| | | |
| November 29, 2025 | W | San Diego Seals 16 at Ottawa Black Bears 13 | Final |
| December 14, 2025 | L | Rochester Knighthawks 15 at San Diego Seals 7 | Final |
| January 3, 2026 | L | Calgary Roughnecks 15 at San Diego Seals 11 | Final |
| January 9, 2026 | L | Toronto Rock 12 at San Diego Seals 7 | Final |
| January 16, 2026 | W | San Diego Seals 11 at Vancouver Warriors 9 | Final |
| January 23, 2026 | W | San Diego Seals 9 at Philadelphia Wings 7 | Final |
| January 30, 2026 | W | Philadelphia Wings 7 at San Diego Seals 13 | Final |
| February 7, 2026 | L | Saskatchewan Rush 12 at San Diego Seals 9 | Final |
| February 14, 2026 | W | San Diego Seals 13 at Oshawa FireWolves 7 | Final |
| February 21, 2026 | W | Halifax Thunderbirds 8 at San Diego Seals 9 | Final |
| February 27, 2026 | L | San Diego Seals 12 at Colorado Mammoth 14 | Final |
| March 1, 2026 | L | Vancouver Warriors 9 at San Diego Seals 7 | Final |
| March 14, 2026 | | San Diego Seals at Saskatchewan Rush | 9:00 p.m. |
| March 21, 2026 | | Buffalo Bandits at San Diego Seals | 10:00 p.m. |
| April 4, 2026 | | San Diego Seals at Toronto Rock | 7:00 p.m. |
| April 12, 2026 | | San Diego Seals at Georgia Swarm | 4:00 p.m. |
| April 17, 2026 | | Las Vegas Desert Dogs at San Diego Seals | 10:30 p.m. |
| April 18, 2026 | | San Diego Seals at Las Vegas Desert Dogs | 10:00 p.m. |
San Diego Seals Schedule
