| | | |
| February 22, 2025 | W | Real Salt Lake 0 at San Jose Earthquakes 4 | Final |
| March 1, 2025 | W | San Jose Earthquakes 2 at Sporting Kansas City 1 | Final |
| March 8, 2025 | L | Minnesota United FC 1 at San Jose Earthquakes 0 | Final |
| March 15, 2025 | L | Colorado Rapids 2 at San Jose Earthquakes 1 | Final |
| March 22, 2025 | L | San Jose Earthquakes 1 at Charlotte FC 4 | Final |
| March 29, 2025 | T | Seattle Sounders FC 1 at San Jose Earthquakes 1 | Final |
| April 6, 2025 | W | D.C. United 1 at San Jose Earthquakes 6 | Final |
| April 12, 2025 | L | San Jose Earthquakes 1 at Los Angeles FC 2 | Final |
| April 19, 2025 | L | Sporting Kansas City 5 at San Jose Earthquakes 3 | Final |
| April 26, 2025 | L | San Jose Earthquakes 1 at Columbus Crew SC 2 | Final |
| May 3, 2025 | W | Portland Timbers 1 at San Jose Earthquakes 4 | Final |
| May 10, 2025 | W | San Jose Earthquakes 2 at Colorado Rapids 0 | Final |
| May 14, 2025 | T | Inter Miami CF 3 at San Jose Earthquakes 3 | Final |
| May 17, 2025 | T | San Jose Earthquakes 0 at New England Revolution 0 | Final |
| May 24, 2025 | T | Houston Dynamo FC 3 at San Jose Earthquakes 3 | Final |
| May 28, 2025 | W | San Jose Earthquakes 1 at LA Galaxy 0 | Final |
| May 31, 2025 | L | San Jose Earthquakes 1 at St. Louis City SC 2 | Final |
| June 13, 2025 | T | San Jose Earthquakes 1 at Portland Timbers 1 | Final |
| June 25, 2025 | W | San Jose Earthquakes 4 at FC Dallas 2 | Final |
| June 28, 2025 | T | LA Galaxy 1 at San Jose Earthquakes 1 | Final |
| July 5, 2025 | T | New York Red Bulls 1 at San Jose Earthquakes 1 | Final |
| July 12, 2025 | L | San Jose Earthquakes 1 at Minnesota United FC 4 | Final |
| July 16, 2025 | T | FC Dallas 2 at San Jose Earthquakes 2 | Final |
| July 19, 2025 | L | San Jose Earthquakes 2 at Seattle Sounders FC 3 | Final |
| July 26, 2025 | L | San Jose Earthquakes 1 at Real Salt Lake 2 | Final |
| August 9, 2025 | W | Vancouver Whitecaps FC 1 at San Jose Earthquakes 2 | Final |
| August 17, 2025 | L | San Diego FC 2 at San Jose Earthquakes 1 | Final |
| August 23, 2025 | W | San Jose Earthquakes 2 at Houston Dynamo FC 1 | Final |
| August 30, 2025 | L | San Jose Earthquakes 1 at Austin FC 3 | Final |
| September 13, 2025 | L | Los Angeles FC 4 at San Jose Earthquakes 2 | Final |
| September 20, 2025 | L | St. Louis City SC 3 at San Jose Earthquakes 1 | Final |
| September 27, 2025 | W | San Jose Earthquakes 1 at San Diego FC 0 | Final |
| October 5, 2025 | L | San Jose Earthquakes 1 at Vancouver Whitecaps FC 4 | Final |
| October 18, 2025 | W | Austin FC 1 at San Jose Earthquakes 2 | Final |
San Jose Earthquakes Schedule
