FC Cincinnati Schedule
All times Eastern
| February 26, 2022 | L | FC Cincinnati 0 at Austin FC 5 | Final |
| March 5, 2022 | L | D.C. United 1 at FC Cincinnati 0 | Final |
| March 12, 2022 | W | FC Cincinnati 2 at Orlando City SC 1 | Final |
| March 19, 2022 | W | Inter Miami CF 1 at FC Cincinnati 3 | Final |
| March 26, 2022 | L | FC Cincinnati 0 at Charlotte FC 2 | Final |
| April 2, 2022 | L | Club de Foot Montreal 4 at FC Cincinnati 3 | Final |
| April 16, 2022 | T | FC Cincinnati 0 at Atlanta United FC 0 | Final |
| April 24, 2022 | L | Los Angeles FC 2 at FC Cincinnati 1 | Final |
| April 30, 2022 | W | FC Cincinnati 2 at Toronto FC 1 | Final |
| May 4, 2022 | W | Toronto FC 0 at FC Cincinnati 2 | Final |
| May 7, 2022 | W | FC Cincinnati 1 at Minnesota United FC 0 | Final |
| May 14, 2022 | W | FC Cincinnati 2 at Chicago Fire FC 1 | Final |
| May 21, 2022 | L | New England Revolution 3 at FC Cincinnati 2 | Final |
| May 28, 2022 | FC Cincinnati at Club de Foot Montreal | 7:30 p.m. | |
| June 18, 2022 | FC Cincinnati at Philadelphia Union | 7:30 p.m. | |
| June 24, 2022 | Orlando City SC at FC Cincinnati | 7:30 p.m. | |
| June 29, 2022 | New York City FC at FC Cincinnati | 7:30 p.m. | |
| July 3, 2022 | FC Cincinnati at New England Revolution | 7:30 p.m. | |
| July 9, 2022 | New York Red Bulls at FC Cincinnati | 7:30 p.m. | |
| July 13, 2022 | Vancouver Whitecaps FC at FC Cincinnati | 8:00 p.m. | |
| July 17, 2022 | FC Cincinnati at Columbus Crew SC | 7:30 p.m. | |
| July 23, 2022 | Nashville SC at FC Cincinnati | 7:30 p.m. | |
| July 30, 2022 | FC Cincinnati at Inter Miami CF | 8:00 p.m. | |
| August 6, 2022 | Philadelphia Union at FC Cincinnati | 7:30 p.m. | |
| August 13, 2022 | Atlanta United FC at FC Cincinnati | 7:30 p.m. | |
| August 20, 2022 | FC Cincinnati at New York Red Bulls | 6:00 p.m. | |
| August 27, 2022 | Columbus Crew SC at FC Cincinnati | 7:30 p.m. | |
| September 3, 2022 | Charlotte FC at FC Cincinnati | 7:30 p.m. | |
| September 7, 2022 | FC Cincinnati at New York City FC | 8:00 p.m. | |
| September 10, 2022 | San Jose Earthquakes at FC Cincinnati | 7:30 p.m. | |
| September 17, 2022 | FC Cincinnati at Real Salt Lake | 9:30 p.m. | |
| September 27, 2022 | FC Cincinnati at Seattle Sounders FC | 10:00 p.m. | |
| October 1, 2022 | Chicago Fire FC at FC Cincinnati | 7:30 p.m. | |
| October 9, 2022 | FC Cincinnati at D.C. United | 9:00 a.m. |
