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| November 7, 2025 | | Oklahoma City Blue at Rio Grande Valley Vipers | 8:00 p.m. |
| November 13, 2025 | | Texas Legends at Rio Grande Valley Vipers | 8:00 p.m. |
| November 15, 2025 | | Texas Legends at Rio Grande Valley Vipers | 8:00 p.m. |
| November 19, 2025 | | Rio Grande Valley Vipers at Memphis Hustle | 11:30 a.m. |
| November 21, 2025 | | Rio Grande Valley Vipers at Memphis Hustle | 8:00 p.m. |
| November 23, 2025 | | Rio Grande Valley Vipers at Austin Spurs | 4:00 p.m. |
| November 24, 2025 | | Rio Grande Valley Vipers at Austin Spurs | 8:00 p.m. |
| November 29, 2025 | | Osceola Magic at Rio Grande Valley Vipers | 8:00 p.m. |
| December 1, 2025 | | Osceola Magic at Rio Grande Valley Vipers | 8:00 p.m. |
| December 4, 2025 | | Mexico City Capitanes at Rio Grande Valley Vipers | 8:00 p.m. |
| December 6, 2025 | | Mexico City Capitanes at Rio Grande Valley Vipers | 8:00 p.m. |
| December 12, 2025 | | Rio Grande Valley Vipers at Oklahoma City Blue | 8:00 p.m. |
| December 14, 2025 | | Rio Grande Valley Vipers at Birmingham Squadron | 4:00 p.m. |
| December 16, 2025 | | Rio Grande Valley Vipers at Birmingham Squadron | 8:00 p.m. |
| December 31, 2025 | | Rio Grande Valley Vipers at Sioux Falls Skyforce | 7:30 p.m. |
| January 3, 2026 | | Valley Suns at Rio Grande Valley Vipers | 8:00 p.m. |
| January 5, 2026 | | Rio Grande Valley Vipers at Stockton Kings | 10:00 p.m. |
| January 7, 2026 | | Rio Grande Valley Vipers at Stockton Kings | 10:00 p.m. |
| January 9, 2026 | | Greensboro Swarm at Rio Grande Valley Vipers | 8:00 p.m. |
| January 10, 2026 | | Greensboro Swarm at Rio Grande Valley Vipers | 8:00 p.m. |
| January 13, 2026 | | Rio Grande Valley Vipers at Mexico City Capitanes | 9:00 p.m. |
| January 14, 2026 | | Rio Grande Valley Vipers at Mexico City Capitanes | 9:00 p.m. |
| January 17, 2026 | | South Bay Lakers at Rio Grande Valley Vipers | 8:00 p.m. |
| January 20, 2026 | | South Bay Lakers at Rio Grande Valley Vipers | 8:00 p.m. |
| January 22, 2026 | | Rip City Remix at Rio Grande Valley Vipers | 8:00 p.m. |
| January 24, 2026 | | Rip City Remix at Rio Grande Valley Vipers | 8:00 p.m. |
| January 26, 2026 | | Rio Grande Valley Vipers at Iowa Wolves | 7:30 p.m. |
| February 1, 2026 | | Rio Grande Valley Vipers at Oklahoma City Blue | 3:00 p.m. |
| February 4, 2026 | | Valley Suns at Rio Grande Valley Vipers | 12:00 p.m. |
| February 7, 2026 | | Austin Spurs at Rio Grande Valley Vipers | 8:00 p.m. |
| February 12, 2026 | | Rio Grande Valley Vipers at Texas Legends | 8:00 p.m. |
| February 19, 2026 | | Rio Grande Valley Vipers at Sioux Falls Skyforce | 7:30 p.m. |
| February 22, 2026 | | Rio Grande Valley Vipers at Iowa Wolves | 4:00 p.m. |
| February 24, 2026 | | San Diego Clippers at Rio Grande Valley Vipers | 8:00 p.m. |
| February 25, 2026 | | San Diego Clippers at Rio Grande Valley Vipers | 8:00 p.m. |
| February 27, 2026 | | Noblesville Boom at Rio Grande Valley Vipers | 8:00 p.m. |
| March 4, 2026 | | Rio Grande Valley Vipers at Raptors 905 | 11:00 a.m. |
| March 6, 2026 | | Rio Grande Valley Vipers at Raptors 905 | 7:30 p.m. |
| March 8, 2026 | | Rio Grande Valley Vipers at Windy City Bulls | 2:00 p.m. |
| March 10, 2026 | | Austin Spurs at Rio Grande Valley Vipers | 8:00 p.m. |
| March 13, 2026 | | Salt Lake City Stars at Rio Grande Valley Vipers | 8:00 p.m. |
| March 14, 2026 | | Salt Lake City Stars at Rio Grande Valley Vipers | 8:00 p.m. |
| March 17, 2026 | | Rio Grande Valley Vipers at Texas Legends | 8:00 p.m. |
| March 19, 2026 | | Rio Grande Valley Vipers at Santa Cruz Warriors | 10:00 p.m. |
| March 21, 2026 | | Rio Grande Valley Vipers at Santa Cruz Warriors | 10:00 p.m. |
| March 24, 2026 | | Rio Grande Valley Vipers at Oklahoma City Blue | 8:00 p.m. |
| March 26, 2026 | | Memphis Hustle at Rio Grande Valley Vipers | 8:00 p.m. |
| March 28, 2026 | | Memphis Hustle at Rio Grande Valley Vipers | 8:00 p.m. |
Rio Grande Valley Vipers Schedule
