| | | |
| May 27, 2021 | W | Southern Illinois Miners 8 at Lake Erie Crushers 5 | Final |
| May 28, 2021 | | Southern Illinois Miners at Lake Erie Crushers | Ppd. |
| May 29, 2021 | L | Southern Illinois Miners 4 at Florence Y'alls 5 | Final |
| May 30, 2021 | L | Southern Illinois Miners 3 at Florence Y'alls 4 | Final |
| May 31, 2021 | L | Southern Illinois Miners 4 at Florence Y'alls 5 | Final |
| June 1, 2021 | | Team Quebec at Southern Illinois Miners | Ppd. |
| June 2, 2021 | T | Team Quebec 5 at Southern Illinois Miners 5 | Final |
| June 3, 2021 | W | Team Quebec 3 at Southern Illinois Miners 4 (Game 1) | Final |
| June 3, 2021 | L | Team Quebec 4 at Southern Illinois Miners 3 (Game 2) | Final |
| June 4, 2021 | T | Lake Erie Crushers 6 at Southern Illinois Miners 6 (SI 4-2 HR Derby) | Final |
| June 5, 2021 | L | Lake Erie Crushers 5 at Southern Illinois Miners 4 | Final |
| June 6, 2021 | L | Lake Erie Crushers 8 at Southern Illinois Miners 7 | Final |
| June 8, 2021 | W | Southern Illinois Miners 3 at Windy City ThunderBolts 2 | Final |
| June 9, 2021 | L | Southern Illinois Miners 3 at Windy City ThunderBolts 5 | Final |
| June 10, 2021 | W | Southern Illinois Miners 4 at Windy City ThunderBolts 0 | Final |
| June 11, 2021 | L | Florence Y'alls 3 at Southern Illinois Miners 2 | Final |
| June 12, 2021 | L | Florence Y'alls 6 at Southern Illinois Miners 1 | Final |
| June 13, 2021 | W | Florence Y'alls 3 at Southern Illinois Miners 4 | Final |
| June 15, 2021 | L | Southern Illinois Miners 0 at Lake Erie Crushers 1 (Game 1) | Final |
| June 15, 2021 | W | Southern Illinois Miners 2 at Lake Erie Crushers 0 (Game 2) | Final |
| June 16, 2021 | W | Southern Illinois Miners 6 at Lake Erie Crushers 1 | Final |
| June 17, 2021 | L | Southern Illinois Miners 1 at Lake Erie Crushers 8 | Final |
| June 18, 2021 | L | Southern Illinois Miners 0 at Schaumburg Boomers 12 | Final |
| June 19, 2021 | W | Southern Illinois Miners 6 at Schaumburg Boomers 0 | Final |
| June 20, 2021 | W | Southern Illinois Miners 13 at Schaumburg Boomers 11 | Final |
| June 23, 2021 | T | Gateway Grizzlies 6 at Southern Illinois Miners 6 (Game 1) | Final |
| June 23, 2021 | W | Gateway Grizzlies 0 at Southern Illinois Miners 3 (Game 2) | Final |
| June 24, 2021 | W | Gateway Grizzlies 3 at Southern Illinois Miners 7 | Final |
| June 25, 2021 | L | Evansville Otters 14 at Southern Illinois Miners 4 | Final |
| June 26, 2021 | W | Evansville Otters 2 at Southern Illinois Miners 3 | Final |
| June 27, 2021 | L | Evansville Otters 6 at Southern Illinois Miners 5 | Final |
| June 28, 2021 | | Southern Illinois Miners at Gateway Grizzlies | Ppd. |
| June 29, 2021 | W | Southern Illinois Miners 8 at Gateway Grizzlies 0 (Game 1) | Final |
| June 29, 2021 | W | Southern Illinois Miners 9 at Gateway Grizzlies 1 (Game 2) | Final |
| June 30, 2021 | | Southern Illinois Miners at Gateway Grizzlies | Ppd. |
| July 1, 2021 | L | Southern Illinois Miners 1 at Gateway Grizzlies 5 (Game 1) | Final |
| July 1, 2021 | L | Southern Illinois Miners 2 at Gateway Grizzlies 5 (Game 2) | Final |
| July 2, 2021 | L | Southern Illinois Miners 0 at Schaumburg Boomers 4 | Final |
| July 3, 2021 | W | Southern Illinois Miners 3 at Schaumburg Boomers 2 | Final |
| July 4, 2021 | W | Southern Illinois Miners 9 at Schaumburg Boomers 2 | Final |
| July 6, 2021 | L | Gateway Grizzlies 3 at Southern Illinois Miners 2 | Final |
| July 7, 2021 | W | Gateway Grizzlies 3 at Southern Illinois Miners 14 | Final |
| July 8, 2021 | W | Gateway Grizzlies 1 at Southern Illinois Miners 7 | Final |
| July 9, 2021 | W | Joliet Slammers 2 at Southern Illinois Miners 3 | Final |
| July 10, 2021 | | Joliet Slammers at Southern Illinois Miners | Ppd. |
| July 11, 2021 | W | Joliet Slammers 1 at Southern Illinois Miners 6 (Game 1) | Final |
| July 11, 2021 | T | Joliet Slammers 3 at Southern Illinois Miners 3 (Game 2) | Final |
| July 13, 2021 | W | Southern Illinois Miners 5 at Windy City ThunderBolts 3 | Final |
| July 14, 2021 | L | Southern Illinois Miners 2 at Windy City ThunderBolts 9 | Final |
| July 15, 2021 | L | Southern Illinois Miners 3 at Windy City ThunderBolts 6 | Final |
| July 16, 2021 | | Southern Illinois Miners at Evansville Otters | Ppd. |
| July 17, 2021 | W | Southern Illinois Miners 4 at Evansville Otters 0 (Game 1) | Final |
| July 17, 2021 | L | Southern Illinois Miners 2 at Evansville Otters 4 (Game 2) | Final |
| July 18, 2021 | | Southern Illinois Miners at Evansville Otters | Ppd. |
| July 20, 2021 | W | Florence Y'alls 1 at Southern Illinois Miners 5 | Final |
| July 21, 2021 | W | Florence Y'alls 0 at Southern Illinois Miners 8 | Final |
| July 22, 2021 | L | Florence Y'alls 3 at Southern Illinois Miners 2 | Final |
| July 23, 2021 | L | Windy City ThunderBolts 4 at Southern Illinois Miners 0 | Final |
| July 24, 2021 | W | Windy City ThunderBolts 2 at Southern Illinois Miners 4 | Final |
| July 25, 2021 | W | Windy City ThunderBolts 2 at Southern Illinois Miners 8 | Final |
| July 28, 2021 | W | Schaumburg Boomers 4 at Southern Illinois Miners 6 (Game 1) | Final |
| July 28, 2021 | L | Schaumburg Boomers 2 at Southern Illinois Miners 0 (Game 2) | Final |
| July 29, 2021 | W | Schaumburg Boomers 2 at Southern Illinois Miners 8 | Final |
| July 30, 2021 | L | Southern Illinois Miners 3 at Evansville Otters 4 | Final |
| July 31, 2021 | T | Southern Illinois Miners 3 at Evansville Otters 3 (Game 1) | Final |
| July 31, 2021 | L | Southern Illinois Miners 1 at Evansville Otters 2 (Game 2) | Final |
| August 1, 2021 | L | Southern Illinois Miners 1 at Evansville Otters 8 | Final |
| August 3, 2021 | L | Southern Illinois Miners 4 at Gateway Grizzlies 7 | Final |
| August 4, 2021 | W | Southern Illinois Miners 12 at Gateway Grizzlies 0 | Final |
| August 5, 2021 | W | Southern Illinois Miners 10 at Gateway Grizzlies 5 | Final |
| August 6, 2021 | L | Joliet Slammers 14 at Southern Illinois Miners 11 | Final |
| August 7, 2021 | W | Joliet Slammers 3 at Southern Illinois Miners 8 | Final |
| August 8, 2021 | W | Joliet Slammers 2 at Southern Illinois Miners 6 | Final |
| August 10, 2021 | W | Southern Illinois Miners 6 at Evansville Otters 3 | Final |
| August 11, 2021 | L | Southern Illinois Miners 8 at Evansville Otters 9 | Final |
| August 12, 2021 | W | Southern Illinois Miners 6 at Evansville Otters 4 | Final |
| August 13, 2021 | W | Southern Illinois Miners 12 at Joliet Slammers 3 | Final |
| August 14, 2021 | L | Southern Illinois Miners 1 at Joliet Slammers 4 | Final |
| August 15, 2021 | T | Southern Illinois Miners 1 at Joliet Slammers 1 | Final |
| August 17, 2021 | W | Evansville Otters 0 at Southern Illinois Miners 2 | Final |
| August 18, 2021 | W | Evansville Otters 0 at Southern Illinois Miners 3 | Final |
| August 19, 2021 | W | Evansville Otters 0 at Southern Illinois Miners 4 | Final |
| August 20, 2021 | W | Schaumburg Boomers 4 at Southern Illinois Miners 6 | Final |
| August 21, 2021 | W | Schaumburg Boomers 3 at Southern Illinois Miners 5 | Final |
| August 22, 2021 | W | Schaumburg Boomers 2 at Southern Illinois Miners 5 | Final |
| August 24, 2021 | W | Southern Illinois Miners 10 at Lake Erie Crushers 7 | Final |
| August 25, 2021 | | Southern Illinois Miners at Lake Erie Crushers | Ppd. |
| August 26, 2021 | W | Southern Illinois Miners 2 at Lake Erie Crushers 0 (Game 1) | Final |
| August 26, 2021 | L | Southern Illinois Miners 1 at Lake Erie Crushers 2 (Game 2) | Final |
| August 27, 2021 | L | Southern Illinois Miners 5 at Florence Y'alls 13 | Final |
| August 28, 2021 | L | Southern Illinois Miners 4 at Florence Y'alls 5 | Final |
| August 29, 2021 | W | Southern Illinois Miners 11 at Florence Y'alls 5 | Final |
| August 31, 2021 | W | Evansville Otters 0 at Southern Illinois Miners 7 | Final |
| September 1, 2021 | L | Evansville Otters 6 at Southern Illinois Miners 4 | Final |
| September 2, 2021 | L | Evansville Otters 6 at Southern Illinois Miners 3 | Final |
| September 3, 2021 | W | Southern Illinois Miners 8 at Gateway Grizzlies 3 | Final |
| September 4, 2021 | | Southern Illinois Miners at Gateway Grizzlies | Ppd. |
| September 5, 2021 | W | Southern Illinois Miners 10 at Gateway Grizzlies 8 (Game 1) | Final |
| September 5, 2021 | T | Southern Illinois Miners 7 at Gateway Grizzlies 7 (Game 2) | Final |
| September 7, 2021 | L | Florence Y'alls 8 at Southern Illinois Miners 5 | Final |
| September 8, 2021 | L | Florence Y'alls 5 at Southern Illinois Miners 4 | Final |
| September 9, 2021 | L | Florence Y'alls 9 at Southern Illinois Miners 0 | Final |
| September 10, 2021 | W | Gateway Grizzlies 4 at Southern Illinois Miners 8 | Final |
| September 11, 2021 | W | Gateway Grizzlies 11 at Southern Illinois Miners 13 | Final |
| September 12, 2021 | W | Gateway Grizzlies 3 at Southern Illinois Miners 7 | Final |
Southern Illinois Miners Schedule
