| | | |
| November 3, 2017 | L | Rio Grande Valley Vipers 109 at Oklahoma City Blue 112 | Final |
| November 6, 2017 | L | Wisconsin Herd 115 at Rio Grande Valley Vipers 113 | Final |
| November 8, 2017 | L | Austin Spurs 111 at Rio Grande Valley Vipers 104 | Final |
| November 10, 2017 | W | Rio Grande Valley Vipers 138 at Memphis Hustle 136 | Final |
| November 14, 2017 | W | Northern Arizona Suns 127 at Rio Grande Valley Vipers 128 | Final |
| November 17, 2017 | W | Rio Grande Valley Vipers 130 at Sioux Falls Skyforce 108 | Final |
| November 18, 2017 | W | Rio Grande Valley Vipers 134 at Sioux Falls Skyforce 100 | Final |
| November 21, 2017 | W | Memphis Hustle 124 at Rio Grande Valley Vipers 138 | Final |
| November 24, 2017 | W | Rio Grande Valley Vipers 139 at Santa Cruz Warriors 121 | Final |
| November 25, 2017 | W | Rio Grande Valley Vipers 114 at Reno Bighorns 100 | Final |
| November 27, 2017 | W | Rio Grande Valley Vipers 117 at Salt Lake City Stars 104 | Final |
| November 29, 2017 | W | Texas Legends 126 at Rio Grande Valley Vipers 130 | Final |
| December 2, 2017 | W | Rio Grande Valley Vipers 118 at Maine Red Claws 110 | Final |
| December 5, 2017 | W | Rio Grande Valley Vipers 117 at Raptors 905 109 | Final |
| December 6, 2017 | W | Rio Grande Valley Vipers 111 at Long Island Nets 94 | Final |
| December 8, 2017 | W | Rio Grande Valley Vipers 122 at Windy City Bulls 112 | Final |
| December 12, 2017 | L | Agua Caliente Clippers 110 at Rio Grande Valley Vipers 109 | Final |
| December 14, 2017 | W | Agua Caliente Clippers 112 at Rio Grande Valley Vipers 117 | Final |
| December 15, 2017 | L | Rio Grande Valley Vipers 95 at Austin Spurs 111 | Final |
| December 19, 2017 | L | Canton Charge 109 at Rio Grande Valley Vipers 107 | Final |
| December 21, 2017 | W | Texas Legends 129 at Rio Grande Valley Vipers 137 | Final |
| December 26, 2017 | L | Rio Grande Valley Vipers 112 at Santa Cruz Warriors 115 | Final |
| December 30, 2017 | L | Reno Bighorns 152 at Rio Grande Valley Vipers 130 | Final |
| January 2, 2018 | L | Northern Arizona Suns 113 at Rio Grande Valley Vipers 108 | Final |
| January 4, 2018 | W | South Bay Lakers 118 at Rio Grande Valley Vipers 124 | Final |
| January 6, 2018 | W | Memphis Hustle 134 at Rio Grande Valley Vipers 157 | Final |
| January 10, 2018 | W | Rio Grande Valley Vipers 127 at Westchester Knicks 114 | Final |
| January 12, 2018 | L | Erie BayHawks 130 at Rio Grande Valley Vipers 115 | Final |
| January 19, 2018 | L | South Bay Lakers 117 at Rio Grande Valley Vipers 114 | Final |
| January 20, 2018 | L | Rio Grande Valley Vipers 141 at Texas Legends 144 | Final |
| January 24, 2018 | W | Rio Grande Valley Vipers 124 at Iowa Wolves 114 | Final |
| January 26, 2018 | L | Grand Rapids Drive 129 at Rio Grande Valley Vipers 101 | Final |
| January 27, 2018 | L | Sioux Falls Skyforce 147 at Rio Grande Valley Vipers 133 | Final |
| January 31, 2018 | L | Rio Grande Valley Vipers 125 at Memphis Hustle 127 | Final |
| February 2, 2018 | W | Rio Grande Valley Vipers 109 at Reno Bighorns 99 | Final |
| February 3, 2018 | L | Rio Grande Valley Vipers 114 at Salt Lake City Stars 115 | Final |
| February 6, 2018 | L | Rio Grande Valley Vipers 117 at Northern Arizona Suns 123 | Final |
| February 9, 2018 | W | Iowa Wolves 101 at Rio Grande Valley Vipers 119 | Final |
| February 10, 2018 | W | Austin Spurs 98 at Rio Grande Valley Vipers 109 | Final |
| February 13, 2018 | W | Oklahoma City Blue 121 at Rio Grande Valley Vipers 132 | Final |
| February 23, 2018 | W | Rio Grande Valley Vipers 117 at Iowa Wolves 111 | Final |
| March 2, 2018 | L | Rio Grande Valley Vipers 112 at Austin Spurs 123 | Final |
| March 6, 2018 | W | Fort Wayne Mad Ants 116 at Rio Grande Valley Vipers 119 | Final |
| March 8, 2018 | L | Rio Grande Valley Vipers 105 at Agua Caliente Clippers 113 | Final |
| March 10, 2018 | L | Rio Grande Valley Vipers 114 at South Bay Lakers 137 | Final |
| March 15, 2018 | W | Santa Cruz Warriors 129 at Rio Grande Valley Vipers 134 | Final |
| March 19, 2018 | W | Salt Lake City Stars 131 at Rio Grande Valley Vipers 132 | Final |
| March 21, 2018 | W | Salt Lake City Stars 105 at Rio Grande Valley Vipers 119 | Final |
| March 23, 2018 | W | Rio Grande Valley Vipers 115 at Texas Legends 104 | Final |
| March 24, 2018 | L | Oklahoma City Blue 114 at Rio Grande Valley Vipers 99 | Final |
| March 30, 2018 | W | Texas Legends 100 at Rio Grande Valley Vipers 107 (Playoff) | Final |
| April 2, 2018 | L | Rio Grande Valley Vipers 91 at Austin Spurs 117 (Playoff) | Final |
Rio Grande Valley Vipers Schedule
