| | | |
| May 24, 2025 | W | Toronto Argonauts 16 at Hamilton Tiger-Cats 24 (Preseason) | Final |
| May 30, 2025 | L | Hamilton Tiger-Cats 23 at Toronto Argonauts 30 (Preseason) | Final |
| June 7, 2025 | L | Hamilton Tiger-Cats 26 at Calgary Stampeders 38 | Final |
| June 14, 2025 | L | Saskatchewan Roughriders 28 at Hamilton Tiger-Cats 23 | Final |
| June 27, 2025 | W | Montreal Alouettes 17 at Hamilton Tiger-Cats 35 | Final |
| July 4, 2025 | W | Hamilton Tiger-Cats 51 at Toronto Argonauts 38 | Final |
| July 12, 2025 | W | Ottawa RedBlacks 20 at Hamilton Tiger-Cats 23 | Final |
| July 20, 2025 | W | Hamilton Tiger-Cats 30 at Ottawa RedBlacks 15 | Final |
| July 27, 2025 | W | Hamilton Tiger-Cats 37 at B.C. Lions 33 | Final |
| August 2, 2025 | W | Hamilton Tiger-Cats 28 at Edmonton Elks 24 | Final |
| August 7, 2025 | L | B.C. Lions 41 at Hamilton Tiger-Cats 38 | Final |
| August 16, 2025 | L | Hamilton Tiger-Cats 9 at Saskatchewan Roughriders 29 | Final |
| September 1, 2025 | | Toronto Argonauts at Hamilton Tiger-Cats | 2:30 p.m. |
| September 6, 2025 | | Hamilton Tiger-Cats at Montreal Alouettes | 1:00 p.m. |
| September 12, 2025 | | Winnipeg Blue Bombers at Hamilton Tiger-Cats | 7:00 p.m. |
| September 20, 2025 | | Edmonton Elks at Hamilton Tiger-Cats | 7:00 p.m. |
| September 27, 2025 | | Hamilton Tiger-Cats at Winnipeg Blue Bombers | 3:00 p.m. |
| October 4, 2025 | | Hamilton Tiger-Cats at Toronto Argonauts | 3:00 p.m. |
| October 11, 2025 | | Calgary Stampeders at Hamilton Tiger-Cats | 3:00 p.m. |
| October 24, 2025 | | Ottawa RedBlacks at Hamilton Tiger-Cats | 7:00 p.m. |
Hamilton Tiger-Cats Schedule
