| | | |
| March 12, 2022 | W | Monterey Bay FC 2 at Phoenix Rising FC 4 | Final |
| March 19, 2022 | L | Phoenix Rising FC 1 at Las Vegas Lights FC 2 | Final |
| March 26, 2022 | L | San Diego Loyal 3 at Phoenix Rising FC 2 | Final |
| April 2, 2022 | W | Phoenix Rising FC 2 at San Antonio FC 0 | Final |
| April 9, 2022 | W | LA Galaxy II 1 at Phoenix Rising FC 3 | Final |
| April 16, 2022 | W | New Mexico United 0 at Phoenix Rising FC 1 | Final |
| April 23, 2022 | W | Miami FC 1 at Phoenix Rising FC 2 | Final |
| May 1, 2022 | L | Phoenix Rising FC 0 at LA Galaxy II 3 | Final |
| May 7, 2022 | W | San Antonio FC 0 at Phoenix Rising FC 3 | Final |
| May 15, 2022 | L | Tampa Bay Rowdies 5 at Phoenix Rising FC 1 | Final |
| May 21, 2022 | | Phoenix Rising FC at New Mexico United | Ppd. |
| May 24, 2022 | L | Phoenix Rising FC 0 at New Mexico United 7 | Final |
| May 28, 2022 | | Phoenix Rising FC at Hartford Athletic | 7:00 p.m. |
| June 4, 2022 | | Birmingham Legion FC at Phoenix Rising FC | 10:30 p.m. |
| June 11, 2022 | | El Paso Locomotive FC at Phoenix Rising FC | 10:30 p.m. |
| June 18, 2022 | | Phoenix Rising FC at Loudoun United FC | 7:30 p.m. |
| June 24, 2022 | | Phoenix Rising FC at Las Vegas Lights FC | 10:30 p.m. |
| July 2, 2022 | | Orange County SC at Phoenix Rising FC | 10:30 p.m. |
| July 9, 2022 | | Phoenix Rising FC at Memphis 901 FC | 8:30 p.m. |
| July 20, 2022 | | Phoenix Rising FC at Louisville City FC | 7:00 p.m. |
| July 23, 2022 | | Sacramento Republic FC at Phoenix Rising FC | 10:30 p.m. |
| July 27, 2022 | | Phoenix Rising FC at Oakland Roots | 10:00 p.m. |
| July 30, 2022 | | Colorado Springs Switchbacks FC at Phoenix Rising FC | 10:30 p.m. |
| August 6, 2022 | | Las Vegas Lights FC at Phoenix Rising FC | 10:30 p.m. |
| August 12, 2022 | | Phoenix Rising FC at Orange County SC | 10:00 p.m. |
| August 27, 2022 | | Phoenix Rising FC at El Paso Locomotive FC | 9:30 p.m. |
| August 31, 2022 | | Rio Grande Valley FC Toros at Phoenix Rising FC | 10:30 p.m. |
| September 3, 2022 | | Phoenix Rising FC at Colorado Springs Switchbacks FC | 9:00 p.m. |
| September 10, 2022 | | Oakland Roots at Phoenix Rising FC | 10:30 p.m. |
| September 17, 2022 | | Phoenix Rising FC at San Diego Loyal | 10:00 p.m. |
| September 21, 2022 | | Phoenix Rising FC at Monterey Bay FC | 10:30 p.m. |
| September 28, 2022 | | Phoenix Rising FC at Sacramento Republic FC | 10:00 p.m. |
| October 1, 2022 | | New York Red Bulls II at Phoenix Rising FC | 10:30 p.m. |
| October 8, 2022 | | Phoenix Rising FC at Rio Grande Valley FC Toros | 8:30 p.m. |
| October 15, 2022 | | Atlanta United 2 at Phoenix Rising FC | 10:30 p.m. |
Phoenix Rising FC Schedule
