| | | |
| February 21, 2026 | L | Chicago Fire FC 1 at Houston Dynamo FC 2 | Final |
| February 28, 2026 | W | Club de Foot Montreal 0 at Chicago Fire FC 3 | Final |
| March 7, 2026 | T | Chicago Fire FC 0 at Columbus Crew SC 0 | Final |
| March 14, 2026 | L | D.C. United 2 at Chicago Fire FC 1 | Final |
| March 21, 2026 | W | Chicago Fire FC 2 at Philadelphia Union 1 | Final |
| April 4, 2026 | | Nashville SC at Chicago Fire FC | 7:30 p.m. |
| April 11, 2026 | | Atlanta United FC at Chicago Fire FC | 7:30 p.m. |
| April 18, 2026 | | Chicago Fire FC at FC Cincinnati | 6:30 p.m. |
| April 25, 2026 | | Sporting Kansas City at Chicago Fire FC | 7:30 p.m. |
| May 2, 2026 | | FC Cincinnati at Chicago Fire FC | 7:30 p.m. |
| May 9, 2026 | | Red Bull New York at Chicago Fire FC | 1:30 p.m. |
| May 13, 2026 | | Chicago Fire FC at D.C. United | 6:30 p.m. |
| May 16, 2026 | | Chicago Fire FC at Club de Foot Montreal | 3:30 p.m. |
| May 23, 2026 | | Toronto FC at Chicago Fire FC | 7:30 p.m. |
| July 16, 2026 | | Vancouver Whitecaps FC at Chicago Fire FC | 7:30 p.m. |
| July 22, 2026 | | Chicago Fire FC at Inter Miami CF | 6:30 p.m. |
| July 25, 2026 | | Chicago Fire FC at New York City FC | 6:30 p.m. |
| August 1, 2026 | | Charlotte FC at Chicago Fire FC | 7:30 p.m. |
| August 16, 2026 | | Portland Timbers at Chicago Fire FC | 5:30 p.m. |
| August 19, 2026 | | Chicago Fire FC at Orlando City SC | 6:30 p.m. |
| August 22, 2026 | | Chicago Fire FC at Red Bull New York | 6:30 p.m. |
| August 29, 2026 | | Chicago Fire FC at Seattle Sounders FC | 3:30 p.m. |
| September 5, 2026 | | Chicago Fire FC at Toronto FC | 6:30 p.m. |
| September 9, 2026 | | Inter Miami CF at Chicago Fire FC | 7:30 p.m. |
| September 13, 2026 | | New England Revolution at Chicago Fire FC | 5:30 p.m. |
| September 19, 2026 | | Chicago Fire FC at Nashville SC | 8:30 p.m. |
| September 26, 2026 | | Chicago Fire FC at Charlotte FC | 6:30 p.m. |
| October 10, 2026 | | New York City FC at Chicago Fire FC | 1:30 p.m. |
| October 14, 2026 | | Philadelphia Union at Chicago Fire FC | 7:30 p.m. |
| October 17, 2026 | | Chicago Fire FC at New England Revolution | 6:30 p.m. |
| October 24, 2026 | | Chicago Fire FC at Atlanta United FC | 6:30 p.m. |
| October 28, 2026 | | Orlando City SC at Chicago Fire FC | 7:30 p.m. |
| October 31, 2026 | | Chicago Fire FC at Colorado Rapids | 8:30 p.m. |
| November 7, 2026 | | Columbus Crew SC at Chicago Fire FC | 4:00 p.m. |
Chicago Fire FC Schedule
