| | | |
| March 15, 2025 | W | Richmond Kickers 0 at Charlotte Independence 1 | Final |
| March 28, 2025 | T | Chattanooga Red Wolves SC 0 at Charlotte Independence 0 | Final |
| April 5, 2025 | L | Charlotte Independence 0 at Greenville Triumph SC 1 | Final |
| April 11, 2025 | T | Forward Madison FC 1 at Charlotte Independence 1 | Final |
| April 20, 2025 | W | South Georgia Tormenta FC 2 at Charlotte Independence 3 | Final |
| April 25, 2025 | W | Charlotte Independence 2 at North Carolina FC 1 (Jagermeister Cup) | Final |
| May 3, 2025 | W | Charlotte Independence 4 at Texoma FC 3 | Final |
| May 10, 2025 | W | Charlotte Independence 3 at Westchester SC 2 | Final |
| May 16, 2025 | W | One Knoxville SC 1 at Charlotte Independence 3 | Final |
| May 24, 2025 | L | Charlotte Independence 1 at AV Alta FC 2 | Final |
| May 31, 2025 | T | Lexington Sporting Club 2 at Charlotte Independence 2 (Jagermeister Cup) | Final |
| June 7, 2025 | W | Charlotte Independence 2 at South Georgia Tormenta FC 0 | Final |
| June 11, 2025 | T | Charlotte Independence 1 at Spokane Velocity FC 1 | Final |
| June 15, 2025 | W | Greenville Triumph SC 0 at Charlotte Independence 1 | Final |
| June 21, 2025 | L | Charlotte Independence 2 at Texoma FC 3 | Final |
| June 28, 2025 | T | Charlotte Independence 1 at Loudoun United FC 1 (Jagermeister Cup) | Final |
| July 12, 2025 | L | Union Omaha 2 at Charlotte Independence 1 | Final |
| July 16, 2025 | T | Charlotte Independence 1 at Forward Madison FC 1 | Final |
| July 19, 2025 | T | Portland Hearts of Pine 1 at Charlotte Independence 1 | Final |
| July 26, 2025 | W | Richmond Kickers 0 at Charlotte Independence 3 (Jagermeister Cup) | Final |
| July 30, 2025 | T | Charlotte Independence 2 at One Knoxville SC 2 | Final |
| August 2, 2025 | T | Texoma FC 3 at Charlotte Independence 3 | Final |
| August 9, 2025 | L | Greenville Triumph SC 5 at Charlotte Independence 4 | Final |
| August 15, 2025 | W | Westchester SC 0 at Charlotte Independence 1 | Final |
| August 20, 2025 | L | Charlotte Independence 1 at Union Omaha 4 | Final |
| August 30, 2025 | L | Charlotte Independence 2 at Portland Hearts of Pine 4 | Final |
| September 6, 2025 | L | Charlotte Independence 0 at Chattanooga Red Wolves SC 1 | Final |
| September 12, 2025 | L | FC Naples 1 at Charlotte Independence 0 | Final |
| September 20, 2025 | W | Charlotte Independence 3 at Richmond Kickers 2 | Final |
| September 26, 2025 | L | Charlotte Independence 0 at One Knoxville SC 1 | Final |
| October 3, 2025 | L | Spokane Velocity FC 1 at Charlotte Independence 0 | Final |
| October 10, 2025 | W | AV Alta FC 2 at Charlotte Independence 3 | Final |
| October 17, 2025 | L | Chattanooga Red Wolves SC 2 at Charlotte Independence 1 | Final |
| October 25, 2025 | L | Charlotte Independence 0 at FC Naples 2 | Final |
| November 2, 2025 | L | Charlotte Independence 1 at One Knoxville SC 2 (Playoff) | Final |
Charlotte Independence Schedule
