| | | |
| February 22, 2025 | W | Real Salt Lake 0 at San Jose Earthquakes 4 | Final |
| March 1, 2025 | W | San Jose Earthquakes 2 at Sporting Kansas City 1 | Final |
| March 8, 2025 | L | Minnesota United FC 1 at San Jose Earthquakes 0 | Final |
| March 15, 2025 | L | Colorado Rapids 2 at San Jose Earthquakes 1 | Final |
| March 22, 2025 | L | San Jose Earthquakes 1 at Charlotte FC 4 | Final |
| March 29, 2025 | T | Seattle Sounders FC 1 at San Jose Earthquakes 1 | Final |
| April 6, 2025 | W | D.C. United 1 at San Jose Earthquakes 6 | Final |
| April 12, 2025 | L | San Jose Earthquakes 1 at Los Angeles FC 2 | Final |
| April 19, 2025 | L | Sporting Kansas City 5 at San Jose Earthquakes 3 | Final |
| April 26, 2025 | L | San Jose Earthquakes 1 at Columbus Crew SC 2 | Final |
| May 3, 2025 | W | Portland Timbers 1 at San Jose Earthquakes 4 | Final |
| May 10, 2025 | | San Jose Earthquakes at Colorado Rapids | 9:30 p.m. |
| May 14, 2025 | | Inter Miami CF at San Jose Earthquakes | 10:30 p.m. |
| May 17, 2025 | | San Jose Earthquakes at New England Revolution | 7:30 p.m. |
| May 24, 2025 | | Houston Dynamo FC at San Jose Earthquakes | 10:30 p.m. |
| May 28, 2025 | | San Jose Earthquakes at LA Galaxy | 10:00 p.m. |
| May 31, 2025 | | San Jose Earthquakes at St. Louis City SC | 2:30 p.m. |
| June 13, 2025 | | San Jose Earthquakes at Portland Timbers | 10:30 p.m. |
| June 25, 2025 | | San Jose Earthquakes at FC Dallas | 8:30 p.m. |
| June 28, 2025 | | LA Galaxy at San Jose Earthquakes | 10:30 p.m. |
| July 5, 2025 | | New York Red Bulls at San Jose Earthquakes | 10:30 p.m. |
| July 12, 2025 | | San Jose Earthquakes at Minnesota United FC | 8:30 p.m. |
| July 16, 2025 | | FC Dallas at San Jose Earthquakes | 10:30 p.m. |
| July 19, 2025 | | San Jose Earthquakes at Seattle Sounders FC | 8:30 p.m. |
| July 26, 2025 | | San Jose Earthquakes at Real Salt Lake | 9:30 p.m. |
| August 9, 2025 | | Vancouver Whitecaps FC at San Jose Earthquakes | 10:30 p.m. |
| August 17, 2025 | | San Diego FC at San Jose Earthquakes | 7:00 p.m. |
| August 23, 2025 | | San Jose Earthquakes at Houston Dynamo FC | 8:30 p.m. |
| August 30, 2025 | | San Jose Earthquakes at Austin FC | 8:30 p.m. |
| September 13, 2025 | | Los Angeles FC at San Jose Earthquakes | 7:30 p.m. |
| September 20, 2025 | | St. Louis City SC at San Jose Earthquakes | 10:30 p.m. |
| September 27, 2025 | | San Jose Earthquakes at San Diego FC | 10:30 p.m. |
| October 5, 2025 | | San Jose Earthquakes at Vancouver Whitecaps FC | 9:00 p.m. |
| October 18, 2025 | | Austin FC at San Jose Earthquakes | 9:00 p.m. |
San Jose Earthquakes Schedule
