| | | |
| March 8, 2025 | T | Pittsburgh Riverhounds SC 1 at North Carolina FC 1 | Final |
| March 15, 2025 | L | Loudoun United FC 2 at North Carolina FC 1 | Final |
| March 22, 2025 | W | North Carolina FC 1 at FC Tulsa 0 | Final |
| March 29, 2025 | W | Charleston Battery 1 at North Carolina FC 2 | Final |
| April 5, 2025 | T | North Carolina FC 2 at Indy Eleven 2 | Final |
| April 12, 2025 | L | North Carolina FC 0 at New Mexico United 1 | Final |
| April 19, 2025 | L | North Carolina FC 1 at Miami FC 2 | Final |
| April 25, 2025 | L | Charlotte Independence 2 at North Carolina FC 1 (Jagermeister Cup) | Final |
| May 3, 2025 | W | North Carolina FC 2 at Pittsburgh Riverhounds SC 0 | Final |
| May 9, 2025 | W | Orange County SC 0 at North Carolina FC 1 | Final |
| May 16, 2025 | W | Oakland Roots 2 at North Carolina FC 4 | Final |
| May 31, 2025 | W | North Carolina FC 1 at Richmond Kickers 0 (Jagermeister Cup) | Final |
| June 6, 2025 | W | North Carolina FC 1 at Hartford Athletic 0 | Final |
| June 14, 2025 | L | North Carolina FC 1 at Rhode Island FC 2 | Final |
| June 20, 2025 | | Louisville City FC at North Carolina FC | 7:30 p.m. |
| June 28, 2025 | | North Carolina FC at Louisville City FC | 8:00 p.m. |
| July 5, 2025 | | North Carolina FC at Charleston Battery | 7:30 p.m. |
| July 11, 2025 | | Birmingham Legion FC at North Carolina FC | 7:30 p.m. |
| July 18, 2025 | | Indy Eleven at North Carolina FC | 7:30 p.m. |
| July 26, 2025 | | Loudoun United FC at North Carolina FC | 7:30 p.m. |
| August 2, 2025 | | North Carolina FC at Louisville City FC | 8:00 p.m. |
| August 9, 2025 | | Tampa Bay Rowdies at North Carolina FC | 7:30 p.m. |
| August 15, 2025 | | Detroit City FC at North Carolina FC | 7:30 p.m. |
| August 23, 2025 | | North Carolina FC at Las Vegas Lights FC | 10:30 p.m. |
| August 30, 2025 | | Hartford Athletic at North Carolina FC | 7:30 p.m. |
| September 5, 2025 | | North Carolina FC at Lexington Sporting Club | 7:00 p.m. |
| September 12, 2025 | | El Paso Locomotive FC at North Carolina FC | 7:00 p.m. |
| September 20, 2025 | | North Carolina FC at Tampa Bay Rowdies | 7:30 p.m. |
| September 26, 2025 | | Miami FC at North Carolina FC | 7:00 p.m. |
| October 4, 2025 | | North Carolina FC at Detroit City FC | 4:00 p.m. |
| October 10, 2025 | | Phoenix Rising FC at North Carolina FC | 7:00 p.m. |
| October 16, 2025 | | North Carolina FC at Birmingham Legion FC | 8:00 p.m. |
| October 18, 2025 | | Rhode Island FC at North Carolina FC | 7:00 p.m. |
| October 25, 2025 | | North Carolina FC at Loudoun United FC | 5:00 p.m. |
North Carolina FC Schedule
