Cincinnati Cyclones Schedule
All times Eastern
| October 23, 2021 | W | Cincinnati Cyclones 3 at Indy Fuel 2 | Final |
| October 29, 2021 | W | Cincinnati Cyclones 1 at Kalamazoo Wings 0 | Final |
| October 30, 2021 | L | Indy Fuel 6 at Cincinnati Cyclones 0 | Final |
| November 4, 2021 | W | Iowa Heartlanders 3 at Cincinnati Cyclones 5 | Final |
| November 5, 2021 | L | Cincinnati Cyclones 2 at Fort Wayne Komets 4 | Final |
| November 6, 2021 | W | Iowa Heartlanders 1 at Cincinnati Cyclones 6 | Final |
| November 9, 2021 | W | Indy Fuel 2 at Cincinnati Cyclones 3 | Final (SO) |
| November 10, 2021 | L | Kalamazoo Wings 4 at Cincinnati Cyclones 2 | Final |
| November 12, 2021 | L | Fort Wayne Komets 2 at Cincinnati Cyclones 1 | Final |
| November 13, 2021 | W | Cincinnati Cyclones 5 at Wheeling Nailers 4 | Final |
| November 19, 2021 | L | Cincinnati Cyclones 1 at Atlanta Gladiators 3 | Final |
| November 20, 2021 | W | Cincinnati Cyclones 4 at Atlanta Gladiators 2 | Final |
| November 24, 2021 | W | Toledo Walleye 2 at Cincinnati Cyclones 9 | Final |
| November 26, 2021 | W | Kalamazoo Wings 2 at Cincinnati Cyclones 6 | Final |
| November 27, 2021 | L | Cincinnati Cyclones 2 at Kalamazoo Wings 4 | Final |
| December 3, 2021 | L | Cincinnati Cyclones 2 at Wheeling Nailers 3 | Final |
| December 4, 2021 | L | Indy Fuel 4 at Cincinnati Cyclones 0 | Final |
| December 5, 2021 | L | Cincinnati Cyclones 3 at Toledo Walleye 4 | Final |
| December 8, 2021 | W | Wheeling Nailers 5 at Cincinnati Cyclones 6 | Final |
| December 10, 2021 | W | Indy Fuel 2 at Cincinnati Cyclones 6 | Final |
| December 11, 2021 | L | Cincinnati Cyclones 1 at Wheeling Nailers 4 | Final |
| December 12, 2021 | W | Cincinnati Cyclones 4 at Wheeling Nailers 1 | Final |
| December 17, 2021 | L | Cincinnati Cyclones 2 at Indy Fuel 7 | Final |
| December 18, 2021 | W | Cincinnati Cyclones 4 at Fort Wayne Komets 3 | Final (OT) |
| December 19, 2021 | W | Cincinnati Cyclones 5 at Fort Wayne Komets 3 | Final |
| December 26, 2021 | W | Cincinnati Cyclones 7 at Wheeling Nailers 1 | Final |
| December 27, 2021 | L | Cincinnati Cyclones 4 at Fort Wayne Komets 5 | Final (OT) |
| December 29, 2021 | W | Greenville Swamp Rabbits 1 at Cincinnati Cyclones 6 | Final |
| December 31, 2021 | W | Greenville Swamp Rabbits 2 at Cincinnati Cyclones 3 | Final (SO) |
| January 7, 2022 | W | Fort Wayne Komets 4 at Cincinnati Cyclones 5 | Final |
| January 8, 2022 | W | Kalamazoo Wings 4 at Cincinnati Cyclones 5 | Final |
| January 12, 2022 | W | Atlanta Gladiators 1 at Cincinnati Cyclones 4 | Final |
| January 15, 2022 | L | Cincinnati Cyclones 3 at Kalamazoo Wings 5 | Final |
| January 16, 2022 | L | Toledo Walleye 4 at Cincinnati Cyclones 1 | Final |
| January 21, 2022 | L | Cincinnati Cyclones 1 at Indy Fuel 3 | Final |
| January 22, 2022 | L | Cincinnati Cyclones 0 at Fort Wayne Komets 4 | Final |
| January 26, 2022 | L | Wheeling Nailers 2 at Cincinnati Cyclones 0 | Final |
| January 28, 2022 | W | Wheeling Nailers 2 at Cincinnati Cyclones 7 | Final |
| January 29, 2022 | W | Indy Fuel 1 at Cincinnati Cyclones 5 | Final |
| February 2, 2022 | W | Iowa Heartlanders 3 at Cincinnati Cyclones 6 | Final |
| February 5, 2022 | L | Toledo Walleye 5 at Cincinnati Cyclones 2 | Final |
| February 6, 2022 | L | Cincinnati Cyclones 4 at Wheeling Nailers 5 | Final (OT) |
| February 9, 2022 | L | Atlanta Gladiators 4 at Cincinnati Cyclones 2 | Final |
| February 11, 2022 | L | Cincinnati Cyclones 2 at Fort Wayne Komets 7 | Final |
| February 12, 2022 | W | Cincinnati Cyclones 8 at Indy Fuel 2 | Final |
| February 16, 2022 | L | Toledo Walleye 3 at Cincinnati Cyclones 2 | Final |
| February 18, 2022 | W | Tulsa Oilers 2 at Cincinnati Cyclones 5 | Final |
| February 20, 2022 | L | Toledo Walleye 3 at Cincinnati Cyclones 2 | Final (OT) |
| February 24, 2022 | W | Allen Americans 2 at Cincinnati Cyclones 3 | Final |
| February 26, 2022 | W | Allen Americans 3 at Cincinnati Cyclones 4 | Final (OT) |
| February 27, 2022 | W | Allen Americans 2 at Cincinnati Cyclones 4 | Final |
| March 5, 2022 | L | Cincinnati Cyclones 3 at Fort Wayne Komets 5 | Final |
| March 6, 2022 | L | Cincinnati Cyclones 1 at Toledo Walleye 7 | Final |
| March 11, 2022 | W | Wheeling Nailers 5 at Cincinnati Cyclones 8 | Final |
| March 12, 2022 | W | Cincinnati Cyclones 5 at Indy Fuel 4 | Final |
| March 13, 2022 | L | Cincinnati Cyclones 2 at Fort Wayne Komets 5 | Final |
| March 16, 2022 | L | Kalamazoo Wings 3 at Cincinnati Cyclones 2 | Final |
| March 18, 2022 | L | Fort Wayne Komets 6 at Cincinnati Cyclones 4 | Final |
| March 19, 2022 | W | Fort Wayne Komets 3 at Cincinnati Cyclones 4 | Final (OT) |
| March 20, 2022 | L | Cincinnati Cyclones 1 at Indy Fuel 4 | Final |
| March 23, 2022 | W | Cincinnati Cyclones 4 at Kalamazoo Wings 0 | Final |
| March 25, 2022 | L | Cincinnati Cyclones 0 at Iowa Heartlanders 5 | Final |
| March 26, 2022 | W | Cincinnati Cyclones 4 at Iowa Heartlanders 2 | Final |
| March 30, 2022 | L | Cincinnati Cyclones 0 at Indy Fuel 3 | Final |
| April 1, 2022 | W | Iowa Heartlanders 2 at Cincinnati Cyclones 4 | Final |
| April 2, 2022 | W | Iowa Heartlanders 2 at Cincinnati Cyclones 5 | Final |
| April 6, 2022 | L | Cincinnati Cyclones 2 at Trois-Rivieres Lions 4 | Final |
| April 8, 2022 | L | Cincinnati Cyclones 2 at Newfoundland Growlers 3 | Final |
| April 9, 2022 | L | Cincinnati Cyclones 3 at Newfoundland Growlers 6 | Final |
| April 10, 2022 | W | Cincinnati Cyclones 5 at Newfoundland Growlers 4 | Final |
| April 15, 2022 | L | Indy Fuel 5 at Cincinnati Cyclones 4 | Final (SO) |
| April 16, 2022 | L | Cincinnati Cyclones 2 at Indy Fuel 4 | Final |
| April 22, 2022 | L | Cincinnati Cyclones 2 at Toledo Walleye 3 (Playoff Gm. 1) | Final (OT) |
| April 23, 2022 | W | Cincinnati Cyclones 3 at Toledo Walleye 2 (Playoff Gm. 2) | Final |
| April 25, 2022 | W | Toledo Walleye 5 at Cincinnati Cyclones 6 (Playoff Gm. 3) | Final (OT) |
| April 27, 2022 | L | Toledo Walleye 4 at Cincinnati Cyclones 1 (Playoff Gm. 4) | Final |
| April 28, 2022 | W | Toledo Walleye 0 at Cincinnati Cyclones 2 (Playoff Gm. 5) | Final |
| April 30, 2022 | L | Cincinnati Cyclones 0 at Toledo Walleye 3 (Playoff Gm. 6) | Final |
| May 3, 2022 | L | Cincinnati Cyclones 2 at Toledo Walleye 4 (Playoff Gm. 7) | Final |
