| | | |
| February 23, 2025 | L | San Diego FC 2 at LA Galaxy 0 | Final |
| March 2, 2025 | L | LA Galaxy 1 at Vancouver Whitecaps FC 2 | Final |
| March 9, 2025 | L | St. Louis City SC 3 at LA Galaxy 0 | Final |
| March 16, 2025 | T | LA Galaxy 1 at Portland Timbers 1 | Final |
| March 22, 2025 | T | LA Galaxy 2 at Minnesota United FC 2 | Final |
| March 29, 2025 | L | Orlando City SC 2 at LA Galaxy 1 | Final |
| April 5, 2025 | L | LA Galaxy 0 at Real Salt Lake 2 | Final |
| April 12, 2025 | T | Houston Dynamo FC 1 at LA Galaxy 1 | Final |
| April 19, 2025 | L | LA Galaxy 0 at Austin FC 1 | Final |
| April 27, 2025 | L | Portland Timbers 4 at LA Galaxy 2 | Final |
| May 4, 2025 | L | LA Galaxy 0 at Sporting Kansas City 1 | Final |
| May 10, 2025 | L | LA Galaxy 0 at New York Red Bulls 7 | Final |
| May 14, 2025 | L | LA Galaxy 2 at Philadelphia Union 3 | Final |
| May 18, 2025 | T | Los Angeles FC 2 at LA Galaxy 2 | Final |
| May 24, 2025 | L | LA Galaxy 1 at San Diego FC 2 | Final |
| May 28, 2025 | L | San Jose Earthquakes 1 at LA Galaxy 0 | Final |
| May 31, 2025 | W | Real Salt Lake 0 at LA Galaxy 2 | Final |
| June 14, 2025 | T | LA Galaxy 3 at St. Louis City SC 3 | Final |
| June 25, 2025 | | LA Galaxy at Colorado Rapids | 9:30 p.m. |
| June 28, 2025 | | LA Galaxy at San Jose Earthquakes | 10:30 p.m. |
| July 4, 2025 | | Vancouver Whitecaps FC at LA Galaxy | 10:30 p.m. |
| July 12, 2025 | | D.C. United at LA Galaxy | 10:30 p.m. |
| July 16, 2025 | | Austin FC at LA Galaxy | 10:30 p.m. |
| July 19, 2025 | | LA Galaxy at Los Angeles FC | 10:30 p.m. |
| July 25, 2025 | | LA Galaxy at Houston Dynamo FC | 8:30 p.m. |
| August 10, 2025 | | Seattle Sounders FC at LA Galaxy | 10:00 p.m. |
| August 16, 2025 | | LA Galaxy at Inter Miami CF | 7:30 p.m. |
| August 23, 2025 | | Colorado Rapids at LA Galaxy | 10:30 p.m. |
| August 30, 2025 | | FC Dallas at LA Galaxy | 10:30 p.m. |
| September 13, 2025 | | LA Galaxy at Seattle Sounders FC | 8:30 p.m. |
| September 20, 2025 | | FC Cincinnati at LA Galaxy | 10:30 p.m. |
| September 27, 2025 | | Sporting Kansas City at LA Galaxy | 10:30 p.m. |
| October 4, 2025 | | LA Galaxy at FC Dallas | 4:30 p.m. |
| October 18, 2025 | | Minnesota United FC at LA Galaxy | 9:00 p.m. |
LA Galaxy Schedule
