| | | |
| March 8, 2025 | W | Loudoun United FC 3 at Birmingham Legion FC 1 | Final |
| March 15, 2025 | W | Loudoun United FC 2 at North Carolina FC 1 | Final |
| March 22, 2025 | L | Loudoun United FC 0 at Louisville City FC 2 | Final |
| March 29, 2025 | W | Rhode Island FC 0 at Loudoun United FC 2 | Final |
| April 5, 2025 | W | Hartford Athletic 0 at Loudoun United FC 2 | Final |
| April 12, 2025 | W | Loudoun United FC 2 at Tampa Bay Rowdies 1 | Final |
| April 19, 2025 | W | Pittsburgh Riverhounds SC 1 at Loudoun United FC 2 | Final |
| April 26, 2025 | W | Loudoun United FC 1 at Lexington Sporting Club 0 (Jagermeister Cup) | Final |
| May 3, 2025 | L | Loudoun United FC 0 at Las Vegas Lights FC 1 | Final |
| May 10, 2025 | W | Lexington Sporting Club 1 at Loudoun United FC 5 | Final |
| May 17, 2025 | L | Loudoun United FC 1 at Miami FC 2 | Final |
| May 31, 2025 | W | Louisville City FC 1 at Loudoun United FC 2 | Final |
| June 7, 2025 | T | Charleston Battery 1 at Loudoun United FC 1 | Final |
| June 14, 2025 | W | Detroit City FC 2 at Loudoun United FC 3 | Final |
| June 20, 2025 | L | Loudoun United FC 0 at Hartford Athletic 3 | Final |
| June 25, 2025 | L | Louisville City FC 4 at Loudoun United FC 1 | Final |
| June 28, 2025 | T | Charlotte Independence 1 at Loudoun United FC 1 (Jagermeister Cup) | Final |
| July 3, 2025 | T | Orange County SC 0 at Loudoun United FC 0 | Final |
| July 13, 2025 | T | Loudoun United FC 2 at Pittsburgh Riverhounds SC 2 | Final |
| July 19, 2025 | L | Oakland Roots 2 at Loudoun United FC 0 | Final |
| July 26, 2025 | T | Loudoun United FC 1 at North Carolina FC 1 (Jagermeister Cup) | Final |
| August 1, 2025 | L | Loudoun United FC 2 at FC Tulsa 3 | Final |
| August 9, 2025 | | Loudoun United FC at Rhode Island FC | 7:00 p.m. |
| August 16, 2025 | | Indy Eleven at Loudoun United FC | 7:00 p.m. |
| August 23, 2025 | | Loudoun United FC at Charleston Battery | 7:30 p.m. |
| August 30, 2025 | | Miami FC at Loudoun United FC | 7:00 p.m. |
| September 6, 2025 | | Loudoun United FC at El Paso Locomotive FC | 9:00 p.m. |
| September 13, 2025 | | San Antonio FC at Loudoun United FC | 6:00 p.m. |
| September 20, 2025 | | Loudoun United FC at Phoenix Rising FC | 10:00 p.m. |
| September 28, 2025 | | Tampa Bay Rowdies at Loudoun United FC | 5:00 p.m. |
| October 4, 2025 | | Birmingham Legion FC at Loudoun United FC | 5:00 p.m. |
| October 11, 2025 | | Loudoun United FC at Detroit City FC | 4:00 p.m. |
| October 18, 2025 | | Loudoun United FC at Indy Eleven | 7:00 p.m. |
| October 25, 2025 | | North Carolina FC at Loudoun United FC | 5:00 p.m. |
Loudoun United FC Schedule
