| | | |
| March 8, 2025 | T | Pittsburgh Riverhounds SC 1 at North Carolina FC 1 | Final |
| March 15, 2025 | L | Pittsburgh Riverhounds SC 0 at San Antonio FC 2 | Final |
| March 22, 2025 | W | Hartford Athletic 0 at Pittsburgh Riverhounds SC 1 | Final |
| March 29, 2025 | W | Birmingham Legion FC 0 at Pittsburgh Riverhounds SC 2 | Final |
| April 12, 2025 | L | Pittsburgh Riverhounds SC 1 at Charleston Battery 2 | Final |
| April 19, 2025 | L | Pittsburgh Riverhounds SC 1 at Loudoun United FC 2 | Final |
| April 26, 2025 | L | Pittsburgh Riverhounds SC 0 at Detroit City FC 1 (Jagermeister Cup) | Final |
| May 3, 2025 | L | North Carolina FC 2 at Pittsburgh Riverhounds SC 0 | Final |
| May 10, 2025 | T | Pittsburgh Riverhounds SC 0 at Louisville City FC 0 | Final |
| May 17, 2025 | L | Pittsburgh Riverhounds SC 0 at Colorado Springs Switchbacks FC 1 | Final |
| May 24, 2025 | W | Pittsburgh Riverhounds SC 1 at Rhode Island FC 0 | Final |
| May 31, 2025 | L | Rhode Island FC 1 at Pittsburgh Riverhounds SC 0 | Final |
| June 7, 2025 | W | Detroit City FC 0 at Pittsburgh Riverhounds SC 2 | Final |
| June 14, 2025 | L | Pittsburgh Riverhounds SC 0 at Indy Eleven 1 | Final |
| June 21, 2025 | W | Tampa Bay Rowdies 1 at Pittsburgh Riverhounds SC 2 | Final |
| June 28, 2025 | W | Westchester SC 0 at Pittsburgh Riverhounds SC 1 (Jagermeister Cup) | Final |
| July 4, 2025 | W | New Mexico United 0 at Pittsburgh Riverhounds SC 1 | Final |
| July 13, 2025 | T | Loudoun United FC 2 at Pittsburgh Riverhounds SC 2 | Final |
| July 18, 2025 | T | Pittsburgh Riverhounds SC 0 at Detroit City FC 0 | Final |
| July 25, 2025 | T | Pittsburgh Riverhounds SC 2 at Portland Hearts of Pine 2 (Jagermeister Cup) | Final |
| July 29, 2025 | T | Miami FC 1 at Pittsburgh Riverhounds SC 1 | Final |
| August 2, 2025 | W | Rhode Island FC 0 at Pittsburgh Riverhounds SC 2 | Final |
| August 9, 2025 | T | Orange County SC 1 at Pittsburgh Riverhounds SC 1 | Final |
| August 16, 2025 | L | Charleston Battery 2 at Pittsburgh Riverhounds SC 1 | Final |
| August 23, 2025 | T | Pittsburgh Riverhounds SC 1 at Birmingham Legion FC 1 | Final |
| August 30, 2025 | L | Pittsburgh Riverhounds SC 1 at Tampa Bay Rowdies 2 | Final |
| September 7, 2025 | W | Pittsburgh Riverhounds SC 2 at Oakland Roots 0 | Final |
| September 13, 2025 | L | Louisville City FC 2 at Pittsburgh Riverhounds SC 0 | Final |
| September 20, 2025 | W | Pittsburgh Riverhounds SC 2 at Hartford Athletic 1 | Final |
| September 28, 2025 | W | Las Vegas Lights FC 0 at Pittsburgh Riverhounds SC 1 | Final |
| October 4, 2025 | L | Pittsburgh Riverhounds SC 1 at Miami FC 3 | Final |
| October 11, 2025 | W | Indy Eleven 1 at Pittsburgh Riverhounds SC 2 | Final |
| October 18, 2025 | W | Pittsburgh Riverhounds SC 3 at Monterey Bay FC 0 | Final |
| October 25, 2025 | T | Phoenix Rising FC 0 at Pittsburgh Riverhounds SC 0 | Final |
| November 1, 2025 | T | Hartford Athletic 0 at Pittsburgh Riverhounds SC 0 (Playoff) | Final (PK 2-4) |
| November 8, 2025 | T | Detroit City FC 0 at Pittsburgh Riverhounds SC 0 (Playoff) | Final (PK 3-4) |
| November 15, 2025 | W | Rhode Island FC 0 at Pittsburgh Riverhounds SC 1 (Playoff) | Final |
| November 22, 2025 | T | Pittsburgh Riverhounds SC 0 at FC Tulsa 0 (Championship) | Final (PK 5-3) |
Pittsburgh Riverhounds SC Schedule
