| | | |
| October 13, 2012 | L | Wilkes-Barre/Scranton Penguins 1 at Binghamton Senators 2 | Final |
| October 19, 2012 | L | Wilkes-Barre/Scranton Penguins 2 at Springfield Falcons 4 | Final |
| October 20, 2012 | L | Bridgeport Sound Tigers 3 at Wilkes-Barre/Scranton Penguins 2 | Final |
| October 21, 2012 | L | Syracuse Crunch 3 at Wilkes-Barre/Scranton Penguins 1 | Final |
| October 26, 2012 | W | Rochester Americans 4 at Wilkes-Barre/Scranton Penguins 5 | Final (OT) |
| October 27, 2012 | W | Wilkes-Barre/Scranton Penguins 4 at Syracuse Crunch 1 | Final |
| October 28, 2012 | L | Wilkes-Barre/Scranton Penguins 2 at Hershey Bears 3 | Final |
| November 2, 2012 | W | Wilkes-Barre/Scranton Penguins 3 at Manchester Monarchs 0 | Final |
| November 4, 2012 | W | Wilkes-Barre/Scranton Penguins 5 at Bridgeport Sound Tigers 3 | Final |
| November 7, 2012 | W | Binghamton Senators 0 at Wilkes-Barre/Scranton Penguins 1 | Final (SO) |
| November 9, 2012 | L | Hershey Bears 3 at Wilkes-Barre/Scranton Penguins 1 | Final |
| November 10, 2012 | W | Portland Pirates 3 at Wilkes-Barre/Scranton Penguins 4 | Final (SO) |
| November 14, 2012 | W | Springfield Falcons 1 at Wilkes-Barre/Scranton Penguins 2 | Final |
| November 16, 2012 | W | Bridgeport Sound Tigers 1 at Wilkes-Barre/Scranton Penguins 3 | Final |
| November 17, 2012 | L | Wilkes-Barre/Scranton Penguins 1 at Hershey Bears 4 | Final |
| November 21, 2012 | W | Wilkes-Barre/Scranton Penguins 4 at Hershey Bears 0 | Final |
| November 24, 2012 | W | Toronto Marlies 1 at Wilkes-Barre/Scranton Penguins 2 | Final |
| November 25, 2012 | W | Wilkes-Barre/Scranton Penguins 5 at Albany Devils 4 (Atlantic City, NJ) | Final (SO) |
| November 30, 2012 | W | Syracuse Crunch 3 at Wilkes-Barre/Scranton Penguins 5 | Final |
| December 1, 2012 | W | St. John's IceCaps 3 at Wilkes-Barre/Scranton Penguins 5 | Final |
| December 7, 2012 | L | Hershey Bears 5 at Wilkes-Barre/Scranton Penguins 4 | Final (OT) |
| December 8, 2012 | L | Portland Pirates 4 at Wilkes-Barre/Scranton Penguins 3 | Final (SO) |
| December 12, 2012 | L | Wilkes-Barre/Scranton Penguins 3 at Albany Devils 6 | Final |
| December 14, 2012 | L | Binghamton Senators 3 at Wilkes-Barre/Scranton Penguins 1 | Final |
| December 15, 2012 | L | Wilkes-Barre/Scranton Penguins 0 at Syracuse Crunch 4 | Final |
| December 19, 2012 | L | Wilkes-Barre/Scranton Penguins 3 at Binghamton Senators 4 | Final |
| December 22, 2012 | W | Wilkes-Barre/Scranton Penguins 3 at Syracuse Crunch 2 | Final |
| December 26, 2012 | L | Wilkes-Barre/Scranton Penguins 0 at Hershey Bears 2 | Final |
| December 27, 2012 | L | Hershey Bears 4 at Wilkes-Barre/Scranton Penguins 1 | Final |
| December 29, 2012 | L | Norfolk Admirals 3 at Wilkes-Barre/Scranton Penguins 2 | Final (OT) |
| December 31, 2012 | L | Syracuse Crunch 2 at Wilkes-Barre/Scranton Penguins 1 | Final |
| January 4, 2013 | L | Wilkes-Barre/Scranton Penguins 1 at Binghamton Senators 3 | Final |
| January 5, 2013 | W | Worcester Sharks 0 at Wilkes-Barre/Scranton Penguins 3 | Final |
| January 6, 2013 | L | Wilkes-Barre/Scranton Penguins 0 at Connecticut Whale 2 | Final |
| January 9, 2013 | L | Binghamton Senators 3 at Wilkes-Barre/Scranton Penguins 1 | Final |
| January 11, 2013 | W | Hershey Bears 0 at Wilkes-Barre/Scranton Penguins 1 | Final |
| January 12, 2013 | W | Adirondack Phantoms 1 at Wilkes-Barre/Scranton Penguins 2 | Final |
| January 15, 2013 | W | Wilkes-Barre/Scranton Penguins 4 at Norfolk Admirals 2 | Final |
| January 20, 2013 | W | Wilkes-Barre/Scranton Penguins 2 at Hershey Bears 1 | Final (OT) |
| January 23, 2013 | W | St. John's IceCaps 0 at Wilkes-Barre/Scranton Penguins 3 | Final |
| January 25, 2013 | L | Wilkes-Barre/Scranton Penguins 2 at Rochester Americans 4 | Final |
| January 26, 2013 | W | Wilkes-Barre/Scranton Penguins 3 at Toronto Marlies 1 | Final |
| February 1, 2013 | W | Manchester Monarchs 1 at Wilkes-Barre/Scranton Penguins 4 | Final |
| February 2, 2013 | W | Adirondack Phantoms 0 at Wilkes-Barre/Scranton Penguins 3 | Final |
| February 3, 2013 | W | Wilkes-Barre/Scranton Penguins 2 at Hershey Bears 1 | Final |
| February 8, 2013 | L | Wilkes-Barre/Scranton Penguins 1 at Norfolk Admirals 4 | Final |
| February 9, 2013 | W | Wilkes-Barre/Scranton Penguins 4 at Norfolk Admirals 1 | Final |
| February 12, 2013 | L | Binghamton Senators 5 at Wilkes-Barre/Scranton Penguins 1 | Final |
| February 15, 2013 | L | Norfolk Admirals 1 at Wilkes-Barre/Scranton Penguins 0 | Final |
| February 16, 2013 | W | Wilkes-Barre/Scranton Penguins 5 at Binghamton Senators 2 | Final |
| February 17, 2013 | L | Syracuse Crunch 3 at Wilkes-Barre/Scranton Penguins 0 | Final |
| February 22, 2013 | W | Wilkes-Barre/Scranton Penguins 2 at Adirondack Phantoms 1 (Philadelphia) | Final |
| February 23, 2013 | W | Connecticut Whale 1 at Wilkes-Barre/Scranton Penguins 2 | Final (OT) |
| February 24, 2013 | W | Wilkes-Barre/Scranton Penguins 2 at Bridgeport Sound Tigers 1 | Final (SO) |
| February 27, 2013 | L | Norfolk Admirals 2 at Wilkes-Barre/Scranton Penguins 1 | Final |
| March 1, 2013 | L | Hershey Bears 3 at Wilkes-Barre/Scranton Penguins 2 | Final |
| March 2, 2013 | W | Albany Devils 1 at Wilkes-Barre/Scranton Penguins 2 | Final |
| March 8, 2013 | L | Wilkes-Barre/Scranton Penguins 0 at Providence Bruins 2 | Final |
| March 9, 2013 | W | Wilkes-Barre/Scranton Penguins 4 at Portland Pirates 3 | Final (OT) |
| March 10, 2013 | W | Wilkes-Barre/Scranton Penguins 5 at Manchester Monarchs 4 | Final (SO) |
| March 13, 2013 | L | Wilkes-Barre/Scranton Penguins 1 at Worcester Sharks 5 | Final |
| March 15, 2013 | W | Wilkes-Barre/Scranton Penguins 5 at Worcester Sharks 3 | Final |
| March 16, 2013 | W | Wilkes-Barre/Scranton Penguins 3 at Portland Pirates 2 | Final |
| March 20, 2013 | L | Wilkes-Barre/Scranton Penguins 0 at Syracuse Crunch 1 | Final |
| March 23, 2013 | L | Norfolk Admirals 4 at Wilkes-Barre/Scranton Penguins 1 | Final |
| March 27, 2013 | W | Binghamton Senators 2 at Wilkes-Barre/Scranton Penguins 4 | Final |
| March 29, 2013 | L | Providence Bruins 3 at Wilkes-Barre/Scranton Penguins 2 | Final (SO) |
| March 30, 2013 | W | Wilkes-Barre/Scranton Penguins 3 at Binghamton Senators 2 | Final (SO) |
| April 2, 2013 | W | Wilkes-Barre/Scranton Penguins 3 at Norfolk Admirals 2 | Final |
| April 5, 2013 | W | Wilkes-Barre/Scranton Penguins 3 at Adirondack Phantoms 2 | Final (OT) |
| April 6, 2013 | W | Albany Devils 0 at Wilkes-Barre/Scranton Penguins 4 | Final |
| April 7, 2013 | W | Hershey Bears 3 at Wilkes-Barre/Scranton Penguins 4 | Final |
| April 13, 2013 | W | Wilkes-Barre/Scranton Penguins 3 at St. John's IceCaps 0 | Final |
| April 14, 2013 | W | Wilkes-Barre/Scranton Penguins 5 at St. John's IceCaps 4 | Final (OT) |
| April 19, 2013 | L | Worcester Sharks 4 at Wilkes-Barre/Scranton Penguins 2 | Final |
| April 20, 2013 | L | Manchester Monarchs 3 at Wilkes-Barre/Scranton Penguins 1 | Final |
| April 27, 2013 | W | Wilkes-Barre/Scranton Penguins 3 at Binghamton Senators 2 (Playoff Gm. 1) | Final (OT) |
| April 28, 2013 | W | Wilkes-Barre/Scranton Penguins 3 at Binghamton Senators 2 (Playoff Gm. 2) | Final |
| May 2, 2013 | W | Binghamton Senators 2 at Wilkes-Barre/Scranton Penguins 3 (Playoff Gm. 3) | Final |
| May 10, 2013 | L | Wilkes-Barre/Scranton Penguins 5 at Providence Bruins 8 (Playoff Gm. 1) | Final |
| May 11, 2013 | L | Wilkes-Barre/Scranton Penguins 2 at Providence Bruins 4 (Playoff Gm. 2) | Final |
| May 15, 2013 | L | Providence Bruins 2 at Wilkes-Barre/Scranton Penguins 1 (Playoff Gm. 3) | Final (OT) |
| May 17, 2013 | W | Providence Bruins 1 at Wilkes-Barre/Scranton Penguins 3 (Playoff Gm. 4) | Final |
| May 18, 2013 | W | Providence Bruins 0 at Wilkes-Barre/Scranton Penguins 4 (Playoff Gm. 5) | Final |
| May 20, 2013 | W | Wilkes-Barre/Scranton Penguins 2 at Providence Bruins 1 (Playoff Gm. 6) | Final (OT) |
| May 22, 2013 | W | Wilkes-Barre/Scranton Penguins 5 at Providence Bruins 0 (Playoff Gm. 7) | Final |
| May 25, 2013 | | Wilkes-Barre/Scranton Penguins at Syracuse Crunch (Playoff Gm. 1) | 7:00 p.m. |
| May 26, 2013 | | Wilkes-Barre/Scranton Penguins at Syracuse Crunch (Playoff Gm. 2) | 7:00 p.m. |
| May 29, 2013 | | Syracuse Crunch at Wilkes-Barre/Scranton Penguins (Playoff Gm. 3) | 7:05 p.m. |
| May 31, 2013 | | Syracuse Crunch at Wilkes-Barre/Scranton Penguins (Playoff Gm. 4) | 7:05 p.m. |
| June 1, 2013 | | Wilkes-Barre/Scranton Penguins at Syracuse Crunch (Playoff Gm. 5, if nec.) | 7:00 p.m. |
| June 3, 2013 | | Syracuse Crunch at Wilkes-Barre/Scranton Penguins (Playoff Gm. 6, if nec.) | 7:05 p.m. |
| June 5, 2013 | | Wilkes-Barre/Scranton Penguins at Syracuse Crunch (Playoff Gm. 7, if nec.) | 7:00 p.m. |
