| | | |
| December 14, 2025 | W | Rochester Knighthawks 15 at San Diego Seals 7 | Final |
| December 20, 2025 | W | Philadelphia Wings 11 at Rochester Knighthawks 15 | Final |
| January 3, 2026 | L | Rochester Knighthawks 13 at Colorado Mammoth 18 | Final |
| January 9, 2026 | W | Rochester Knighthawks 16 at Philadelphia Wings 13 | Final |
| January 10, 2026 | W | Buffalo Bandits 9 at Rochester Knighthawks 12 | Final |
| January 17, 2026 | L | Toronto Rock 11 at Rochester Knighthawks 10 | Final |
| January 31, 2026 | L | Vancouver Warriors 16 at Rochester Knighthawks 6 | Final |
| February 7, 2026 | L | Rochester Knighthawks 15 at Vancouver Warriors 16 | Final |
| February 14, 2026 | L | Ottawa Black Bears 10 at Rochester Knighthawks 8 | Final |
| February 28, 2026 | W | Saskatchewan Rush 12 at Rochester Knighthawks 13 | Final |
| March 8, 2026 | L | Calgary Roughnecks 14 at Rochester Knighthawks 7 | Final |
| March 15, 2026 | L | Rochester Knighthawks 10 at Las Vegas Desert Dogs 17 | Final |
| March 21, 2026 | L | Las Vegas Desert Dogs 17 at Rochester Knighthawks 13 | Final |
| March 28, 2026 | W | Rochester Knighthawks 18 at Oshawa FireWolves 11 | Final |
| April 4, 2026 | L | Rochester Knighthawks 10 at Halifax Thunderbirds 15 | Final |
| April 11, 2026 | L | Rochester Knighthawks 6 at Buffalo Bandits 12 | Final |
| April 18, 2026 | L | Rochester Knighthawks 6 at Georgia Swarm 13 | Final |
| April 19, 2026 | L | Georgia Swarm 17 at Rochester Knighthawks 12 | Final |
Rochester Knighthawks Schedule
