| | | |
| March 28, 2025 | W | Omaha Storm Chasers 3 at Iowa Cubs 6 | Final |
| March 29, 2025 | L | Omaha Storm Chasers 12 at Iowa Cubs 7 | Final |
| March 30, 2025 | | Omaha Storm Chasers at Iowa Cubs | Ppd. |
| April 1, 2025 | W | Iowa Cubs 2 at Indianapolis Indians 1 | Final |
| April 2, 2025 | | Iowa Cubs at Indianapolis Indians | Ppd. |
| April 3, 2025 | L | Iowa Cubs 6 at Indianapolis Indians 7 | Final (8) |
| April 3, 2025 | W | Iowa Cubs 6 at Indianapolis Indians 1 | Final (7) |
| April 4, 2025 | | Iowa Cubs at Indianapolis Indians | Susp. |
| April 5, 2025 | | Iowa Cubs at Indianapolis Indians (Game 2) | Cancelled |
| April 5, 2025 | | Iowa Cubs at Indianapolis Indians (Game 1) | Susp. |
| April 6, 2025 | L | Iowa Cubs 4 at Indianapolis Indians 5 (Game 1) | Final (10) |
| April 6, 2025 | W | Iowa Cubs 4 at Indianapolis Indians 1 (Game 2) | Final |
| April 8, 2025 | W | Iowa Cubs 14 at Toledo Mud Hens 1 | Final |
| April 9, 2025 | | Iowa Cubs at Toledo Mud Hens | Ppd. |
| April 10, 2025 | L | Iowa Cubs 0 at Toledo Mud Hens 1 | Final |
| April 11, 2025 | L | Iowa Cubs 3 at Toledo Mud Hens 7 | Final |
| April 12, 2025 | W | Iowa Cubs 3 at Toledo Mud Hens 1 (Game 1) | Final (7) |
| April 12, 2025 | W | Iowa Cubs 4 at Toledo Mud Hens 2 (Game 2) | Final |
| April 13, 2025 | W | Iowa Cubs 2 at Toledo Mud Hens 0 | Final |
| April 15, 2025 | L | St. Paul Saints 2 at Iowa Cubs 1 | Final |
| April 16, 2025 | W | St. Paul Saints 6 at Iowa Cubs 20 | Final |
| April 17, 2025 | W | St. Paul Saints 2 at Iowa Cubs 6 | Final |
| April 18, 2025 | L | St. Paul Saints 11 at Iowa Cubs 8 | Final |
| April 19, 2025 | W | St. Paul Saints 0 at Iowa Cubs 1 | Final |
| April 20, 2025 | | St. Paul Saints at Iowa Cubs | Ppd. |
| April 22, 2025 | L | Iowa Cubs 4 at Louisville Bats 8 | Final |
| April 23, 2025 | L | Iowa Cubs 0 at Louisville Bats 1 | Final (11) |
| April 24, 2025 | | Iowa Cubs at Louisville Bats | Ppd. |
| April 25, 2025 | | Iowa Cubs at Louisville Bats (Game 1) | Ppd. |
| April 25, 2025 | | Iowa Cubs at Louisville Bats (Game 2) | Ppd. |
| April 26, 2025 | W | Iowa Cubs 4 at Louisville Bats 2 (Game 1) | Final (7) |
| April 26, 2025 | L | Iowa Cubs 2 at Louisville Bats 5 (Game 2) | Final (7) |
| April 27, 2025 | W | Iowa Cubs 6 at Louisville Bats 4 | Final |
| April 29, 2025 | W | Buffalo Bisons 1 at Iowa Cubs 9 | Final |
| April 30, 2025 | L | Buffalo Bisons 10 at Iowa Cubs 8 | Final |
| May 1, 2025 | L | Buffalo Bisons 8 at Iowa Cubs 1 | Final |
| May 2, 2025 | W | Buffalo Bisons 2 at Iowa Cubs 4 | Final |
| May 3, 2025 | W | Buffalo Bisons 2 at Iowa Cubs 10 | Final |
| May 4, 2025 | L | Buffalo Bisons 3 at Iowa Cubs 1 | Final |
| May 6, 2025 | L | Iowa Cubs 4 at Toledo Mud Hens 5 | Final (10) |
| May 7, 2025 | L | Iowa Cubs 1 at Toledo Mud Hens 2 | Final |
| May 8, 2025 | W | Iowa Cubs 12 at Toledo Mud Hens 0 | Final |
| May 9, 2025 | L | Iowa Cubs 3 at Toledo Mud Hens 7 | Final |
| May 10, 2025 | W | Iowa Cubs 7 at Toledo Mud Hens 6 | Final (10) |
| May 11, 2025 | W | Iowa Cubs 3 at Toledo Mud Hens 1 | Final |
| May 13, 2025 | L | St. Paul Saints 6 at Iowa Cubs 4 | Final |
| May 14, 2025 | W | St. Paul Saints 5 at Iowa Cubs 10 | Final |
| May 15, 2025 | W | St. Paul Saints 2 at Iowa Cubs 8 (Game 1) | Final (7) |
| May 15, 2025 | W | St. Paul Saints 7 at Iowa Cubs 8 (Game 2) | Final (8) |
| May 16, 2025 | W | St. Paul Saints 7 at Iowa Cubs 12 | Final |
| May 17, 2025 | W | St. Paul Saints 9 at Iowa Cubs 10 | Final |
| May 18, 2025 | L | St. Paul Saints 3 at Iowa Cubs 1 | Final |
| May 20, 2025 | L | Iowa Cubs 2 at Columbus Clippers 3 | Final |
| May 21, 2025 | L | Iowa Cubs 5 at Columbus Clippers 14 | Final |
| May 22, 2025 | W | Iowa Cubs 10 at Columbus Clippers 2 | Final |
| May 23, 2025 | W | Iowa Cubs 7 at Columbus Clippers 5 | Final |
| May 24, 2025 | L | Iowa Cubs 1 at Columbus Clippers 5 | Final |
| May 25, 2025 | W | Iowa Cubs 9 at Columbus Clippers 3 | Final |
| May 27, 2025 | | Syracuse Mets at Iowa Cubs | Ppd. |
| May 28, 2025 | L | Syracuse Mets 3 at Iowa Cubs 2 (Game 1) | Final (7) |
| May 28, 2025 | L | Syracuse Mets 4 at Iowa Cubs 2 (Game 2) | Final (7) |
| May 29, 2025 | L | Syracuse Mets 12 at Iowa Cubs 3 | Final |
| May 30, 2025 | W | Syracuse Mets 5 at Iowa Cubs 8 | Final |
| May 31, 2025 | L | Syracuse Mets 6 at Iowa Cubs 4 | Final |
| June 1, 2025 | L | Syracuse Mets 5 at Iowa Cubs 4 | Final |
| June 3, 2025 | | Iowa Cubs at Omaha Storm Chasers | Ppd. |
| June 4, 2025 | W | Omaha Storm Chasers 0 at Iowa Cubs 1 (Game 1) | Final (7) |
| June 4, 2025 | W | Iowa Cubs 4 at Omaha Storm Chasers 0 (Game 2) | Final (7) |
| June 5, 2025 | W | Iowa Cubs 8 at Omaha Storm Chasers 5 | Final |
| June 6, 2025 | W | Iowa Cubs 5 at Omaha Storm Chasers 3 (Game 1) | Final (7) |
| June 6, 2025 | L | Iowa Cubs 5 at Omaha Storm Chasers 9 (Game 2) | Final (7) |
| June 7, 2025 | L | Iowa Cubs 5 at Omaha Storm Chasers 6 | Final |
| June 8, 2025 | W | Iowa Cubs 7 at Omaha Storm Chasers 3 | Final |
| June 10, 2025 | L | Louisville Bats 8 at Iowa Cubs 5 | Final |
| June 11, 2025 | W | Louisville Bats 4 at Iowa Cubs 7 | Final |
| June 12, 2025 | W | Iowa Cubs 10 at Louisville Bats 2 | Final (7) |
| June 12, 2025 | W | Louisville Bats 4 at Iowa Cubs 5 | Final |
| June 13, 2025 | L | Louisville Bats 9 at Iowa Cubs 6 | Final |
| June 14, 2025 | L | Louisville Bats 14 at Iowa Cubs 2 | Final |
| June 15, 2025 | | Louisville Bats at Iowa Cubs | 2:08 p.m. |
| June 17, 2025 | | Iowa Cubs at Nashville Sounds | 7:35 p.m. |
| June 18, 2025 | | Iowa Cubs at Nashville Sounds | 7:35 p.m. |
| June 19, 2025 | | Iowa Cubs at Nashville Sounds | 7:35 p.m. |
| June 20, 2025 | | Iowa Cubs at Nashville Sounds | 7:35 p.m. |
| June 21, 2025 | | Iowa Cubs at Nashville Sounds | 7:35 p.m. |
| June 22, 2025 | | Iowa Cubs at Nashville Sounds | 3:05 p.m. |
| June 24, 2025 | | Columbus Clippers at Iowa Cubs | 7:38 p.m. |
| June 25, 2025 | | Columbus Clippers at Iowa Cubs | 1:08 p.m. |
| June 26, 2025 | | Columbus Clippers at Iowa Cubs | 7:38 p.m. |
| June 27, 2025 | | Columbus Clippers at Iowa Cubs | 8:08 p.m. |
| June 28, 2025 | | Columbus Clippers at Iowa Cubs | 7:08 p.m. |
| June 29, 2025 | | Columbus Clippers at Iowa Cubs | 2:08 p.m. |
| July 1, 2025 | | Omaha Storm Chasers at Iowa Cubs | 7:38 p.m. |
| July 2, 2025 | | Omaha Storm Chasers at Iowa Cubs | 1:08 p.m. |
| July 3, 2025 | | Omaha Storm Chasers at Iowa Cubs | 8:08 p.m. |
| July 4, 2025 | | Iowa Cubs at Omaha Storm Chasers | 8:05 p.m. |
| July 5, 2025 | | Iowa Cubs at Omaha Storm Chasers | 7:05 p.m. |
| July 6, 2025 | | Iowa Cubs at Omaha Storm Chasers | 6:05 p.m. |
| July 8, 2025 | | Iowa Cubs at St. Paul Saints | 8:07 p.m. |
| July 9, 2025 | | Iowa Cubs at St. Paul Saints | 8:07 p.m. |
| July 10, 2025 | | Iowa Cubs at St. Paul Saints | 8:07 p.m. |
| July 11, 2025 | | Iowa Cubs at St. Paul Saints | 8:07 p.m. |
| July 12, 2025 | | Iowa Cubs at St. Paul Saints | 7:37 p.m. |
| July 13, 2025 | | Iowa Cubs at St. Paul Saints | 3:07 p.m. |
| July 18, 2025 | | Columbus Clippers at Iowa Cubs | 8:08 p.m. |
| July 19, 2025 | | Columbus Clippers at Iowa Cubs | 7:08 p.m. |
| July 20, 2025 | | Columbus Clippers at Iowa Cubs | 2:08 p.m. |
| July 22, 2025 | | Iowa Cubs at Louisville Bats | 6:35 p.m. |
| July 23, 2025 | | Iowa Cubs at Louisville Bats | 6:35 p.m. |
| July 24, 2025 | | Iowa Cubs at Louisville Bats | 6:35 p.m. |
| July 25, 2025 | | Iowa Cubs at Louisville Bats | 7:15 p.m. |
| July 26, 2025 | | Iowa Cubs at Louisville Bats | 7:15 p.m. |
| July 27, 2025 | | Iowa Cubs at Louisville Bats | 1:05 p.m. |
| July 29, 2025 | | Indianapolis Indians at Iowa Cubs | 7:38 p.m. |
| July 30, 2025 | | Indianapolis Indians at Iowa Cubs | 1:08 p.m. |
| July 31, 2025 | | Indianapolis Indians at Iowa Cubs | 7:38 p.m. |
| August 1, 2025 | | Indianapolis Indians at Iowa Cubs | 8:08 p.m. |
| August 2, 2025 | | Indianapolis Indians at Iowa Cubs | 7:08 p.m. |
| August 3, 2025 | | Indianapolis Indians at Iowa Cubs | 2:08 p.m. |
| August 5, 2025 | | Iowa Cubs at St. Paul Saints | 8:07 p.m. |
| August 6, 2025 | | Iowa Cubs at St. Paul Saints | 2:07 p.m. |
| August 7, 2025 | | Iowa Cubs at St. Paul Saints | 8:07 p.m. |
| August 8, 2025 | | Iowa Cubs at St. Paul Saints | 8:07 p.m. |
| August 9, 2025 | | Iowa Cubs at St. Paul Saints | 7:37 p.m. |
| August 10, 2025 | | Iowa Cubs at St. Paul Saints | 3:07 p.m. |
| August 12, 2025 | | Worcester Red Sox at Iowa Cubs | 7:38 p.m. |
| August 13, 2025 | | Worcester Red Sox at Iowa Cubs | 1:08 p.m. |
| August 14, 2025 | | Worcester Red Sox at Iowa Cubs | 7:38 p.m. |
| August 15, 2025 | | Worcester Red Sox at Iowa Cubs | 8:08 p.m. |
| August 16, 2025 | | Worcester Red Sox at Iowa Cubs | 7:08 p.m. |
| August 17, 2025 | | Worcester Red Sox at Iowa Cubs | 2:08 p.m. |
| August 19, 2025 | | Sugar Land Space Cowboys at Iowa Cubs | 7:38 p.m. |
| August 20, 2025 | | Sugar Land Space Cowboys at Iowa Cubs | 1:08 p.m. |
| August 21, 2025 | | Sugar Land Space Cowboys at Iowa Cubs | 7:38 p.m. |
| August 22, 2025 | | Sugar Land Space Cowboys at Iowa Cubs | 8:08 p.m. |
| August 23, 2025 | | Sugar Land Space Cowboys at Iowa Cubs | 7:08 p.m. |
| August 24, 2025 | | Sugar Land Space Cowboys at Iowa Cubs | 2:08 p.m. |
| August 26, 2025 | | Iowa Cubs at Las Vegas Aviators | 10:05 p.m. |
| August 27, 2025 | | Iowa Cubs at Las Vegas Aviators | 10:05 p.m. |
| August 28, 2025 | | Iowa Cubs at Las Vegas Aviators | 10:05 p.m. |
| August 29, 2025 | | Iowa Cubs at Las Vegas Aviators | 10:05 p.m. |
| August 30, 2025 | | Iowa Cubs at Las Vegas Aviators | 10:05 p.m. |
| August 31, 2025 | | Iowa Cubs at Las Vegas Aviators | 9:05 p.m. |
| September 2, 2025 | | Omaha Storm Chasers at Iowa Cubs | 7:38 p.m. |
| September 3, 2025 | | Omaha Storm Chasers at Iowa Cubs | 1:08 p.m. |
| September 4, 2025 | | Omaha Storm Chasers at Iowa Cubs | 1:08 p.m. |
| September 5, 2025 | | Omaha Storm Chasers at Iowa Cubs | 8:08 p.m. |
| September 6, 2025 | | Omaha Storm Chasers at Iowa Cubs | 7:08 p.m. |
| September 7, 2025 | | Omaha Storm Chasers at Iowa Cubs | 2:08 p.m. |
| September 9, 2025 | | Iowa Cubs at Indianapolis Indians | 6:35 p.m. |
| September 10, 2025 | | Iowa Cubs at Indianapolis Indians | 1:35 p.m. |
| September 11, 2025 | | Iowa Cubs at Indianapolis Indians | 6:35 p.m. |
| September 12, 2025 | | Iowa Cubs at Indianapolis Indians | 7:05 p.m. |
| September 13, 2025 | | Iowa Cubs at Indianapolis Indians | 6:35 p.m. |
| September 14, 2025 | | Iowa Cubs at Indianapolis Indians | 1:35 p.m. |
| September 16, 2025 | | Toledo Mud Hens at Iowa Cubs | 7:38 p.m. |
| September 17, 2025 | | Toledo Mud Hens at Iowa Cubs | 1:08 p.m. |
| September 18, 2025 | | Toledo Mud Hens at Iowa Cubs | 7:38 p.m. |
| September 19, 2025 | | Toledo Mud Hens at Iowa Cubs | 8:08 p.m. |
| September 20, 2025 | | Toledo Mud Hens at Iowa Cubs | 7:08 p.m. |
| September 21, 2025 | | Toledo Mud Hens at Iowa Cubs | 2:08 p.m. |
Iowa Cubs Schedule
