| | | |
| November 5, 2021 | W | Austin Spurs 117 at Rio Grande Valley Vipers 127 | Final |
| November 10, 2021 | W | Rio Grande Valley Vipers 123 at Greensboro Swarm 101 | Final |
| November 13, 2021 | W | Rio Grande Valley Vipers 111 at Greensboro Swarm 104 | Final |
| November 20, 2021 | W | Rio Grande Valley Vipers 112 at Mexico City Capitanes 104 | Final |
| November 22, 2021 | W | Rio Grande Valley Vipers 125 at Mexico City Capitanes 123 | Final |
| November 24, 2021 | W | Austin Spurs 99 at Rio Grande Valley Vipers 134 | Final |
| November 26, 2021 | W | Birmingham Squadron 105 at Rio Grande Valley Vipers 112 | Final |
| November 28, 2021 | W | Birmingham Squadron 89 at Rio Grande Valley Vipers 101 | Final |
| December 7, 2021 | L | Rio Grande Valley Vipers 92 at Memphis Hustle 116 | Final |
| December 9, 2021 | L | Rio Grande Valley Vipers 117 at Memphis Hustle 121 | Final |
| December 13, 2021 | L | Texas Legends 129 at Rio Grande Valley Vipers 122 | Final |
| December 15, 2021 | W | Texas Legends 90 at Rio Grande Valley Vipers 128 | Final |
| December 19, 2021 | L | Oklahoma City Blue 119 at Rio Grande Valley Vipers 113 (Las Vegas) | Final |
| December 21, 2021 | W | Rio Grande Valley Vipers 105 at Maine Celtics 98 (Las Vegas) | Final |
| December 30, 2021 | | Memphis Hustle at Rio Grande Valley Vipers | Ppd. |
| January 1, 2022 | | Rio Grande Valley Vipers at Iowa Wolves | Ppd. |
| January 3, 2022 | | Rio Grande Valley Vipers at Iowa Wolves | Ppd. |
| January 8, 2022 | W | Rio Grande Valley Vipers 122 at Texas Legends 105 | Final |
| January 13, 2022 | L | Rio Grande Valley Vipers 121 at South Bay Lakers 130 | Final |
| January 15, 2022 | L | Rio Grande Valley Vipers 115 at Agua Caliente Clippers of Ontario 117 | Final |
| January 17, 2022 | L | Rio Grande Valley Vipers 124 at Austin Spurs 127 | Final |
| January 19, 2022 | W | Austin Spurs 100 at Rio Grande Valley Vipers 112 | Final |
| January 21, 2022 | W | Salt Lake City Stars 93 at Rio Grande Valley Vipers 130 | Final |
| January 22, 2022 | W | Salt Lake City Stars 122 at Rio Grande Valley Vipers 146 | Final |
| January 25, 2022 | W | Santa Cruz Warriors 110 at Rio Grande Valley Vipers 134 | Final |
| January 27, 2022 | W | Santa Cruz Warriors 111 at Rio Grande Valley Vipers 126 | Final |
| January 29, 2022 | L | Birmingham Squadron 117 at Rio Grande Valley Vipers 116 | Final |
| February 1, 2022 | W | Rio Grande Valley Vipers 111 at Salt Lake City Stars 109 | Final |
| February 4, 2022 | W | Rio Grande Valley Vipers 127 at Santa Cruz Warriors 115 | Final |
| February 8, 2022 | W | Rio Grande Valley Vipers 121 at Stockton Kings 103 | Final |
| February 10, 2022 | W | Rio Grande Valley Vipers 139 at Austin Spurs 127 | Final |
| February 12, 2022 | W | Rio Grande Valley Vipers 140 at Birmingham Squadron 120 | Final |
| February 15, 2022 | L | Rio Grande Valley Vipers 119 at Sioux Falls Skyforce 130 | Final |
| February 17, 2022 | W | Rio Grande Valley Vipers 127 at Sioux Falls Skyforce 117 | Final |
| February 23, 2022 | W | Rio Grande Valley Vipers 141 at Texas Legends 95 | Final |
| February 25, 2022 | W | Oklahoma City Blue 118 at Rio Grande Valley Vipers 126 | Final |
| February 26, 2022 | W | Texas Legends 110 at Rio Grande Valley Vipers 137 | Final |
| March 3, 2022 | W | South Bay Lakers 111 at Rio Grande Valley Vipers 115 | Final |
| March 4, 2022 | L | South Bay Lakers 126 at Rio Grande Valley Vipers 100 | Final |
| March 8, 2022 | W | Rio Grande Valley Vipers 117 at Oklahoma City Blue 107 | Final |
| March 10, 2022 | W | Rio Grande Valley Vipers 140 at Oklahoma City Blue 135 | Final |
| March 11, 2022 | W | Iowa Wolves 106 at Rio Grande Valley Vipers 124 | Final |
| March 14, 2022 | W | Rio Grande Valley Vipers 135 at Birmingham Squadron 114 | Final |
| March 17, 2022 | W | Sioux Falls Skyforce 89 at Rio Grande Valley Vipers 125 | Final |
| March 19, 2022 | L | Memphis Hustle 139 at Rio Grande Valley Vipers 131 | Final |
| March 21, 2022 | L | Memphis Hustle 128 at Rio Grande Valley Vipers 126 | Final |
| March 25, 2022 | W | Stockton Kings 100 at Rio Grande Valley Vipers 110 | Final |
| March 26, 2022 | W | Stockton Kings 99 at Rio Grande Valley Vipers 114 | Final |
| March 28, 2022 | W | Rio Grande Valley Vipers 128 at Memphis Hustle 115 | Final |
| March 30, 2022 | L | Agua Caliente Clippers of Ontario 112 at Rio Grande Valley Vipers 105 | Final |
| April 2, 2022 | L | Agua Caliente Clippers of Ontario 130 at Rio Grande Valley Vipers 128 | Final |
| April 7, 2022 | W | Texas Legends 103 at Rio Grande Valley Vipers 120 (Playoff) | Final |
| April 9, 2022 | W | Agua Caliente Clippers of Ontario 114 at Rio Grande Valley Vipers 125 (Playoff) | Final |
| April 12, 2022 | W | Delaware Blue Coats 128 at Rio Grande Valley Vipers 145 (Champ. Gm. 1) | Final |
| April 14, 2022 | W | Rio Grande Valley Vipers 131 at Delaware Blue Coats 114 (Champ. Gm. 2) | Final |
Rio Grande Valley Vipers Schedule
