| | | |
| March 14, 2025 | L | Chicago Stars FC 0 at Orlando Pride 6 | Final |
| March 23, 2025 | L | Houston Dash 2 at Chicago Stars FC 1 | Final |
| March 30, 2025 | L | Racing Louisville FC 1 at Chicago Stars FC 0 | Final |
| April 13, 2025 | W | Chicago Stars FC 2 at Bay FC 1 | Final |
| April 18, 2025 | L | Chicago Stars FC 0 at Utah Royals FC 1 | Final |
| April 26, 2025 | L | San Diego Wave FC 3 at Chicago Stars FC 0 | Final |
| May 4, 2025 | T | Chicago Stars FC 0 at NJ/NY Gotham FC 0 | Final |
| May 10, 2025 | L | Washington Spirit 3 at Chicago Stars FC 2 | Final |
| May 17, 2025 | L | Chicago Stars FC 0 at North Carolina Courage 2 | Final |
| May 24, 2025 | L | Kansas City Current 3 at Chicago Stars FC 1 | Final |
| June 7, 2025 | T | Chicago Stars FC 2 at Angel City FC 2 | Final |
| June 14, 2025 | T | Seattle Reign FC 2 at Chicago Stars FC 2 | Final |
| June 21, 2025 | | Chicago Stars FC at Portland Thorns FC | 10:00 p.m. |
| August 1, 2025 | | NJ/NY Gotham FC at Chicago Stars FC | 8:00 p.m. |
| August 10, 2025 | | Bay FC at Chicago Stars FC | 2:00 p.m. |
| August 18, 2025 | | Chicago Stars FC at Seattle Reign FC | 10:00 p.m. |
| August 22, 2025 | | North Carolina Courage at Chicago Stars FC | 8:00 p.m. |
| August 31, 2025 | | Chicago Stars FC at Washington Spirit | 4:00 p.m. |
| September 7, 2025 | | Orlando Pride at Chicago Stars FC | 3:00 p.m. |
| September 14, 2025 | | Portland Thorns FC at Chicago Stars FC | 3:00 p.m. |
| September 19, 2025 | | Chicago Stars FC at Houston Dash | 8:00 p.m. |
| September 26, 2025 | | Chicago Stars FC at Kansas City Current | 8:00 p.m. |
| October 5, 2025 | | Utah Royals FC at Chicago Stars FC | 4:00 p.m. |
| October 10, 2025 | | Chicago Stars FC at Racing Louisville FC | 7:30 p.m. |
| October 18, 2025 | | Chicago Stars FC at San Diego Wave FC | 10:00 p.m. |
| November 2, 2025 | | Angel City FC at Chicago Stars FC | TBD |
Chicago Stars FC Schedule
