| | | |
| March 15, 2025 | W | Indy Eleven 3 at Miami FC 1 | Final |
| March 22, 2025 | T | Indy Eleven 1 at Lexington Sporting Club 1 | Final |
| March 29, 2025 | L | Colorado Springs Switchbacks FC 3 at Indy Eleven 2 | Final |
| April 5, 2025 | T | North Carolina FC 2 at Indy Eleven 2 | Final |
| April 12, 2025 | | Indy Eleven at Hartford Athletic | Ppd. |
| April 19, 2025 | L | Charleston Battery 3 at Indy Eleven 1 | Final |
| April 26, 2025 | W | Indy Eleven 4 at Forward Madison FC 0 (Jagermeister Cup) | Final |
| May 3, 2025 | T | Detroit City FC 2 at Indy Eleven 2 | Final |
| May 10, 2025 | T | Indy Eleven 1 at Sacramento Republic FC 1 | Final |
| May 16, 2025 | L | Indy Eleven 1 at El Paso Locomotive FC 3 | Final |
| May 24, 2025 | W | Indy Eleven 1 at One Knoxville SC 0 (Jagermeister Cup) | Final |
| May 28, 2025 | T | Hartford Athletic 4 at Indy Eleven 4 | Final |
| June 4, 2025 | W | Indy Eleven 1 at Birmingham Legion FC 0 | Final |
| June 14, 2025 | W | Pittsburgh Riverhounds SC 0 at Indy Eleven 1 | Final |
| June 21, 2025 | L | Las Vegas Lights FC 1 at Indy Eleven 0 | Final |
| June 25, 2025 | L | Indy Eleven 1 at Tampa Bay Rowdies 3 | Final |
| June 28, 2025 | T | Birmingham Legion FC 1 at Indy Eleven 1 | Final |
| July 5, 2025 | W | Monterey Bay FC 0 at Indy Eleven 3 | Final |
| July 12, 2025 | W | Rhode Island FC 0 at Indy Eleven 1 | Final |
| July 18, 2025 | L | Indy Eleven 2 at North Carolina FC 4 | Final |
| July 26, 2025 | W | FC Tulsa 1 at Indy Eleven 2 (Jagermeister Cup) | Final |
| August 2, 2025 | L | Tampa Bay Rowdies 3 at Indy Eleven 1 | Final |
| August 9, 2025 | | Indy Eleven at Detroit City FC | 7:00 p.m. |
| August 16, 2025 | | Indy Eleven at Loudoun United FC | 7:00 p.m. |
| August 23, 2025 | | Miami FC at Indy Eleven | 7:00 p.m. |
| August 30, 2025 | | Louisville City FC at Indy Eleven | 7:00 p.m. |
| September 3, 2025 | | Indy Eleven at Hartford Athletic | 7:30 p.m. |
| September 6, 2025 | | Indy Eleven at Charleston Battery | 7:30 p.m. |
| September 13, 2025 | | Indy Eleven at Rhode Island FC | 4:00 p.m. |
| September 21, 2025 | | Birmingham Legion FC at Indy Eleven | 5:00 p.m. |
| September 27, 2025 | | FC Tulsa at Indy Eleven | 7:00 p.m. |
| October 4, 2025 | | Indy Eleven at Louisville City FC | 7:30 p.m. |
| October 11, 2025 | | Indy Eleven at Pittsburgh Riverhounds SC | 7:00 p.m. |
| October 18, 2025 | | Loudoun United FC at Indy Eleven | 7:00 p.m. |
| October 25, 2025 | | Indy Eleven at Orange County SC | 10:00 p.m. |
Indy Eleven Schedule
