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| February 21, 2026 | W | Chicago Fire FC 1 at Houston Dynamo FC 2 | Final |
| February 28, 2026 | | Los Angeles FC at Houston Dynamo FC | 8:30 p.m. |
| March 7, 2026 | | Houston Dynamo FC at New England Revolution | 2:30 p.m. |
| March 14, 2026 | | Portland Timbers at Houston Dynamo FC | 7:30 p.m. |
| March 21, 2026 | | Houston Dynamo FC at FC Dallas | 7:30 p.m. |
| April 4, 2026 | | Seattle Sounders FC at Houston Dynamo FC | 7:30 p.m. |
| April 11, 2026 | | Houston Dynamo FC at Colorado Rapids | 8:30 p.m. |
| April 18, 2026 | | Houston Dynamo FC at Orlando City SC | 6:30 p.m. |
| April 22, 2026 | | San Diego FC at Houston Dynamo FC | 7:30 p.m. |
| April 25, 2026 | | Houston Dynamo FC at Austin FC | 7:30 p.m. |
| May 2, 2026 | | Colorado Rapids at Houston Dynamo FC | 7:30 p.m. |
| May 10, 2026 | | Houston Dynamo FC at Los Angeles FC | 8:00 p.m. |
| May 13, 2026 | | Houston Dynamo FC at Real Salt Lake | 8:30 p.m. |
| May 16, 2026 | | Vancouver Whitecaps FC at Houston Dynamo FC | 7:30 p.m. |
| May 23, 2026 | | Houston Dynamo FC at LA Galaxy | 9:30 p.m. |
| July 22, 2026 | | D.C. United at Houston Dynamo FC | 7:30 p.m. |
| July 25, 2026 | | Austin FC at Houston Dynamo FC | 7:30 p.m. |
| August 1, 2026 | | Houston Dynamo FC at Sporting Kansas City | 7:30 p.m. |
| August 15, 2026 | | LA Galaxy at Houston Dynamo FC | 7:30 p.m. |
| August 19, 2026 | | Houston Dynamo FC at Vancouver Whitecaps FC | 9:30 p.m. |
| August 22, 2026 | | Houston Dynamo FC at St. Louis City SC | 7:30 p.m. |
| August 29, 2026 | | San Jose Earthquakes at Houston Dynamo FC | 7:30 p.m. |
| September 5, 2026 | | Houston Dynamo FC at Charlotte FC | 6:30 p.m. |
| September 9, 2026 | | Real Salt Lake at Houston Dynamo FC | 7:30 p.m. |
| September 12, 2026 | | Houston Dynamo FC at San Jose Earthquakes | 9:30 p.m. |
| September 19, 2026 | | FC Cincinnati at Houston Dynamo FC | 7:30 p.m. |
| September 26, 2026 | | Sporting Kansas City at Houston Dynamo FC | 7:30 p.m. |
| October 10, 2026 | | Houston Dynamo FC at Minnesota United FC | 7:30 p.m. |
| October 14, 2026 | | Houston Dynamo FC at San Diego FC | 9:30 p.m. |
| October 17, 2026 | | FC Dallas at Houston Dynamo FC | 7:30 p.m. |
| October 24, 2026 | | Minnesota United FC at Houston Dynamo FC | 7:30 p.m. |
| October 28, 2026 | | Houston Dynamo FC at Seattle Sounders FC | 9:30 p.m. |
| November 1, 2026 | | Houston Dynamo FC at Portland Timbers | 9:15 p.m. |
| November 7, 2026 | | St. Louis City SC at Houston Dynamo FC | 7:00 p.m. |
Houston Dynamo FC Schedule
