| | | |
| March 14, 2026 | W | Brooklyn FC 0 at Detroit City FC 3 | Final |
| March 21, 2026 | L | Detroit City FC 1 at Indy Eleven 2 | Final |
| March 28, 2026 | W | Charleston Battery 0 at Detroit City FC 1 | Final |
| April 4, 2026 | | Detroit City FC at Rhode Island FC | 3:00 p.m. |
| April 11, 2026 | | Sporting Club Jacksonville at Detroit City FC | 3:00 p.m. |
| April 18, 2026 | | Detroit City FC at Pittsburgh Riverhounds SC | 6:00 p.m. |
| May 2, 2026 | | Louisville City FC at Detroit City FC | 6:00 p.m. |
| May 9, 2026 | | Detroit City FC at Hartford Athletic | 6:00 p.m. |
| May 16, 2026 | | Detroit City FC at Forward Madison FC (USL Cup) | 5:00 p.m. |
| May 20, 2026 | | Miami FC at Detroit City FC | 6:30 p.m. |
| May 23, 2026 | | Detroit City FC at Loudoun United FC | 5:00 p.m. |
| May 30, 2026 | | Detroit City FC at Charleston Battery | 5:00 p.m. |
| June 6, 2026 | | Lexington SC at Detroit City FC | 3:00 p.m. |
| June 10, 2026 | | El Paso Locomotive FC at Detroit City FC | 6:30 p.m. |
| June 13, 2026 | | Detroit City FC at Sporting Club Jacksonville | 6:00 p.m. |
| June 20, 2026 | | Louisville City FC at Detroit City FC | 3:00 p.m. |
| July 2, 2026 | | Detroit City FC at Birmingham Legion FC | 7:00 p.m. |
| July 11, 2026 | | Detroit City FC at Fort Wayne FC (USL Cup) | 6:30 p.m. |
| July 18, 2026 | | Indy Eleven at Detroit City FC | 6:00 p.m. |
| July 25, 2026 | | Las Vegas Lights FC at Detroit City FC | 6:00 p.m. |
| August 1, 2026 | | Detroit City FC at Miami FC | 6:00 p.m. |
| August 8, 2026 | | Detroit City FC at FC Tulsa | 7:30 p.m. |
| August 15, 2026 | | Loudoun United FC at Detroit City FC | 6:00 p.m. |
| August 22, 2026 | | Tampa Bay Rowdies at Detroit City FC | 6:00 p.m. |
| August 29, 2026 | | Detroit City FC at Louisville City FC | 7:00 p.m. |
| September 5, 2026 | | Hartford Athletic at Detroit City FC | 6:00 p.m. |
| September 12, 2026 | | Detroit City FC at Sacramento Republic FC | 9:00 p.m. |
| September 19, 2026 | | Pittsburgh Riverhounds SC at Detroit City FC | 6:00 p.m. |
| September 26, 2026 | | Colorado Springs Switchbacks FC at Detroit City FC | 6:00 p.m. |
| September 30, 2026 | | Detroit City FC at Brooklyn FC | 6:00 p.m. |
| October 3, 2026 | | Birmingham Legion FC at Detroit City FC | 6:00 p.m. |
| October 10, 2026 | | Rhode Island FC at Detroit City FC | 6:00 p.m. |
| October 17, 2026 | | Detroit City FC at Tampa Bay Rowdies | 6:30 p.m. |
| October 24, 2026 | | Detroit City FC at Louisville City FC | 6:00 p.m. |
Detroit City FC Schedule
