| | | |
| May 24, 2025 | L | Saskatchewan Roughriders 9 at Winnipeg Blue Bombers 15 (Preseason) | Final |
| May 30, 2025 | L | Winnipeg Blue Bombers 27 at Saskatchewan Roughriders 20 (Preseason) | Final |
| June 5, 2025 | W | Ottawa RedBlacks 26 at Saskatchewan Roughriders 31 | Final |
| June 14, 2025 | W | Saskatchewan Roughriders 28 at Hamilton Tiger-Cats 23 | Final |
| June 20, 2025 | W | Saskatchewan Roughriders 39 at Toronto Argonauts 32 | Final |
| June 28, 2025 | W | B.C. Lions 18 at Saskatchewan Roughriders 37 | Final |
| July 12, 2025 | L | Calgary Stampeders 24 at Saskatchewan Roughriders 10 | Final |
| July 19, 2025 | W | Saskatchewan Roughriders 33 at B.C. Lions 27 | Final |
| July 25, 2025 | W | Edmonton Elks 18 at Saskatchewan Roughriders 21 | Final |
| August 2, 2025 | W | Saskatchewan Roughriders 34 at Montreal Alouettes 6 | Final |
| August 16, 2025 | W | Hamilton Tiger-Cats 9 at Saskatchewan Roughriders 29 | Final |
| August 23, 2025 | | Saskatchewan Roughriders at Calgary Stampeders | 7:00 p.m. |
| August 31, 2025 | | Winnipeg Blue Bombers at Saskatchewan Roughriders | 7:00 p.m. |
| September 6, 2025 | | Saskatchewan Roughriders at Winnipeg Blue Bombers | 4:00 p.m. |
| September 13, 2025 | | Montreal Alouettes at Saskatchewan Roughriders | 7:00 p.m. |
| September 27, 2025 | | Saskatchewan Roughriders at Edmonton Elks | 7:00 p.m. |
| October 3, 2025 | | Saskatchewan Roughriders at Ottawa RedBlacks | 7:30 p.m. |
| October 10, 2025 | | Toronto Argonauts at Saskatchewan Roughriders | 9:00 p.m. |
| October 17, 2025 | | Saskatchewan Roughriders at Winnipeg Blue Bombers | 8:00 p.m. |
| October 25, 2025 | | B.C. Lions at Saskatchewan Roughriders | 7:00 p.m. |
Saskatchewan Roughriders Schedule
