| | | |
| March 26, 2022 | L | Vancouver Whitecaps FC 2 0 at Houston Dynamo 2 1 | Final |
| April 2, 2022 | T | Vancouver Whitecaps FC 2 2 at Real Monarchs 2 | Final (PK 3-1) |
| April 10, 2022 | T | Portland Timbers 2 2 at Vancouver Whitecaps FC 2 2 | Final (PK 4-1) |
| April 17, 2022 | W | Vancouver Whitecaps FC 2 2 at Tacoma Defiance 1 | Final |
| April 24, 2022 | W | Sporting Kansas City II 1 at Vancouver Whitecaps FC 2 4 | Final |
| April 30, 2022 | W | Earthquakes II 0 at Vancouver Whitecaps FC 2 2 | Final |
| May 7, 2022 | W | Vancouver Whitecaps FC 2 2 at St. Louis City SC 2 1 | Final |
| May 14, 2022 | L | Vancouver Whitecaps FC 2 0 at North Texas SC 1 | Final |
| May 21, 2022 | | Minnesota United FC 2 at Vancouver Whitecaps FC 2 | 6:00 p.m. |
| May 29, 2022 | | Vancouver Whitecaps FC 2 at Sporting Kansas City II | 2:00 p.m. |
| June 5, 2022 | | Real Monarchs at Vancouver Whitecaps FC 2 | 8:00 p.m. |
| June 12, 2022 | | Tacoma Defiance at Vancouver Whitecaps FC 2 | 5:00 p.m. |
| June 17, 2022 | | North Texas SC at Vancouver Whitecaps FC 2 | 10:00 p.m. |
| June 24, 2022 | | Earthquakes II at Vancouver Whitecaps FC 2 | 10:00 p.m. |
| July 2, 2022 | | Vancouver Whitecaps FC 2 at Minnesota United FC 2 | 8:00 p.m. |
| July 16, 2022 | | Vancouver Whitecaps FC 2 at Portland Timbers 2 | 10:00 p.m. |
| July 24, 2022 | | Vancouver Whitecaps FC 2 at Colorado Rapids 2 | 8:00 p.m. |
| July 29, 2022 | | Houston Dynamo 2 at Vancouver Whitecaps FC 2 | 10:00 p.m. |
| August 5, 2022 | | Vancouver Whitecaps FC 2 at Real Monarchs | 8:30 p.m. |
| August 14, 2022 | | St. Louis City SC 2 at Vancouver Whitecaps FC 2 | 5:00 p.m. |
| August 18, 2022 | | Vancouver Whitecaps FC 2 at Portland Timbers 2 | 10:00 p.m. |
| August 25, 2022 | | Colorado Rapids 2 at Vancouver Whitecaps FC 2 | 10:00 p.m. |
| September 5, 2022 | | Vancouver Whitecaps FC 2 at Earthquakes II | 9:00 p.m. |
| September 9, 2022 | | Tacoma Defiance at Vancouver Whitecaps FC 2 | 10:00 p.m. |
Vancouver Whitecaps FC 2 Schedule
