| | | |
| February 23, 2025 | W | Vancouver Whitecaps FC 4 at Portland Timbers 1 | Final |
| March 2, 2025 | W | LA Galaxy 1 at Vancouver Whitecaps FC 2 | Final |
| March 8, 2025 | W | Club de Foot Montreal 0 at Vancouver Whitecaps FC 2 | Final |
| March 15, 2025 | W | Vancouver Whitecaps FC 1 at FC Dallas 0 | Final |
| March 22, 2025 | L | Chicago Fire FC 3 at Vancouver Whitecaps FC 1 | Final |
| March 29, 2025 | T | Vancouver Whitecaps FC 0 at Toronto FC 0 | Final |
| April 5, 2025 | W | Colorado Rapids 0 at Vancouver Whitecaps FC 2 | Final |
| April 12, 2025 | W | Austin FC 1 at Vancouver Whitecaps FC 5 | Final |
| April 19, 2025 | T | Vancouver Whitecaps FC 0 at St. Louis City SC 0 | Final |
| April 27, 2025 | W | Vancouver Whitecaps FC 3 at Minnesota United FC 1 | Final |
| May 3, 2025 | W | Real Salt Lake 1 at Vancouver Whitecaps FC 2 | Final |
| May 11, 2025 | T | Los Angeles FC 2 at Vancouver Whitecaps FC 2 | Final |
| May 17, 2025 | T | Vancouver Whitecaps FC 0 at Austin FC 0 | Final |
| May 24, 2025 | W | Vancouver Whitecaps FC 3 at Real Salt Lake 2 | Final |
| May 28, 2025 | T | Minnesota United FC 0 at Vancouver Whitecaps FC 0 | Final |
| June 8, 2025 | W | Seattle Sounders FC 0 at Vancouver Whitecaps FC 3 | Final |
| June 14, 2025 | L | Vancouver Whitecaps FC 1 at Columbus Crew SC 2 | Final |
| June 25, 2025 | | San Diego FC at Vancouver Whitecaps FC | 10:30 p.m. |
| June 29, 2025 | | Vancouver Whitecaps FC at Los Angeles FC | 9:30 p.m. |
| July 4, 2025 | | Vancouver Whitecaps FC at LA Galaxy | 10:30 p.m. |
| July 12, 2025 | | Vancouver Whitecaps FC at Colorado Rapids | 9:30 p.m. |
| July 16, 2025 | | Vancouver Whitecaps FC at Houston Dynamo FC | 8:30 p.m. |
| July 19, 2025 | | Vancouver Whitecaps FC at San Diego FC | 10:30 p.m. |
| July 26, 2025 | | Sporting Kansas City at Vancouver Whitecaps FC | 10:30 p.m. |
| August 9, 2025 | | Vancouver Whitecaps FC at San Jose Earthquakes | 10:30 p.m. |
| August 17, 2025 | | Houston Dynamo FC at Vancouver Whitecaps FC | 9:00 p.m. |
| August 23, 2025 | | St. Louis City SC at Vancouver Whitecaps FC | 9:30 p.m. |
| August 30, 2025 | | Vancouver Whitecaps FC at Orlando City SC | 7:30 p.m. |
| September 13, 2025 | | Philadelphia Union at Vancouver Whitecaps FC | 9:30 p.m. |
| September 20, 2025 | | Vancouver Whitecaps FC at Sporting Kansas City | 8:30 p.m. |
| September 24, 2025 | | Portland Timbers at Vancouver Whitecaps FC | 9:30 p.m. |
| September 27, 2025 | | Vancouver Whitecaps FC at Seattle Sounders FC | 10:30 p.m. |
| October 5, 2025 | | San Jose Earthquakes at Vancouver Whitecaps FC | 9:00 p.m. |
| October 18, 2025 | | FC Dallas at Vancouver Whitecaps FC | 9:00 p.m. |
Vancouver Whitecaps FC Schedule
