| | | |
| March 15, 2025 | W | Richmond Kickers 0 at Charlotte Independence 1 | Final |
| March 28, 2025 | T | Chattanooga Red Wolves SC 0 at Charlotte Independence 0 | Final |
| April 5, 2025 | L | Charlotte Independence 0 at Greenville Triumph SC 1 | Final |
| April 11, 2025 | T | Forward Madison FC 1 at Charlotte Independence 1 | Final |
| April 20, 2025 | W | South Georgia Tormenta FC 2 at Charlotte Independence 3 | Final |
| April 25, 2025 | W | Charlotte Independence 2 at North Carolina FC 1 (Jagermeister Cup) | Final |
| May 2, 2025 | | Charlotte Independence at Texoma FC | 8:00 p.m. |
| May 10, 2025 | | Charlotte Independence at Westchester SC | 4:00 p.m. |
| May 16, 2025 | | One Knoxville SC at Charlotte Independence | 7:00 p.m. |
| May 24, 2025 | | Charlotte Independence at AV Alta FC | 10:30 p.m. |
| May 31, 2025 | | Lexington Sporting Club at Charlotte Independence | 7:00 p.m. |
| June 7, 2025 | | Charlotte Independence at South Georgia Tormenta FC | 7:30 p.m. |
| June 11, 2025 | | Charlotte Independence at Spokane Velocity FC | 10:00 p.m. |
| June 15, 2025 | | Greenville Triumph SC at Charlotte Independence | 7:00 p.m. |
| June 21, 2025 | | Charlotte Independence at Texoma FC | 8:30 p.m. |
| June 28, 2025 | | Charlotte Independence at Loudoun United FC | 6:00 p.m. |
| July 12, 2025 | | Union Omaha at Charlotte Independence | 7:00 p.m. |
| July 16, 2025 | | Charlotte Independence at Forward Madison FC | 8:00 p.m. |
| July 19, 2025 | | Portland Hearts of Pine at Charlotte Independence | 7:00 p.m. |
| July 26, 2025 | | Richmond Kickers at Charlotte Independence | 7:00 p.m. |
| July 30, 2025 | | Charlotte Independence at One Knoxville SC | 7:00 p.m. |
| August 2, 2025 | | Texoma FC at Charlotte Independence | 7:00 p.m. |
| August 9, 2025 | | Greenville Triumph SC at Charlotte Independence | 7:00 p.m. |
| August 15, 2025 | | Westchester SC at Charlotte Independence | 7:00 p.m. |
| August 20, 2025 | | Charlotte Independence at Union Omaha | 8:00 p.m. |
| August 30, 2025 | | Charlotte Independence at Portland Hearts of Pine | 6:00 p.m. |
| September 6, 2025 | | Charlotte Independence at Chattanooga Red Wolves SC | 7:00 p.m. |
| September 12, 2025 | | FC Naples at Charlotte Independence | 7:00 p.m. |
| September 20, 2025 | | Charlotte Independence at Richmond Kickers | 6:00 p.m. |
| September 26, 2025 | | Charlotte Independence at One Knoxville SC | 6:30 p.m. |
| October 3, 2025 | | Spokane Velocity FC at Charlotte Independence | 7:00 p.m. |
| October 10, 2025 | | AV Alta FC at Charlotte Independence | 7:00 p.m. |
| October 17, 2025 | | Chattanooga Red Wolves SC at Charlotte Independence | 7:00 p.m. |
| October 25, 2025 | | Charlotte Independence at FC Naples | 7:00 p.m. |
Charlotte Independence Schedule
