| | | |
| February 22, 2025 | T | New England Revolution 0 at Nashville SC 0 | Final |
| March 1, 2025 | L | Columbus Crew SC 1 at New England Revolution 0 | Final |
| March 8, 2025 | L | Philadelphia Union 2 at New England Revolution 0 | Final |
| March 15, 2025 | L | New England Revolution 1 at New York City FC 2 | Final |
| March 29, 2025 | W | New York Red Bulls 1 at New England Revolution 2 | Final |
| April 5, 2025 | L | New England Revolution 0 at FC Cincinnati 1 | Final |
| April 12, 2025 | W | New England Revolution 1 at Atlanta United FC 0 | Final |
| April 19, 2025 | W | New York City FC 0 at New England Revolution 2 | Final |
| April 26, 2025 | W | New England Revolution 1 at Charlotte FC 0 | Final |
| May 3, 2025 | W | New England Revolution 2 at Toronto FC 0 | Final |
| May 10, 2025 | T | New England Revolution 3 at Orlando City SC 3 | Final |
| May 17, 2025 | T | San Jose Earthquakes 0 at New England Revolution 0 | Final |
| May 24, 2025 | T | New England Revolution 3 at Sporting Kansas City 3 | Final |
| May 28, 2025 | T | New England Revolution 1 at D.C. United 1 | Final |
| May 31, 2025 | W | New England Revolution 3 at Club de Foot Montreal 0 | Final |
| June 14, 2025 | L | FC Cincinnati 1 at New England Revolution 0 | Final |
| June 25, 2025 | | Nashville SC at New England Revolution | 7:30 p.m. |
| June 28, 2025 | | Colorado Rapids at New England Revolution | 7:30 p.m. |
| July 5, 2025 | | New England Revolution at Portland Timbers | 10:30 p.m. |
| July 9, 2025 | | Inter Miami CF at New England Revolution | 7:30 p.m. |
| July 12, 2025 | | New England Revolution at Austin FC | 8:30 p.m. |
| July 16, 2025 | | New England Revolution at New York Red Bulls | 7:30 p.m. |
| July 19, 2025 | | Orlando City SC at New England Revolution | 7:30 p.m. |
| July 25, 2025 | | Club de Foot Montreal at New England Revolution | 7:30 p.m. |
| August 9, 2025 | | D.C. United at New England Revolution | 7:30 p.m. |
| August 16, 2025 | | Los Angeles FC at New England Revolution | 7:30 p.m. |
| August 23, 2025 | | New England Revolution at Columbus Crew SC | 7:30 p.m. |
| August 30, 2025 | | Charlotte FC at New England Revolution | 7:30 p.m. |
| September 6, 2025 | | New England Revolution at Chicago Fire FC | 8:30 p.m. |
| September 13, 2025 | | Toronto FC at New England Revolution | 7:30 p.m. |
| September 20, 2025 | | New England Revolution at Philadelphia Union | 2:30 p.m. |
| September 27, 2025 | | Atlanta United FC at New England Revolution | 7:30 p.m. |
| October 4, 2025 | | New England Revolution at Inter Miami CF | 7:30 p.m. |
| October 18, 2025 | | Chicago Fire FC at New England Revolution | 6:00 p.m. |
New England Revolution Schedule
