| | | |
| May 24, 2025 | W | Toronto Argonauts 16 at Hamilton Tiger-Cats 24 (Preseason) | Final |
| May 30, 2025 | L | Hamilton Tiger-Cats 23 at Toronto Argonauts 30 (Preseason) | Final |
| June 7, 2025 | L | Hamilton Tiger-Cats 26 at Calgary Stampeders 38 | Final |
| June 14, 2025 | L | Saskatchewan Roughriders 28 at Hamilton Tiger-Cats 23 | Final |
| June 27, 2025 | W | Montreal Alouettes 17 at Hamilton Tiger-Cats 35 | Final |
| July 4, 2025 | W | Hamilton Tiger-Cats 51 at Toronto Argonauts 38 | Final |
| July 12, 2025 | W | Ottawa RedBlacks 20 at Hamilton Tiger-Cats 23 | Final |
| July 20, 2025 | W | Hamilton Tiger-Cats 30 at Ottawa RedBlacks 15 | Final |
| July 27, 2025 | W | Hamilton Tiger-Cats 37 at B.C. Lions 33 | Final |
| August 2, 2025 | W | Hamilton Tiger-Cats 28 at Edmonton Elks 24 | Final |
| August 7, 2025 | L | B.C. Lions 41 at Hamilton Tiger-Cats 38 | Final |
| August 16, 2025 | L | Hamilton Tiger-Cats 9 at Saskatchewan Roughriders 29 | Final |
| September 1, 2025 | L | Toronto Argonauts 35 at Hamilton Tiger-Cats 33 | Final |
| September 6, 2025 | W | Hamilton Tiger-Cats 26 at Montreal Alouettes 9 | Final |
| September 12, 2025 | W | Winnipeg Blue Bombers 21 at Hamilton Tiger-Cats 32 | Final |
| September 20, 2025 | W | Edmonton Elks 27 at Hamilton Tiger-Cats 29 | Final |
| September 27, 2025 | L | Hamilton Tiger-Cats 3 at Winnipeg Blue Bombers 40 | Final |
| October 4, 2025 | W | Hamilton Tiger-Cats 47 at Toronto Argonauts 29 | Final |
| October 11, 2025 | L | Calgary Stampeders 37 at Hamilton Tiger-Cats 20 | Final |
| October 24, 2025 | W | Ottawa RedBlacks 15 at Hamilton Tiger-Cats 35 | Final |
| November 8, 2025 | | Montreal Alouettes at Hamilton Tiger-Cats (Playoff) | 3:00 p.m. |
Hamilton Tiger-Cats Schedule
