| | | |
| February 23, 2025 | W | Vancouver Whitecaps FC 4 at Portland Timbers 1 | Final |
| March 2, 2025 | W | LA Galaxy 1 at Vancouver Whitecaps FC 2 | Final |
| March 8, 2025 | W | Club de Foot Montreal 0 at Vancouver Whitecaps FC 2 | Final |
| March 15, 2025 | W | Vancouver Whitecaps FC 1 at FC Dallas 0 | Final |
| March 22, 2025 | L | Chicago Fire FC 3 at Vancouver Whitecaps FC 1 | Final |
| March 29, 2025 | T | Vancouver Whitecaps FC 0 at Toronto FC 0 | Final |
| April 5, 2025 | W | Colorado Rapids 0 at Vancouver Whitecaps FC 2 | Final |
| April 12, 2025 | W | Austin FC 1 at Vancouver Whitecaps FC 5 | Final |
| April 19, 2025 | T | Vancouver Whitecaps FC 0 at St. Louis City SC 0 | Final |
| April 27, 2025 | W | Vancouver Whitecaps FC 3 at Minnesota United FC 1 | Final |
| May 3, 2025 | W | Real Salt Lake 1 at Vancouver Whitecaps FC 2 | Final |
| May 11, 2025 | T | Los Angeles FC 2 at Vancouver Whitecaps FC 2 | Final |
| May 17, 2025 | T | Vancouver Whitecaps FC 0 at Austin FC 0 | Final |
| May 24, 2025 | W | Vancouver Whitecaps FC 3 at Real Salt Lake 2 | Final |
| May 28, 2025 | T | Minnesota United FC 0 at Vancouver Whitecaps FC 0 | Final |
| June 8, 2025 | W | Seattle Sounders FC 0 at Vancouver Whitecaps FC 3 | Final |
| June 14, 2025 | L | Vancouver Whitecaps FC 1 at Columbus Crew SC 2 | Final |
| June 25, 2025 | L | San Diego FC 5 at Vancouver Whitecaps FC 3 | Final |
| June 29, 2025 | W | Vancouver Whitecaps FC 1 at Los Angeles FC 0 | Final |
| July 4, 2025 | L | Vancouver Whitecaps FC 0 at LA Galaxy 3 | Final |
| July 12, 2025 | L | Vancouver Whitecaps FC 0 at Colorado Rapids 3 | Final |
| July 16, 2025 | W | Vancouver Whitecaps FC 3 at Houston Dynamo FC 0 | Final |
| July 19, 2025 | T | Vancouver Whitecaps FC 1 at San Diego FC 1 | Final |
| July 26, 2025 | W | Sporting Kansas City 0 at Vancouver Whitecaps FC 3 | Final |
| August 9, 2025 | L | Vancouver Whitecaps FC 1 at San Jose Earthquakes 2 | Final |
| August 17, 2025 | T | Houston Dynamo FC 1 at Vancouver Whitecaps FC 1 | Final |
| August 23, 2025 | W | St. Louis City SC 2 at Vancouver Whitecaps FC 3 | Final |
| September 13, 2025 | W | Philadelphia Union 0 at Vancouver Whitecaps FC 7 | Final |
| September 20, 2025 | W | Vancouver Whitecaps FC 2 at Sporting Kansas City 0 | Final |
| September 24, 2025 | T | Portland Timbers 1 at Vancouver Whitecaps FC 1 | Final |
| September 27, 2025 | T | Vancouver Whitecaps FC 2 at Seattle Sounders FC 2 | Final |
| October 5, 2025 | W | San Jose Earthquakes 1 at Vancouver Whitecaps FC 4 | Final |
| October 11, 2025 | W | Vancouver Whitecaps FC 2 at Orlando City SC 1 | Final |
| October 18, 2025 | L | FC Dallas 2 at Vancouver Whitecaps FC 1 | Final |
| October 26, 2025 | W | FC Dallas 0 at Vancouver Whitecaps FC 3 (Playoff Gm. 1) | Final |
| November 1, 2025 | | Vancouver Whitecaps FC at FC Dallas (Playoff Gm. 2) | 9:30 p.m. |
| November 7, 2025 | | FC Dallas at Vancouver Whitecaps FC (Playoff Gm. 3, if nec.) | 1:00 p.m. |
Vancouver Whitecaps FC Schedule
