| | | |
| March 8, 2025 | T | Pittsburgh Riverhounds SC 1 at North Carolina FC 1 | Final |
| March 15, 2025 | L | Pittsburgh Riverhounds SC 0 at San Antonio FC 2 | Final |
| March 22, 2025 | W | Hartford Athletic 0 at Pittsburgh Riverhounds SC 1 | Final |
| March 29, 2025 | W | Birmingham Legion FC 0 at Pittsburgh Riverhounds SC 2 | Final |
| April 12, 2025 | L | Pittsburgh Riverhounds SC 1 at Charleston Battery 2 | Final |
| April 19, 2025 | L | Pittsburgh Riverhounds SC 1 at Loudoun United FC 2 | Final |
| April 26, 2025 | L | Pittsburgh Riverhounds SC 0 at Detroit City FC 1 (Jagermeister Cup) | Final |
| May 3, 2025 | L | North Carolina FC 2 at Pittsburgh Riverhounds SC 0 | Final |
| May 10, 2025 | T | Pittsburgh Riverhounds SC 0 at Louisville City FC 0 | Final |
| May 17, 2025 | L | Pittsburgh Riverhounds SC 0 at Colorado Springs Switchbacks FC 1 | Final |
| May 24, 2025 | W | Pittsburgh Riverhounds SC 1 at Rhode Island FC 0 | Final |
| May 31, 2025 | L | Rhode Island FC 1 at Pittsburgh Riverhounds SC 0 | Final |
| June 7, 2025 | W | Detroit City FC 0 at Pittsburgh Riverhounds SC 2 | Final |
| June 14, 2025 | L | Pittsburgh Riverhounds SC 0 at Indy Eleven 1 | Final |
| June 21, 2025 | | Tampa Bay Rowdies at Pittsburgh Riverhounds SC | 7:00 p.m. |
| June 28, 2025 | | Westchester SC at Pittsburgh Riverhounds SC | 7:00 p.m. |
| July 4, 2025 | | New Mexico United at Pittsburgh Riverhounds SC | 7:00 p.m. |
| July 13, 2025 | | Loudoun United FC at Pittsburgh Riverhounds SC | 5:00 p.m. |
| July 19, 2025 | | Pittsburgh Riverhounds SC at Detroit City FC | 7:00 p.m. |
| July 25, 2025 | | Pittsburgh Riverhounds SC at Portland Hearts of Pine | 6:30 p.m. |
| July 29, 2025 | | Miami FC at Pittsburgh Riverhounds SC | 7:00 p.m. |
| August 2, 2025 | | Rhode Island FC at Pittsburgh Riverhounds SC | 7:00 p.m. |
| August 9, 2025 | | Orange County SC at Pittsburgh Riverhounds SC | 7:00 p.m. |
| August 16, 2025 | | Charleston Battery at Pittsburgh Riverhounds SC | 7:00 p.m. |
| August 23, 2025 | | Pittsburgh Riverhounds SC at Birmingham Legion FC | 8:00 p.m. |
| August 30, 2025 | | Pittsburgh Riverhounds SC at Tampa Bay Rowdies | 7:30 p.m. |
| September 7, 2025 | | Pittsburgh Riverhounds SC at Oakland Roots | 4:00 p.m. |
| September 13, 2025 | | Louisville City FC at Pittsburgh Riverhounds SC | 7:00 p.m. |
| September 20, 2025 | | Pittsburgh Riverhounds SC at Hartford Athletic | 7:00 p.m. |
| September 27, 2025 | | Las Vegas Lights FC at Pittsburgh Riverhounds SC | 7:00 p.m. |
| October 4, 2025 | | Pittsburgh Riverhounds SC at Miami FC | 7:00 p.m. |
| October 11, 2025 | | Indy Eleven at Pittsburgh Riverhounds SC | 7:00 p.m. |
| October 18, 2025 | | Pittsburgh Riverhounds SC at Monterey Bay FC | 10:00 p.m. |
| October 25, 2025 | | Phoenix Rising FC at Pittsburgh Riverhounds SC | 7:00 p.m. |
Pittsburgh Riverhounds SC Schedule
