| | | |
| May 24, 2025 | L | Saskatchewan Roughriders 9 at Winnipeg Blue Bombers 15 (Preseason) | Final |
| May 30, 2025 | L | Winnipeg Blue Bombers 27 at Saskatchewan Roughriders 20 (Preseason) | Final |
| June 5, 2025 | W | Ottawa RedBlacks 26 at Saskatchewan Roughriders 31 | Final |
| June 14, 2025 | W | Saskatchewan Roughriders 28 at Hamilton Tiger-Cats 23 | Final |
| June 20, 2025 | W | Saskatchewan Roughriders 39 at Toronto Argonauts 32 | Final |
| June 28, 2025 | W | B.C. Lions 18 at Saskatchewan Roughriders 37 | Final |
| July 12, 2025 | L | Calgary Stampeders 24 at Saskatchewan Roughriders 10 | Final |
| July 19, 2025 | W | Saskatchewan Roughriders 33 at B.C. Lions 27 | Final |
| July 25, 2025 | W | Edmonton Elks 18 at Saskatchewan Roughriders 21 | Final |
| August 2, 2025 | W | Saskatchewan Roughriders 34 at Montreal Alouettes 6 | Final |
| August 16, 2025 | W | Hamilton Tiger-Cats 9 at Saskatchewan Roughriders 29 | Final |
| August 23, 2025 | L | Saskatchewan Roughriders 15 at Calgary Stampeders 32 | Final |
| August 31, 2025 | W | Winnipeg Blue Bombers 30 at Saskatchewan Roughriders 34 | Final |
| September 6, 2025 | W | Saskatchewan Roughriders 21 at Winnipeg Blue Bombers 13 | Final |
| September 13, 2025 | L | Montreal Alouettes 48 at Saskatchewan Roughriders 31 | Final |
| September 27, 2025 | L | Saskatchewan Roughriders 25 at Edmonton Elks 27 | Final |
| October 3, 2025 | W | Saskatchewan Roughriders 20 at Ottawa RedBlacks 13 | Final |
| October 10, 2025 | W | Toronto Argonauts 19 at Saskatchewan Roughriders 27 | Final |
| October 17, 2025 | L | Saskatchewan Roughriders 16 at Winnipeg Blue Bombers 17 | Final |
| October 25, 2025 | L | B.C. Lions 27 at Saskatchewan Roughriders 21 | Final |
| November 8, 2025 | W | B.C. Lions 21 at Saskatchewan Roughriders 24 (Playoff) | Final |
| November 16, 2025 | W | Saskatchewan Roughriders 25 at Montreal Alouettes 17 (Championship; Winnipeg, MB) | Final |
Saskatchewan Roughriders Schedule
