailers | 7:10 p.m. |
| November 2, 2025 | | Norfolk Admirals at Wheeling Nailers | 4:10 p.m. |
| November 6, 2025 | | Wheeling Nailers at Greensboro Gargoyles | 7:00 p.m. |
| November 7, 2025 | | Wheeling Nailers at Greensboro Gargoyles | 7:00 p.m. |
| November 8, 2025 | | Wheeling Nailers at Greensboro Gargoyles | 7:00 p.m. |
| November 14, 2025 | | Maine Mariners at Wheeling Nailers | 7:10 p.m. |
| November 15, 2025 | | Maine Mariners at Wheeling Nailers | 7:10 p.m. |
| November 16, 2025 | | Wheeling Nailers at Reading Royals | 3:00 p.m. |
| November 18, 2025 | | Wheeling Nailers at Reading Royals | 10:30 a.m. |
| November 21, 2025 | | Reading Royals at Wheeling Nailers | 7:10 p.m. |
| November 22, 2025 | | Wheeling Nailers at Reading Royals | 7:00 p.m. |
| November 26, 2025 | | Indy Fuel at Wheeling Nailers | 7:10 p.m. |
| November 28, 2025 | | Wheeling Nailers at Toledo Walleye | 7:15 p.m. |
| November 29, 2025 | | Cincinnati Cyclones at Wheeling Nailers | 7:10 p.m. |
| November 30, 2025 | | Cincinnati Cyclones at Wheeling Nailers | 4:10 p.m. |
| December 3, 2025 | | Wheeling Nailers at Reading Royals | 7:00 p.m. |
| December 5, 2025 | | Greensboro Gargoyles at Wheeling Nailers | 7:10 p.m. |
| December 6, 2025 | | Greensboro Gargoyles at Wheeling Nailers | 7:10 p.m. |
| December 7, 2025 | | Greensboro Gargoyles at Wheeling Nailers | 4:10 p.m. |
| December 10, 2025 | | Wheeling Nailers at Reading Royals | 7:00 p.m. |
| December 12, 2025 | | Wheeling Nailers at Adirondack Thunder | 7:00 p.m. |
| December 13, 2025 | | Wheeling Nailers at Adirondack Thunder | 7:00 p.m. |
| December 19, 2025 | | Wheeling Nailers at Greensboro Gargoyles | 7:00 p.m. |
| December 20, 2025 | | Wheeling Nailers at Greensboro Gargoyles | 7:00 p.m. |
| December 26, 2025 | | Wheeling Nailers at Toledo Walleye | 7:15 p.m. |
| December 27, 2025 | | Indy Fuel at Wheeling Nailers | 7:10 p.m. |
| December 28, 2025 | | Cincinnati Cyclones at Wheeling Nailers | 4:10 p.m. |
| December 31, 2025 | | Worcester Railers HC at Wheeling Nailers | 6:10 p.m. |
| January 2, 2026 | | Worcester Railers HC at Wheeling Nailers | 7:10 p.m. |
| January 3, 2026 | | Bloomington Bison at Wheeling Nailers | 7:10 p.m. |
| January 9, 2026 | | Trois-Rivieres Lions at Wheeling Nailers | 7:10 p.m. |
| January 10, 2026 | | Trois-Rivieres Lions at Wheeling Nailers | 7:10 p.m. |
| January 11, 2026 | | Trois-Rivieres Lions at Wheeling Nailers | 4:10 p.m. |
| January 16, 2026 | | Wheeling Nailers at Norfolk Admirals | 7:05 p.m. |
| January 17, 2026 | | Wheeling Nailers at Norfolk Admirals | 7:05 p.m. |
| January 23, 2026 | | Reading Royals at Wheeling Nailers | 7:10 p.m. |
| January 24, 2026 | | Reading Royals at Wheeling Nailers | 7:10 p.m. |
| January 25, 2026 | | Fort Wayne Komets at Wheeling Nailers | 4:10 p.m. |
| January 28, 2026 | | Wheeling Nailers at Maine Mariners | 7:00 p.m. |
| January 30, 2026 | | Wheeling Nailers at Worcester Railers HC | 7:05 p.m. |
| January 31, 2026 | | Wheeling Nailers at Worcester Railers HC | 6:05 p.m. |
| February 1, 2026 | | Wheeling Nailers at Worcester Railers HC | 3:05 p.m. |
| February 4, 2026 | | Fort Wayne Komets at Wheeling Nailers | 7:10 p.m. |
| February 6, 2026 | | Indy Fuel at Wheeling Nailers | 7:10 p.m. |
| February 7, 2026 | | Cincinnati Cyclones at Wheeling Nailers | 7:10 p.m. |
| February 11, 2026 | | Wheeling Nailers at Indy Fuel | 7:00 p.m. |
| February 13, 2026 | | Reading Royals at Wheeling Nailers | 7:10 p.m. |
| February 14, 2026 | | Reading Royals at Wheeling Nailers | 7:10 p.m. |
| February 15, 2026 | | Reading Royals at Wheeling Nailers | 4:10 p.m. |
| February 27, 2026 | | Kalamazoo Wings at Wheeling Nailers | 7:10 p.m. |
| February 28, 2026 | | Wheeling Nailers at Fort Wayne Komets | 7:35 p.m. |
| March 1, 2026 | | Fort Wayne Komets at Wheeling Nailers | 4:10 p.m. |
| March 4, 2026 | | Wheeling Nailers at Rapid City Rush | 9:05 p.m. |
| March 6, 2026 | | Wheeling Nailers at Rapid City Rush | 9:05 p.m. |
| March 7, 2026 | | Wheeling Nailers at Rapid City Rush | 9:05 p.m. |
| March 11, 2026 | | Reading Royals at Wheeling Nailers | 10:45 a.m. |
| March 13, 2026 | | Adirondack Thunder at Wheeling Nailers | 7:10 p.m. |
| March 14, 2026 | | Adirondack Thunder at Wheeling Nailers | 7:10 p.m. |
| March 20, 2026 | | Wheeling Nailers at Trois-Rivieres Lions | 7:00 p.m. |
| March 21, 2026 | | Wheeling Nailers at Trois-Rivieres Lions | 3:00 p.m. |
| March 22, 2026 | | Wheeling Nailers at Trois-Rivieres Lions | 3:00 p.m. |
| March 27, 2026 | | Worcester Railers HC at Wheeling Nailers | 7:10 p.m. |
| March 28, 2026 | | Worcester Railers HC at Wheeling Nailers | 7:10 p.m. |
| March 29, 2026 | | Worcester Railers HC at Wheeling Nailers | 4:10 p.m. |
| April 1, 2026 | | Wheeling Nailers at Fort Wayne Komets | 7:35 p.m. |
| April 4, 2026 | | Wheeling Nailers at Toledo Walleye | 7:15 p.m. |
| April 10, 2026 | | Wheeling Nailers at Reading Royals | 7:00 p.m. |
| April 11, 2026 | | Wheeling Nailers at Reading Royals | 7:00 p.m. |
| April 12, 2026 | | Wheeling Nailers at Reading Royals | 3:00 p.m. |
Wheeling Nailers Schedule
