| | | |
| October 16, 2021 | L | Charlotte Checkers 2 at Hershey Bears 5 | Final |
| October 17, 2021 | W | Charlotte Checkers 4 at Wilkes-Barre/Scranton Penguins 1 | Final |
| October 22, 2021 | W | Hershey Bears 3 at Charlotte Checkers 5 | Final |
| October 23, 2021 | L | Hershey Bears 2 at Charlotte Checkers 1 | Final (OT) |
| October 29, 2021 | L | Charlotte Checkers 3 at Providence Bruins 4 | Final |
| October 30, 2021 | W | Charlotte Checkers 3 at Hartford Wolf Pack 2 | Final |
| October 31, 2021 | L | Charlotte Checkers 3 at Springfield Thunderbirds 5 | Final |
| November 6, 2021 | W | Lehigh Valley Phantoms 3 at Charlotte Checkers 7 | Final |
| November 7, 2021 | L | Lehigh Valley Phantoms 5 at Charlotte Checkers 3 | Final |
| November 12, 2021 | L | Charlotte Checkers 1 at Wilkes-Barre/Scranton Penguins 2 | Final |
| November 13, 2021 | W | Charlotte Checkers 4 at Wilkes-Barre/Scranton Penguins 0 | Final |
| November 14, 2021 | W | Charlotte Checkers 5 at Hershey Bears 2 | Final |
| November 17, 2021 | W | Charlotte Checkers 4 at Lehigh Valley Phantoms 3 | Final |
| November 19, 2021 | L | Charlotte Checkers 1 at Utica Comets 4 | Final |
| November 21, 2021 | L | Charlotte Checkers 2 at Hershey Bears 4 | Final |
| November 23, 2021 | L | Wilkes-Barre/Scranton Penguins 3 at Charlotte Checkers 2 | Final (OT) |
| November 24, 2021 | W | Wilkes-Barre/Scranton Penguins 3 at Charlotte Checkers 4 | Final |
| November 27, 2021 | L | Utica Comets 1 at Charlotte Checkers 0 | Final |
| November 28, 2021 | L | Utica Comets 5 at Charlotte Checkers 2 | Final |
| December 3, 2021 | W | Charlotte Checkers 5 at Lehigh Valley Phantoms 3 | Final |
| December 4, 2021 | | Charlotte Checkers at Wilkes-Barre/Scranton Penguins | Ppd. |
| December 5, 2021 | W | Charlotte Checkers 3 at Bridgeport Islanders 2 | Final |
| December 10, 2021 | L | Syracuse Crunch 5 at Charlotte Checkers 3 | Final |
| December 11, 2021 | W | Syracuse Crunch 3 at Charlotte Checkers 5 | Final |
| December 14, 2021 | W | Rochester Americans 1 at Charlotte Checkers 11 | Final |
| December 15, 2021 | W | Rochester Americans 2 at Charlotte Checkers 4 | Final |
| December 18, 2021 | L | Bridgeport Islanders 5 at Charlotte Checkers 1 | Final |
| December 19, 2021 | W | Bridgeport Islanders 1 at Charlotte Checkers 3 | Final |
| December 31, 2021 | | Charlotte Checkers at Texas Stars | Ppd. |
| January 1, 2022 | | Charlotte Checkers at Texas Stars | Ppd. |
| January 8, 2022 | L | Charlotte Checkers 1 at Bridgeport Islanders 5 | Final |
| January 9, 2022 | W | Charlotte Checkers 3 at Bridgeport Islanders 2 | Final (SO) |
| January 12, 2022 | W | Charlotte Checkers 2 at Hartford Wolf Pack 1 | Final (OT) |
| January 15, 2022 | W | Texas Stars 3 at Charlotte Checkers 8 | Final |
| January 16, 2022 | L | Texas Stars 6 at Charlotte Checkers 5 | Final |
| January 18, 2022 | L | Springfield Thunderbirds 4 at Charlotte Checkers 2 | Final |
| January 20, 2022 | W | Springfield Thunderbirds 2 at Charlotte Checkers 4 | Final |
| January 22, 2022 | W | Lehigh Valley Phantoms 1 at Charlotte Checkers 4 | Final |
| January 23, 2022 | L | Lehigh Valley Phantoms 5 at Charlotte Checkers 2 | Final |
| January 28, 2022 | W | Charlotte Checkers 4 at Utica Comets 3 | Final (OT) |
| January 29, 2022 | W | Charlotte Checkers 6 at Syracuse Crunch 1 | Final |
| February 2, 2022 | L | Charlotte Checkers 1 at Rochester Americans 5 | Final |
| February 4, 2022 | W | Charlotte Checkers 5 at Rochester Americans 2 | Final |
| February 5, 2022 | L | Charlotte Checkers 1 at Syracuse Crunch 3 | Final |
| February 11, 2022 | L | Bridgeport Islanders 4 at Charlotte Checkers 3 | Final |
| February 12, 2022 | W | Bridgeport Islanders 0 at Charlotte Checkers 2 | Final |
| February 15, 2022 | W | Wilkes-Barre/Scranton Penguins 4 at Charlotte Checkers 5 | Final |
| February 16, 2022 | W | Wilkes-Barre/Scranton Penguins 1 at Charlotte Checkers 4 | Final |
| February 19, 2022 | W | Cleveland Monsters 2 at Charlotte Checkers 4 | Final |
| February 20, 2022 | L | Cleveland Monsters 6 at Charlotte Checkers 5 | Final (OT) |
| February 25, 2022 | L | Charlotte Checkers 1 at Providence Bruins 5 | Final |
| February 26, 2022 | L | Charlotte Checkers 2 at Springfield Thunderbirds 4 | Final |
| February 27, 2022 | L | Charlotte Checkers 3 at Bridgeport Islanders 5 | Final |
| March 2, 2022 | W | Charlotte Checkers 3 at Hershey Bears 0 | Final |
| March 4, 2022 | W | Charlotte Checkers 5 at Lehigh Valley Phantoms 2 | Final |
| March 5, 2022 | W | Charlotte Checkers 5 at Lehigh Valley Phantoms 2 | Final |
| March 8, 2022 | W | Charlotte Checkers 3 at Texas Stars 1 | Final |
| March 9, 2022 | L | Charlotte Checkers 1 at Texas Stars 7 | Final |
| March 11, 2022 | W | Springfield Thunderbirds 1 at Charlotte Checkers 5 | Final |
| March 12, 2022 | L | Springfield Thunderbirds 4 at Charlotte Checkers 3 | Final (OT) |
| March 17, 2022 | W | Providence Bruins 1 at Charlotte Checkers 2 | Final (SO) |
| March 19, 2022 | W | Providence Bruins 2 at Charlotte Checkers 3 | Final (SO) |
| March 20, 2022 | W | Providence Bruins 1 at Charlotte Checkers 2 | Final (SO) |
| March 25, 2022 | L | Charlotte Checkers 0 at Cleveland Monsters 1 | Final |
| March 27, 2022 | W | Charlotte Checkers 6 at Cleveland Monsters 3 | Final |
| April 1, 2022 | W | Hershey Bears 3 at Charlotte Checkers 5 | Final |
| April 2, 2022 | W | Hershey Bears 1 at Charlotte Checkers 3 | Final |
| April 7, 2022 | W | Hartford Wolf Pack 1 at Charlotte Checkers 4 | Final |
| April 8, 2022 | W | Hartford Wolf Pack 2 at Charlotte Checkers 3 | Final |
| April 10, 2022 | L | Hartford Wolf Pack 4 at Charlotte Checkers 3 | Final (OT) |
| April 13, 2022 | W | Charlotte Checkers 4 at Wilkes-Barre/Scranton Penguins 1 | Final |
| April 15, 2022 | L | Charlotte Checkers 1 at Springfield Thunderbirds 3 | Final |
| April 16, 2022 | L | Charlotte Checkers 1 at Springfield Thunderbirds 2 | Final (SO) |
| April 22, 2022 | W | Charlotte Checkers 2 at Hartford Wolf Pack 1 | Final |
| April 23, 2022 | W | Charlotte Checkers 2 at Providence Bruins 1 | Final |
| May 10, 2022 | W | Charlotte Checkers 3 at Bridgeport Islanders 2 (Playoff Gm. 1) | Final |
| May 12, 2022 | W | Charlotte Checkers 7 at Bridgeport Islanders 6 (Playoff Gm. 2) | Final (OT) |
| May 14, 2022 | L | Bridgeport Islanders 3 at Charlotte Checkers 2 (Playoff Gm. 3) | Final |
| May 16, 2022 | W | Bridgeport Islanders 0 at Charlotte Checkers 4 (Playoff Gm. 4) | Final |
| May 22, 2022 | L | Charlotte Checkers 0 at Springfield Thunderbirds 6 (Playoff Gm. 1) | Final |
| May 25, 2022 | L | Charlotte Checkers 3 at Springfield Thunderbirds 4 (Playoff Gm. 2) | Final |
| May 28, 2022 | | Springfield Thunderbirds at Charlotte Checkers (Playoff Gm. 3) | 6:00 p.m. |
| May 29, 2022 | | Springfield Thunderbirds at Charlotte Checkers (Playoff Gm. 4, if nec.) | 6:00 p.m. |
| May 31, 2022 | | Springfield Thunderbirds at Charlotte Checkers (Playoff Gm. 5, if nec.) | 7:00 p.m. |
Charlotte Checkers Schedule
