| | | |
| February 22, 2025 | T | Toronto FC 2 at D.C. United 2 | Final |
| March 1, 2025 | L | Toronto FC 2 at Orlando City SC 4 | Final |
| March 8, 2025 | L | Toronto FC 0 at FC Cincinnati 2 | Final |
| March 15, 2025 | L | Chicago Fire FC 2 at Toronto FC 1 | Final |
| March 22, 2025 | L | Toronto FC 1 at New York Red Bulls 2 | Final |
| March 29, 2025 | T | Vancouver Whitecaps FC 0 at Toronto FC 0 | Final |
| April 6, 2025 | T | Toronto FC 1 at Inter Miami CF 1 | Final |
| April 12, 2025 | T | Minnesota United FC 0 at Toronto FC 0 | Final |
| April 19, 2025 | W | Toronto FC 1 at Real Salt Lake 0 | Final |
| April 26, 2025 | L | New York City FC 1 at Toronto FC 0 | Final |
| May 3, 2025 | L | New England Revolution 2 at Toronto FC 0 | Final |
| May 10, 2025 | W | D.C. United 0 at Toronto FC 2 | Final |
| May 14, 2025 | L | FC Cincinnati 1 at Toronto FC 0 | Final |
| May 17, 2025 | W | Toronto FC 6 at Club de Foot Montreal 1 | Final |
| May 24, 2025 | L | Nashville SC 2 at Toronto FC 1 | Final |
| May 28, 2025 | L | Philadelphia Union 2 at Toronto FC 1 | Final |
| May 31, 2025 | L | Charlotte FC 2 at Toronto FC 0 | Final |
| June 25, 2025 | T | New York Red Bulls 1 at Toronto FC 1 | Final |
| June 28, 2025 | W | Portland Timbers 0 at Toronto FC 3 | Final |
| July 3, 2025 | L | Toronto FC 1 at New York City FC 3 | Final |
| July 12, 2025 | T | Atlanta United FC 1 at Toronto FC 1 | Final |
| July 16, 2025 | W | Toronto FC 1 at San Diego FC 0 | Final |
| July 19, 2025 | L | Toronto FC 0 at Nashville SC 1 | Final |
| July 26, 2025 | L | Toronto FC 0 at Charlotte FC 2 | Final |
| August 9, 2025 | | Toronto FC at Philadelphia Union | 7:30 p.m. |
| August 16, 2025 | | Columbus Crew SC at Toronto FC | 7:30 p.m. |
| August 24, 2025 | | Toronto FC at Atlanta United FC | 4:00 p.m. |
| August 30, 2025 | | Club de Foot Montreal at Toronto FC | 7:30 p.m. |
| September 13, 2025 | | Toronto FC at New England Revolution | 7:30 p.m. |
| September 20, 2025 | | Toronto FC at Columbus Crew SC | 7:30 p.m. |
| September 27, 2025 | | Inter Miami CF at Toronto FC | 4:30 p.m. |
| October 4, 2025 | | Toronto FC at Chicago Fire FC | 8:30 p.m. |
| October 8, 2025 | | Toronto FC at Los Angeles FC | 10:30 p.m. |
| October 18, 2025 | | Orlando City SC at Toronto FC | 6:00 p.m. |
Toronto FC Schedule
