| | | |
| March 16, 2025 | T | San Diego Wave FC 1 at Angel City FC 1 | Final |
| March 22, 2025 | W | Utah Royals FC 2 at San Diego Wave FC 3 | Final |
| March 29, 2025 | L | San Diego Wave FC 1 at Orlando Pride 2 | Final |
| April 12, 2025 | L | Kansas City Current 2 at San Diego Wave FC 0 | Final |
| April 19, 2025 | W | San Diego Wave FC 4 at Racing Louisville FC 1 | Final |
| April 26, 2025 | W | San Diego Wave FC 3 at Chicago Stars FC 0 | Final |
| May 4, 2025 | W | Bay FC 1 at San Diego Wave FC 2 | Final |
| May 10, 2025 | T | Portland Thorns FC 1 at San Diego Wave FC 1 | Final |
| May 16, 2025 | W | San Diego Wave FC 1 at NJ/NY Gotham FC 0 | Final |
| May 25, 2025 | W | North Carolina Courage 2 at San Diego Wave FC 5 | Final |
| June 6, 2025 | L | Seattle Reign FC 2 at San Diego Wave FC 1 | Final |
| June 13, 2025 | W | San Diego Wave FC 3 at Houston Dash 2 | Final |
| June 22, 2025 | T | Washington Spirit 0 at San Diego Wave FC 0 | Final |
| August 2, 2025 | T | San Diego Wave FC 0 at North Carolina Courage 0 | Final |
| August 9, 2025 | T | Angel City FC 1 at San Diego Wave FC 1 | Final |
| August 16, 2025 | W | San Diego Wave FC 2 at Bay FC 1 | Final |
| August 24, 2025 | L | Racing Louisville FC 1 at San Diego Wave FC 0 | Final |
| August 29, 2025 | | San Diego Wave FC at Seattle Reign FC | 10:30 p.m. |
| September 7, 2025 | | Houston Dash at San Diego Wave FC | 8:30 p.m. |
| September 12, 2025 | | NJ/NY Gotham FC at San Diego Wave FC | 10:00 p.m. |
| September 20, 2025 | | San Diego Wave FC at Portland Thorns FC | 10:00 p.m. |
| September 26, 2025 | | Orlando Pride at San Diego Wave FC | 10:30 p.m. |
| October 5, 2025 | | San Diego Wave FC at Washington Spirit | 1:00 p.m. |
| October 11, 2025 | | San Diego Wave FC at Utah Royals FC | 10:00 p.m. |
| October 18, 2025 | | Chicago Stars FC at San Diego Wave FC | 10:00 p.m. |
| November 2, 2025 | | San Diego Wave FC at Kansas City Current | TBD |
San Diego Wave FC Schedule
