| | | |
| February 22, 2025 | T | Charlotte FC 2 at Seattle Sounders FC 2 | Final |
| March 1, 2025 | L | Seattle Sounders FC 0 at Real Salt Lake 2 | Final |
| March 8, 2025 | W | Los Angeles FC 2 at Seattle Sounders FC 5 | Final |
| March 15, 2025 | L | Seattle Sounders FC 0 at St. Louis City SC 1 | Final |
| March 22, 2025 | T | Houston Dynamo FC 0 at Seattle Sounders FC 0 | Final |
| March 29, 2025 | T | Seattle Sounders FC 1 at San Jose Earthquakes 1 | Final |
| April 5, 2025 | L | Seattle Sounders FC 0 at San Diego FC 3 | Final |
| April 12, 2025 | W | Seattle Sounders FC 1 at FC Dallas 0 | Final |
| April 19, 2025 | W | Nashville SC 0 at Seattle Sounders FC 3 | Final |
| April 26, 2025 | T | Seattle Sounders FC 1 at Colorado Rapids 1 | Final |
| May 3, 2025 | W | St. Louis City SC 1 at Seattle Sounders FC 4 | Final |
| May 10, 2025 | W | Seattle Sounders FC 3 at Houston Dynamo FC 1 | Final |
| May 14, 2025 | L | Seattle Sounders FC 0 at Los Angeles FC 4 | Final |
| May 17, 2025 | T | Seattle Sounders FC 1 at Portland Timbers 1 | Final |
| May 24, 2025 | W | FC Dallas 0 at Seattle Sounders FC 1 | Final |
| May 28, 2025 | W | San Diego FC 0 at Seattle Sounders FC 1 | Final |
| June 1, 2025 | L | Minnesota United FC 3 at Seattle Sounders FC 2 | Final |
| June 8, 2025 | L | Seattle Sounders FC 0 at Vancouver Whitecaps FC 3 | Final |
| June 28, 2025 | W | Austin FC 0 at Seattle Sounders FC 2 | Final |
| July 6, 2025 | T | Columbus Crew SC 1 at Seattle Sounders FC 1 | Final |
| July 12, 2025 | W | Seattle Sounders FC 3 at Sporting Kansas City 2 | Final |
| July 16, 2025 | T | Colorado Rapids 3 at Seattle Sounders FC 3 | Final |
| July 19, 2025 | W | San Jose Earthquakes 2 at Seattle Sounders FC 3 | Final |
| July 26, 2025 | T | Seattle Sounders FC 2 at Atlanta United FC 2 | Final |
| August 10, 2025 | W | Seattle Sounders FC 4 at LA Galaxy 0 | Final |
| August 16, 2025 | L | Seattle Sounders FC 0 at Minnesota United FC 1 | Final |
| August 24, 2025 | W | Sporting Kansas City 2 at Seattle Sounders FC 5 | Final |
| September 13, 2025 | T | LA Galaxy 2 at Seattle Sounders FC 2 | Final |
| September 16, 2025 | L | Seattle Sounders FC 1 at Inter Miami CF 3 | Final |
| September 21, 2025 | L | Seattle Sounders FC 1 at Austin FC 2 | Final |
| September 27, 2025 | T | Vancouver Whitecaps FC 2 at Seattle Sounders FC 2 | Final |
| October 4, 2025 | W | Portland Timbers 0 at Seattle Sounders FC 1 | Final |
| October 11, 2025 | W | Real Salt Lake 0 at Seattle Sounders FC 1 | Final |
| October 18, 2025 | W | Seattle Sounders FC 2 at New York City FC 1 | Final |
| October 27, 2025 | T | Seattle Sounders FC 0 at Minnesota United FC 0 (Playoff Gm. 1) | Final (PK 2-3) |
| November 3, 2025 | | Minnesota United FC at Seattle Sounders FC (Playoff Gm. 2) | 11:30 p.m. |
| November 8, 2025 | | Seattle Sounders FC at Minnesota United FC (Playoff Gm. 3, if nec.) | 1:00 p.m. |
Seattle Sounders FC Schedule
