| | | |
| February 22, 2025 | T | New England Revolution 0 at Nashville SC 0 | Final |
| March 1, 2025 | L | Nashville SC 0 at New York Red Bulls 2 | Final |
| March 8, 2025 | W | Portland Timbers 0 at Nashville SC 2 | Final |
| March 16, 2025 | W | Nashville SC 3 at Philadelphia Union 1 | Final |
| March 22, 2025 | W | Club de Foot Montreal 0 at Nashville SC 3 | Final |
| March 29, 2025 | L | FC Cincinnati 2 at Nashville SC 1 | Final |
| April 5, 2025 | L | Nashville SC 1 at Charlotte FC 2 | Final |
| April 12, 2025 | W | Real Salt Lake 1 at Nashville SC 2 | Final |
| April 19, 2025 | L | Nashville SC 0 at Seattle Sounders FC 3 | Final |
| April 26, 2025 | W | Chicago Fire FC 2 at Nashville SC 7 | Final |
| May 3, 2025 | T | Nashville SC 1 at Atlanta United FC 1 | Final |
| May 10, 2025 | W | Charlotte FC 1 at Nashville SC 2 | Final |
| May 14, 2025 | W | New York Red Bulls 1 at Nashville SC 2 | Final |
| May 17, 2025 | T | D.C. United 0 at Nashville SC 0 | Final |
| May 24, 2025 | W | Nashville SC 2 at Toronto FC 1 | Final |
| May 28, 2025 | T | Nashville SC 2 at Columbus Crew SC 2 | Final |
| May 31, 2025 | T | New York City FC 2 at Nashville SC 2 | Final |
| June 14, 2025 | W | Nashville SC 2 at Chicago Fire FC 0 | Final |
| June 25, 2025 | W | Nashville SC 3 at New England Revolution 2 | Final |
| June 28, 2025 | W | Nashville SC 1 at D.C. United 0 | Final |
| July 5, 2025 | W | Philadelphia Union 0 at Nashville SC 1 | Final |
| July 12, 2025 | L | Nashville SC 1 at Inter Miami CF 2 | Final |
| July 16, 2025 | W | Columbus Crew SC 0 at Nashville SC 3 | Final |
| July 19, 2025 | W | Toronto FC 0 at Nashville SC 1 | Final |
| July 25, 2025 | L | Nashville SC 0 at San Diego FC 1 | Final |
| August 9, 2025 | L | Nashville SC 1 at St. Louis City SC 3 | Final |
| August 17, 2025 | L | Nashville SC 1 at New York City FC 2 | Final |
| August 23, 2025 | W | Orlando City SC 1 at Nashville SC 5 | Final |
| August 30, 2025 | L | Atlanta United FC 1 at Nashville SC 0 | Final |
| September 13, 2025 | L | Nashville SC 1 at FC Cincinnati 2 | Final |
| September 20, 2025 | L | Nashville SC 2 at Orlando City SC 3 | Final |
| September 27, 2025 | W | Houston Dynamo FC 1 at Nashville SC 3 | Final |
| October 4, 2025 | T | Nashville SC 1 at Club de Foot Montreal 1 | Final |
| October 18, 2025 | L | Inter Miami CF 5 at Nashville SC 2 | Final |
| October 24, 2025 | L | Nashville SC 1 at Inter Miami CF 3 (Playoff Gm. 1) | Final |
| November 1, 2025 | W | Inter Miami CF 1 at Nashville SC 2 (Playoff Gm. 2) | Final |
| November 8, 2025 | | Nashville SC at Inter Miami CF (Playoff Gm. 3) | 8:00 p.m. |
Nashville SC Schedule
