| | | |
| February 21, 2026 | L | Red Bull New York 2 at Orlando City SC 1 | Final |
| March 1, 2026 | L | Inter Miami CF 4 at Orlando City SC 2 | Final |
| March 7, 2026 | L | Orlando City SC 0 at New York City FC 5 | Final |
| March 14, 2026 | W | Club de Foot Montreal 1 at Orlando City SC 2 | Final |
| March 21, 2026 | L | Orlando City SC 0 at Nashville SC 5 | Final |
| April 4, 2026 | | Orlando City SC at Los Angeles FC | 8:30 p.m. |
| April 12, 2026 | | Orlando City SC at Columbus Crew SC | 6:00 p.m. |
| April 18, 2026 | | Houston Dynamo FC at Orlando City SC | 6:30 p.m. |
| April 22, 2026 | | Charlotte FC at Orlando City SC | 6:30 p.m. |
| April 25, 2026 | | Orlando City SC at D.C. United | 6:30 p.m. |
| May 2, 2026 | | Orlando City SC at Inter Miami CF | 6:00 p.m. |
| May 9, 2026 | | Orlando City SC at Club de Foot Montreal | 3:30 p.m. |
| May 13, 2026 | | Philadelphia Union at Orlando City SC | 6:30 p.m. |
| May 16, 2026 | | Atlanta United FC at Orlando City SC | 6:30 p.m. |
| May 23, 2026 | | Orlando City SC at FC Cincinnati | 6:30 p.m. |
| July 22, 2026 | | Orlando City SC at San Jose Earthquakes | 9:30 p.m. |
| July 25, 2026 | | Nashville SC at Orlando City SC | 6:30 p.m. |
| August 1, 2026 | | Orlando City SC at Red Bull New York | 6:30 p.m. |
| August 15, 2026 | | FC Cincinnati at Orlando City SC | 6:30 p.m. |
| August 19, 2026 | | Chicago Fire FC at Orlando City SC | 6:30 p.m. |
| August 22, 2026 | | Real Salt Lake at Orlando City SC | 6:30 p.m. |
| August 29, 2026 | | Orlando City SC at Minnesota United FC | 7:30 p.m. |
| September 5, 2026 | | San Diego FC at Orlando City SC | 6:30 p.m. |
| September 9, 2026 | | Orlando City SC at Atlanta United FC | 6:30 p.m. |
| September 12, 2026 | | Toronto FC at Orlando City SC | 6:30 p.m. |
| September 19, 2026 | | Orlando City SC at New England Revolution | 6:30 p.m. |
| September 26, 2026 | | Orlando City SC at Philadelphia Union | 6:30 p.m. |
| October 10, 2026 | | Columbus Crew SC at Orlando City SC | 6:30 p.m. |
| October 14, 2026 | | Orlando City SC at Toronto FC | 6:30 p.m. |
| October 17, 2026 | | D.C. United at Orlando City SC | 6:30 p.m. |
| October 24, 2026 | | New York City FC at Orlando City SC | 6:30 p.m. |
| October 28, 2026 | | Orlando City SC at Chicago Fire FC | 7:30 p.m. |
| October 31, 2026 | | Orlando City SC at Charlotte FC | 12:00 p.m. |
| November 7, 2026 | | New England Revolution at Orlando City SC | 4:00 p.m. |
Orlando City SC Schedule
