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| December 14, 2025 | | Rochester Knighthawks at San Diego Seals | 6:00 p.m. |
| December 20, 2025 | | Philadelphia Wings at Rochester Knighthawks | 7:00 p.m. |
| January 3, 2026 | | Rochester Knighthawks at Colorado Mammoth | 9:00 p.m. |
| January 9, 2026 | | Rochester Knighthawks at Philadelphia Wings | 7:00 p.m. |
| January 10, 2026 | | Buffalo Bandits at Rochester Knighthawks | 7:00 p.m. |
| January 17, 2026 | | Toronto Rock at Rochester Knighthawks | 7:00 p.m. |
| January 31, 2026 | | Vancouver Warriors at Rochester Knighthawks | 7:00 p.m. |
| February 7, 2026 | | Rochester Knighthawks at Vancouver Warriors | 10:00 p.m. |
| February 14, 2026 | | Ottawa Black Bears at Rochester Knighthawks | 7:00 p.m. |
| February 28, 2026 | | Saskatchewan Rush at Rochester Knighthawks | 7:00 p.m. |
| March 8, 2026 | | Calgary Roughnecks at Rochester Knighthawks | 1:00 p.m. |
| March 15, 2026 | | Rochester Knighthawks at Las Vegas Desert Dogs | 6:00 p.m. |
| March 21, 2026 | | Las Vegas Desert Dogs at Rochester Knighthawks | 7:00 p.m. |
| March 28, 2026 | | Rochester Knighthawks at Oshawa FireWolves | 7:00 p.m. |
| April 4, 2026 | | Rochester Knighthawks at Halifax Thunderbirds | 6:00 p.m. |
| April 11, 2026 | | Rochester Knighthawks at Buffalo Bandits | 7:00 p.m. |
| April 18, 2026 | | Rochester Knighthawks at Georgia Swarm | 4:00 p.m. |
| April 19, 2026 | | Georgia Swarm at Rochester Knighthawks | 3:00 p.m. |
Rochester Knighthawks Schedule
