| | | |
| February 21, 2026 | L | Columbus Crew SC 2 at Portland Timbers 3 | Final |
| February 28, 2026 | T | Columbus Crew SC 2 at Sporting Kansas City 2 | Final |
| March 7, 2026 | | Chicago Fire FC at Columbus Crew SC | 7:30 p.m. |
| March 14, 2026 | | Nashville SC at Columbus Crew SC | 5:00 p.m. |
| March 21, 2026 | | Columbus Crew SC at Toronto FC | 12:00 p.m. |
| April 4, 2026 | | Columbus Crew SC at Atlanta United FC | 6:30 p.m. |
| April 12, 2026 | | Orlando City SC at Columbus Crew SC | 6:00 p.m. |
| April 18, 2026 | | Columbus Crew SC at New England Revolution | 6:30 p.m. |
| April 22, 2026 | | LA Galaxy at Columbus Crew SC | 6:30 p.m. |
| April 25, 2026 | | Philadelphia Union at Columbus Crew SC | 6:30 p.m. |
| May 2, 2026 | | Minnesota United FC at Columbus Crew SC | 6:30 p.m. |
| May 10, 2026 | | Columbus Crew SC at New York City FC | 3:30 p.m. |
| May 13, 2026 | | Columbus Crew SC at Red Bull New York | 6:30 p.m. |
| May 16, 2026 | | Columbus Crew SC at Philadelphia Union | 6:30 p.m. |
| May 24, 2026 | | Atlanta United FC at Columbus Crew SC | 4:00 p.m. |
| July 22, 2026 | | New York City FC at Columbus Crew SC | 6:30 p.m. |
| July 25, 2026 | | FC Cincinnati at Columbus Crew SC | 6:00 p.m. |
| August 1, 2026 | | Columbus Crew SC at Inter Miami CF | 6:30 p.m. |
| August 15, 2026 | | Columbus Crew SC at Charlotte FC | 6:30 p.m. |
| August 19, 2026 | | Club de Foot Montreal at Columbus Crew SC | 6:30 p.m. |
| August 22, 2026 | | Columbus Crew SC at Nashville SC | 7:30 p.m. |
| August 29, 2026 | | New England Revolution at Columbus Crew SC | 6:30 p.m. |
| September 5, 2026 | | Colorado Rapids at Columbus Crew SC | 6:30 p.m. |
| September 9, 2026 | | Columbus Crew SC at D.C. United | 6:30 p.m. |
| September 12, 2026 | | Red Bull New York at Columbus Crew SC | 6:30 p.m. |
| September 19, 2026 | | Columbus Crew SC at Club de Foot Montreal | 6:30 p.m. |
| September 27, 2026 | | Inter Miami CF at Columbus Crew SC | 6:00 p.m. |
| October 10, 2026 | | Columbus Crew SC at Orlando City SC | 6:30 p.m. |
| October 14, 2026 | | Charlotte FC at Columbus Crew SC | 6:30 p.m. |
| October 18, 2026 | | Columbus Crew SC at FC Cincinnati | 6:00 p.m. |
| October 24, 2026 | | Toronto FC at Columbus Crew SC | 1:30 p.m. |
| October 28, 2026 | | Columbus Crew SC at FC Dallas | 7:30 p.m. |
| October 31, 2026 | | D.C. United at Columbus Crew SC | 1:00 p.m. |
| November 7, 2026 | | Columbus Crew SC at Chicago Fire FC | 4:00 p.m. |
Columbus Crew SC Schedule
