| | | |
| March 15, 2025 | | Portland Thorns FC at Kansas City Current | 12:45 p.m. |
| March 21, 2025 | | Angel City FC at Portland Thorns FC | 10:00 p.m. |
| March 29, 2025 | | North Carolina Courage at Portland Thorns FC | 10:00 p.m. |
| April 11, 2025 | | Portland Thorns FC at Utah Royals FC | 10:00 p.m. |
| April 18, 2025 | | Portland Thorns FC at Seattle Reign FC | 10:00 p.m. |
| April 22, 2025 | | NJ/NY Gotham FC at Portland Thorns FC | 10:30 p.m. |
| April 27, 2025 | | Racing Louisville FC at Portland Thorns FC | 4:00 p.m. |
| May 3, 2025 | | Orlando Pride at Portland Thorns FC | 7:30 p.m. |
| May 10, 2025 | | Portland Thorns FC at San Diego Wave FC | 10:00 p.m. |
| May 16, 2025 | | Portland Thorns FC at Houston Dash | 8:00 p.m. |
| June 7, 2025 | | Portland Thorns FC at Bay FC | 7:30 p.m. |
| June 15, 2025 | | Washington Spirit at Portland Thorns FC | 4:00 p.m. |
| June 21, 2025 | | Chicago Stars FC at Portland Thorns FC | 10:00 p.m. |
| August 3, 2025 | | Portland Thorns FC at Washington Spirit | 12:30 p.m. |
| August 10, 2025 | | Seattle Reign FC at Portland Thorns FC | 4:00 p.m. |
| August 16, 2025 | | Portland Thorns FC at North Carolina Courage | 7:30 p.m. |
| August 23, 2025 | | Kansas City Current at Portland Thorns FC | 10:00 p.m. |
| August 29, 2025 | | Utah Royals FC at Portland Thorns FC | 10:30 p.m. |
| September 5, 2025 | | Portland Thorns FC at Racing Louisville FC | 8:00 p.m. |
| September 14, 2025 | | Portland Thorns FC at Chicago Stars FC | 3:00 p.m. |
| September 20, 2025 | | San Diego Wave FC at Portland Thorns FC | 10:00 p.m. |
| September 26, 2025 | | Portland Thorns FC at NJ/NY Gotham FC | 8:00 p.m. |
| October 4, 2025 | | Bay FC at Portland Thorns FC | 10:00 p.m. |
| October 10, 2025 | | Portland Thorns FC at Orlando Pride | 8:00 p.m. |
| October 19, 2025 | | Portland Thorns FC at Angel City FC | 5:00 p.m. |
| November 2, 2025 | | Houston Dash at Portland Thorns FC | TBD |
Portland Thorns FC Schedule
