Toronto FC Schedule
All times Eastern
| February 26, 2022 | T | Toronto FC 1 at FC Dallas 1 | Final |
| March 5, 2022 | L | New York Red Bulls 4 at Toronto FC 1 | Final |
| March 12, 2022 | L | Toronto FC 1 at Columbus Crew SC 2 | Final |
| March 19, 2022 | W | D.C. United 1 at Toronto FC 2 | Final |
| April 2, 2022 | W | New York City FC 1 at Toronto FC 2 | Final |
| April 9, 2022 | T | Toronto FC 2 at Real Salt Lake 2 | Final |
| April 16, 2022 | W | Philadelphia Union 1 at Toronto FC 2 | Final |
| April 24, 2022 | L | Toronto FC 4 at New York City FC 5 | Final |
| April 30, 2022 | L | FC Cincinnati 2 at Toronto FC 1 | Final |
| May 4, 2022 | L | Toronto FC 0 at FC Cincinnati 2 | Final |
| May 8, 2022 | L | Toronto FC 0 at Vancouver Whitecaps FC 1 | Final |
| May 14, 2022 | L | Orlando City SC 1 at Toronto FC 0 | Final |
| May 21, 2022 | T | Toronto FC 2 at D.C. United 2 | Final |
| May 28, 2022 | Chicago Fire FC at Toronto FC | 7:00 p.m. | |
| June 18, 2022 | Toronto FC at New York Red Bulls | 7:00 p.m. | |
| June 25, 2022 | Atlanta United FC at Toronto FC | 7:30 p.m. | |
| June 29, 2022 | Columbus Crew SC at Toronto FC | 7:30 p.m. | |
| July 2, 2022 | Seattle Sounders FC at Toronto FC | 7:30 p.m. | |
| July 9, 2022 | San Jose Earthquakes at Toronto FC | 7:30 p.m. | |
| July 13, 2022 | Toronto FC at Chicago Fire FC | 8:00 p.m. | |
| July 16, 2022 | Toronto FC at Club de Foot Montreal | 7:30 p.m. | |
| July 23, 2022 | Charlotte FC at Toronto FC | 7:30 p.m. | |
| July 30, 2022 | Toronto FC at New England Revolution | 8:00 p.m. | |
| August 6, 2022 | Toronto FC at Nashville SC | 8:00 p.m. | |
| August 13, 2022 | Portland Timbers at Toronto FC | 7:30 p.m. | |
| August 17, 2022 | New England Revolution at Toronto FC | 7:30 p.m. | |
| August 20, 2022 | Toronto FC at Inter Miami CF | 8:00 p.m. | |
| August 27, 2022 | Toronto FC at Charlotte FC | 7:00 p.m. | |
| August 31, 2022 | LA Galaxy at Toronto FC | 7:30 p.m. | |
| September 4, 2022 | Club de Foot Montreal at Toronto FC | 7:30 p.m. | |
| September 10, 2022 | Toronto FC at Atlanta United FC | 7:30 p.m. | |
| September 17, 2022 | Toronto FC at Orlando City SC | 7:30 p.m. | |
| September 30, 2022 | Inter Miami CF at Toronto FC | 7:30 p.m. | |
| October 9, 2022 | Toronto FC at Philadelphia Union | 9:00 a.m. |
