| | | |
| November 29, 2025 | W | San Diego Seals 16 at Ottawa Black Bears 13 | Final |
| December 14, 2025 | L | Rochester Knighthawks 15 at San Diego Seals 7 | Final |
| January 3, 2026 | L | Calgary Roughnecks 15 at San Diego Seals 11 | Final |
| January 9, 2026 | L | Toronto Rock 12 at San Diego Seals 7 | Final |
| January 16, 2026 | W | San Diego Seals 11 at Vancouver Warriors 9 | Final |
| January 23, 2026 | W | San Diego Seals 9 at Philadelphia Wings 7 | Final |
| January 30, 2026 | W | Philadelphia Wings 7 at San Diego Seals 13 | Final |
| February 7, 2026 | L | Saskatchewan Rush 12 at San Diego Seals 9 | Final |
| February 14, 2026 | W | San Diego Seals 13 at Oshawa FireWolves 7 | Final |
| February 21, 2026 | W | Halifax Thunderbirds 8 at San Diego Seals 9 | Final |
| February 27, 2026 | L | San Diego Seals 12 at Colorado Mammoth 14 | Final |
| March 1, 2026 | L | Vancouver Warriors 9 at San Diego Seals 7 | Final |
| March 14, 2026 | L | San Diego Seals 9 at Saskatchewan Rush 10 | Final |
| March 21, 2026 | L | Buffalo Bandits 9 at San Diego Seals 8 | Final (OT) |
| April 4, 2026 | L | San Diego Seals 5 at Toronto Rock 7 | Final |
| April 12, 2026 | W | San Diego Seals 9 at Georgia Swarm 7 | Final |
| April 17, 2026 | W | Las Vegas Desert Dogs 12 at San Diego Seals 14 | Final |
| April 18, 2026 | L | San Diego Seals 16 at Las Vegas Desert Dogs 18 | Final |
| April 25, 2026 | W | San Diego Seals 13 at Colorado Mammoth 12 (Playoff) | Final |
San Diego Seals Schedule
