| | | |
| February 22, 2025 | T | Colorado Rapids 0 at St. Louis City SC 0 | Final |
| March 1, 2025 | T | FC Dallas 3 at Colorado Rapids 3 | Final |
| March 8, 2025 | W | Colorado Rapids 1 at Austin FC 0 | Final |
| March 15, 2025 | W | Colorado Rapids 2 at San Jose Earthquakes 1 | Final |
| March 22, 2025 | L | Portland Timbers 3 at Colorado Rapids 0 | Final |
| March 29, 2025 | W | Charlotte FC 0 at Colorado Rapids 2 | Final |
| April 5, 2025 | L | Colorado Rapids 0 at Vancouver Whitecaps FC 2 | Final |
| April 12, 2025 | W | San Diego FC 2 at Colorado Rapids 3 | Final |
| April 19, 2025 | T | Colorado Rapids 2 at Houston Dynamo FC 2 | Final |
| April 26, 2025 | T | Seattle Sounders FC 1 at Colorado Rapids 1 | Final |
| May 3, 2025 | L | Colorado Rapids 1 at D.C. United 2 | Final |
| May 10, 2025 | L | San Jose Earthquakes 2 at Colorado Rapids 0 | Final |
| May 14, 2025 | L | Colorado Rapids 0 at San Diego FC 2 | Final |
| May 17, 2025 | W | Real Salt Lake 0 at Colorado Rapids 1 | Final |
| May 24, 2025 | W | St. Louis City SC 0 at Colorado Rapids 1 | Final |
| May 28, 2025 | L | Colorado Rapids 1 at Portland Timbers 2 | Final |
| June 7, 2025 | L | Austin FC 2 at Colorado Rapids 0 | Final |
| June 14, 2025 | L | Orlando City SC 1 at Colorado Rapids 0 | Final |
| June 25, 2025 | | LA Galaxy at Colorado Rapids | 9:30 p.m. |
| June 28, 2025 | | Colorado Rapids at New England Revolution | 7:30 p.m. |
| July 4, 2025 | | Sporting Kansas City at Colorado Rapids | 9:30 p.m. |
| July 9, 2025 | | Colorado Rapids at Los Angeles FC | 10:30 p.m. |
| July 12, 2025 | | Vancouver Whitecaps FC at Colorado Rapids | 9:30 p.m. |
| July 16, 2025 | | Colorado Rapids at Seattle Sounders FC | 10:00 p.m. |
| July 26, 2025 | | Colorado Rapids at Philadelphia Union | 7:30 p.m. |
| August 10, 2025 | | Colorado Rapids at Minnesota United FC | 6:00 p.m. |
| August 16, 2025 | | Atlanta United FC at Colorado Rapids | 9:30 p.m. |
| August 23, 2025 | | Colorado Rapids at LA Galaxy | 10:30 p.m. |
| August 30, 2025 | | Colorado Rapids at Sporting Kansas City | 8:30 p.m. |
| September 13, 2025 | | Houston Dynamo FC at Colorado Rapids | 9:30 p.m. |
| September 20, 2025 | | Colorado Rapids at FC Dallas | 8:30 p.m. |
| September 27, 2025 | | Minnesota United FC at Colorado Rapids | 9:30 p.m. |
| October 4, 2025 | | Colorado Rapids at Real Salt Lake | 9:30 p.m. |
| October 18, 2025 | | Los Angeles FC at Colorado Rapids | 9:00 p.m. |
Colorado Rapids Schedule
