| | | |
| September 19, 2025 | L | Erie Otters 2 at Guelph Storm 5 | Final |
| September 20, 2025 | L | Kitchener Rangers 3 at Erie Otters 1 | Final |
| September 26, 2025 | L | Erie Otters 2 at Kitchener Rangers 5 | Final |
| September 27, 2025 | W | London Knights 3 at Erie Otters 4 | Final (OT) |
| October 2, 2025 | W | Erie Otters 3 at Peterborough Petes 2 | Final (SO) |
| October 4, 2025 | L | Erie Otters 1 at Ottawa 67's 4 | Final |
| October 5, 2025 | L | Erie Otters 0 at Kingston Frontenacs 1 | Final |
| October 10, 2025 | L | Erie Otters 1 at London Knights 6 | Final |
| October 11, 2025 | L | Sudbury Wolves 6 at Erie Otters 3 | Final |
| October 17, 2025 | W | Niagara IceDogs 1 at Erie Otters 3 | Final |
| October 18, 2025 | L | Erie Otters 3 at Niagara IceDogs 4 | Final (OT) |
| October 19, 2025 | L | Erie Otters 2 at Brampton Steelheads 7 | Final |
| October 22, 2025 | W | Erie Otters 5 at Soo Greyhounds 2 | Final |
| October 24, 2025 | L | Erie Otters 3 at Saginaw Spirit 5 | Final |
| October 25, 2025 | L | Erie Otters 0 at Flint Firebirds 5 | Final |
| October 30, 2025 | W | Guelph Storm 3 at Erie Otters 4 | Final |
| November 1, 2025 | L | Erie Otters 2 at Barrie Colts 4 | Final |
| November 2, 2025 | L | Erie Otters 3 at Owen Sound Attack 8 | Final |
| November 7, 2025 | L | Ottawa 67's 5 at Erie Otters 2 | Final |
| November 8, 2025 | W | Niagara IceDogs 2 at Erie Otters 5 | Final |
| November 13, 2025 | L | Erie Otters 2 at North Bay Battalion 4 | Final |
| November 14, 2025 | W | Erie Otters 6 at Sudbury Wolves 3 | Final |
| November 16, 2025 | L | Erie Otters 0 at Oshawa Generals 1 | Final |
| November 21, 2025 | L | Barrie Colts 3 at Erie Otters 2 | Final (SO) |
| November 22, 2025 | W | Sarnia Sting 2 at Erie Otters 4 | Final |
| November 26, 2025 | L | Brampton Steelheads 5 at Erie Otters 2 | Final |
| November 29, 2025 | W | Peterborough Petes 2 at Erie Otters 5 | Final |
| December 2, 2025 | W | Erie Otters 3 at Kitchener Rangers 2 | Final |
| December 5, 2025 | L | Erie Otters 2 at Owen Sound Attack 6 | Final |
| December 6, 2025 | W | Erie Otters 5 at Owen Sound Attack 1 | Final |
| December 11, 2025 | L | Brantford Bulldogs 8 at Erie Otters 4 | Final |
| December 13, 2025 | W | North Bay Battalion 1 at Erie Otters 3 | Final |
| December 19, 2025 | W | Sarnia Sting 2 at Erie Otters 6 | Final |
| December 20, 2025 | L | Flint Firebirds 5 at Erie Otters 3 | Final |
| December 28, 2025 | L | Erie Otters 3 at Kitchener Rangers 5 | Final |
| December 30, 2025 | W | Erie Otters 3 at Brantford Bulldogs 2 | Final |
| December 31, 2025 | L | Brantford Bulldogs 5 at Erie Otters 2 | Final |
| January 3, 2026 | L | Windsor Spitfires 4 at Erie Otters 1 | Final |
| January 8, 2026 | L | Erie Otters 1 at Windsor Spitfires 9 | Final |
| January 9, 2026 | L | Erie Otters 1 at Sarnia Sting 9 | Final |
| January 10, 2026 | L | Erie Otters 1 at London Knights 4 | Final |
| January 16, 2026 | L | Windsor Spitfires 3 at Erie Otters 2 | Final |
| January 17, 2026 | L | Saginaw Spirit 6 at Erie Otters 1 | Final |
| January 23, 2026 | L | Erie Otters 3 at Guelph Storm 4 | Final (SO) |
| January 24, 2026 | L | Kitchener Rangers 4 at Erie Otters 3 | Final (OT) |
| January 30, 2026 | W | Soo Greyhounds 2 at Erie Otters 3 | Final (SO) |
| January 31, 2026 | L | London Knights 6 at Erie Otters 1 | Final |
| February 5, 2026 | L | Guelph Storm 3 at Erie Otters 2 | Final |
| February 6, 2026 | L | Erie Otters 1 at Saginaw Spirit 4 | Final |
| February 7, 2026 | L | Erie Otters 1 at Flint Firebirds 3 | Final |
| February 11, 2026 | | Owen Sound Attack at Erie Otters | 7:00 p.m. |
| February 13, 2026 | | Erie Otters at Brantford Bulldogs | 7:00 p.m. |
| February 14, 2026 | | Flint Firebirds at Erie Otters | 7:00 p.m. |
| February 16, 2026 | | Erie Otters at Guelph Storm | 2:07 p.m. |
| February 20, 2026 | | Oshawa Generals at Erie Otters | 7:00 p.m. |
| February 21, 2026 | | Kitchener Rangers at Erie Otters | 7:00 p.m. |
| February 26, 2026 | | Erie Otters at Niagara IceDogs | 7:00 p.m. |
| February 28, 2026 | | Owen Sound Attack at Erie Otters | 7:00 p.m. |
| March 1, 2026 | | Owen Sound Attack at Erie Otters | 4:00 p.m. |
| March 6, 2026 | | Erie Otters at London Knights | 7:00 p.m. |
| March 7, 2026 | | London Knights at Erie Otters | 7:00 p.m. |
| March 8, 2026 | | Saginaw Spirit at Erie Otters | 4:00 p.m. |
| March 13, 2026 | | Kingston Frontenacs at Erie Otters | 7:00 p.m. |
| March 14, 2026 | | Niagara IceDogs at Erie Otters | 7:00 p.m. |
| March 17, 2026 | | Erie Otters at Windsor Spitfires | 7:05 p.m. |
| March 18, 2026 | | Erie Otters at Sarnia Sting | 7:05 p.m. |
| March 21, 2026 | | Guelph Storm at Erie Otters | 7:00 p.m. |
| March 22, 2026 | | Erie Otters at Niagara IceDogs | 2:00 p.m. |
Erie Otters Schedule
