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| February 21, 2026 | | Columbus Crew SC at Portland Timbers | 11:30 p.m. |
| February 28, 2026 | | Columbus Crew SC at Sporting Kansas City | 9:30 p.m. |
| March 7, 2026 | | Chicago Fire FC at Columbus Crew SC | 8:30 p.m. |
| March 14, 2026 | | Nashville SC at Columbus Crew SC | 6:15 p.m. |
| March 21, 2026 | | Columbus Crew SC at Toronto FC | 1:00 p.m. |
| April 4, 2026 | | Columbus Crew SC at Atlanta United FC | 7:30 p.m. |
| April 12, 2026 | | Orlando City SC at Columbus Crew SC | 7:00 p.m. |
| April 18, 2026 | | Columbus Crew SC at New England Revolution | 7:30 p.m. |
| April 22, 2026 | | LA Galaxy at Columbus Crew SC | 7:30 p.m. |
| April 25, 2026 | | Philadelphia Union at Columbus Crew SC | 7:30 p.m. |
| May 2, 2026 | | Minnesota United FC at Columbus Crew SC | 7:30 p.m. |
| May 10, 2026 | | Columbus Crew SC at New York City FC | 4:30 p.m. |
| May 13, 2026 | | Columbus Crew SC at Red Bull New York | 7:30 p.m. |
| May 16, 2026 | | Columbus Crew SC at Philadelphia Union | 7:30 p.m. |
| May 24, 2026 | | Atlanta United FC at Columbus Crew SC | 5:00 p.m. |
| July 22, 2026 | | New York City FC at Columbus Crew SC | 7:30 p.m. |
| July 25, 2026 | | FC Cincinnati at Columbus Crew SC | 7:15 p.m. |
| August 1, 2026 | | Columbus Crew SC at Inter Miami CF | 7:30 p.m. |
| August 15, 2026 | | Columbus Crew SC at Charlotte FC | 7:30 p.m. |
| August 19, 2026 | | Club de Foot Montreal at Columbus Crew SC | 7:30 p.m. |
| August 22, 2026 | | Columbus Crew SC at Nashville SC | 8:30 p.m. |
| August 29, 2026 | | New England Revolution at Columbus Crew SC | 7:30 p.m. |
| September 5, 2026 | | Colorado Rapids at Columbus Crew SC | 7:30 p.m. |
| September 9, 2026 | | Columbus Crew SC at D.C. United | 7:30 p.m. |
| September 12, 2026 | | Red Bull New York at Columbus Crew SC | 7:30 p.m. |
| September 19, 2026 | | Columbus Crew SC at Club de Foot Montreal | 7:30 p.m. |
| September 27, 2026 | | Inter Miami CF at Columbus Crew SC | 7:00 p.m. |
| October 10, 2026 | | Columbus Crew SC at Orlando City SC | 7:30 p.m. |
| October 14, 2026 | | Charlotte FC at Columbus Crew SC | 7:30 p.m. |
| October 18, 2026 | | Columbus Crew SC at FC Cincinnati | 7:00 p.m. |
| October 24, 2026 | | Toronto FC at Columbus Crew SC | 2:30 p.m. |
| October 28, 2026 | | Columbus Crew SC at FC Dallas | 8:30 p.m. |
| October 31, 2026 | | D.C. United at Columbus Crew SC | 2:00 p.m. |
| November 7, 2026 | | Columbus Crew SC at Chicago Fire FC | 5:00 p.m. |
Columbus Crew SC Schedule
