| | | |
| February 22, 2025 | T | New York City FC 2 at Inter Miami CF 2 | Final |
| March 1, 2025 | L | New York City FC 0 at Los Angeles FC 1 | Final |
| March 8, 2025 | W | Orlando City SC 1 at New York City FC 2 | Final |
| March 15, 2025 | W | New England Revolution 1 at New York City FC 2 | Final |
| March 22, 2025 | T | New York City FC 0 at Columbus Crew SC 0 | Final |
| March 29, 2025 | L | New York City FC 3 at Atlanta United FC 4 | Final |
| April 6, 2025 | L | Minnesota United FC 2 at New York City FC 1 | Final |
| April 12, 2025 | W | Philadelphia Union 0 at New York City FC 1 | Final |
| April 19, 2025 | L | New York City FC 0 at New England Revolution 2 | Final |
| April 26, 2025 | W | New York City FC 1 at Toronto FC 0 | Final |
| May 4, 2025 | W | FC Cincinnati 0 at New York City FC 1 | Final |
| May 10, 2025 | L | Club de Foot Montreal 1 at New York City FC 0 | Final |
| May 14, 2025 | T | New York City FC 0 at D.C. United 0 | Final |
| May 17, 2025 | W | New York Red Bulls 0 at New York City FC 2 | Final |
| May 25, 2025 | W | Chicago Fire FC 1 at New York City FC 3 | Final |
| May 28, 2025 | L | Houston Dynamo FC 3 at New York City FC 0 | Final |
| May 31, 2025 | T | New York City FC 2 at Nashville SC 2 | Final |
| June 12, 2025 | W | Atlanta United FC 0 at New York City FC 4 | Final |
| June 28, 2025 | L | New York City FC 0 at Club de Foot Montreal 1 | Final |
| July 3, 2025 | W | Toronto FC 1 at New York City FC 3 | Final |
| July 12, 2025 | L | New York City FC 0 at Charlotte FC 2 | Final |
| July 16, 2025 | W | New York City FC 2 at Orlando City SC 1 | Final |
| July 19, 2025 | T | New York City FC 1 at Sporting Kansas City 1 | Final |
| July 25, 2025 | W | New York City FC 4 at FC Dallas 3 | Final |
| August 17, 2025 | W | Nashville SC 1 at New York City FC 2 | Final |
| August 23, 2025 | W | New York City FC 1 at FC Cincinnati 0 | Final |
| August 30, 2025 | L | D.C. United 2 at New York City FC 1 | Final |
| September 13, 2025 | W | New York City FC 3 at Chicago Fire FC 1 | Final |
| September 17, 2025 | W | Columbus Crew SC 2 at New York City FC 3 | Final |
| September 20, 2025 | W | Charlotte FC 0 at New York City FC 2 | Final |
| September 24, 2025 | L | Inter Miami CF 4 at New York City FC 0 | Final |
| September 27, 2025 | | New York City FC at New York Red Bulls | 7:30 p.m. |
| October 4, 2025 | | New York City FC at Philadelphia Union | 7:30 p.m. |
| October 18, 2025 | | Seattle Sounders FC at New York City FC | 6:00 p.m. |
New York City FC Schedule
