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| March 14, 2026 | | Charlotte Independence at Westchester SC | 6:00 p.m. |
| March 27, 2026 | | Spokane Velocity FC at Charlotte Independence | 6:00 p.m. |
| April 3, 2026 | | Charlotte Independence at New York Cosmos | 6:00 p.m. |
| April 12, 2026 | | South Georgia Tormenta FC at Charlotte Independence | 6:00 p.m. |
| April 18, 2026 | | Charlotte Independence at One Knoxville SC | 6:00 p.m. |
| April 25, 2026 | | Charlotte Independence at Richmond Kickers (USL Cup) | 5:00 p.m. |
| May 2, 2026 | | Charlotte Independence at Fort Wayne FC | 6:30 p.m. |
| May 6, 2026 | | Athletic Club Boise at Charlotte Independence | 6:00 p.m. |
| May 9, 2026 | | Charlotte Independence at Corpus Christi FC | 7:30 p.m. |
| May 15, 2026 | | Pittsburgh Riverhounds SC at Charlotte Independence (USL Cup) | 6:00 p.m. |
| May 23, 2026 | | Forward Madison FC at Charlotte Independence | 6:00 p.m. |
| May 30, 2026 | | Charlotte Independence at Chattanooga Red Wolves SC | 6:00 p.m. |
| June 3, 2026 | | Charlotte Independence at FC Naples | 6:30 p.m. |
| June 10, 2026 | | Union Omaha at Charlotte Independence | 6:00 p.m. |
| June 13, 2026 | | FC Naples at Charlotte Independence | 6:00 p.m. |
| June 20, 2026 | | Charlotte Independence at South Georgia Tormenta FC | 6:30 p.m. |
| June 24, 2026 | | Greenville Triumph SC at Charlotte Independence (USL Cup) | 6:00 p.m. |
| July 1, 2026 | | Corpus Christi FC at Charlotte Independence | 6:00 p.m. |
| July 5, 2026 | | Charlotte Independence at AV Alta FC | 10:00 p.m. |
| July 11, 2026 | | Charlotte Independence at Charleston Battery (USL Cup) | 6:30 p.m. |
| July 18, 2026 | | Chattanooga Red Wolves SC at Charlotte Independence | 6:00 p.m. |
| July 22, 2026 | | Charlotte Independence at Spokane Velocity FC | 8:00 p.m. |
| July 25, 2026 | | Richmond Kickers at Charlotte Independence | 6:00 p.m. |
| August 1, 2026 | | One Knoxville SC at Charlotte Independence | 6:00 p.m. |
| August 8, 2026 | | Greenville Triumph SC at Charlotte Independence | 6:00 p.m. |
| August 15, 2026 | | Sarasota Paradise at Charlotte Independence | 6:00 p.m. |
| August 22, 2026 | | Charlotte Independence at Forward Madison FC | 7:00 p.m. |
| August 29, 2026 | | AV Alta FC at Charlotte Independence | 6:00 p.m. |
| September 2, 2026 | | Portland Hearts of Pine at Charlotte Independence | 6:00 p.m. |
| September 5, 2026 | | Charlotte Independence at Union Omaha | #VALUE! |
| September 12, 2026 | | Westchester SC at Charlotte Independence | 6:00 p.m. |
| September 16, 2026 | | Charlotte Independence at Athletic Club Boise | 8:00 p.m. |
| September 19, 2026 | | Charlotte Independence at Richmond Kickers | 5:00 p.m. |
| September 26, 2026 | | Fort Wayne FC at Charlotte Independence | 6:00 p.m. |
| October 3, 2026 | | Charlotte Independence at Sarasota Paradise | 6:30 p.m. |
| October 10, 2026 | | New York Cosmos at Charlotte Independence | 6:00 p.m. |
| October 17, 2026 | | Charlotte Independence at Greenville Triumph SC | 6:00 p.m. |
| October 24, 2026 | | Charlotte Independence at Portland Hearts of Pine | 4:00 p.m. |
Charlotte Independence Schedule
