| | | |
| February 21, 2026 | W | Club de Foot Montreal 0 at San Diego FC 5 | Final |
| March 1, 2026 | W | St. Louis City SC 0 at San Diego FC 2 | Final |
| March 7, 2026 | W | San Diego FC 1 at Sporting Kansas City 0 | Final |
| March 14, 2026 | T | San Diego FC 3 at FC Dallas 3 | Final |
| March 22, 2026 | T | Real Salt Lake 2 at San Diego FC 2 | Final |
| April 4, 2026 | L | San Diego FC 0 at San Jose Earthquakes 3 | Final |
| April 11, 2026 | L | Minnesota United FC 2 at San Diego FC 1 | Final |
| April 18, 2026 | L | San Diego FC 2 at Real Salt Lake 4 | Final |
| April 22, 2026 | L | San Diego FC 0 at Houston Dynamo FC 1 | Final |
| April 25, 2026 | L | Portland Timbers 2 at San Diego FC 1 | Final |
| May 2, 2026 | | Los Angeles FC at San Diego FC | 8:30 p.m. |
| May 9, 2026 | | San Diego FC at Seattle Sounders FC | 9:30 p.m. |
| May 13, 2026 | | Austin FC at San Diego FC | 8:30 p.m. |
| May 16, 2026 | | FC Cincinnati at San Diego FC | 8:30 p.m. |
| May 23, 2026 | | Vancouver Whitecaps FC at San Diego FC | 8:30 p.m. |
| July 22, 2026 | | San Diego FC at Colorado Rapids | 8:30 p.m. |
| July 25, 2026 | | FC Dallas at San Diego FC | 8:30 p.m. |
| August 1, 2026 | | San Diego FC at Minnesota United FC | 7:30 p.m. |
| August 15, 2026 | | San Diego FC at Los Angeles FC | 9:30 p.m. |
| August 19, 2026 | | San Diego FC at Portland Timbers | 9:30 p.m. |
| August 22, 2026 | | Colorado Rapids at San Diego FC | 9:30 p.m. |
| August 29, 2026 | | LA Galaxy at San Diego FC | 9:30 p.m. |
| September 5, 2026 | | San Diego FC at Orlando City SC | 6:30 p.m. |
| September 9, 2026 | | San Jose Earthquakes at San Diego FC | 9:30 p.m. |
| September 13, 2026 | | Philadelphia Union at San Diego FC | 8:00 p.m. |
| September 20, 2026 | | San Diego FC at Inter Miami CF | 6:00 p.m. |
| September 26, 2026 | | San Diego FC at Austin FC | 7:30 p.m. |
| October 10, 2026 | | San Diego FC at Red Bull New York | 6:30 p.m. |
| October 14, 2026 | | Houston Dynamo FC at San Diego FC | 9:30 p.m. |
| October 17, 2026 | | San Diego FC at LA Galaxy | 9:30 p.m. |
| October 24, 2026 | | Seattle Sounders FC at San Diego FC | 9:30 p.m. |
| October 28, 2026 | | San Diego FC at Vancouver Whitecaps FC | 9:30 p.m. |
| October 31, 2026 | | San Diego FC at St. Louis City SC | 1:00 p.m. |
| November 7, 2026 | | Sporting Kansas City at San Diego FC | 7:00 p.m. |
San Diego FC Schedule
