| | | |
| February 22, 2025 | Minnesota United FC 0 at Los Angeles FC 1 | Final |
| February 22, 2025 | Club de Foot Montreal 2 at Atlanta United FC 3 | Final |
| February 22, 2025 | Chicago Fire FC 2 at Columbus Crew SC 4 | Final |
| February 22, 2025 | Toronto FC 2 at D.C. United 2 | Final |
| February 22, 2025 | New York Red Bulls 0 at FC Cincinnati 1 | Final |
| February 22, 2025 | New York City FC 2 at Inter Miami CF 2 | Final |
| February 22, 2025 | Philadelphia Union 4 at Orlando City SC 2 | Final |
| February 22, 2025 | Sporting Kansas City 0 at Austin FC 1 | Final |
| February 22, 2025 | FC Dallas 2 at Houston Dynamo FC 1 | Final |
| February 22, 2025 | New England Revolution 0 at Nashville SC 0 | Final |
| February 22, 2025 | Colorado Rapids 0 at St. Louis City SC 0 | Final |
| February 22, 2025 | Real Salt Lake 0 at San Jose Earthquakes 4 | Final |
| February 22, 2025 | Charlotte FC 2 at Seattle Sounders FC 2 | Final |
| February 23, 2025 | Vancouver Whitecaps FC 4 at Portland Timbers 1 | Final |
| February 23, 2025 | San Diego FC 2 at LA Galaxy 0 | Final |
| March 1, 2025 | Atlanta United FC 0 at Charlotte FC 2 | Final |
| March 1, 2025 | Seattle Sounders FC 0 at Real Salt Lake 2 | Final |
| March 1, 2025 | Columbus Crew SC 1 at New England Revolution 0 | Final |
| March 1, 2025 | Nashville SC 0 at New York Red Bulls 2 | Final |
| March 1, 2025 | Toronto FC 2 at Orlando City SC 4 | Final |
| March 1, 2025 | FC Cincinnati 1 at Philadelphia Union 4 | Final |
| March 1, 2025 | D.C. United 2 at Chicago Fire FC 2 | Final |
| March 1, 2025 | Club de Foot Montreal 0 at Minnesota United FC 1 | Final |
| March 1, 2025 | San Jose Earthquakes 2 at Sporting Kansas City 1 | Final |
| March 1, 2025 | FC Dallas 3 at Colorado Rapids 3 | Final |
| March 1, 2025 | New York City FC 0 at Los Angeles FC 1 | Final |
| March 1, 2025 | Austin FC 0 at Portland Timbers 1 | Final |
| March 1, 2025 | St. Louis City SC 0 at San Diego FC 0 | Final |
| March 2, 2025 | LA Galaxy 1 at Vancouver Whitecaps FC 2 | Final |
| March 2, 2025 | Inter Miami CF 4 at Houston Dynamo FC 1 | Final |
| March 8, 2025 | Houston Dynamo FC 0 at Columbus Crew SC 0 | Final |
| March 8, 2025 | Los Angeles FC 2 at Seattle Sounders FC 5 | Final |
| March 8, 2025 | New York Red Bulls 0 at Atlanta United FC 0 | Final |
| March 8, 2025 | Sporting Kansas City 1 at D.C. United 2 | Final |
| March 8, 2025 | Toronto FC 0 at FC Cincinnati 2 | Final |
| March 8, 2025 | Philadelphia Union 2 at New England Revolution 0 | Final |
| March 8, 2025 | Orlando City SC 1 at New York City FC 2 | Final |
| March 8, 2025 | Colorado Rapids 1 at Austin FC 0 | Final |
| March 8, 2025 | Chicago Fire FC 3 at FC Dallas 1 | Final |
| March 8, 2025 | Portland Timbers 0 at Nashville SC 2 | Final |
| March 8, 2025 | San Diego FC 3 at Real Salt Lake 1 | Final |
| March 8, 2025 | Club de Foot Montreal 0 at Vancouver Whitecaps FC 2 | Final |
| March 8, 2025 | Minnesota United FC 1 at San Jose Earthquakes 0 | Final |
| March 9, 2025 | Charlotte FC 0 at Inter Miami CF 1 | Final |
| March 9, 2025 | St. Louis City SC 3 at LA Galaxy 0 | Final |
| March 15, 2025 | Orlando City SC 2 at New York Red Bulls 2 | Final |
| March 15, 2025 | Chicago Fire FC 2 at Toronto FC 1 | Final |
| March 15, 2025 | Austin FC 1 at Los Angeles FC 0 | Final |
| March 15, 2025 | FC Cincinnati 0 at Charlotte FC 2 | Final |
| March 15, 2025 | Club de Foot Montreal 0 at D.C. United 0 | Final |
| March 15, 2025 | New England Revolution 1 at New York City FC 2 | Final |
| March 15, 2025 | Minnesota United FC 3 at Sporting Kansas City 3 | Final |
| March 15, 2025 | Vancouver Whitecaps FC 1 at FC Dallas 0 | Final |
| March 15, 2025 | Real Salt Lake 2 at Houston Dynamo FC 1 | Final |
| March 15, 2025 | Seattle Sounders FC 0 at St. Louis City SC 1 | Final |
| March 15, 2025 | Columbus Crew SC 1 at San Diego FC 1 | Final |
| March 15, 2025 | Colorado Rapids 2 at San Jose Earthquakes 1 | Final |
| March 16, 2025 | Nashville SC 3 at Philadelphia Union 1 | Final |
| March 16, 2025 | LA Galaxy 1 at Portland Timbers 1 | Final |
| March 16, 2025 | Inter Miami CF 2 at Atlanta United FC 1 | Final |
| March 22, 2025 | Atlanta United FC 2 at FC Cincinnati 2 | Final |
| March 22, 2025 | LA Galaxy 2 at Minnesota United FC 2 | Final |
| March 22, 2025 | San Jose Earthquakes 1 at Charlotte FC 4 | Final |
| March 22, 2025 | New York City FC 0 at Columbus Crew SC 0 | Final |
| March 22, 2025 | Toronto FC 1 at New York Red Bulls 2 | Final |
| March 22, 2025 | D.C. United 1 at Orlando City SC 4 | Final |
| March 22, 2025 | St. Louis City SC 0 at Philadelphia Union 1 | Final |
| March 22, 2025 | Club de Foot Montreal 0 at Nashville SC 3 | Final |
| March 22, 2025 | Los Angeles FC 2 at Sporting Kansas City 0 | Final |
| March 22, 2025 | Portland Timbers 3 at Colorado Rapids 0 | Final |
| March 22, 2025 | FC Dallas 1 at Real Salt Lake 0 | Final |
| March 22, 2025 | Houston Dynamo FC 0 at Seattle Sounders FC 0 | Final |
| March 22, 2025 | Chicago Fire FC 3 at Vancouver Whitecaps FC 1 | Final |
| March 23, 2025 | San Diego FC 1 at Austin FC 2 | Final |
| March 29, 2025 | New York Red Bulls 1 at New England Revolution 2 | Final |
| March 29, 2025 | Vancouver Whitecaps FC 0 at Toronto FC 0 | Final |
| March 29, 2025 | Charlotte FC 0 at Colorado Rapids 2 | Final |
| March 29, 2025 | New York City FC 3 at Atlanta United FC 4 | Final |
| March 29, 2025 | Columbus Crew SC 2 at D.C. United 1 | Final |
| March 29, 2025 | Philadelphia Union 1 at Inter Miami CF 2 | Final |
| March 29, 2025 | Club de Foot Montreal 1 at Chicago Fire FC 1 | Final |
| March 29, 2025 | Sporting Kansas City 1 at FC Dallas 2 | Final |
| March 29, 2025 | Real Salt Lake 0 at Minnesota United FC 2 | Final |
| March 29, 2025 | FC Cincinnati 2 at Nashville SC 1 | Final |
| March 29, 2025 | Orlando City SC 2 at LA Galaxy 1 | Final |
| March 29, 2025 | Los Angeles FC 2 at San Diego FC 3 | Final |
| March 29, 2025 | Seattle Sounders FC 1 at San Jose Earthquakes 1 | Final |
| March 30, 2025 | Austin FC 1 at St. Louis City SC 0 | Final |
| March 30, 2025 | Houston Dynamo FC 1 at Portland Timbers 3 | Final |
| April 5, 2025 | Nashville SC 1 at Charlotte FC 2 | Final |
| April 5, 2025 | LA Galaxy 0 at Real Salt Lake 2 | Final |
| April 5, 2025 | FC Dallas 1 at Atlanta United FC 1 | Final |
| April 5, 2025 | Portland Timbers 0 at Austin FC 0 | Final |
| April 5, 2025 | Club de Foot Montreal 1 at Columbus Crew SC 2 | Final |
| April 5, 2025 | New England Revolution 0 at FC Cincinnati 1 | Final |
| April 5, 2025 | Chicago Fire FC 1 at New York Red Bulls 2 | Final |
| April 5, 2025 | Orlando City SC 0 at Philadelphia Union 0 | Final |
| April 5, 2025 | Los Angeles FC 0 at Houston Dynamo FC 1 | Final |
| April 5, 2025 | St. Louis City SC 0 at Sporting Kansas City 2 | Final |
| April 5, 2025 | Colorado Rapids 0 at Vancouver Whitecaps FC 2 | Final |
| April 5, 2025 | Seattle Sounders FC 0 at San Diego FC 3 | Final |
| April 6, 2025 | Minnesota United FC 2 at New York City FC 1 | Final |
| April 6, 2025 | D.C. United 1 at San Jose Earthquakes 6 | Final |
| April 6, 2025 | Toronto FC 1 at Inter Miami CF 1 | Final |
| April 12, 2025 | New England Revolution 1 at Atlanta United FC 0 | Final |
| April 12, 2025 | Minnesota United FC 0 at Toronto FC 0 | Final |
| April 12, 2025 | New York Red Bulls 0 at Orlando City SC 0 | Final |
| April 12, 2025 | Charlotte FC 1 at Club de Foot Montreal 0 | Final |
| April 12, 2025 | FC Cincinnati 1 at D.C. United 0 | Final |
| April 12, 2025 | Philadelphia Union 0 at New York City FC 1 | Final |
| April 12, 2025 | Austin FC 1 at Vancouver Whitecaps FC 5 | Final |
| April 12, 2025 | Seattle Sounders FC 1 at FC Dallas 0 | Final |
| April 12, 2025 | Real Salt Lake 1 at Nashville SC 2 | Final |
| April 12, 2025 | San Diego FC 2 at Colorado Rapids 3 | Final |
| April 12, 2025 | Houston Dynamo FC 1 at LA Galaxy 1 | Final |
| April 12, 2025 | San Jose Earthquakes 1 at Los Angeles FC 2 | Final |
| April 13, 2025 | Portland Timbers 4 at Sporting Kansas City 2 | Final |
| April 13, 2025 | Inter Miami CF 0 at Chicago Fire FC 0 | Final |
| April 13, 2025 | Columbus Crew SC 2 at St. Louis City SC 1 | Final |
| April 19, 2025 | LA Galaxy 0 at Austin FC 1 | Final |
| April 19, 2025 | Inter Miami CF 1 at Columbus Crew SC 0 | Final |
| April 19, 2025 | San Diego FC 0 at Charlotte FC 3 | Final |
| April 19, 2025 | Orlando City SC 0 at Club de Foot Montreal 0 | Final |
| April 19, 2025 | New York City FC 0 at New England Revolution 2 | Final |
| April 19, 2025 | D.C. United 2 at New York Red Bulls 1 | Final |
| April 19, 2025 | Atlanta United FC 0 at Philadelphia Union 3 | Final |
| April 19, 2025 | Nashville SC 0 at Seattle Sounders FC 3 | Final |
| April 19, 2025 | FC Cincinnati 3 at Chicago Fire FC 2 | Final |
| April 19, 2025 | Colorado Rapids 2 at Houston Dynamo FC 2 | Final |
| April 19, 2025 | FC Dallas 0 at Minnesota United FC 0 | Final |
| April 19, 2025 | Vancouver Whitecaps FC 0 at St. Louis City SC 0 | Final |
| April 19, 2025 | Toronto FC 1 at Real Salt Lake 0 | Final |
| April 19, 2025 | Los Angeles FC 3 at Portland Timbers 3 | Final |
| April 19, 2025 | Sporting Kansas City 5 at San Jose Earthquakes 3 | Final |
| April 26, 2025 | Sporting Kansas City 1 at FC Cincinnati 2 | Final |
| April 26, 2025 | New York City FC 1 at Toronto FC 0 | Final |
| April 26, 2025 | Club de Foot Montreal 0 at New York Red Bulls 1 | Final |
| April 26, 2025 | D.C. United 0 at Philadelphia Union 3 | Final |
| April 26, 2025 | Atlanta United FC 0 at Orlando City SC 3 | Final |
| April 26, 2025 | New England Revolution 1 at Charlotte FC 0 | Final |
| April 26, 2025 | San Jose Earthquakes 1 at Columbus Crew SC 2 | Final |
| April 26, 2025 | Real Salt Lake 3 at San Diego FC 1 | Final |
| April 26, 2025 | Austin FC 0 at Houston Dynamo FC 2 | Final |
| April 26, 2025 | Chicago Fire FC 2 at Nashville SC 7 | Final |
| April 26, 2025 | Seattle Sounders FC 1 at Colorado Rapids 1 | Final |
| April 27, 2025 | Vancouver Whitecaps FC 3 at Minnesota United FC 1 | Final |
| April 27, 2025 | FC Dallas 4 at Inter Miami CF 3 | Final |
| April 27, 2025 | St. Louis City SC 2 at Los Angeles FC 2 | Final |
| April 27, 2025 | Portland Timbers 4 at LA Galaxy 2 | Final |
| May 3, 2025 | Nashville SC 1 at Atlanta United FC 1 | Final |
| May 3, 2025 | New England Revolution 2 at Toronto FC 0 | Final |
| May 3, 2025 | Philadelphia Union 2 at Club de Foot Montreal 1 | Final |
| May 3, 2025 | Charlotte FC 2 at Columbus Crew SC 4 | Final |
| May 3, 2025 | Colorado Rapids 1 at D.C. United 2 | Final |
| May 3, 2025 | New York Red Bulls 1 at Inter Miami CF 4 | Final |
| May 3, 2025 | Minnesota United FC 3 at Austin FC 0 | Final |
| May 3, 2025 | Orlando City SC 0 at Chicago Fire FC 0 | Final |
| May 3, 2025 | FC Dallas 0 at San Diego FC 5 | Final |
| May 3, 2025 | Real Salt Lake 1 at Vancouver Whitecaps FC 2 | Final |
| May 3, 2025 | Houston Dynamo FC 0 at Los Angeles FC 2 | Final |
| May 3, 2025 | Portland Timbers 1 at San Jose Earthquakes 4 | Final |
| May 3, 2025 | St. Louis City SC 1 at Seattle Sounders FC 4 | Final |
| May 4, 2025 | FC Cincinnati 0 at New York City FC 1 | Final |
| May 4, 2025 | LA Galaxy 0 at Sporting Kansas City 1 | Final |
| May 10, 2025 | Atlanta United FC 1 at Chicago Fire FC 2 | Final |
| May 10, 2025 | Inter Miami CF 1 at Minnesota United FC 4 | Final |
| May 10, 2025 | D.C. United 0 at Toronto FC 2 | Final |
| May 10, 2025 | Austin FC 1 at FC Cincinnati 2 | Final |
| May 10, 2025 | Club de Foot Montreal 1 at New York City FC 0 | Final |
| May 10, 2025 | LA Galaxy 0 at New York Red Bulls 7 | Final |
| May 10, 2025 | New England Revolution 3 at Orlando City SC 3 | Final |
| May 10, 2025 | Columbus Crew SC 2 at Philadelphia Union 2 | Final |
| May 10, 2025 | Real Salt Lake 1 at FC Dallas 1 | Final |
| May 10, 2025 | Seattle Sounders FC 3 at Houston Dynamo FC 1 | Final |
| May 10, 2025 | Charlotte FC 1 at Nashville SC 2 | Final |
| May 10, 2025 | San Diego FC 2 at St. Louis City SC 1 | Final |
| May 10, 2025 | San Jose Earthquakes 2 at Colorado Rapids 0 | Final |
| May 10, 2025 | Sporting Kansas City 0 at Portland Timbers 1 | Final |
| May 11, 2025 | Los Angeles FC 2 at Vancouver Whitecaps FC 2 | Final |
| May 14, 2025 | Columbus Crew SC 1 at Club de Foot Montreal 1 | Final |
| May 14, 2025 | New York City FC 0 at D.C. United 0 | Final |
| May 14, 2025 | Charlotte FC 1 at Orlando City SC 3 | Final |
| May 14, 2025 | LA Galaxy 2 at Philadelphia Union 3 | Final |
| May 14, 2025 | FC Cincinnati 1 at Toronto FC 0 | Final |
| May 14, 2025 | Minnesota United FC 0 at Houston Dynamo FC 2 | Final |
| May 14, 2025 | New York Red Bulls 1 at Nashville SC 2 | Final |
| May 14, 2025 | Sporting Kansas City 2 at St. Louis City SC 2 | Final |
| May 14, 2025 | Atlanta United FC 1 at Austin FC 1 | Final |
| May 14, 2025 | Portland Timbers 0 at Real Salt Lake 0 | Final |
| May 14, 2025 | Seattle Sounders FC 0 at Los Angeles FC 4 | Final |
| May 14, 2025 | Colorado Rapids 0 at San Diego FC 2 | Final |
| May 14, 2025 | Inter Miami CF 3 at San Jose Earthquakes 3 | Final |
| May 17, 2025 | Toronto FC 6 at Club de Foot Montreal 1 | Final |
| May 17, 2025 | New York Red Bulls 0 at New York City FC 2 | Final |
| May 17, 2025 | FC Cincinnati 1 at Columbus Crew SC 1 | Final |
| May 17, 2025 | Philadelphia Union 1 at Atlanta United FC 0 | Final |
| May 17, 2025 | Chicago Fire FC 4 at Charlotte FC 1 | Final |
| May 17, 2025 | San Jose Earthquakes 0 at New England Revolution 0 | Final |
| May 17, 2025 | Vancouver Whitecaps FC 0 at Austin FC 0 | Final |
| May 17, 2025 | Houston Dynamo FC 2 at FC Dallas 0 | Final |
| May 17, 2025 | St. Louis City SC 0 at Minnesota United FC 3 | Final |
| May 17, 2025 | D.C. United 0 at Nashville SC 0 | Final |
| May 17, 2025 | Real Salt Lake 0 at Colorado Rapids 1 | Final |
| May 17, 2025 | Seattle Sounders FC 1 at Portland Timbers 1 | Final |
| May 17, 2025 | Sporting Kansas City 0 at San Diego FC 0 | Final |
| May 18, 2025 | Orlando City SC 3 at Inter Miami CF 0 | Final |
| May 18, 2025 | Los Angeles FC 2 at LA Galaxy 2 | Final |
| May 24, 2025 | FC Dallas 0 at Seattle Sounders FC 1 | Final |
| May 24, 2025 | LA Galaxy 1 at San Diego FC 2 | Final |
| May 24, 2025 | Columbus Crew SC 2 at Charlotte FC 3 | Final |
| May 24, 2025 | Los Angeles FC 2 at Club de Foot Montreal 2 | Final |
| May 24, 2025 | New York Red Bulls 2 at D.C. United 0 | Final |
| May 24, 2025 | Portland Timbers 0 at Orlando City SC 1 | Final |
| May 24, 2025 | Inter Miami CF 3 at Philadelphia Union 3 | Final |
| May 24, 2025 | Nashville SC 2 at Toronto FC 1 | Final |
| May 24, 2025 | Austin FC 1 at Minnesota United FC 1 | Final |
| May 24, 2025 | New England Revolution 3 at Sporting Kansas City 3 | Final |
| May 24, 2025 | St. Louis City SC 0 at Colorado Rapids 1 | Final |
| May 24, 2025 | Vancouver Whitecaps FC 3 at Real Salt Lake 2 | Final |
| May 24, 2025 | Houston Dynamo FC 3 at San Jose Earthquakes 3 | Final |
| May 25, 2025 | Chicago Fire FC 1 at New York City FC 3 | Final |
| May 25, 2025 | FC Cincinnati 2 at Atlanta United FC 4 | Final |
| May 28, 2025 | Orlando City SC 2 at Atlanta United FC 3 | Final |
| May 28, 2025 | New England Revolution 1 at D.C. United 1 | Final |
| May 28, 2025 | FC Dallas 3 at FC Cincinnati 3 | Final |
| May 28, 2025 | Club de Foot Montreal 2 at Inter Miami CF 4 | Final |
| May 28, 2025 | Houston Dynamo FC 3 at New York City FC 0 | Final |
| May 28, 2025 | Charlotte FC 2 at New York Red Bulls 4 | Final |
| May 28, 2025 | Philadelphia Union 2 at Toronto FC 1 | Final |
| May 28, 2025 | Nashville SC 2 at Columbus Crew SC 2 | Final |
| May 28, 2025 | Real Salt Lake 1 at Austin FC 1 | Final |
| May 28, 2025 | San Diego FC 0 at Seattle Sounders FC 1 | Final |
| May 28, 2025 | San Jose Earthquakes 1 at LA Galaxy 0 | Final |
| May 28, 2025 | Colorado Rapids 1 at Portland Timbers 2 | Final |
| May 28, 2025 | Minnesota United FC 0 at Vancouver Whitecaps FC 0 | Final |
| May 31, 2025 | San Jose Earthquakes 1 at St. Louis City SC 2 | Final |
| May 31, 2025 | New York City FC 2 at Nashville SC 2 | Final |
| May 31, 2025 | New England Revolution 3 at Club de Foot Montreal 0 | Final |
| May 31, 2025 | D.C. United 2 at FC Cincinnati 1 | Final |
| May 31, 2025 | Columbus Crew SC 1 at Inter Miami CF 5 | Final |
| May 31, 2025 | Atlanta United FC 0 at New York Red Bulls 2 | Final |
| May 31, 2025 | Chicago Fire FC 3 at Orlando City SC 1 | Final |
| May 31, 2025 | Charlotte FC 2 at Toronto FC 0 | Final |
| May 31, 2025 | Philadelphia Union 0 at FC Dallas 0 | Final |
| May 31, 2025 | Sporting Kansas City 3 at Houston Dynamo FC 1 | Final |
| May 31, 2025 | Real Salt Lake 0 at LA Galaxy 2 | Final |
| May 31, 2025 | Austin FC 0 at San Diego FC 2 | Final |
| June 1, 2025 | Minnesota United FC 3 at Seattle Sounders FC 2 | Final |
| June 7, 2025 | Chicago Fire FC 7 at D.C. United 1 | Final |
| June 7, 2025 | Austin FC 2 at Colorado Rapids 0 | Final |
| June 8, 2025 | St. Louis City SC 1 at Portland Timbers 2 | Final |
| June 8, 2025 | Sporting Kansas City 1 at Los Angeles FC 3 | Final |
| June 8, 2025 | Seattle Sounders FC 0 at Vancouver Whitecaps FC 3 | Final |
| June 12, 2025 | Atlanta United FC 0 at New York City FC 4 | Final |
| June 13, 2025 | San Jose Earthquakes 1 at Portland Timbers 1 | Final |
| June 14, 2025 | LA Galaxy 3 at St. Louis City SC 3 | Final |
| June 14, 2025 | Vancouver Whitecaps FC 1 at Columbus Crew SC 2 | Final |
| June 14, 2025 | FC Cincinnati 1 at New England Revolution 0 | Final |
| June 14, 2025 | Charlotte FC 1 at Philadelphia Union 2 | Final |
| June 14, 2025 | New York Red Bulls 1 at Austin FC 2 | Final |
| June 14, 2025 | Nashville SC 2 at Chicago Fire FC 0 | Final |
| June 14, 2025 | Club de Foot Montreal 3 at Houston Dynamo FC 1 | Final |
| June 14, 2025 | San Diego FC 4 at Minnesota United FC 2 | Final |
| June 14, 2025 | FC Dallas 4 at Sporting Kansas City 2 | Final |
| June 14, 2025 | Orlando City SC 1 at Colorado Rapids 0 | Final |
| June 14, 2025 | D.C. United 0 at Real Salt Lake 2 | Final |
| June 25, 2025 | FC Cincinnati at Club de Foot Montreal | 7:30 p.m. |
| June 25, 2025 | Atlanta United FC at Columbus Crew SC | 7:30 p.m. |
| June 25, 2025 | Nashville SC at New England Revolution | 7:30 p.m. |
| June 25, 2025 | New York Red Bulls at Toronto FC | 7:30 p.m. |
| June 25, 2025 | Philadelphia Union at Chicago Fire FC | 8:30 p.m. |
| June 25, 2025 | San Jose Earthquakes at FC Dallas | 8:30 p.m. |
| June 25, 2025 | Houston Dynamo FC at Minnesota United FC | 8:30 p.m. |
| June 25, 2025 | Charlotte FC at Sporting Kansas City | 8:30 p.m. |
| June 25, 2025 | Orlando City SC at St. Louis City SC | 8:30 p.m. |
| June 25, 2025 | LA Galaxy at Colorado Rapids | 9:30 p.m. |
| June 25, 2025 | San Diego FC at Vancouver Whitecaps FC | 10:30 p.m. |
| June 28, 2025 | New York City FC at Club de Foot Montreal | 7:30 p.m. |
| June 28, 2025 | Nashville SC at D.C. United | 7:30 p.m. |
| June 28, 2025 | Atlanta United FC at Inter Miami CF | 7:30 p.m. |
| June 28, 2025 | Colorado Rapids at New England Revolution | 7:30 p.m. |
| June 28, 2025 | Minnesota United FC at New York Red Bulls | 7:30 p.m. |
| June 28, 2025 | FC Cincinnati at Orlando City SC | 7:30 p.m. |
| June 28, 2025 | Portland Timbers at Toronto FC | 7:30 p.m. |
| June 28, 2025 | Charlotte FC at Chicago Fire FC | 8:30 p.m. |
| June 28, 2025 | San Diego FC at FC Dallas | 8:30 p.m. |
| June 28, 2025 | St. Louis City SC at Houston Dynamo FC | 8:30 p.m. |
| June 28, 2025 | Real Salt Lake at Sporting Kansas City | 8:30 p.m. |
| June 28, 2025 | LA Galaxy at San Jose Earthquakes | 10:30 p.m. |
| June 28, 2025 | Austin FC at Seattle Sounders FC | 10:30 p.m. |
| June 29, 2025 | Philadelphia Union at Columbus Crew SC | 6:00 p.m. |
| June 29, 2025 | Vancouver Whitecaps FC at Los Angeles FC | 9:30 p.m. |
| July 3, 2025 | Toronto FC at New York City FC | 7:30 p.m. |
| July 4, 2025 | Minnesota United FC at FC Dallas | 8:30 p.m. |
| July 4, 2025 | Sporting Kansas City at Colorado Rapids | 9:30 p.m. |
| July 4, 2025 | Vancouver Whitecaps FC at LA Galaxy | 10:30 p.m. |
| July 5, 2025 | Orlando City SC at Charlotte FC | 7:00 p.m. |
| July 5, 2025 | Inter Miami CF at Club de Foot Montreal | 7:30 p.m. |
| July 5, 2025 | Atlanta United FC at D.C. United | 7:30 p.m. |
| July 5, 2025 | Chicago Fire FC at FC Cincinnati | 7:30 p.m. |
| July 5, 2025 | Los Angeles FC at Austin FC | 8:30 p.m. |
| July 5, 2025 | Philadelphia Union at Nashville SC | 8:30 p.m. |
| July 5, 2025 | St. Louis City SC at Real Salt Lake | 9:30 p.m. |
| July 5, 2025 | New England Revolution at Portland Timbers | 10:30 p.m. |
| July 5, 2025 | Houston Dynamo FC at San Diego FC | 10:30 p.m. |
| July 5, 2025 | New York Red Bulls at San Jose Earthquakes | 10:30 p.m. |
| July 6, 2025 | Columbus Crew SC at Seattle Sounders FC | 5:00 p.m. |
| July 9, 2025 | Inter Miami CF at New England Revolution | 7:30 p.m. |
| July 9, 2025 | Colorado Rapids at Los Angeles FC | 10:30 p.m. |
| July 12, 2025 | New York City FC at Charlotte FC | 7:30 p.m. |
| July 12, 2025 | Columbus Crew SC at FC Cincinnati | 7:30 p.m. |
| July 12, 2025 | Nashville SC at Inter Miami CF | 7:30 p.m. |
| July 12, 2025 | Club de Foot Montreal at Orlando City SC | 7:30 p.m. |
| July 12, 2025 | New York Red Bulls at Philadelphia Union | 7:30 p.m. |
| July 12, 2025 | Atlanta United FC at Toronto FC | 7:30 p.m. |
| July 12, 2025 | New England Revolution at Austin FC | 8:30 p.m. |
| July 12, 2025 | San Diego FC at Chicago Fire FC | 8:30 p.m. |
| July 12, 2025 | San Jose Earthquakes at Minnesota United FC | 8:30 p.m. |
| July 12, 2025 | Seattle Sounders FC at Sporting Kansas City | 8:30 p.m. |
| July 12, 2025 | Vancouver Whitecaps FC at Colorado Rapids | 9:30 p.m. |
| July 12, 2025 | Houston Dynamo FC at Real Salt Lake | 9:30 p.m. |
| July 12, 2025 | D.C. United at LA Galaxy | 10:30 p.m. |
| July 12, 2025 | FC Dallas at Los Angeles FC | 10:30 p.m. |
| July 13, 2025 | Portland Timbers at St. Louis City SC | 7:00 p.m. |
| July 16, 2025 | Chicago Fire FC at Atlanta United FC | 7:30 p.m. |
| July 16, 2025 | D.C. United at Charlotte FC | 7:30 p.m. |
| July 16, 2025 | Inter Miami CF at FC Cincinnati | 7:30 p.m. |
| July 16, 2025 | New England Revolution at New York Red Bulls | 7:30 p.m. |
| July 16, 2025 | New York City FC at Orlando City SC | 7:30 p.m. |
| July 16, 2025 | Club de Foot Montreal at Philadelphia Union | 7:30 p.m. |
| July 16, 2025 | Vancouver Whitecaps FC at Houston Dynamo FC | 8:30 p.m. |
| July 16, 2025 | Los Angeles FC at Minnesota United FC | 8:30 p.m. |
| July 16, 2025 | Columbus Crew SC at Nashville SC | 8:30 p.m. |
| July 16, 2025 | Colorado Rapids at Seattle Sounders FC | 10:00 p.m. |
| July 16, 2025 | Austin FC at LA Galaxy | 10:30 p.m. |
| July 16, 2025 | Real Salt Lake at Portland Timbers | 10:30 p.m. |
| July 16, 2025 | Toronto FC at San Diego FC | 10:30 p.m. |
| July 16, 2025 | FC Dallas at San Jose Earthquakes | 10:30 p.m. |
| July 19, 2025 | Charlotte FC at Atlanta United FC | 7:30 p.m. |
| July 19, 2025 | Chicago Fire FC at Club de Foot Montreal | 7:30 p.m. |
| July 19, 2025 | D.C. United at Columbus Crew SC | 7:30 p.m. |
| July 19, 2025 | Orlando City SC at New England Revolution | 7:30 p.m. |
| July 19, 2025 | Inter Miami CF at New York Red Bulls | 7:30 p.m. |
| July 19, 2025 | St. Louis City SC at FC Dallas | 8:30 p.m. |
| July 19, 2025 | Philadelphia Union at Houston Dynamo FC | 8:30 p.m. |
| July 19, 2025 | Toronto FC at Nashville SC | 8:30 p.m. |
| July 19, 2025 | San Jose Earthquakes at Seattle Sounders FC | 8:30 p.m. |
| July 19, 2025 | New York City FC at Sporting Kansas City | 8:30 p.m. |
| July 19, 2025 | FC Cincinnati at Real Salt Lake | 9:30 p.m. |
| July 19, 2025 | LA Galaxy at Los Angeles FC | 10:30 p.m. |
| July 19, 2025 | Minnesota United FC at Portland Timbers | 10:30 p.m. |
| July 19, 2025 | Vancouver Whitecaps FC at San Diego FC | 10:30 p.m. |
| July 25, 2025 | Orlando City SC at Columbus Crew SC | 7:30 p.m. |
| July 25, 2025 | Club de Foot Montreal at New England Revolution | 7:30 p.m. |
| July 25, 2025 | New York City FC at FC Dallas | 8:30 p.m. |
| July 25, 2025 | LA Galaxy at Houston Dynamo FC | 8:30 p.m. |
| July 25, 2025 | Portland Timbers at Los Angeles FC | 10:30 p.m. |
| July 25, 2025 | Nashville SC at San Diego FC | 10:30 p.m. |
| July 26, 2025 | FC Cincinnati at Inter Miami CF | 7:00 p.m. |
| July 26, 2025 | Seattle Sounders FC at Atlanta United FC | 7:30 p.m. |
| July 26, 2025 | Toronto FC at Charlotte FC | 7:30 p.m. |
| July 26, 2025 | Austin FC at D.C. United | 7:30 p.m. |
| July 26, 2025 | Colorado Rapids at Philadelphia Union | 7:30 p.m. |
| July 26, 2025 | New York Red Bulls at Chicago Fire FC | 8:30 p.m. |
| July 26, 2025 | Minnesota United FC at St. Louis City SC | 8:30 p.m. |
| July 26, 2025 | San Jose Earthquakes at Real Salt Lake | 9:30 p.m. |
| July 26, 2025 | Sporting Kansas City at Vancouver Whitecaps FC | 10:30 p.m. |
| August 9, 2025 | Atlanta United FC at Club de Foot Montreal | 7:30 p.m. |
| August 9, 2025 | D.C. United at New England Revolution | 7:30 p.m. |
| August 9, 2025 | Columbus Crew SC at New York City FC | 7:30 p.m. |
| August 9, 2025 | Toronto FC at Philadelphia Union | 7:30 p.m. |
| August 9, 2025 | Houston Dynamo FC at Austin FC | 8:30 p.m. |
| August 9, 2025 | Los Angeles FC at Chicago Fire FC | 8:30 p.m. |
| August 9, 2025 | Portland Timbers at FC Dallas | 8:30 p.m. |
| August 9, 2025 | San Diego FC at Sporting Kansas City | 8:30 p.m. |
| August 9, 2025 | Nashville SC at St. Louis City SC | 8:30 p.m. |
| August 9, 2025 | Vancouver Whitecaps FC at San Jose Earthquakes | 10:30 p.m. |
| August 10, 2025 | Charlotte FC at FC Cincinnati | 6:00 p.m. |
| August 10, 2025 | Colorado Rapids at Minnesota United FC | 6:00 p.m. |
| August 10, 2025 | Real Salt Lake at New York Red Bulls | 6:00 p.m. |
| August 10, 2025 | Inter Miami CF at Orlando City SC | 8:00 p.m. |
| August 10, 2025 | Seattle Sounders FC at LA Galaxy | 10:00 p.m. |
| August 16, 2025 | Real Salt Lake at Charlotte FC | 7:30 p.m. |
| August 16, 2025 | D.C. United at Club de Foot Montreal | 7:30 p.m. |
| August 16, 2025 | LA Galaxy at Inter Miami CF | 7:30 p.m. |
| August 16, 2025 | Los Angeles FC at New England Revolution | 7:30 p.m. |
| August 16, 2025 | Philadelphia Union at New York Red Bulls | 7:30 p.m. |
| August 16, 2025 | Sporting Kansas City at Orlando City SC | 7:30 p.m. |
| August 16, 2025 | Columbus Crew SC at Toronto FC | 7:30 p.m. |
| August 16, 2025 | FC Dallas at Austin FC | 8:30 p.m. |
| August 16, 2025 | St. Louis City SC at Chicago Fire FC | 8:30 p.m. |
| August 16, 2025 | Seattle Sounders FC at Minnesota United FC | 8:30 p.m. |
| August 16, 2025 | Atlanta United FC at Colorado Rapids | 9:30 p.m. |
| August 16, 2025 | FC Cincinnati at Portland Timbers | 10:30 p.m. |
| August 17, 2025 | Nashville SC at New York City FC | 5:00 p.m. |
| August 17, 2025 | San Diego FC at San Jose Earthquakes | 7:00 p.m. |
| August 17, 2025 | Houston Dynamo FC at Vancouver Whitecaps FC | 9:00 p.m. |
| August 23, 2025 | Austin FC at Club de Foot Montreal | 7:30 p.m. |
| August 23, 2025 | New England Revolution at Columbus Crew SC | 7:30 p.m. |
| August 23, 2025 | Inter Miami CF at D.C. United | 7:30 p.m. |
| August 23, 2025 | New York City FC at FC Cincinnati | 7:30 p.m. |
| August 23, 2025 | Chicago Fire FC at Philadelphia Union | 7:30 p.m. |
| August 23, 2025 | Los Angeles FC at FC Dallas | 8:30 p.m. |
| August 23, 2025 | San Jose Earthquakes at Houston Dynamo FC | 8:30 p.m. |
| August 23, 2025 | Orlando City SC at Nashville SC | 8:30 p.m. |
| August 23, 2025 | Minnesota United FC at Real Salt Lake | 9:30 p.m. |
| August 23, 2025 | St. Louis City SC at Vancouver Whitecaps FC | 9:30 p.m. |
| August 23, 2025 | Colorado Rapids at LA Galaxy | 10:30 p.m. |
| August 23, 2025 | Portland Timbers at San Diego FC | 10:30 p.m. |
| August 24, 2025 | Toronto FC at Atlanta United FC | 4:00 p.m. |
| August 24, 2025 | New York Red Bulls at Charlotte FC | 7:00 p.m. |
| August 24, 2025 | Sporting Kansas City at Seattle Sounders FC | 9:00 p.m. |
| August 30, 2025 | Philadelphia Union at FC Cincinnati | 7:30 p.m. |
| August 30, 2025 | Chicago Fire FC at Inter Miami CF | 7:30 p.m. |
| August 30, 2025 | Charlotte FC at New England Revolution | 7:30 p.m. |
| August 30, 2025 | D.C. United at New York City FC | 7:30 p.m. |
| August 30, 2025 | Columbus Crew SC at New York Red Bulls | 7:30 p.m. |
| August 30, 2025 | Vancouver Whitecaps FC at Orlando City SC | 7:30 p.m. |
| August 30, 2025 | Club de Foot Montreal at Toronto FC | 7:30 p.m. |
| August 30, 2025 | San Jose Earthquakes at Austin FC | 8:30 p.m. |
| August 30, 2025 | Portland Timbers at Minnesota United FC | 8:30 p.m. |
| August 30, 2025 | Atlanta United FC at Nashville SC | 8:30 p.m. |
| August 30, 2025 | Colorado Rapids at Sporting Kansas City | 8:30 p.m. |
| August 30, 2025 | Houston Dynamo FC at St. Louis City SC | 8:30 p.m. |
| August 30, 2025 | FC Dallas at LA Galaxy | 10:30 p.m. |
| August 30, 2025 | Real Salt Lake at Seattle Sounders FC | 10:30 p.m. |
| August 31, 2025 | San Diego FC at Los Angeles FC | 10:30 p.m. |
| September 6, 2025 | New England Revolution at Chicago Fire FC | 8:30 p.m. |
| September 6, 2025 | FC Dallas at St. Louis City SC | 8:30 p.m. |
| September 7, 2025 | Austin FC at Sporting Kansas City | 7:00 p.m. |
| September 13, 2025 | Columbus Crew SC at Atlanta United FC | 7:30 p.m. |
| September 13, 2025 | Inter Miami CF at Charlotte FC | 7:30 p.m. |
| September 13, 2025 | St. Louis City SC at Club de Foot Montreal | 7:30 p.m. |
| September 13, 2025 | Orlando City SC at D.C. United | 7:30 p.m. |
| September 13, 2025 | Nashville SC at FC Cincinnati | 7:30 p.m. |
| September 13, 2025 | Toronto FC at New England Revolution | 7:30 p.m. |
| September 13, 2025 | Los Angeles FC at San Jose Earthquakes | 7:30 p.m. |
| September 13, 2025 | New York City FC at Chicago Fire FC | 8:30 p.m. |
| September 13, 2025 | Austin FC at FC Dallas | 8:30 p.m. |
| September 13, 2025 | LA Galaxy at Seattle Sounders FC | 8:30 p.m. |
| September 13, 2025 | Houston Dynamo FC at Colorado Rapids | 9:30 p.m. |
| September 13, 2025 | Sporting Kansas City at Real Salt Lake | 9:30 p.m. |
| September 13, 2025 | Philadelphia Union at Vancouver Whitecaps FC | 9:30 p.m. |
| September 13, 2025 | New York Red Bulls at Portland Timbers | 10:30 p.m. |
| September 13, 2025 | Minnesota United FC at San Diego FC | 10:30 p.m. |
| September 16, 2025 | Seattle Sounders FC at Inter Miami CF | 7:30 p.m. |
| September 17, 2025 | Los Angeles FC at Real Salt Lake | 9:30 p.m. |
| September 19, 2025 | Charlotte FC at New York City FC | 7:30 p.m. |
| September 20, 2025 | New England Revolution at Philadelphia Union | 2:30 p.m. |
| September 20, 2025 | San Diego FC at Atlanta United FC | 4:30 p.m. |
| September 20, 2025 | New York Red Bulls at Club de Foot Montreal | 7:30 p.m. |
| September 20, 2025 | Toronto FC at Columbus Crew SC | 7:30 p.m. |
| September 20, 2025 | D.C. United at Inter Miami CF | 7:30 p.m. |
| September 20, 2025 | Nashville SC at Orlando City SC | 7:30 p.m. |
| September 20, 2025 | Seattle Sounders FC at Austin FC | 8:30 p.m. |
| September 20, 2025 | Colorado Rapids at FC Dallas | 8:30 p.m. |
| September 20, 2025 | Portland Timbers at Houston Dynamo FC | 8:30 p.m. |
| September 20, 2025 | Chicago Fire FC at Minnesota United FC | 8:30 p.m. |
| September 20, 2025 | Vancouver Whitecaps FC at Sporting Kansas City | 8:30 p.m. |
| September 20, 2025 | FC Cincinnati at LA Galaxy | 10:30 p.m. |
| September 20, 2025 | St. Louis City SC at San Jose Earthquakes | 10:30 p.m. |
| September 21, 2025 | Real Salt Lake at Los Angeles FC | 9:00 p.m. |
| September 24, 2025 | Inter Miami CF at New York City FC | 7:30 p.m. |
| September 24, 2025 | Portland Timbers at Vancouver Whitecaps FC | 9:30 p.m. |
| September 27, 2025 | Orlando City SC at FC Cincinnati | 2:30 p.m. |
| September 27, 2025 | Inter Miami CF at Toronto FC | 4:30 p.m. |
| September 27, 2025 | Club de Foot Montreal at Charlotte FC | 7:30 p.m. |
| September 27, 2025 | Philadelphia Union at D.C. United | 7:30 p.m. |
| September 27, 2025 | Atlanta United FC at New England Revolution | 7:30 p.m. |
| September 27, 2025 | New York City FC at New York Red Bulls | 7:30 p.m. |
| September 27, 2025 | Columbus Crew SC at Chicago Fire FC | 8:30 p.m. |
| September 27, 2025 | Houston Dynamo FC at Nashville SC | 8:30 p.m. |
| September 27, 2025 | Los Angeles FC at St. Louis City SC | 8:30 p.m. |
| September 27, 2025 | Minnesota United FC at Colorado Rapids | 9:30 p.m. |
| September 27, 2025 | Austin FC at Real Salt Lake | 9:30 p.m. |
| September 27, 2025 | Sporting Kansas City at LA Galaxy | 10:30 p.m. |
| September 27, 2025 | FC Dallas at Portland Timbers | 10:30 p.m. |
| September 27, 2025 | San Jose Earthquakes at San Diego FC | 10:30 p.m. |
| September 27, 2025 | Vancouver Whitecaps FC at Seattle Sounders FC | 10:30 p.m. |
| October 4, 2025 | Nashville SC at Club de Foot Montreal | 2:30 p.m. |
| October 4, 2025 | Charlotte FC at D.C. United | 2:30 p.m. |
| October 4, 2025 | LA Galaxy at FC Dallas | 4:30 p.m. |
| October 4, 2025 | New England Revolution at Inter Miami CF | 7:30 p.m. |
| October 4, 2025 | FC Cincinnati at New York Red Bulls | 7:30 p.m. |
| October 4, 2025 | Columbus Crew SC at Orlando City SC | 7:30 p.m. |
| October 4, 2025 | New York City FC at Philadelphia Union | 7:30 p.m. |
| October 4, 2025 | St. Louis City SC at Austin FC | 8:30 p.m. |
| October 4, 2025 | Toronto FC at Chicago Fire FC | 8:30 p.m. |
| October 4, 2025 | San Diego FC at Houston Dynamo FC | 8:30 p.m. |
| October 4, 2025 | Sporting Kansas City at Minnesota United FC | 8:30 p.m. |
| October 4, 2025 | Colorado Rapids at Real Salt Lake | 9:30 p.m. |
| October 4, 2025 | Portland Timbers at Seattle Sounders FC | 10:30 p.m. |
| October 5, 2025 | San Jose Earthquakes at Vancouver Whitecaps FC | 9:00 p.m. |
| October 5, 2025 | Atlanta United FC at Los Angeles FC | 10:30 p.m. |
| October 8, 2025 | Toronto FC at Los Angeles FC | 10:30 p.m. |
| October 18, 2025 | D.C. United at Atlanta United FC | 6:00 p.m. |
| October 18, 2025 | Philadelphia Union at Charlotte FC | 6:00 p.m. |
| October 18, 2025 | New York Red Bulls at Columbus Crew SC | 6:00 p.m. |
| October 18, 2025 | Club de Foot Montreal at FC Cincinnati | 6:00 p.m. |
| October 18, 2025 | Inter Miami CF at Nashville SC | 6:00 p.m. |
| October 18, 2025 | Chicago Fire FC at New England Revolution | 6:00 p.m. |
| October 18, 2025 | Seattle Sounders FC at New York City FC | 6:00 p.m. |
| October 18, 2025 | Orlando City SC at Toronto FC | 6:00 p.m. |
| October 18, 2025 | Los Angeles FC at Colorado Rapids | 9:00 p.m. |
| October 18, 2025 | Minnesota United FC at LA Galaxy | 9:00 p.m. |
| October 18, 2025 | San Diego FC at Portland Timbers | 9:00 p.m. |
| October 18, 2025 | Austin FC at San Jose Earthquakes | 9:00 p.m. |
| October 18, 2025 | Houston Dynamo FC at Sporting Kansas City | 9:00 p.m. |
| October 18, 2025 | Real Salt Lake at St. Louis City SC | 9:00 p.m. |
| October 18, 2025 | FC Dallas at Vancouver Whitecaps FC | 9:00 p.m. |
Major League Soccer Schedule
