| | | |
| October 11, 2024 | L | Belleville Senators 3 at Rochester Americans 2 | Final |
| October 12, 2024 | W | Rochester Americans 4 at Utica Comets 1 | Final |
| October 18, 2024 | L | Toronto Marlies 4 at Rochester Americans 2 | Final |
| October 19, 2024 | L | Rochester Americans 2 at Toronto Marlies 3 | Final |
| October 23, 2024 | W | Cleveland Monsters 1 at Rochester Americans 6 | Final |
| October 26, 2024 | W | Rochester Americans 5 at Cleveland Monsters 4 | Final (SO) |
| November 1, 2024 | W | Rochester Americans 8 at Utica Comets 1 | Final |
| November 2, 2024 | W | Rochester Americans 3 at Utica Comets 2 | Final (SO) |
| November 6, 2024 | W | Rochester Americans 4 at Cleveland Monsters 2 | Final |
| November 8, 2024 | W | Hartford Wolf Pack 3 at Rochester Americans 6 | Final |
| November 9, 2024 | L | Rochester Americans 0 at Wilkes-Barre/Scranton Penguins 5 | Final |
| November 13, 2024 | L | Laval Rocket 3 at Rochester Americans 2 | Final (OT) |
| November 16, 2024 | L | Laval Rocket 4 at Rochester Americans 1 | Final |
| November 17, 2024 | L | Rochester Americans 1 at Toronto Marlies 2 | Final (OT) |
| November 20, 2024 | W | Rochester Americans 2 at Laval Rocket 1 | Final (OT) |
| November 22, 2024 | L | Hershey Bears 4 at Rochester Americans 3 | Final (OT) |
| November 23, 2024 | L | Utica Comets 5 at Rochester Americans 1 | Final |
| November 27, 2024 | L | Cleveland Monsters 5 at Rochester Americans 4 | Final |
| November 29, 2024 | W | Syracuse Crunch 0 at Rochester Americans 3 | Final |
| November 30, 2024 | W | Rochester Americans 3 at Syracuse Crunch 2 | Final (SO) |
| December 4, 2024 | W | Utica Comets 2 at Rochester Americans 3 | Final |
| December 6, 2024 | L | Rochester Americans 0 at Charlotte Checkers 6 | Final |
| December 7, 2024 | W | Rochester Americans 3 at Charlotte Checkers 0 | Final |
| December 11, 2024 | W | Rochester Americans 3 at Laval Rocket 1 | Final |
| December 13, 2024 | W | Rochester Americans 7 at Belleville Senators 4 | Final |
| December 14, 2024 | W | Rochester Americans 8 at Belleville Senators 2 | Final |
| December 18, 2024 | L | Syracuse Crunch 5 at Rochester Americans 2 | Final |
| December 20, 2024 | W | Syracuse Crunch 1 at Rochester Americans 3 | Final |
| December 22, 2024 | W | Rochester Americans 3 at Cleveland Monsters 2 | Final |
| December 27, 2024 | W | Utica Comets 3 at Rochester Americans 6 | Final |
| December 28, 2024 | W | Rochester Americans 3 at Utica Comets 2 | Final (OT) |
| January 3, 2025 | W | Rochester Americans 5 at Springfield Thunderbirds 2 | Final |
| January 4, 2025 | W | Rochester Americans 6 at Bridgeport Islanders 3 | Final |
| January 10, 2025 | W | Utica Comets 1 at Rochester Americans 5 | Final |
| January 11, 2025 | L | Rochester Americans 2 at Syracuse Crunch 6 | Final |
| January 17, 2025 | L | Lehigh Valley Phantoms 3 at Rochester Americans 2 | Final (SO) |
| January 18, 2025 | W | Rochester Americans 3 at Lehigh Valley Phantoms 2 | Final |
| January 19, 2025 | L | Rochester Americans 4 at Hershey Bears 5 | Final |
| January 24, 2025 | L | Rochester Americans 0 at Providence Bruins 3 | Final |
| January 25, 2025 | W | Rochester Americans 6 at Hartford Wolf Pack 3 | Final |
| January 29, 2025 | W | Utica Comets 4 at Rochester Americans 7 | Final |
| January 31, 2025 | W | Syracuse Crunch 1 at Rochester Americans 4 | Final |
| February 1, 2025 | W | Rochester Americans 4 at Syracuse Crunch 3 | Final (OT) |
| February 7, 2025 | W | Belleville Senators 0 at Rochester Americans 4 | Final |
| February 11, 2025 | W | Rochester Americans 5 at Cleveland Monsters 1 | Final |
| February 14, 2025 | L | Syracuse Crunch 5 at Rochester Americans 1 | Final |
| February 15, 2025 | W | Rochester Americans 4 at Utica Comets 3 | Final (OT) |
| February 16, 2025 | L | Laval Rocket 5 at Rochester Americans 2 | Final |
| February 19, 2025 | W | Cleveland Monsters 0 at Rochester Americans 4 | Final |
| February 21, 2025 | W | Belleville Senators 3 at Rochester Americans 6 | Final |
| February 22, 2025 | W | Toronto Marlies 0 at Rochester Americans 1 | Final (SO) |
| February 26, 2025 | W | Wilkes-Barre/Scranton Penguins 2 at Rochester Americans 5 | Final |
| February 28, 2025 | L | Rochester Americans 2 at Utica Comets 3 | Final (SO) |
| March 1, 2025 | L | Rochester Americans 3 at Syracuse Crunch 4 | Final (SO) |
| March 7, 2025 | L | Rochester Americans 3 at Laval Rocket 4 | Final |
| March 8, 2025 | L | Rochester Americans 1 at Laval Rocket 2 | Final |
| March 12, 2025 | L | Charlotte Checkers 4 at Rochester Americans 3 | Final |
| March 14, 2025 | W | Providence Bruins 3 at Rochester Americans 4 | Final (SO) |
| March 21, 2025 | L | Charlotte Checkers 2 at Rochester Americans 1 | Final |
| March 22, 2025 | W | Rochester Americans 4 at Syracuse Crunch 1 | Final |
| March 23, 2025 | W | Utica Comets 3 at Rochester Americans 4 | Final |
| March 28, 2025 | W | Bridgeport Islanders 0 at Rochester Americans 6 | Final |
| March 29, 2025 | W | Rochester Americans 4 at Syracuse Crunch 2 | Final |
| March 30, 2025 | L | Syracuse Crunch 3 at Rochester Americans 2 | Final (OT) |
| April 2, 2025 | W | Springfield Thunderbirds 2 at Rochester Americans 4 | Final |
| April 4, 2025 | L | Rochester Americans 0 at Belleville Senators 5 | Final |
| April 5, 2025 | W | Rochester Americans 4 at Belleville Senators 0 | Final |
| April 9, 2025 | L | Belleville Senators 4 at Rochester Americans 2 | Final |
| April 11, 2025 | L | Laval Rocket 4 at Rochester Americans 2 | Final |
| April 16, 2025 | W | Cleveland Monsters 1 at Rochester Americans 4 | Final |
| April 18, 2025 | L | Toronto Marlies 3 at Rochester Americans 0 | Final |
| April 19, 2025 | L | Rochester Americans 2 at Toronto Marlies 3 | Final (OT) |
| April 25, 2025 | W | Syracuse Crunch 2 at Rochester Americans 3 (Playoff Gm. 1) | Final |
| April 27, 2025 | W | Syracuse Crunch 0 at Rochester Americans 4 (Playoff Gm. 2) | Final |
| May 1, 2025 | | Rochester Americans at Syracuse Crunch (Playoff Gm. 3) | 7:00 p.m. |
| May 3, 2025 | | Rochester Americans at Syracuse Crunch (Playoff Gm. 4, if nec.) | 7:00 p.m. |
| May 9, 2025 | | Syracuse Crunch at Rochester Americans (Playoff Gm. 5, if nec.) | 7:05 p.m. |
Rochester Americans Schedule
