| | | |
| March 15, 2025 | T | NJ/NY Gotham FC 1 at Seattle Reign FC 1 | Final |
| March 22, 2025 | W | Seattle Reign FC 2 at North Carolina Courage 1 | Final |
| March 30, 2025 | L | Seattle Reign FC 1 at Angel City FC 2 | Final |
| April 12, 2025 | L | Orlando Pride 1 at Seattle Reign FC 0 | Final |
| April 18, 2025 | W | Portland Thorns FC 0 at Seattle Reign FC 1 | Final |
| April 26, 2025 | T | Seattle Reign FC 1 at Bay FC 1 | Final |
| May 2, 2025 | W | Kansas City Current 0 at Seattle Reign FC 1 | Final |
| May 11, 2025 | L | Houston Dash 1 at Seattle Reign FC 0 | Final |
| May 17, 2025 | W | Seattle Reign FC 1 at Racing Louisville FC 0 | Final |
| May 23, 2025 | L | Washington Spirit 2 at Seattle Reign FC 1 | Final |
| June 6, 2025 | W | Seattle Reign FC 2 at San Diego Wave FC 1 | Final |
| June 14, 2025 | T | Seattle Reign FC 2 at Chicago Stars FC 2 | Final |
| June 21, 2025 | W | Seattle Reign FC 4 at Utah Royals FC 1 | Final |
| August 1, 2025 | W | Angel City FC 0 at Seattle Reign FC 2 | Final |
| August 10, 2025 | L | Seattle Reign FC 2 at Portland Thorns FC 4 | Final |
| August 18, 2025 | T | Chicago Stars FC 3 at Seattle Reign FC 3 | Final |
| August 24, 2025 | T | Seattle Reign FC 1 at Houston Dash 1 | Final |
| August 29, 2025 | T | San Diego Wave FC 0 at Seattle Reign FC 0 | Final |
| September 7, 2025 | L | Seattle Reign FC 0 at Washington Spirit 2 | Final |
| September 14, 2025 | | Racing Louisville FC 0 at Seattle Reign FC 0 | Susp. |
| September 16, 2025 | W | Racing Louisville FC 0 at Seattle Reign FC 1 | Final |
| September 20, 2025 | L | Seattle Reign FC 0 at Kansas City Current 2 | Final |
| September 28, 2025 | W | North Carolina Courage 1 at Seattle Reign FC 2 | Final |
| October 5, 2025 | T | Seattle Reign FC 0 at NJ/NY Gotham FC 0 | Final |
| October 10, 2025 | T | Bay FC 1 at Seattle Reign FC 1 | Final |
| October 17, 2025 | W | Utah Royals FC 1 at Seattle Reign FC 2 | Final |
| November 2, 2025 | T | Seattle Reign FC 1 at Orlando Pride 1 | Final |
| November 7, 2025 | L | Seattle Reign FC 0 at Orlando Pride 2 (Playoff) | Final |
Seattle Reign FC Schedule
