| | | |
| May 31, 2022 | L | Winnipeg Blue Bombers 25 at Saskatchewan Roughriders 16 (Preseason) | Final |
| June 3, 2022 | L | Saskatchewan Roughriders 18 at B.C. Lions 20 (Preseason) | Final |
| June 11, 2022 | W | Hamilton Tiger-Cats 13 at Saskatchewan Roughriders 30 | Final |
| June 18, 2022 | W | Saskatchewan Roughriders 26 at Edmonton Elks 16 | Final |
| June 23, 2022 | L | Saskatchewan Roughriders 13 at Montreal Alouettes 37 | Final |
| July 2, 2022 | W | Montreal Alouettes 20 at Saskatchewan Roughriders 41 | Final |
| July 8, 2022 | W | Ottawa RedBlacks 13 at Saskatchewan Roughriders 28 | Final |
| July 16, 2022 | L | Saskatchewan Roughriders 24 at Toronto Argonauts 30 (Wolfville, NS) | Final |
| July 24, 2022 | L | Toronto Argonauts 31 at Saskatchewan Roughriders 21 | Final |
| July 29, 2022 | L | B.C. Lions 32 at Saskatchewan Roughriders 17 | Final |
| August 13, 2022 | W | Saskatchewan Roughriders 34 at Edmonton Elks 23 | Final |
| August 19, 2022 | L | B.C. Lions 28 at Saskatchewan Roughriders 10 | Final |
| August 26, 2022 | W | Saskatchewan Roughriders 23 at B.C. Lions 16 | Final |
| September 4, 2022 | L | Winnipeg Blue Bombers 20 at Saskatchewan Roughriders 18 | Final |
| September 10, 2022 | L | Saskatchewan Roughriders 20 at Winnipeg Blue Bombers 54 | Final |
| September 16, 2022 | L | Edmonton Elks 26 at Saskatchewan Roughriders 24 | Final |
| September 30, 2022 | L | Saskatchewan Roughriders 13 at Winnipeg Blue Bombers 31 | Final |
| October 7, 2022 | L | Saskatchewan Roughriders 14 at Hamilton Tiger-Cats 18 | Final |
| October 22, 2022 | L | Calgary Stampeders 32 at Saskatchewan Roughriders 21 | Final |
| October 29, 2022 | L | Saskatchewan Roughriders 10 at Calgary Stampeders 36 | Final |
Saskatchewan Roughriders Schedule
