| | | |
| November 9, 2024 | W | Memphis Hustle 97 at Rio Grande Valley Vipers 103 | Final |
| November 12, 2024 | W | Austin Spurs 109 at Rio Grande Valley Vipers 124 | Final |
| November 14, 2024 | L | Birmingham Squadron 121 at Rio Grande Valley Vipers 95 | Final |
| November 15, 2024 | W | Birmingham Squadron 79 at Rio Grande Valley Vipers 117 | Final |
| November 22, 2024 | L | Rio Grande Valley Vipers 97 at Oklahoma City Blue 104 | Final |
| November 24, 2024 | L | Rio Grande Valley Vipers 105 at Mexico City Capitanes 119 | Final |
| November 26, 2024 | W | Rio Grande Valley Vipers 143 at Mexico City Capitanes 99 | Final |
| November 30, 2024 | L | Oklahoma City Blue 124 at Rio Grande Valley Vipers 104 | Final |
| December 2, 2024 | W | Oklahoma City Blue 124 at Rio Grande Valley Vipers 128 | Final |
| December 6, 2024 | L | Rio Grande Valley Vipers 107 at Texas Legends 129 | Final |
| December 7, 2024 | W | Rio Grande Valley Vipers 139 at Texas Legends 105 | Final |
| December 10, 2024 | L | Austin Spurs 124 at Rio Grande Valley Vipers 112 | Final |
| December 12, 2024 | W | Rio Grande Valley Vipers 116 at Osceola Magic 110 | Final |
| December 14, 2024 | L | Rio Grande Valley Vipers 111 at Osceola Magic 122 | Final |
| December 19, 2024 | W | Raptors 905 103 at Rio Grande Valley Vipers 120 (Orlando) | Final |
| December 20, 2024 | L | Rio Grande Valley Vipers 115 at Indiana Mad Ants 127 (Orlando) | Final |
| December 27, 2024 | L | Santa Cruz Warriors 115 at Rio Grande Valley Vipers 109 | Final |
| December 28, 2024 | L | Santa Cruz Warriors 106 at Rio Grande Valley Vipers 103 | Final |
| January 1, 2025 | L | Rio Grande Valley Vipers 117 at Salt Lake City Stars 121 | Final |
| January 3, 2025 | W | Rio Grande Valley Vipers 132 at Salt Lake City Stars 116 | Final |
| January 7, 2025 | L | Oklahoma City Blue 130 at Rio Grande Valley Vipers 125 | Final |
| January 9, 2025 | W | Oklahoma City Blue 118 at Rio Grande Valley Vipers 130 | Final |
| January 11, 2025 | W | Iowa Wolves 113 at Rio Grande Valley Vipers 132 | Final |
| January 17, 2025 | L | Rio Grande Valley Vipers 110 at Austin Spurs 133 | Final |
| January 20, 2025 | L | Rio Grande Valley Vipers 81 at Austin Spurs 136 | Final |
| January 25, 2025 | W | Mexico City Capitanes 109 at Rio Grande Valley Vipers 113 | Final |
| January 31, 2025 | W | Sioux Falls Skyforce 96 at Rio Grande Valley Vipers 114 | Final |
| February 1, 2025 | L | Cleveland Charge 110 at Rio Grande Valley Vipers 104 | Final |
| February 3, 2025 | W | Cleveland Charge 114 at Rio Grande Valley Vipers 124 | Final |
| February 7, 2025 | W | Rio Grande Valley Vipers 110 at Rip City Remix 103 | Final |
| February 8, 2025 | W | Rio Grande Valley Vipers 125 at Rip City Remix 98 | Final |
| February 10, 2025 | W | Mexico City Capitanes 110 at Rio Grande Valley Vipers 115 | Final |
| February 13, 2025 | L | Rio Grande Valley Vipers 123 at Valley Suns 137 | Final |
| February 20, 2025 | W | Rio Grande Valley Vipers 134 at Memphis Hustle 110 | Final |
| February 22, 2025 | L | Rio Grande Valley Vipers 120 at Memphis Hustle 136 | Final |
| February 26, 2025 | L | Rio Grande Valley Vipers 121 at Delaware Blue Coats 124 | Final (OT) |
| February 28, 2025 | W | Rio Grande Valley Vipers 100 at College Park Skyhawks 87 | Final |
| March 2, 2025 | W | Rio Grande Valley Vipers 126 at College Park Skyhawks 108 | Final |
| March 4, 2025 | W | Sioux Falls Skyforce 119 at Rio Grande Valley Vipers 124 | Final |
| March 6, 2025 | W | Texas Legends 118 at Rio Grande Valley Vipers 140 | Final |
| March 8, 2025 | W | Texas Legends 104 at Rio Grande Valley Vipers 115 | Final |
| March 11, 2025 | L | Rio Grande Valley Vipers 118 at Valley Suns 123 | Final |
| March 13, 2025 | L | Rio Grande Valley Vipers 100 at South Bay Lakers 107 | Final |
| March 15, 2025 | L | Rio Grande Valley Vipers 108 at South Bay Lakers 109 | Final |
| March 18, 2025 | W | Rio Grande Valley Vipers 121 at San Diego Clippers 108 | Final |
| March 20, 2025 | W | Rio Grande Valley Vipers 109 at San Diego Clippers 95 | Final |
| March 22, 2025 | W | Iowa Wolves 115 at Rio Grande Valley Vipers 133 | Final |
| March 25, 2025 | W | Birmingham Squadron 114 at Rio Grande Valley Vipers 119 | Final |
| March 28, 2025 | W | Stockton Kings 102 at Rio Grande Valley Vipers 113 | Final |
| March 29, 2025 | L | Stockton Kings 111 at Rio Grande Valley Vipers 107 | Final |
| April 1, 2025 | L | Rio Grande Valley Vipers 102 at Salt Lake City Stars 129 (Playoff) | Final |
Rio Grande Valley Vipers Schedule
