| | | |
| February 22, 2025 | T | New York City FC 2 at Inter Miami CF 2 | Final |
| March 2, 2025 | W | Inter Miami CF 4 at Houston Dynamo FC 1 | Final |
| March 9, 2025 | W | Charlotte FC 0 at Inter Miami CF 1 | Final |
| March 16, 2025 | W | Inter Miami CF 2 at Atlanta United FC 1 | Final |
| March 29, 2025 | W | Philadelphia Union 1 at Inter Miami CF 2 | Final |
| April 6, 2025 | T | Toronto FC 1 at Inter Miami CF 1 | Final |
| April 13, 2025 | T | Inter Miami CF 0 at Chicago Fire FC 0 | Final |
| April 19, 2025 | W | Inter Miami CF 1 at Columbus Crew SC 0 | Final |
| April 27, 2025 | L | FC Dallas 4 at Inter Miami CF 3 | Final |
| May 3, 2025 | W | New York Red Bulls 1 at Inter Miami CF 4 | Final |
| May 10, 2025 | L | Inter Miami CF 1 at Minnesota United FC 4 | Final |
| May 14, 2025 | T | Inter Miami CF 3 at San Jose Earthquakes 3 | Final |
| May 18, 2025 | L | Orlando City SC 3 at Inter Miami CF 0 | Final |
| May 24, 2025 | T | Inter Miami CF 3 at Philadelphia Union 3 | Final |
| May 28, 2025 | W | Club de Foot Montreal 2 at Inter Miami CF 4 | Final |
| May 31, 2025 | W | Columbus Crew SC 1 at Inter Miami CF 5 | Final |
| July 5, 2025 | W | Inter Miami CF 4 at Club de Foot Montreal 1 | Final |
| July 9, 2025 | W | Inter Miami CF 2 at New England Revolution 1 | Final |
| July 12, 2025 | W | Nashville SC 1 at Inter Miami CF 2 | Final |
| July 16, 2025 | L | Inter Miami CF 0 at FC Cincinnati 3 | Final |
| July 19, 2025 | W | Inter Miami CF 5 at New York Red Bulls 1 | Final |
| July 26, 2025 | T | FC Cincinnati 0 at Inter Miami CF 0 | Final |
| August 10, 2025 | L | Inter Miami CF 1 at Orlando City SC 4 | Final |
| August 16, 2025 | W | LA Galaxy 1 at Inter Miami CF 3 | Final |
| August 23, 2025 | T | Inter Miami CF 1 at D.C. United 1 | Final |
| September 13, 2025 | L | Inter Miami CF 0 at Charlotte FC 3 | Final |
| September 16, 2025 | W | Seattle Sounders FC 1 at Inter Miami CF 3 | Final |
| September 20, 2025 | W | D.C. United 2 at Inter Miami CF 3 | Final |
| September 24, 2025 | W | Inter Miami CF 4 at New York City FC 0 | Final |
| September 27, 2025 | T | Inter Miami CF 1 at Toronto FC 1 | Final |
| September 30, 2025 | L | Chicago Fire FC 5 at Inter Miami CF 3 | Final |
| October 4, 2025 | W | New England Revolution 1 at Inter Miami CF 4 | Final |
| October 11, 2025 | W | Atlanta United FC 0 at Inter Miami CF 4 | Final |
| October 18, 2025 | W | Inter Miami CF 5 at Nashville SC 2 | Final |
| October 24, 2025 | W | Nashville SC 1 at Inter Miami CF 3 (Playoff Gm. 1) | Final |
| November 1, 2025 | | Inter Miami CF at Nashville SC (Playoff Gm. 2) | 7:30 p.m. |
| November 8, 2025 | | Nashville SC at Inter Miami CF (Playoff Gm. 3, if nec.) | 1:00 p.m. |
Inter Miami CF Schedule
