| | | |
| April 10, 2021 | New England Revolution II 1 at Fort Lauderdale CF 0 | Final |
| April 17, 2021 | Richmond Kickers 3 at New England Revolution II 0 | Final |
| April 17, 2021 | Fort Lauderdale CF 1 at South Georgia Tormenta FC 0 | Final |
| April 24, 2021 | Fort Lauderdale CF 2 at North Texas SC 4 | Final |
| May 1, 2021 | North Texas SC 0 at Greenville Triumph SC 4 | Final |
| May 1, 2021 | Sporting Kansas City II 0 at FC Tulsa 2 | Final |
| May 2, 2021 | Richmond Kickers 1 at Fort Lauderdale CF 2 | Final |
| May 7, 2021 | Union Omaha 2 at Fort Lauderdale CF 0 | Final |
| May 7, 2021 | OKC Energy FC 1 at Sporting Kansas City II 1 | Final |
| May 8, 2021 | Chattanooga Red Wolves SC 1 at North Texas SC 0 | Final |
| May 8, 2021 | Real Monarchs SLC 2 at San Antonio FC 2 | Final |
| May 9, 2021 | Tacoma Defiance 1 at LA Galaxy II 1 | Final |
| May 12, 2021 | Union Omaha 1 at New England Revolution II 0 | Final |
| May 13, 2021 | San Diego Loyal 1 at Tacoma Defiance 3 | Final |
| May 14, 2021 | Colorado Springs Switchbacks FC 4 at Sporting Kansas City II 0 | Final |
| May 14, 2021 | LA Galaxy II 2 at Real Monarchs SLC 0 | Final |
| May 16, 2021 | Orange County SC 0 at Tacoma Defiance 1 | Final |
| May 16, 2021 | South Georgia Tormenta FC 1 at North Texas SC 2 | Final |
| May 16, 2021 | FC Tucson 1 at Fort Lauderdale CF 5 | Final |
| May 16, 2021 | Chattanooga Red Wolves SC 2 at New England Revolution II 2 | Final |
| May 19, 2021 | Sporting Kansas City II 1 at LA Galaxy II 1 | Final |
| May 21, 2021 | Austin Bold FC 1 at Real Monarchs SLC 1 | Final |
| May 22, 2021 | Sporting Kansas City II 0 at Indy Eleven 2 | Final |
| May 22, 2021 | Fort Lauderdale CF 1 at Chattanooga Red Wolves SC 2 | Final |
| May 22, 2021 | North Texas SC 1 at Toronto FC II 2 | Final |
| May 26, 2021 | Real Monarchs SLC 0 at Austin Bold FC 2 | Final |
| May 26, 2021 | FC Tucson 2 at Toronto FC II 1 | Final |
| May 28, 2021 | Fort Lauderdale CF 0 at New England Revolution II 1 | Final |
| May 29, 2021 | Toronto FC II 1 at North Texas SC 1 | Final |
| May 29, 2021 | Real Monarchs SLC at Hartford Athletic | Ppd. |
| May 30, 2021 | El Paso Locomotive FC 0 at Sporting Kansas City II 0 | Final |
| May 30, 2021 | Tacoma Defiance at Austin Bold FC | Ppd. |
| June 1, 2021 | Forward Madison FC 2 at Fort Lauderdale CF 2 | Final |
| June 2, 2021 | FC Tulsa 1 at Sporting Kansas City II 4 | Final |
| June 2, 2021 | Union Omaha 1 at Toronto FC II 1 | Final |
| June 4, 2021 | New Mexico United 1 at Real Monarchs SLC 0 | Final |
| June 5, 2021 | New England Revolution II 2 at Richmond Kickers 3 | Final |
| June 5, 2021 | Fort Lauderdale CF 2 at North Carolina FC 1 | Final |
| June 5, 2021 | Toronto FC II 1 at FC Tucson 1 | Final |
| June 5, 2021 | Tacoma Defiance 0 at Las Vegas Lights FC 2 | Final |
| June 9, 2021 | South Georgia Tormenta FC 1 at Toronto FC II 0 | Final |
| June 9, 2021 | Sporting Kansas City II 2 at Atlanta United 2 2 | Final |
| June 9, 2021 | Sacramento Republic FC 0 at Real Monarchs SLC 2 | Final |
| June 12, 2021 | Real Monarchs SLC 0 at Rio Grande Valley FC Toros 1 | Final |
| June 12, 2021 | New England Revolution II 2 at Union Omaha 4 | Final |
| June 12, 2021 | Tacoma Defiance 0 at Phoenix Rising FC 3 | Final |
| June 13, 2021 | Greenville Triumph SC 0 at North Texas SC 3 | Final |
| June 13, 2021 | Toronto FC II 0 at South Georgia Tormenta FC 1 | Final |
| June 16, 2021 | Toronto FC II 2 at Fort Lauderdale CF 2 | Final |
| June 16, 2021 | Sporting Kansas City II 3 at FC Tulsa 4 | Final |
| June 16, 2021 | Tacoma Defiance 2 at Colorado Springs Switchbacks FC 4 | Final |
| June 18, 2021 | El Paso Locomotive FC 2 at Real Monarchs SLC 1 | Final |
| June 19, 2021 | Fort Lauderdale CF 1 at Toronto FC II 2 | Final |
| June 19, 2021 | New England Revolution II 2 at Forward Madison FC 0 | Final |
| June 19, 2021 | FC Tucson 0 at North Texas SC 0 | Final |
| June 20, 2021 | Indy Eleven 2 at Sporting Kansas City II 1 | Final |
| June 23, 2021 | South Georgia Tormenta FC 1 at Toronto FC II 3 | Final |
| June 23, 2021 | Sporting Kansas City II 0 at OKC Energy FC 1 | Final |
| June 23, 2021 | Real Monarchs SLC 1 at Tacoma Defiance 1 | Final |
| June 26, 2021 | North Texas SC 0 at New England Revolution II 3 | Final |
| June 26, 2021 | Toronto FC II 1 at Fort Lauderdale CF 2 | Final |
| June 26, 2021 | Sporting Kansas City II 3 at Memphis 901 FC 2 | Final |
| June 26, 2021 | San Antonio FC 1 at Real Monarchs SLC 1 | Final |
| June 27, 2021 | LA Galaxy II 0 at Tacoma Defiance 2 | Final |
| June 30, 2021 | New England Revolution II 0 at Forward Madison FC 1 | Final |
| June 30, 2021 | Toronto FC II 2 at South Georgia Tormenta FC 1 | Final |
| June 30, 2021 | New Mexico United 2 at Real Monarchs SLC 3 | Final |
| July 2, 2021 | Louisville City FC 4 at Sporting Kansas City II 2 | Final |
| July 3, 2021 | North Texas SC 2 at Richmond Kickers 3 | Final |
| July 3, 2021 | Fort Lauderdale CF 1 at FC Tucson 2 | Final |
| July 3, 2021 | Tacoma Defiance 0 at Las Vegas Lights FC 1 | Final |
| July 4, 2021 | Greenville Triumph SC 3 at New England Revolution II 0 | Final |
| July 4, 2021 | Real Monarchs SLC 1 at Colorado Springs Switchbacks FC 3 | Final |
| July 6, 2021 | Tacoma Defiance 0 at Orange County SC 0 | Final |
| July 9, 2021 | Toronto FC II 0 at New England Revolution II 1 | Final |
| July 9, 2021 | El Paso Locomotive FC 3 at Real Monarchs SLC 1 | Final |
| July 10, 2021 | Sporting Kansas City II 1 at Atlanta United 2 0 | Final |
| July 10, 2021 | Forward Madison FC 1 at North Texas SC 4 | Final |
| July 11, 2021 | Tacoma Defiance 1 at LA Galaxy II 1 | Final |
| July 17, 2021 | Fort Lauderdale CF 1 at Richmond Kickers 1 | Final |
| July 17, 2021 | Chattanooga Red Wolves SC 1 at North Texas SC 1 | Final |
| July 17, 2021 | New England Revolution II 2 at FC Tucson 4 | Final |
| July 18, 2021 | Toronto FC II 4 at North Carolina FC 2 | Final |
| July 18, 2021 | Real Monarchs SLC 0 at Austin Bold FC 1 | Final |
| July 23, 2021 | Toronto FC II 0 at New England Revolution II 1 | Final |
| July 23, 2021 | Las Vegas Lights FC 2 at Real Monarchs SLC 3 | Final |
| July 24, 2021 | Fort Lauderdale CF 1 at Forward Madison FC 1 | Final |
| July 24, 2021 | Sporting Kansas City II 0 at OKC Energy FC 0 | Final |
| July 28, 2021 | Louisville City FC 2 at Sporting Kansas City II 1 | Final |
| July 29, 2021 | San Diego Loyal 1 at Tacoma Defiance 2 | Final |
| July 30, 2021 | Greenville Triumph SC 0 at Toronto FC II 0 | Final |
| July 31, 2021 | North Texas SC 1 at Union Omaha 1 | Final |
| July 31, 2021 | Real Monarchs SLC 1 at El Paso Locomotive FC 3 | Final |
| August 1, 2021 | New Mexico United 0 at Tacoma Defiance 0 | Final |
| August 1, 2021 | Memphis 901 FC 2 at Sporting Kansas City II 1 | Final |
| August 1, 2021 | North Carolina FC 3 at Fort Lauderdale CF 2 | Final |
| August 4, 2021 | Rio Grande Valley FC Toros 3 at Real Monarchs SLC 0 | Final |
| August 5, 2021 | North Carolina FC 0 at New England Revolution II 3 | Final |
| August 5, 2021 | Sacramento Republic FC 1 at Tacoma Defiance 1 | Final |
| August 6, 2021 | Richmond Kickers 1 at Toronto FC II 2 | Final |
| August 7, 2021 | Sporting Kansas City II 1 at Louisville City FC 4 | Final |
| August 7, 2021 | North Texas SC 2 at FC Tucson 0 | Final |
| August 7, 2021 | Real Monarchs SLC 1 at San Diego Loyal 0 | Final |
| August 8, 2021 | Oakland Roots 1 at Tacoma Defiance 3 | Final |
| August 11, 2021 | Sporting Kansas City II 2 at Birmingham Legion FC 4 | Final |
| August 14, 2021 | Atlanta United 2 4 at Sporting Kansas City II 1 | Final |
| August 14, 2021 | New England Revolution II 2 at Richmond Kickers 2 | Final |
| August 14, 2021 | North Carolina FC 0 at North Texas SC 4 | Final |
| August 14, 2021 | Tacoma Defiance 2 at San Diego Loyal 1 | Final |
| August 15, 2021 | Greenville Triumph SC 0 at Fort Lauderdale CF 2 | Final |
| August 17, 2021 | North Texas SC 1 at Chattanooga Red Wolves SC 1 | Final |
| August 18, 2021 | Toronto FC II 2 at Forward Madison FC 2 | Final |
| August 18, 2021 | Tacoma Defiance 3 at Orange County SC 0 | Final |
| August 21, 2021 | North Texas SC 1 at Forward Madison FC 1 | Final |
| August 21, 2021 | New England Revolution II 1 at South Georgia Tormenta FC 1 | Final |
| August 22, 2021 | Indy Eleven 1 at Sporting Kansas City II 1 | Final |
| August 22, 2021 | FC Tucson 4 at Fort Lauderdale CF 0 | Final |
| August 27, 2021 | Chattanooga Red Wolves SC 0 at Toronto FC II 0 | Final |
| August 28, 2021 | Real Monarchs SLC 0 at Indy Eleven 2 | Final |
| August 28, 2021 | Fort Lauderdale CF 4 at South Georgia Tormenta FC 2 | Final |
| August 28, 2021 | North Texas SC 0 at Union Omaha 0 | Final |
| August 28, 2021 | Tacoma Defiance 1 at Oakland Roots 3 | Final |
| August 29, 2021 | Memphis 901 FC 0 at Sporting Kansas City II 0 | Final |
| September 1, 2021 | FC Tucson 2 at New England Revolution II 1 | Final |
| September 1, 2021 | Birmingham Legion FC 1 at Sporting Kansas City II 0 | Final |
| September 1, 2021 | Real Monarchs SLC 2 at San Antonio FC 3 | Final |
| September 2, 2021 | Las Vegas Lights FC 0 at Tacoma Defiance 1 | Final |
| September 3, 2021 | Toronto FC II 0 at Greenville Triumph SC 3 | Final |
| September 4, 2021 | OKC Energy FC 0 at Sporting Kansas City II 3 | Final |
| September 4, 2021 | Chattanooga Red Wolves SC 0 at Fort Lauderdale CF 0 | Final |
| September 4, 2021 | FC Tucson 1 at North Texas SC 1 | Final |
| September 5, 2021 | Phoenix Rising FC 3 at Tacoma Defiance 1 | Final |
| September 5, 2021 | South Georgia Tormenta FC 1 at New England Revolution II 1 | Final |
| September 8, 2021 | North Texas SC 0 at Chattanooga Red Wolves SC 1 | Final |
| September 8, 2021 | Real Monarchs SLC 0 at Colorado Springs Switchbacks FC 2 | Final |
| September 11, 2021 | Sporting Kansas City II 0 at Indy Eleven 1 | Final |
| September 11, 2021 | New England Revolution II 1 at North Carolina FC 4 | Final |
| September 11, 2021 | North Texas SC 0 at South Georgia Tormenta FC 2 | Final |
| September 11, 2021 | Toronto FC II 1 at Union Omaha 2 | Final |
| September 11, 2021 | San Antonio FC 1 at Real Monarchs SLC 0 | Final |
| September 11, 2021 | Fort Lauderdale CF 0 at FC Tucson 3 | Final |
| September 15, 2021 | Real Monarchs SLC 0 at Hartford Athletic 2 | Final |
| September 15, 2021 | Tacoma Defiance 1 at Oakland Roots 3 | Final |
| September 17, 2021 | Forward Madison FC 1 at Toronto FC II 1 | Final |
| September 17, 2021 | Richmond Kickers 1 at New England Revolution II 3 | Final |
| September 18, 2021 | Real Monarchs SLC 1 at New Mexico United 2 | Final |
| September 19, 2021 | Tacoma Defiance 0 at San Diego Loyal 1 | Final |
| September 19, 2021 | Union Omaha 2 at North Texas SC 2 | Final |
| September 19, 2021 | South Georgia Tormenta FC 2 at Fort Lauderdale CF 2 | Final |
| September 22, 2021 | Sacramento Republic FC 1 at Tacoma Defiance 0 | Final |
| September 24, 2021 | FC Tulsa 1 at Sporting Kansas City II 1 | Final |
| September 25, 2021 | Toronto FC II 0 at Richmond Kickers 1 | Final |
| September 25, 2021 | New England Revolution II 1 at Chattanooga Red Wolves SC 0 | Final |
| September 25, 2021 | Phoenix Rising FC 2 at Tacoma Defiance 1 | Final |
| September 26, 2021 | North Texas SC 1 at North Carolina FC 0 | Final |
| September 26, 2021 | New York Red Bulls II 0 at Real Monarchs SLC 0 | Final |
| September 29, 2021 | Real Monarchs SLC 0 at El Paso Locomotive FC 1 | Final |
| October 1, 2021 | North Carolina FC 0 at Toronto FC II 3 | Final |
| October 1, 2021 | Forward Madison FC 0 at New England Revolution II 1 | Final |
| October 1, 2021 | Fort Lauderdale CF 0 at Greenville Triumph SC 1 | Final |
| October 1, 2021 | Birmingham Legion FC 1 at Sporting Kansas City II 0 | Final |
| October 2, 2021 | Real Monarchs SLC 0 at Rio Grande Valley FC Toros 3 | Final |
| October 2, 2021 | North Texas SC 2 at FC Tucson 0 | Final |
| October 2, 2021 | Tacoma Defiance 1 at Sacramento Republic FC 3 | Final |
| October 6, 2021 | Sporting Kansas City II 1 at Memphis 901 FC 3 | Final |
| October 6, 2021 | Fort Lauderdale CF 1 at Union Omaha 4 | Final |
| October 6, 2021 | Tacoma Defiance 0 at Austin Bold FC 1 | Final |
| October 8, 2021 | New England Revolution II 0 at Toronto FC II 1 | Final |
| October 8, 2021 | Colorado Springs Switchbacks FC 0 at Real Monarchs SLC 0 | Final |
| October 9, 2021 | Sporting Kansas City II 3 at Louisville City FC 4 | Final |
| October 9, 2021 | Orange County SC 1 at Tacoma Defiance 4 | Final |
| October 10, 2021 | Richmond Kickers 2 at North Texas SC 1 | Final |
| October 10, 2021 | South Georgia Tormenta FC 4 at Fort Lauderdale CF 4 | Final |
| October 12, 2021 | Forward Madison FC 0 at New England Revolution II 1 | Final |
| October 13, 2021 | Atlanta United 2 0 at Sporting Kansas City II 1 | Final |
| October 13, 2021 | Las Vegas Lights FC 1 at Tacoma Defiance 0 | Final |
| October 16, 2021 | Austin Bold FC 3 at Real Monarchs SLC 4 | Final |
| October 16, 2021 | Toronto FC II 2 at Chattanooga Red Wolves SC 1 | Final |
| October 16, 2021 | New England Revolution II 0 at Greenville Triumph SC 1 | Final |
| October 17, 2021 | Tacoma Defiance 0 at Sacramento Republic FC 0 | Final |
| October 17, 2021 | North Texas SC 1 at Fort Lauderdale CF 0 | Final |
| October 20, 2021 | Oakland Roots 0 at Tacoma Defiance 0 | Final |
| October 22, 2021 | Fort Lauderdale CF 2 at Toronto FC II 1 | Final |
| October 22, 2021 | Colorado Springs Switchbacks FC 1 at Real Monarchs SLC 1 | Final |
| October 23, 2021 | New England Revolution II 1 at North Texas SC 4 | Final |
| October 24, 2021 | LA Galaxy II 2 at Tacoma Defiance 3 | Final |
| October 24, 2021 | Sporting Kansas City II 0 at Birmingham Legion FC 6 | Final |
| October 27, 2021 | Rio Grande Valley FC Toros 3 at Real Monarchs SLC 1 | Final |
| October 29, 2021 | New England Revolution II 0 at Toronto FC II 1 | Final |
| October 30, 2021 | Real Monarchs SLC 1 at New Mexico United 3 | Final |
| October 30, 2021 | Union Omaha 1 at North Texas SC 1 | Final |
| October 30, 2021 | Sporting Kansas City II 0 at Oakland Roots 1 | Final |
| October 30, 2021 | Tacoma Defiance 1 at Phoenix Rising FC 1 | Final |
| November 6, 2021 | North Texas SC 1 at Chattanooga Red Wolves SC 2 (Playoff) | Final |
MLS NEXT Pro Schedule
