| | | |
| October 16, 2021 | L | Lehigh Valley Phantoms 1 at Wilkes-Barre/Scranton Penguins 2 | Final |
| October 17, 2021 | L | Lehigh Valley Phantoms 1 at Hershey Bears 2 | Final |
| October 23, 2021 | L | Hartford Wolf Pack 3 at Lehigh Valley Phantoms 1 | Final |
| October 24, 2021 | L | Wilkes-Barre/Scranton Penguins 2 at Lehigh Valley Phantoms 1 | Final (OT) |
| October 27, 2021 | L | Lehigh Valley Phantoms 2 at Wilkes-Barre/Scranton Penguins 4 | Final |
| October 29, 2021 | L | Lehigh Valley Phantoms 2 at Utica Comets 5 | Final |
| October 30, 2021 | L | Syracuse Crunch 3 at Lehigh Valley Phantoms 2 | Final (OT) |
| November 3, 2021 | W | Wilkes-Barre/Scranton Penguins 0 at Lehigh Valley Phantoms 4 | Final |
| November 6, 2021 | L | Lehigh Valley Phantoms 3 at Charlotte Checkers 7 | Final |
| November 7, 2021 | W | Lehigh Valley Phantoms 5 at Charlotte Checkers 3 | Final |
| November 10, 2021 | W | Lehigh Valley Phantoms 4 at Hershey Bears 1 | Final |
| November 12, 2021 | L | Lehigh Valley Phantoms 3 at Providence Bruins 6 | Final |
| November 13, 2021 | L | Springfield Thunderbirds 2 at Lehigh Valley Phantoms 1 | Final (OT) |
| November 17, 2021 | L | Charlotte Checkers 4 at Lehigh Valley Phantoms 3 | Final |
| November 19, 2021 | L | Lehigh Valley Phantoms 4 at Rochester Americans 5 | Final (SO) |
| November 20, 2021 | L | Lehigh Valley Phantoms 2 at Toronto Marlies 3 | Final (OT) |
| November 26, 2021 | L | Lehigh Valley Phantoms 1 at Syracuse Crunch 4 | Final |
| November 27, 2021 | L | Bridgeport Islanders 4 at Lehigh Valley Phantoms 1 | Final |
| November 28, 2021 | | Lehigh Valley Phantoms at Hershey Bears | Ppd. |
| December 1, 2021 | | Hershey Bears at Lehigh Valley Phantoms | Ppd. |
| December 3, 2021 | L | Charlotte Checkers 5 at Lehigh Valley Phantoms 3 | Final |
| December 4, 2021 | | Hershey Bears at Lehigh Valley Phantoms | Ppd. |
| December 11, 2021 | W | Cleveland Monsters 2 at Lehigh Valley Phantoms 4 | Final |
| December 12, 2021 | W | Hartford Wolf Pack 3 at Lehigh Valley Phantoms 4 | Final (SO) |
| December 15, 2021 | | Belleville Senators at Lehigh Valley Phantoms | Ppd. |
| December 17, 2021 | W | Lehigh Valley Phantoms 3 at Hartford Wolf Pack 1 | Final |
| December 18, 2021 | L | Rochester Americans 4 at Lehigh Valley Phantoms 3 | Final (SO) |
| December 21, 2021 | W | Hershey Bears 1 at Lehigh Valley Phantoms 2 | Final |
| December 22, 2021 | | Lehigh Valley Phantoms at Hershey Bears | Ppd. |
| December 29, 2021 | | Cleveland Monsters at Lehigh Valley Phantoms | Ppd. |
| December 31, 2021 | W | Lehigh Valley Phantoms 6 at Utica Comets 5 | Final (OT) |
| January 1, 2022 | W | Bridgeport Islanders 1 at Lehigh Valley Phantoms 2 | Final (OT) |
| January 5, 2022 | L | Lehigh Valley Phantoms 3 at Hershey Bears 4 | Final (OT) |
| January 6, 2022 | | Belleville Senators at Lehigh Valley Phantoms | Ppd. |
| January 14, 2022 | W | Lehigh Valley Phantoms 4 at Wilkes-Barre/Scranton Penguins 3 | Final |
| January 15, 2022 | L | Wilkes-Barre/Scranton Penguins 5 at Lehigh Valley Phantoms 2 | Final |
| January 16, 2022 | L | Toronto Marlies 4 at Lehigh Valley Phantoms 3 | Final (OT) |
| January 19, 2022 | W | Lehigh Valley Phantoms 3 at Wilkes-Barre/Scranton Penguins 1 | Final |
| January 22, 2022 | L | Lehigh Valley Phantoms 1 at Charlotte Checkers 4 | Final |
| January 23, 2022 | W | Lehigh Valley Phantoms 5 at Charlotte Checkers 2 | Final |
| January 28, 2022 | L | Lehigh Valley Phantoms 2 at Springfield Thunderbirds 6 | Final |
| January 29, 2022 | W | Lehigh Valley Phantoms 4 at Hartford Wolf Pack 0 | Final |
| January 30, 2022 | W | Hershey Bears 2 at Lehigh Valley Phantoms 3 | Final |
| February 2, 2022 | L | Lehigh Valley Phantoms 1 at Bridgeport Islanders 4 | Final |
| February 4, 2022 | W | Providence Bruins 1 at Lehigh Valley Phantoms 5 | Final |
| February 5, 2022 | L | Lehigh Valley Phantoms 4 at Hartford Wolf Pack 6 | Final |
| February 11, 2022 | W | Hershey Bears 3 at Lehigh Valley Phantoms 6 | Final |
| February 12, 2022 | L | Wilkes-Barre/Scranton Penguins 3 at Lehigh Valley Phantoms 2 | Final |
| February 13, 2022 | W | Hershey Bears 2 at Lehigh Valley Phantoms 3 | Final |
| February 19, 2022 | L | Utica Comets 3 at Lehigh Valley Phantoms 2 | Final (SO) |
| February 20, 2022 | L | Springfield Thunderbirds 3 at Lehigh Valley Phantoms 1 | Final |
| February 23, 2022 | W | Lehigh Valley Phantoms 3 at Wilkes-Barre/Scranton Penguins 2 | Final (SO) |
| February 25, 2022 | L | Lehigh Valley Phantoms 1 at Cleveland Monsters 2 | Final (OT) |
| February 26, 2022 | L | Lehigh Valley Phantoms 1 at Cleveland Monsters 2 | Final |
| March 2, 2022 | L | Providence Bruins 5 at Lehigh Valley Phantoms 3 | Final |
| March 4, 2022 | L | Charlotte Checkers 5 at Lehigh Valley Phantoms 2 | Final |
| March 5, 2022 | L | Charlotte Checkers 5 at Lehigh Valley Phantoms 2 | Final |
| March 8, 2022 | L | Lehigh Valley Phantoms 0 at Hershey Bears 4 | Final |
| March 11, 2022 | W | Laval Rocket 3 at Lehigh Valley Phantoms 4 | Final |
| March 12, 2022 | W | Hartford Wolf Pack 5 at Lehigh Valley Phantoms 6 | Final |
| March 13, 2022 | L | Lehigh Valley Phantoms 0 at Hershey Bears 2 | Final |
| March 18, 2022 | W | Lehigh Valley Phantoms 3 at Springfield Thunderbirds 1 | Final |
| March 19, 2022 | W | Lehigh Valley Phantoms 7 at Springfield Thunderbirds 4 | Final |
| March 23, 2022 | L | Lehigh Valley Phantoms 1 at Hershey Bears 5 | Final |
| March 25, 2022 | L | Lehigh Valley Phantoms 1 at Laval Rocket 5 | Final |
| March 26, 2022 | L | Lehigh Valley Phantoms 2 at Belleville Senators 3 | Final (SO) |
| April 1, 2022 | W | Wilkes-Barre/Scranton Penguins 2 at Lehigh Valley Phantoms 4 | Final |
| April 2, 2022 | W | Utica Comets 2 at Lehigh Valley Phantoms 3 | Final |
| April 3, 2022 | W | Lehigh Valley Phantoms 4 at Bridgeport Islanders 3 | Final |
| April 6, 2022 | L | Lehigh Valley Phantoms 1 at Wilkes-Barre/Scranton Penguins 3 | Final |
| April 8, 2022 | W | Hershey Bears 1 at Lehigh Valley Phantoms 4 | Final |
| April 10, 2022 | L | Lehigh Valley Phantoms 2 at Bridgeport Islanders 4 | Final |
| April 11, 2022 | L | Lehigh Valley Phantoms 1 at Providence Bruins 2 | Final |
| April 13, 2022 | W | Hershey Bears 1 at Lehigh Valley Phantoms 2 | Final |
| April 15, 2022 | L | Bridgeport Islanders 2 at Lehigh Valley Phantoms 1 | Final (OT) |
| April 16, 2022 | L | Providence Bruins 3 at Lehigh Valley Phantoms 2 | Final (SO) |
| April 19, 2022 | L | Lehigh Valley Phantoms 4 at Providence Bruins 5 | Final (OT) |
| April 22, 2022 | L | Hershey Bears 4 at Lehigh Valley Phantoms 3 | Final (OT) |
| April 23, 2022 | W | Lehigh Valley Phantoms 2 at Hershey Bears 0 | Final |
| April 26, 2022 | L | Springfield Thunderbirds 5 at Lehigh Valley Phantoms 0 | Final |
| April 27, 2022 | L | Cleveland Monsters 6 at Lehigh Valley Phantoms 1 | Final |
| April 30, 2022 | W | Wilkes-Barre/Scranton Penguins 0 at Lehigh Valley Phantoms 3 | Final |
Lehigh Valley Phantoms Schedule
