| | | |
| March 16, 2022 | New York Red Bulls II 1 at Atlanta United 2 0 | Final |
| March 19, 2022 | Loudoun United FC 3 at New York Red Bulls II 0 | Final |
| March 19, 2022 | San Antonio FC 2 at LA Galaxy II 1 | Final |
| March 23, 2022 | Louisville City FC 2 at New York Red Bulls II 0 | Final |
| March 23, 2022 | Tampa Bay Rowdies 3 at Atlanta United 2 0 | Final |
| March 23, 2022 | Rio Grande Valley FC Toros 0 at LA Galaxy II 1 | Final |
| March 25, 2022 | Rochester New York FC 0 at St. Louis City SC 2 2 | Final |
| March 26, 2022 | Chicago Fire FC II 0 at Orlando City B 2 | Final |
| March 26, 2022 | Columbus Crew 2 0 at Inter Miami CF II 2 | Final |
| March 26, 2022 | Vancouver Whitecaps FC 2 0 at Houston Dynamo 2 1 | Final |
| March 26, 2022 | Minnesota United FC 2 1 at North Texas SC 3 | Final |
| March 27, 2022 | FC Cincinnati 2 0 at Philadelphia Union II 2 | Final |
| March 27, 2022 | Real Monarchs 0 at Tacoma Defiance 4 | Final |
| March 27, 2022 | New England Revolution II 2 at New York City FC II 2 | Final (PK 4-3) |
| March 27, 2022 | Sporting Kansas City II 1 at Colorado Rapids 2 1 | Final (PK 2-4) |
| March 27, 2022 | Charleston Battery 1 at Atlanta United 2 4 | Final |
| March 30, 2022 | Earthquakes II 2 at Portland Timbers 2 0 | Final |
| April 2, 2022 | Vancouver Whitecaps FC 2 2 at Real Monarchs 2 | Final (PK 3-1) |
| April 2, 2022 | Atlanta United 2 2 at Hartford Athletic 1 | Final |
| April 2, 2022 | LA Galaxy II 1 at Indy Eleven 1 | Final |
| April 2, 2022 | New York Red Bulls II 2 at FC Tulsa 3 | Final |
| April 2, 2022 | North Texas SC 1 at Tacoma Defiance 1 | Final (PK 6-5) |
| April 3, 2022 | Toronto FC II 1 at FC Cincinnati 2 2 | Final |
| April 3, 2022 | Sporting Kansas City II 2 at Minnesota United FC 2 0 | Final |
| April 3, 2022 | Rochester New York FC 1 at New England Revolution II 3 | Final |
| April 3, 2022 | New York City FC II 2 at Orlando City B 2 | Final (PK 3-4) |
| April 3, 2022 | Columbus Crew 2 1 at Chicago Fire FC II 0 | Final |
| April 3, 2022 | Earthquakes II 0 at Houston Dynamo 2 1 | Final |
| April 5, 2022 | Philadelphia Union II 3 at Inter Miami CF II 3 | Final (PK 4-3) |
| April 8, 2022 | Minnesota United FC 2 3 at Real Monarchs 2 | Final |
| April 9, 2022 | Detroit City FC 4 at Atlanta United 2 0 | Final |
| April 9, 2022 | LA Galaxy II 1 at Phoenix Rising FC 3 | Final |
| April 10, 2022 | New York City FC II 1 at Toronto FC II 3 | Final |
| April 10, 2022 | Rochester New York FC 0 at Chicago Fire FC II 0 | Final (PK 6-5) |
| April 10, 2022 | Colorado Rapids 2 1 at North Texas SC 3 | Final |
| April 10, 2022 | Columbus Crew 2 1 at Philadelphia Union II 0 | Final |
| April 10, 2022 | Portland Timbers 2 2 at Vancouver Whitecaps FC 2 2 | Final (PK 4-1) |
| April 10, 2022 | Orlando City B 0 at Inter Miami CF II 2 | Final |
| April 10, 2022 | Houston Dynamo 2 3 at Sporting Kansas City II 0 | Final |
| April 10, 2022 | Tacoma Defiance 3 at St. Louis City SC 2 4 | Final |
| April 15, 2022 | Orlando City B 0 at Columbus Crew 2 2 | Final |
| April 15, 2022 | Rio Grande Valley FC Toros 1 at New York Red Bulls II 0 | Final |
| April 16, 2022 | Inter Miami CF II 0 at New York City FC II 7 | Final |
| April 16, 2022 | Atlanta United 2 1 at Indy Eleven 2 | Final |
| April 16, 2022 | St. Louis City SC 2 1 at Sporting Kansas City II 0 | Final |
| April 16, 2022 | Portland Timbers 2 1 at Houston Dynamo 2 4 | Final |
| April 16, 2022 | Monterey Bay FC 1 at LA Galaxy II 3 | Final |
| April 17, 2022 | Colorado Rapids 2 0 at Minnesota United FC 2 4 | Final |
| April 17, 2022 | FC Cincinnati 2 2 at New England Revolution II 3 | Final |
| April 17, 2022 | Chicago Fire FC II 2 at Toronto FC II 4 | Final |
| April 17, 2022 | Vancouver Whitecaps FC 2 2 at Tacoma Defiance 1 | Final |
| April 17, 2022 | North Texas SC 1 at Earthquakes II 0 | Final |
| April 23, 2022 | Inter Miami CF II 1 at FC Cincinnati 2 0 | Final |
| April 23, 2022 | Tampa Bay Rowdies 1 at New York Red Bulls II 1 | Final |
| April 23, 2022 | Houston Dynamo 2 3 at North Texas SC 2 | Final |
| April 23, 2022 | New York City FC II 3 at Rochester New York FC 2 | Final |
| April 23, 2022 | Atlanta United 2 0 at Pittsburgh Riverhounds SC 4 | Final |
| April 23, 2022 | LA Galaxy II 1 at Las Vegas Lights FC 1 | Final |
| April 24, 2022 | Toronto FC II 1 at Columbus Crew 2 2 | Final |
| April 24, 2022 | New England Revolution II 0 at Orlando City B 0 | Final (PK 3-4) |
| April 24, 2022 | Philadelphia Union II 3 at Chicago Fire FC II 3 | Final (PK 4-5) |
| April 24, 2022 | Sporting Kansas City II 1 at Vancouver Whitecaps FC 2 4 | Final |
| April 24, 2022 | Minnesota United FC 2 4 at St. Louis City SC 2 0 | Final |
| April 24, 2022 | Real Monarchs 1 at Portland Timbers 2 1 | Final (PK 2-4) |
| April 25, 2022 | Tacoma Defiance 2 at Earthquakes II 2 | Final (PK 5-4) |
| April 29, 2022 | Orlando City B at Rochester New York FC | Ppd. |
| April 29, 2022 | St. Louis City SC 2 2 at Real Monarchs 0 | Final |
| April 30, 2022 | New York City FC II 1 at Philadelphia Union II 2 | Final |
| April 30, 2022 | New York Red Bulls II 0 at Detroit City FC 2 | Final |
| April 30, 2022 | FC Cincinnati 2 2 at Toronto FC II 4 | Final |
| April 30, 2022 | Earthquakes II 0 at Vancouver Whitecaps FC 2 2 | Final |
| May 1, 2022 | Portland Timbers 2 1 at Colorado Rapids 2 3 | Final |
| May 1, 2022 | Inter Miami CF II 0 at New England Revolution II 1 | Final |
| May 1, 2022 | Houston Dynamo 2 1 at Tacoma Defiance 4 | Final |
| May 1, 2022 | Phoenix Rising FC 0 at LA Galaxy II 3 | Final |
| May 1, 2022 | North Texas SC 2 at Sporting Kansas City II 0 | Final |
| May 4, 2022 | Louisville City FC 4 at Atlanta United 2 0 | Final |
| May 7, 2022 | Philadelphia Union II 2 at Inter Miami CF II 1 | Final |
| May 7, 2022 | Vancouver Whitecaps FC 2 2 at St. Louis City SC 2 1 | Final |
| May 7, 2022 | LA Galaxy II 0 at El Paso Locomotive FC 4 | Final |
| May 8, 2022 | Sacramento Republic FC 1 at New York Red Bulls II 0 | Final |
| May 8, 2022 | Real Monarchs 2 at Sporting Kansas City II 4 | Final |
| May 8, 2022 | Toronto FC II 1 at New York City FC II 4 | Final |
| May 8, 2022 | Minnesota United FC 2 0 at Chicago Fire FC II 0 | Final (PK 7-6) |
| May 8, 2022 | Portland Timbers 2 0 at Earthquakes II 3 | Final |
| May 8, 2022 | Rochester New York FC 2 at FC Cincinnati 2 1 | Final |
| May 8, 2022 | Columbus Crew 2 4 at New England Revolution II 0 | Final |
| May 8, 2022 | Tacoma Defiance 1 at North Texas SC 1 | Final (PK 4-2) |
| May 8, 2022 | Colorado Rapids 2 0 at Houston Dynamo 2 2 | Final |
| May 13, 2022 | Louisville City FC 3 at LA Galaxy II 4 | Final |
| May 14, 2022 | Houston Dynamo 2 1 at Minnesota United FC 2 1 | Final (PK 4-5) |
| May 14, 2022 | Inter Miami CF II 1 at Rochester New York FC 4 | Final |
| May 14, 2022 | New England Revolution II 1 at Toronto FC II 0 | Final |
| May 14, 2022 | New York Red Bulls II 2 at Hartford Athletic 3 | Final |
| May 14, 2022 | Vancouver Whitecaps FC 2 0 at North Texas SC 1 | Final |
| May 15, 2022 | Columbus Crew 2 1 at New York City FC II 0 | Final |
| May 15, 2022 | FC Cincinnati 2 1 at Chicago Fire FC II 3 | Final |
| May 15, 2022 | Sporting Kansas City II 2 at Portland Timbers 2 1 | Final |
| May 15, 2022 | Real Monarchs 0 at Tacoma Defiance 2 | Final |
| May 15, 2022 | Colorado Rapids 2 1 at Earthquakes II 7 | Final |
| May 16, 2022 | Orlando City B 0 at Philadelphia Union II 1 | Final |
| May 18, 2022 | LA Galaxy II 0 at Memphis 901 FC 5 | Final |
| May 20, 2022 | North Texas SC 3 at Real Monarchs 0 | Final |
| May 20, 2022 | Sporting Kansas City II 2 at Earthquakes II 1 | Final |
| May 21, 2022 | Chicago Fire FC II 0 at New York City FC II 3 | Final |
| May 21, 2022 | Inter Miami CF II 0 at Orlando City B 6 | Final |
| May 21, 2022 | Philadelphia Union II 0 at Rochester New York FC 3 | Final |
| May 21, 2022 | Minnesota United FC 2 2 at Vancouver Whitecaps FC 2 2 | Final (PK 3-1) |
| May 21, 2022 | New York Red Bulls II 0 at Indy Eleven 2 | Final |
| May 21, 2022 | Atlanta United 2 1 at Detroit City FC 3 | Final |
| May 21, 2022 | LA Galaxy II 0 at Oakland Roots 1 | Final |
| May 22, 2022 | Toronto FC II 2 at Columbus Crew 2 4 | Final |
| May 22, 2022 | New England Revolution II 1 at FC Cincinnati 2 0 | Final |
| May 22, 2022 | Portland Timbers 2 1 at St. Louis City SC 2 3 | Final |
| May 22, 2022 | Tacoma Defiance 2 at Colorado Rapids 2 0 | Final |
| May 25, 2022 | Houston Dynamo 2 1 at Real Monarchs 0 | Final |
| May 27, 2022 | Philadelphia Union II 0 at New England Revolution II 1 | Final |
| May 27, 2022 | Birmingham Legion FC 2 at New York Red Bulls II 1 | Final |
| May 27, 2022 | Chicago Fire FC II 6 at Toronto FC II 2 | Final |
| May 27, 2022 | Orange County SC 0 at Atlanta United 2 0 | Final |
| May 28, 2022 | San Diego Loyal 2 at LA Galaxy II 2 | Final |
| May 29, 2022 | Rochester New York FC 4 at Columbus Crew 2 0 | Final |
| May 29, 2022 | Colorado Rapids 2 1 at Minnesota United FC 2 5 | Final |
| May 29, 2022 | Vancouver Whitecaps FC 2 1 at Sporting Kansas City II 1 | Final (PK 5-4) |
| May 29, 2022 | New York City FC II 2 at Inter Miami CF II 1 | Final |
| May 29, 2022 | FC Cincinnati 2 5 at Orlando City B 3 | Final |
| May 29, 2022 | Earthquakes II 1 at St. Louis City SC 2 1 | Final (PK 4-3) |
| May 31, 2022 | Portland Timbers 2 0 at Tacoma Defiance 3 | Final |
| June 1, 2022 | Rio Grande Valley FC Toros 4 at Atlanta United 2 3 | Final |
| June 2, 2022 | San Diego Loyal 2 at New York Red Bulls II 2 | Final |
| June 2, 2022 | Toronto FC II 1 at Rochester New York FC 1 | Final (PK 3-4) |
| June 4, 2022 | Columbus Crew 2 4 at Chicago Fire FC II 2 | Final |
| June 4, 2022 | North Texas SC 3 at Colorado Rapids 2 1 | Final |
| June 4, 2022 | New England Revolution II 0 at Inter Miami CF II 2 | Final |
| June 4, 2022 | New York City FC II 1 at Orlando City B 1 | Final (PK 5-3) |
| June 4, 2022 | Minnesota United FC 2 2 at Sporting Kansas City II 1 | Final |
| June 4, 2022 | Houston Dynamo 2 0 at St. Louis City SC 2 2 | Final |
| June 4, 2022 | Atlanta United 2 2 at Memphis 901 FC 5 | Final |
| June 4, 2022 | LA Galaxy II 1 at Rio Grande Valley FC Toros 0 | Final |
| June 4, 2022 | Earthquakes II 1 at Tacoma Defiance 6 | Final |
| June 5, 2022 | Real Monarchs 0 at Vancouver Whitecaps FC 2 4 | Final |
| June 8, 2022 | New York Red Bulls II 0 at Loudoun United FC 1 | Final |
| June 8, 2022 | St. Louis City SC 2 2 at Colorado Rapids 2 2 | Final (PK 4-3) |
| June 8, 2022 | Minnesota United FC 2 1 at Earthquakes II 2 | Final |
| June 9, 2022 | Inter Miami CF II 0 at Columbus Crew 2 5 | Final |
| June 11, 2022 | Sporting Kansas City II 1 at Houston Dynamo 2 0 | Final |
| June 11, 2022 | Loudoun United FC 0 at Atlanta United 2 2 | Final |
| June 11, 2022 | St. Louis City SC 2 5 at Chicago Fire FC II 0 | Final |
| June 11, 2022 | Rochester New York FC 0 at FC Cincinnati 2 1 | Final |
| June 11, 2022 | Orlando City B 1 at New England Revolution II 2 | Final |
| June 11, 2022 | Philadelphia Union II 0 at Toronto FC II 1 | Final |
| June 11, 2022 | Portland Timbers 2 1 at North Texas SC 2 | Final |
| June 11, 2022 | Colorado Springs Switchbacks FC 3 at LA Galaxy II 1 | Final |
| June 12, 2022 | Tacoma Defiance 2 at Vancouver Whitecaps FC 2 2 | Final (PK 4-2) |
| June 12, 2022 | Real Monarchs 1 at Colorado Rapids 2 3 | Final |
| June 15, 2022 | FC Tulsa 0 at New York Red Bulls II 0 | Final |
| June 15, 2022 | Monterey Bay FC 2 at LA Galaxy II 3 | Final |
| June 17, 2022 | St. Louis City SC 2 2 at Sporting Kansas City II 1 | Final |
| June 17, 2022 | Earthquakes II 1 at Real Monarchs 0 | Final |
| June 17, 2022 | North Texas SC 1 at Vancouver Whitecaps FC 2 3 | Final |
| June 18, 2022 | Toronto FC II 2 at New York City FC II 0 | Final |
| June 18, 2022 | Rochester New York FC 1 at New England Revolution II 1 | Final (PK 5-4) |
| June 18, 2022 | Hartford Athletic 3 at Atlanta United 2 0 | Final |
| June 18, 2022 | Colorado Rapids 2 1 at Tacoma Defiance 4 | Final |
| June 18, 2022 | LA Galaxy II 0 at Sacramento Republic FC 2 | Final |
| June 19, 2022 | Orlando City B 1 at Columbus Crew 2 6 | Final |
| June 19, 2022 | Chicago Fire FC II 1 at Philadelphia Union II 1 | Final (PK 0-3) |
| June 19, 2022 | FC Cincinnati 2 0 at Inter Miami CF II 4 | Final |
| June 19, 2022 | Houston Dynamo 2 1 at Portland Timbers 2 2 | Final |
| June 24, 2022 | Columbus Crew 2 0 at Rochester New York FC 0 | Final (PK 2-4) |
| June 24, 2022 | Earthquakes II 3 at Vancouver Whitecaps FC 2 2 | Final |
| June 25, 2022 | Orlando City B 3 at FC Cincinnati 2 1 | Final |
| June 25, 2022 | Real Monarchs 0 at St. Louis City SC 2 2 | Final |
| June 25, 2022 | LA Galaxy II 3 at Miami FC 1 | Final |
| June 25, 2022 | New York Red Bulls II 0 at El Paso Locomotive FC 5 | Final |
| June 25, 2022 | Atlanta United 2 1 at Oakland Roots 3 | Final |
| June 26, 2022 | New England Revolution II 3 at Chicago Fire FC II 4 | Final |
| June 26, 2022 | Tacoma Defiance 0 at Houston Dynamo 2 1 | Final |
| June 26, 2022 | Minnesota United FC 2 0 at North Texas SC 4 | Final |
| June 26, 2022 | Colorado Rapids 2 4 at Portland Timbers 2 2 | Final |
| June 27, 2022 | New York City FC II 5 at Philadelphia Union II 0 | Final |
| June 29, 2022 | Atlanta United 2 4 at Charleston Battery 3 | Final |
| July 1, 2022 | Pittsburgh Riverhounds SC 3 at New York Red Bulls II 0 | Final |
| July 1, 2022 | Portland Timbers 2 0 at Real Monarchs 4 | Final |
| July 1, 2022 | Houston Dynamo 2 1 at Earthquakes II 1 | Final (PK 4-3) |
| July 1, 2022 | Oakland Roots 1 at LA Galaxy II 3 | Final |
| July 2, 2022 | Chicago Fire FC II 1 at Inter Miami CF II 3 | Final |
| July 2, 2022 | FC Cincinnati 2 1 at New York City FC II 5 | Final |
| July 2, 2022 | Philadelphia Union II at Columbus Crew 2 | Ppd. |
| July 2, 2022 | El Paso Locomotive FC 2 at Atlanta United 2 2 | Final |
| July 2, 2022 | Vancouver Whitecaps FC 2 0 at Minnesota United FC 2 2 | Final |
| July 2, 2022 | North Texas SC 2 at Sporting Kansas City II 4 | Final |
| July 2, 2022 | Colorado Rapids 2 2 at St. Louis City SC 2 1 | Final |
| July 3, 2022 | New England Revolution II 1 at Toronto FC II 1 | Final (PK 5-3) |
| July 6, 2022 | Birmingham Legion FC 3 at Atlanta United 2 3 | Final |
| July 7, 2022 | Philadelphia Union II 0 at Rochester New York FC 3 | Final |
| July 9, 2022 | New York Red Bulls II 0 at Louisville City FC 6 | Final |
| July 9, 2022 | Atlanta United 2 1 at FC Tulsa 2 | Final |
| July 9, 2022 | LA Galaxy II 5 at San Diego Loyal 0 | Final |
| July 10, 2022 | Chicago Fire FC II 3 at FC Cincinnati 2 0 | Final |
| July 10, 2022 | New York City FC II 4 at New England Revolution II 0 | Final |
| July 10, 2022 | Inter Miami CF II 3 at Orlando City B 1 | Final |
| July 10, 2022 | Columbus Crew 2 0 at Toronto FC II 0 | Final (PK 3-4) |
| July 10, 2022 | Sporting Kansas City II 2 at Colorado Rapids 2 0 | Final |
| July 10, 2022 | Real Monarchs 1 at Houston Dynamo 2 4 | Final |
| July 10, 2022 | Earthquakes II 3 at North Texas SC 1 | Final |
| July 10, 2022 | St. Louis City SC 2 2 at Minnesota United FC 2 1 | Final |
| July 10, 2022 | Tacoma Defiance 6 at Portland Timbers 2 1 | Final |
| July 15, 2022 | Earthquakes II 1 at Colorado Rapids 2 2 | Final |
| July 15, 2022 | Indy Eleven 0 at New York Red Bulls II 1 | Final |
| July 15, 2022 | Houston Dynamo 2 3 at North Texas SC 3 | Final (PK 5-4) |
| July 15, 2022 | LA Galaxy II 2 at Colorado Springs Switchbacks FC 4 | Final |
| July 16, 2022 | FC Cincinnati 2 0 at Columbus Crew 2 4 | Final |
| July 16, 2022 | Rochester New York FC 1 at New York City FC II 0 | Final |
| July 16, 2022 | Sporting Kansas City II 0 at Real Monarchs 1 | Final |
| July 16, 2022 | Atlanta United 2 0 at San Antonio FC 5 | Final |
| July 16, 2022 | Vancouver Whitecaps FC 2 2 at Portland Timbers 2 1 | Final |
| July 17, 2022 | Orlando City B 4 at Chicago Fire FC II 3 | Final |
| July 17, 2022 | Minnesota United FC 2 2 at Tacoma Defiance 3 | Final |
| July 18, 2022 | Toronto FC II 2 at Philadelphia Union II 1 | Final |
| July 22, 2022 | FC Cincinnati 2 2 at Rochester New York FC 0 | Final |
| July 22, 2022 | Tacoma Defiance 3 at Sporting Kansas City II 0 | Final |
| July 22, 2022 | North Texas SC 0 at St. Louis City SC 2 2 | Final |
| July 22, 2022 | Earthquakes II 2 at Portland Timbers 2 1 | Final |
| July 23, 2022 | Atlanta United 2 1 at Tampa Bay Rowdies 3 | Final |
| July 23, 2022 | New York Red Bulls II 0 at Monterey Bay FC 2 | Final |
| July 23, 2022 | Orange County SC 5 at LA Galaxy II 2 | Final |
| July 24, 2022 | New England Revolution II 1 at Columbus Crew 2 4 | Final |
| July 24, 2022 | Inter Miami CF II 2 at New York City FC II 2 | Final (PK 2-4) |
| July 24, 2022 | Philadelphia Union II 3 at Orlando City B 1 | Final |
| July 24, 2022 | Vancouver Whitecaps FC 2 2 at Colorado Rapids 2 2 | Final (PK 2-3) |
| July 24, 2022 | Minnesota United FC 2 0 at Houston Dynamo 2 1 | Final |
| July 29, 2022 | Houston Dynamo 2 2 at Vancouver Whitecaps FC 2 2 | Final (PK 3-5) |
| July 30, 2022 | Chicago Fire FC II 1 at Rochester New York FC 1 | Final (PK 5-4) |
| July 30, 2022 | Las Vegas Lights FC 1 at Atlanta United 2 1 | Final |
| July 30, 2022 | LA Galaxy II 1 at San Antonio FC 1 | Final |
| July 30, 2022 | St. Louis City SC 2 1 at Tacoma Defiance 5 | Final |
| July 31, 2022 | Inter Miami CF II 1 at FC Cincinnati 2 1 | Final (PK 4-3) |
| July 31, 2022 | Portland Timbers 2 1 at Minnesota United FC 2 3 | Final |
| July 31, 2022 | New Mexico United 2 at New York Red Bulls II 1 | Final |
| July 31, 2022 | Toronto FC II 2 at New England Revolution II 0 | Final |
| July 31, 2022 | Columbus Crew 2 1 at Philadelphia Union II 2 | Final |
| July 31, 2022 | Sporting Kansas City II 0 at North Texas SC 3 | Final |
| July 31, 2022 | Real Monarchs 1 at Earthquakes II 3 | Final |
| August 3, 2022 | Memphis 901 FC 2 at New York Red Bulls II 1 | Final |
| August 5, 2022 | Vancouver Whitecaps FC 2 1 at Real Monarchs 3 | Final |
| August 5, 2022 | Tacoma Defiance 2 at Earthquakes II 0 | Final |
| August 6, 2022 | Minnesota United FC 2 3 at Colorado Rapids 2 3 | Final (PK 4-5) |
| August 6, 2022 | Atlanta United 2 0 at Birmingham Legion FC 6 | Final |
| August 6, 2022 | LA Galaxy II 0 at Loudoun United FC 2 | Final |
| August 6, 2022 | Chicago Fire FC II 1 at St. Louis City SC 2 2 | Final |
| August 7, 2022 | New York City FC II 0 at Columbus Crew 2 3 | Final |
| August 7, 2022 | Philadelphia Union II 3 at FC Cincinnati 2 2 | Final |
| August 7, 2022 | New England Revolution II 2 at Inter Miami CF II 4 | Final |
| August 7, 2022 | Orlando City B 0 at Toronto FC II 3 | Final |
| August 7, 2022 | Sporting Kansas City II 0 at Houston Dynamo 2 3 | Final |
| August 7, 2022 | North Texas SC 2 at Portland Timbers 2 2 | Final (PK 6-7) |
| August 9, 2022 | Atlanta United 2 1 at New York Red Bulls II 2 | Final |
| August 12, 2022 | Charleston Battery 3 at New York Red Bulls II 1 | Final |
| August 12, 2022 | Toronto FC II 2 at Rochester New York FC 1 | Final |
| August 12, 2022 | Orlando City B 2 at New York City FC II 0 | Final |
| August 12, 2022 | Real Monarchs 0 at North Texas SC 4 | Final |
| August 13, 2022 | Miami FC 2 at Atlanta United 2 0 | Final |
| August 14, 2022 | St. Louis City SC 2 4 at Vancouver Whitecaps FC 2 1 | Final |
| August 14, 2022 | Columbus Crew 2 3 at FC Cincinnati 2 3 | Final (PK 2-4) |
| August 14, 2022 | Chicago Fire FC II 0 at New England Revolution II 1 | Final |
| August 14, 2022 | Inter Miami CF II 2 at Philadelphia Union II 2 | Final (PK 4-5) |
| August 14, 2022 | Portland Timbers 2 0 at Sporting Kansas City II 2 | Final |
| August 14, 2022 | New Mexico United 2 at LA Galaxy II 2 | Final |
| August 14, 2022 | Colorado Rapids 2 1 at Houston Dynamo 2 1 | Final (PK 5-4) |
| August 15, 2022 | Tacoma Defiance 1 at Minnesota United FC 2 2 | Final |
| August 17, 2022 | Rochester New York FC 2 at Orlando City B 5 | Final |
| August 20, 2022 | Columbus Crew 2 2 at Orlando City B 2 | Final (PK 3-1) |
| August 20, 2022 | New York Red Bulls II 2 at Pittsburgh Riverhounds SC 2 | Final |
| August 20, 2022 | Atlanta United 2 1 at Loudoun United FC 3 | Final |
| August 20, 2022 | New York City FC II 0 at Chicago Fire FC II 5 | Final |
| August 20, 2022 | Sporting Kansas City II 0 at Tacoma Defiance 1 | Final |
| August 20, 2022 | Charleston Battery 1 at LA Galaxy II 1 | Final |
| August 21, 2022 | Rochester New York FC 1 at Inter Miami CF II 2 | Final |
| August 21, 2022 | New England Revolution II 1 at Philadelphia Union II 5 | Final |
| August 21, 2022 | FC Cincinnati 2 1 at Toronto FC II 2 | Final |
| August 21, 2022 | Real Monarchs 1 at Minnesota United FC 2 1 | Final (PK 1-3) |
| August 21, 2022 | North Texas SC 1 at Colorado Rapids 2 1 | Final (PK 3-0) |
| August 21, 2022 | St. Louis City SC 2 5 at Earthquakes II 2 | Final |
| August 24, 2022 | Philadelphia Union II 2 at New York City FC II 1 | Final |
| August 25, 2022 | Toronto FC II 1 at Chicago Fire FC II 2 | Final |
| August 25, 2022 | Colorado Rapids 2 2 at Vancouver Whitecaps FC 2 1 | Final |
| August 26, 2022 | Tacoma Defiance 0 at Real Monarchs 1 | Final |
| August 27, 2022 | Philadelphia Union II 0 at Columbus Crew 2 2 | Final |
| August 27, 2022 | Houston Dynamo 2 1 at Minnesota United FC 2 0 | Final |
| August 27, 2022 | St. Louis City SC 2 5 at Portland Timbers 2 3 | Final |
| August 27, 2022 | New England Revolution II 0 at Rochester New York FC 2 | Final |
| August 27, 2022 | Pittsburgh Riverhounds SC 2 at Atlanta United 2 1 | Final |
| August 27, 2022 | LA Galaxy II 2 at Monterey Bay FC 0 | Final |
| August 28, 2022 | New York Red Bulls II 1 at Birmingham Legion FC 3 | Final |
| August 28, 2022 | Earthquakes II 4 at Sporting Kansas City II 1 | Final |
| August 29, 2022 | FC Cincinnati 2 2 at Orlando City B 2 | Final (PK 7-6) |
| August 31, 2022 | Hartford Athletic 3 at New York Red Bulls II 3 | Final |
| September 2, 2022 | Orlando City B 0 at New England Revolution II 2 | Final |
| September 3, 2022 | Toronto FC II 4 at Inter Miami CF II 1 | Final |
| September 3, 2022 | North Texas SC 2 at Minnesota United FC 2 1 | Final |
| September 3, 2022 | New York Red Bulls II 0 at Charleston Battery 3 | Final |
| September 3, 2022 | FC Tulsa 1 at Atlanta United 2 2 | Final |
| September 3, 2022 | St. Louis City SC 2 0 at Houston Dynamo 2 1 | Final |
| September 3, 2022 | Chicago Fire FC II 1 at Columbus Crew 2 3 | Final |
| September 3, 2022 | Portland Timbers 2 2 at Real Monarchs 4 | Final |
| September 4, 2022 | Rochester New York FC 2 at Philadelphia Union II 1 | Final |
| September 5, 2022 | Colorado Rapids 2 0 at Sporting Kansas City II 5 | Final |
| September 5, 2022 | Vancouver Whitecaps FC 2 1 at Earthquakes II 3 | Final |
| September 5, 2022 | Hartford Athletic 3 at LA Galaxy II 1 | Final |
| September 7, 2022 | Memphis 901 FC 4 at Atlanta United 2 0 | Final |
| September 9, 2022 | Miami FC 7 at New York Red Bulls II 1 | Final |
| September 9, 2022 | Real Monarchs 2 at Earthquakes II 2 | Final (PK 4-3) |
| September 9, 2022 | Tacoma Defiance 1 at Vancouver Whitecaps FC 2 0 | Final |
| September 10, 2022 | New England Revolution II 0 at New York City FC II 0 | Final (PK 2-4) |
| September 10, 2022 | LA Galaxy II 0 at Orange County SC 1 | Final |
| September 11, 2022 | Orlando City B 1 at Philadelphia Union II 6 | Final |
| September 11, 2022 | Chicago Fire FC II 2 at FC Cincinnati 2 0 | Final |
| September 11, 2022 | Rochester New York FC 1 at Toronto FC II 0 | Final |
| September 11, 2022 | Columbus Crew 2 1 at Inter Miami CF II 1 | Final (PK 6-5) |
| September 11, 2022 | Houston Dynamo 2 0 at Colorado Rapids 2 1 | Final |
| September 11, 2022 | Minnesota United FC 2 4 at Portland Timbers 2 2 | Final |
| September 11, 2022 | St. Louis City SC 2 1 at North Texas SC 3 | Final |
| September 14, 2022 | New York City FC II 4 at FC Cincinnati 2 0 | Final |
| September 14, 2022 | Inter Miami CF II 4 at Toronto FC II 3 | Final |
| September 14, 2022 | Vancouver Whitecaps FC 2 2 at Portland Timbers 2 2 | Final (PK 4-5) |
| September 17, 2022 | Atlanta United 2 2 at Miami FC 2 | Final |
| September 17, 2022 | New York Red Bulls II 0 at Oakland Roots 1 | Final |
| September 18, 2022 | Inter Miami CF II 0 at Chicago Fire FC II 1 | Final |
| September 18, 2022 | FC Cincinnati 2 0 at Columbus Crew 2 9 | Final |
| September 18, 2022 | Philadelphia Union II 3 at New England Revolution II 1 | Final |
| September 18, 2022 | Toronto FC II 2 at Orlando City B 1 | Final |
| September 18, 2022 | New York City FC II 2 at Rochester New York FC 2 | Final (PK 5-3) |
| September 18, 2022 | North Texas SC 0 at Houston Dynamo 2 2 | Final |
| September 18, 2022 | Earthquakes II 4 at Minnesota United FC 2 1 | Final |
| September 18, 2022 | Colorado Rapids 2 1 at Real Monarchs 2 | Final |
| September 18, 2022 | Sporting Kansas City II 1 at St. Louis City SC 2 1 | Final (PK 5-4) |
| September 18, 2022 | Portland Timbers 2 2 at Tacoma Defiance 0 | Final |
| September 18, 2022 | El Paso Locomotive FC 3 at LA Galaxy II 2 | Final |
| September 21, 2022 | Detroit City FC 0 at New York Red Bulls II 0 | Final |
| September 24, 2022 | Rochester New York FC 1 at Columbus Crew 2 4 (Playoff) | Final |
| September 24, 2022 | Philadelphia Union II 0 at Toronto FC II 1 (Playoff) | Final |
| September 25, 2022 | North Texas SC 0 at St. Louis City SC 2 2 (Playoff) | Final |
| September 25, 2022 | Houston Dynamo 2 2 at Tacoma Defiance 2 (Playoff) | Final (PK 4-5) |
| September 28, 2022 | Indy Eleven 1 at Atlanta United 2 0 | Final |
| October 1, 2022 | New York Red Bulls II 1 at Phoenix Rising FC 5 | Final |
| October 2, 2022 | Toronto FC II 3 at Columbus Crew 2 4 (Playoff) | Final |
| October 2, 2022 | Sacramento Republic FC 0 at LA Galaxy II 2 | Final |
| October 2, 2022 | Tacoma Defiance 1 at St. Louis City SC 2 2 (Playoff) | Final |
| October 5, 2022 | LA Galaxy II at New Mexico United | Ppd. |
| October 8, 2022 | St. Louis City SC 2 1 at Columbus Crew 2 4 | Final |
| October 8, 2022 | Atlanta United 2 3 at LA Galaxy II 1 | Final |
| October 9, 2022 | New York Red Bulls II 1 at Memphis 901 FC 2 | Final |
| October 12, 2022 | LA Galaxy II 2 at New Mexico United 3 | Final |
| October 15, 2022 | New York Red Bulls II 0 at Tampa Bay Rowdies 1 | Final |
| October 15, 2022 | Las Vegas Lights FC 1 at LA Galaxy II 1 | Final |
| October 15, 2022 | Atlanta United 2 1 at Phoenix Rising FC 3 | Final |
MLS NEXT Pro Schedule
